Involvement of Anteroventral Periventricular Metastin/Kisspeptin Neurons in Estrogen Positive Feedback Action on Luteinizing Hormone Release in Female Rats

The GPR54 Gene as a Regulator of Puberty

Seminara, S. B., Messager, S., Chatzidaki, E. E., Thresher, R. R., Acierno, J. S., Shagoury, J. K., Bo-Abbas, Y., Kuohung, W., Schwinof, K. M., Hendrick, A. G., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa035322 · Cited by 2,557

Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54

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The Metastasis Suppressor Gene KiSS-1 Encodes Kisspeptins, the Natural Ligands of the Orphan G Protein-coupled Receptor GPR54

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Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor

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Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54

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Regulation of Kiss1 gene expression in the brain of the female mouse

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AXOR12, a Novel Human G Protein-coupled Receptor, Activated by the Peptide KiSS-1

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The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system

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Peripheral administration of metastin induces marked gonadotropin release and ovulation in the rat

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Involvement of central metastin in the regulation of preovulatory luteinizing hormone surge and estrous cyclicity in female rats

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Role of kisspeptin neurons as a GnRH surge generator: Comparative aspects in rodents and non‐rodent mammals

Matsuda, F., Ohkura, S., Magata, F., Munetomo, A., Chen, J., Sato, M., Inoue, N., Uenoyama, Y., & Tsukamura, H. (2019) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.14124 · Cited by 48

A Gatekeeping Role of ESR2 to Maintain the Primordial Follicle Reserve

Chakravarthi, V. P., Ghosh, S., Roby, K. F., Wolfe, M. W., & Rumi, M. A. K. (2020) · Endocrinology · doi:10.1210/endocr/bqaa037 · Cited by 46

Kisspeptin‐Immunoreactivity Changes in a Sex‐ and Hypothalamic‐Region‐Specific Manner Across Rat Postnatal Development

Desroziers, E., Mikkelsen, J. D., Duittoz, A. H., & Franceschini, I. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02317.x · Cited by 44

Neurokinin B and reproductive functions: “KNDy neuron” model in mammals and the emerging story in fish

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Kisspeptin expression in guinea pig hypothalamus: Effects of 17β‐estradiol

Bosch, M. A., Xue, C., & Rønnekleiv, O. K. (2011) · The Journal of Comparative Neurology · doi:10.1002/cne.23032 · Cited by 44

Effects of Full-Length Kisspeptin Administration on Follicular Development in Japanese Black Beef Cows

Naniwa, Y., NAKATSUKASA, K., Setsuda, S., Oishi, S., Fujii, N., Matsuda, F., Uenoyama, Y., Tsukamura, H., Maeda, K., & Ohkura, S. (2013) · