Bacterial vaginosis is conducive to the persistence of HPV infection

Guo, Y-l; You, K; Qiao, J; Zhao, Y-m; Geng, L

doi:10.1258/ijsa.2012.011342

Cited by 116Cervical Cancer and HPV ResearchReproductive tract infections researchHelicobacter pylori-related gastroenterology studies

Bacterial vaginosis is conducive to the persistence of HPV infection

Guo, Y-l, You, K, Qiao, J, Zhao, Y-m, Geng, L·2012·International Journal of STD & AIDS

DOI 10.1258/ijsa.2012.011342

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Abstract

We investigated the effects of bacterial vaginosis (BV) on the outcomes of high-risk human papillomavirus infection (HR-HPV). BV was diagnosed on Papanicolaou-stained cytology slides of 707 HPV-positive patients. HR-HPV DNA expression was analysed using the Hybrid Capture II (HC-II) assay. Of the 707 HR-HPV-positive female patients, 298 (42.1%) exhibited clearance of HR-HPV. The remaining 409 patients had persistent HR-HPV infection. The persistent HR-HPV group and the clearing group had similar rates of BV at the beginning of the study. At the end of the study, the persistent HR-HPV group had a BV prevalence of 11.2% while the clearing group had a significant lower BV prevalence of 5.0%. A decreased clearance of HPV was found in women with current BV, compared with women without BV. Furthermore, the natural history of HPV was not affected by the HPV viral load or the BV prevalence at the beginning of the study (P > 0.05). Bacterial vaginosis appears conducive to the persistence of HPV infection.

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Dysbiotic or high diversity vaginal microbiota coupled with chronic subclinical inflammation, hallmarks of BV, is correlated with higher incidence, prevalence and persistence of HPV infection.
“A dysbiotic or high diversity vaginal microbiota coupled with chronic subclinical inflammation, hallmarks of BV, has been correlated with higher incidence, prevalence and persistence of HPV infection (Gillet et al., 2011; Guo et al., 2012).”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Guo et al., 2012

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ORIGINAL RESEARCH ARTICLE Bacterial vaginosis is conducive to the persistence of HPV infection
(2016)
Bacterial Vaginosis and the Natural History of Human Papillomavirus
King, C. C., Jamieson, D. J., Wiener, J. B., Cu‐Uvin, S., Klein, R. S., Rompalo, A. M., Shah, K. V., & Sobel, J. D. (2011) · Infectious Diseases in Obstetrics and Gynecology · doi:10.1155/2011/319460 · Cited by 119 · see citing works
Association between bacterial vaginosis and high risk human papilloma virus in female genital tract
Ke, R.-L., & Hua, Y.-Y. (2011) · Zhongguo jiceng yiyao · doi:10.3760/cma.j.issn.1008-6706.2011.18.014
Bacterial vaginosis is significantly associated with a higher risk of high-risk human papillomavirus persistence: a cohort study in Nairobi, Kenya
Chibvongodze, R., Kyama, M. C., & Muchiri, L. (2026) · Frontiers in Global Women s Health · doi:10.3389/fgwh.2026.1825375 · Cited by 1 · see citing works
Hindawi Publishing Corporation Infectious Diseases in Obstetrics and Gynecology Volume 2011, Article ID 319460, 8 pages doi:10.1155/2011/319460 Research Article Bacterial Vaginosis and the Natural History of
Papillomavirus, H., Rompalo, A. M., Shah, K. V., & Sobel, J. D. (2011)

Authors: Guo, Y.-L., You, K., Qiao, J., Zhao, Y.-M., & Geng, L.
Affiliations: Department of Obstetrics and Gynecology
Peking University Third Hospital (CN)
Corresponding author: Geng, L
ORCID: Qiao, J
Geng, L
Venue: International Journal of STD & AIDS
Publisher: SAGE Publications
Published: 2012-08
Volume: 23
Issue: 8
Pages: 581-584
ISSN: 0956-4624 (ISSN-L)
1758-1052
DOI: 10.1258/ijsa.2012.011342
OpenAlex: W1969732431
Cited by: 116
References: 29
Citations by year: 2026: 9 · 2025: 5 · 2024: 12 · 2023: 18 · 2022: 11 · 2021: 9 · 2020: 13 · 2019: 9 · 2018: 8 · 2017: 8 · 2016: 5 · 2015: 7 · 2014: 1 · 2013: 1
FWCI: 2.16
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: International Journal of STD & AIDS (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
Keywords: bacterial vaginosis, high-risk HPV, persistent HPV infection, HPV clearance, viral load, natural history of HPV infection
MeSH terms: Adult, Age Factors, Aged, Female, Humans, Middle Aged, Vaginal Smears, DNA Probes, HPV, Vaginosis, Bacterial, Viral Load, Papillomaviridae, Papillomavirus Infections, Young Adult, Coinfection, Papanicolaou Test

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Bacterial vaginosis is conducive to the persistence of HPV infection

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