Cited by 279Artificial Intelligence in Healthcare and EducationEthics and Social Impacts of AIExplainable Artificial Intelligence (XAI)

The DOI matches its Crossref record; 56 of the 66 references it cites were found in a registry or an index; none of the 86 sources its claims cite is checked for support yet.

AI pitfalls and what not to do: mitigating bias in AI

Open access

Abstract

Various forms of artificial intelligence (AI) applications are being deployed and used in many healthcare systems. As the use of these applications increases, we are learning the failures of these models and how they can perpetuate bias. With these new lessons, we need to prioritize bias evaluation and mitigation for radiology applications; all the while not ignoring the impact of changes in the larger enterprise AI deployment which may have downstream impact on performance of AI models. In this paper, we provide an updated review of known pitfalls causing AI bias and discuss strategies for mitigating these biases within the context of AI deployment in the larger healthcare enterprise. We describe these pitfalls by framing them in the larger AI lifecycle from problem definition, data set selection and curation, model training and deployment emphasizing that bias exists across a spectrum and is a sequela of a combination of both human and machine factors.

Overview

AI snapshot

Written from the paper’s full text.

TL;DR

This review argues that bias in radiology AI arises across the entire lifecycle—problem definition, data acquisition, model development, validation, and deployment—from human, machine, and systems factors. It recommends mitigation at every stage, including diverse teams and data, rigorous validation, ongoing monitoring, and caution with purely mathematical fairness approaches.

Key findings

  • Bias can persist even when race is excluded from model inputs: a commercial algorithm referred fewer Black patients with similar disease burden than White patients because healthcare costs were used as a proxy for need, learning from a system where Black patients are less likely to seek or receive care.
  • Imaging AI data are geographically and demographically narrow: a review of published AI articles from 2015–2019 found data largely from California, Massachusetts, and New York, with none from 34 states; among 23 chest X-ray datasets, only 8.7% reported race or ethnicity and 4.3% reported insurance status; the UK Biobank has 500,000 patients but only 6% of non-European ancestry, and only 8% has been used for research.
  • Validation gaps are common: among 151 FDA-cleared imaging AI products by November 2021, only 64% used clinical data for validation, 4% had patient demographics, 5% reported machine specifications, and 34% had multi-institutional validation; a systematic review of external validation found 86 studies with a median of 240 cases, about 47% positive.
  • Deployment failures and human–machine interactions matter: the Epic sepsis model at Michigan Medicine identified only 7% of patients whose sepsis diagnosis was missed by a clinician, failed to flag 67% of patients with sepsis, and generated alerts on 18% of all hospitalized patients; in another example, pathologist accuracy worsened when a model’s prediction was incorrect.

Methods

  • Narrative/updated review, not a systematic review; it frames AI bias pitfalls across the AI lifecycle: problem definition, dataset selection and curation, model training and deployment, and post-deployment evaluation and monitoring.
  • Uses cited literature and examples—such as Obermeyer et al., the Epic sepsis model, COVID-19 imaging prediction models, RadImageNet, and federated learning—to illustrate bias sources and mitigation strategies.
  • No new primary data, sample, or statistical analysis are reported; a formal methods section is not stated in the paper.

Limitations

  • The paper does not include a dedicated limitations section; as a narrative review, it lacks systematic search or selection criteria and does not quantitatively synthesize evidence (evident from the text).
  • It relies on selected published examples and author experience, so its coverage may not be exhaustive or generalizable (evident from the text).
  • It states field-level limitations: lack of a unified definition of bias, limited model explainability, proprietary “black box inside a black box” models, and difficulty detecting harmful hidden signals in imaging datasets.

Model-written summary. Check it against the paper before relying on it.

Integrity signals

Registry

Crossref · 10.1259/bjr.20230023

Cites

56 of 56 references verified0 citation errors · 0 not checkable

Statistics

Nothing to recompute.

Verification

Claims the paper makes

0 of 86 cited sources checked · 0 supported · 0 flagged

Show all 62 claims

  • It may state two separate claims as one. 29
  • Probably not a substantial claim. 21
44 of 44
  • The paper relies on this without support.

    Bias principles are largely considered too late, if at all, when designing AI.

    “Bias principles are largely considered too late, if at all, when designing AI.”
  • The paper relies on this without support.

    Comprehensive AI data sets are limited and expensive to curate.

    “Comprehensive AI data sets are limited and expensive to curate.”
  • The paper relies on this without support.

    Presently, AI models are trained on data collected from tertiary care academic institutions.

    “While there have been initiatives to build data sets from “data deserts”, presently, AI models are trained on data collected from tertiary care academic institutions.”
  • The paper relies on this without support.

    Class imbalance occurs frequently in radiology.

    “Class imbalance occurs frequently in radiology.”
  • The paper relies on this without support.

    Radiology images tend to have high pixel dimensions and resolutions, yet pathology is represented on a small percentage of the pixels.

    “Radiology images tend to have high pixel dimensions and resolutions, yet pathology is represented on a small percentage of the pixels.”
  • The paper relies on this without support.

    Model validation remains a barrier that limits incorporation of AI into clinical care.

    “Model validation remains a barrier that limits incorporation of AI into clinical care.”
  • The paper relies on this without support.

    Many factors affect AI validation, including high costs and lack of consensus on proper validation protocol.

    “Many factors affect AI validation—including high costs of validation (technical pipeline for data set preparation and curation, diverse team of machine learning and clinical experts, regulatory approval burden), and lack of consensus on what is the proper protocol of validation.”
  • The paper relies on this without support.

    AI models 'fail silently' i.e. they do not provide an output to the user when they do not recognize the model input.

    “In these cases, the AI models “fail silently” i.e. they do not provide an output to the user when they do not recognize the model input.”
  • The paper relies on this without support.

    AI models will make a guess estimate of the prediction for wrong input data without providing the level of uncertainty.

    “These AI models will make a guess estimate of the prediction for wrong input data without providing the level of uncertainty.”
  • The paper relies on this without support.

    The greatest challenge of bias detection and mitigation remains the lack of a consensus definition of algorithmic bias despite many toolkits developed for this purpose.

    “The greatest challenge of bias detection and mitigation remains the lack of a consensus definition of algorithmic bias despite many toolkits developed for this purpose.”
  • The paper relies on this without support.

    External validation can ensure models generalize well across populations.

    “External validation can ensure models generalize well across populations.”
  • The paper relies on this without support.

    Bias evaluation and mitigation frequently occurs post-hoc.

    “Bias evaluation and mitigation frequently occurs post-hoc”
  • The paper relies on this without support.

    A review of AI reporting guidelines noted that references to bias are either absent, made in passing or included in the guideline supplement.

    “A review of AI reporting guidelines noted that references to bias are either absent, made in passing or included in the guideline supplement.”
  • The paper relies on this without support.

    Clinical trials have limitations including high costs, most trials never meet their enrollment proportions, and bias still exists in clinical trials despite their rigor.

    “While some people have called for more clinical trials in validating AI, we must acknowledge the limitations of such trials including high costs, the fact that most trials never meet their enrollment proportions, and that bias still exists in clinical trials despite their rigor.”
  • The paper relies on this without support.

    Proprietary models are usually trained and validated on private data sets that are not accessible for other researchers to evaluate the model.

    “Proprietary models present an additional layer of complexity because they are usually trained and validated on private data sets that are not accessible for other researchers to evaluate the model.”
  • The paper relies on this without support.

    Evaluation of proprietary algorithms, when performed, involves simulations to try and replicate model performance.

    “Evaluation of proprietary algorithms, when performed, involves simulations to try and replicate model performance.”
  • The paper relies on this without support.

    Vendors must navigate the convoluted process of integrating with current hospital IT systems, and engaging clinicians and patients.

    “Vendors must navigate the convoluted process of integrating with current hospital IT systems, and engaging clinicians and patients.”
  • The paper relies on this without support.

    In many cases, models do not automatically perform well out of the box and require some fine tuning and calibration to the local site data.

    “Moreover, in many cases, the models do not automatically perform well out of the box and require some fine tuning and calibration to the local site data.”
  • The paper relies on this without support.

