The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
tRNA cleavage is a conserved response to oxidative stress in eukaryotes
Open accessAbstract
Recent results have identified a diversity of small RNAs in a wide range of organisms. In this work, we demonstrate that Saccharomyces cerevisiae contains a small RNA population consisting primarily of tRNA halves and rRNA fragments. Both 5′ and 3′ fragments of tRNAs are detectable by Northern blot analysis, suggesting a process of endonucleolytic cleavage. tRNA and rRNA fragment production in yeast is most pronounced during oxidative stress conditions, especially during entry into stationary phase. Similar tRNA fragments are also observed in human cell lines and in plants during oxidative stress. These results demonstrate that tRNA cleavage is a conserved aspect of the response to oxidative stress.
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Cites
Functional Characterization of the S. cerevisiae Genome by Gene Deletion and Parallel Analysis
Winzeler, E. A., Shoemaker, D. D., Astromoff, A., Liang, H., Anderson, K., Andre, B., Bangham, R., Benito, R., Boeke, J. D., Bussey, H., et al. (1999) · Science · doi:10.1126/science.285.5429.901 · Cited by 3,953
Reactive oxygen species in cancer cells: Live by the sword, die by the sword
Schumacker, P. T. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.08.015 · Cited by 1,242
Metabolism of sulfur amino acids in Saccharomyces cerevisiae.
Thomas, D., & Surdin-Kerjan, Y. (1997) · Microbiology and molecular biology reviews : MMBR · doi:10.1128/.61.4.503-532.1997 · Cited by 678
Cited by
A novel class of small RNAs: tRNA-derived RNA fragments (tRFs)
Lee, Y. S., Shibata, Y., Malhotra, A., & Dutta, A. (2009) · Genes & Development · doi:10.1101/gad.1837609 · Cited by 1,173
RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage
Schaefer, M., Pollex, T., Hanna, K., Tuorto, F., Meusburger, M., Helm, M., & Lyko, F. (2010) · Genes & Development · doi:10.1101/gad.586710 · Cited by 746
Biogenesis and Function of Transfer RNA-Related Fragments (tRFs)
Kumar, P., Kuscu, C., & Dutta, A. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.05.004 · Cited by 511
Small RNAs Are Trafficked from the Epididymis to Developing Mammalian Sperm
Sharma, U., Sun, F., Conine, C. C., Reichholf, B., Kukreja, S., Herzog, V. A., Ameres, S. L., & Rando, O. J. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.06.023 · Cited by 429
Furman, D., Chang, J., Lartigue, L., Bolen, C. R., Haddad, F., Gaudilliere, B., Ganio, E. A., Fragiadakis, G. K., Spitzer, M. H., Douchet, I., et al. (2017) · Nature Medicine · doi:10.1038/nm.4267 · Cited by 389
Metadata
- Authors
- Thompson, D. M., Lu, C., Green, P. J., & Parker, R.
- Venue
- RNA
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2008-08-21
- Volume
- 14
- Issue
- 10
- Pages
- 2095-2103
- ISSN
- 1355-8382 (ISSN-L)
- 1469-9001
- OpenAlex
- W2141707748
- Cited by
- 569
- References
- 3
- FWCI
- 9.18
- Type
- journal article
- Language
- en
- Open access
- hybrid
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