    Due to lack of IT infrastructure and process for continuous model monitoring, changes in software or image acquisition equipment or protocols can result in model failure that may not be immediately detected, if at all.

    “Due to lack of IT infrastructure and process for continuous model monitoring, changes in software or image acquisition equipment or protocols can result in model failure that may not be immediately detected, if at all.”
  • The paper relies on this without support.

    Human–machine collaboration is now at the forefront of improving model performance, and to prevent unintended consequences including automation bias.

    “Human–machine collaboration is now at the forefront of improving model performance, and to prevent unintended consequences including automation bias.”
  • The paper relies on this without support.

    Broad grouping of underrepresented populations into the “Other” category is common when researchers have small sample sizes.

    “We also caution against broad grouping of underrepresented populations into the “Other” category which is common when researchers have small sample sizes.”
  • The paper relies on this without support.

    Mathematical approaches of fairness evaluation (e.g., fairness through unawareness, demographic parity, equalized odds or opportunity) may overlook nuanced biases and fail to address systemic issues.

    “We urge caution on relying on only mathematical approaches of fairness evaluation (e.g. relying solely on fairness through unawareness, demographic parity, or equalized odds or opportunity), as these approaches may overlook nuanced biases and fail to address systemic issues.”
22 of 22

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Citations

Cites

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10 of the 66 references couldn’t be matched to a known paper.

Research works printed but not linked: 5

  1. Gebru T , Morgenstern J , Vecchione B , Vaughan JW , Wallach H , Daumé III H . Datasheets for Datasets . arXiv 2018 .
  2. Garbin C , Rajpurkar P , Irvin J , Lungren MP , Marques O . Structured dataset documentation: a datasheet for CheXpert . arXiv 2021 .
  3. Chambon P et al . RoentGen: Vision-Language Foundation Model for Chest X-ray Generation . arXiv 2022 .
  4. Tsipras D , Santurkar S , Engstrom L , Ilyas A , Madry A . From ImageNet to Image Classification: Contextualizing Progress on Benchmarks . arXiv 2020 .
  5. Yang K , Yau J , Fei-Fei L , Deng J , Russakovsky O . A Study of Face Obfuscation in ImageNet . arXiv 2021 .

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Metadata

Authors
Gichoya, J. W., Thomas, K., Celi, L. A., Safdar, N., Banerjee, I., Banja, J. D., Seyyed-Kalantari, L., Trivedi, H., & Purkayastha, S.
Affiliations
  • Emory University (US)
  • Beth Israel Deaconess Medical Center (US)
  • Arizona State University (US)
  • York University (CA)
  • Indiana University – Purdue University Indianapolis (US)
Corresponding author
  • Gichoya, Judy Wawira
  • Purkayastha, Saptarshi
Venue
The British Journal of Radiology
Published
2023-09-25
Volume
96
Issue
1150
Pages
20230023-20230023
ISSN
  • 0007-1285 (ISSN-L)
  • 1748-880X
OpenAlex
W4386624058
Cited by
277
References
66
Citations by year
2026: 88 · 2025: 118 · 2024: 67 · 2023: 4
FWCI
3.25
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • British Journal of Radiology (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • National Science Foundation (1928481)
  • Radiological Society of North America (#EIHD2204)
  • National Institutes of Health (75N92020C00021, 5r01eb017205-07, 75N92020C00008, R01-EB017205, EB017205)
  • National Heart, Lung, and Blood Institute (75N92020C00008, 75N92020C00021)
  • National Institute of Biomedical Imaging and Bioengineering (75N92020C00021, R01-EB017205, EB017205, 75N92020C00008)
  • National Institute on Minority Health and Health Disparities
Topics
  • Health Sciences › Medicine › Health Informatics › Artificial Intelligence in Healthcare and Education
  • Physical Sciences › Computer Science › Artificial Intelligence › Ethics and Social Impacts of AI
  • Physical Sciences › Computer Science › Artificial Intelligence › Explainable Artificial Intelligence (XAI)
Keywords
algorithmic bias, bias mitigation, artificial intelligence in radiology, AI lifecycle, model training, model deployment, algorithmic fairness
MeSH terms
Artificial Intelligence, Humans, Learning, Radiology, Bias, Disease Progression

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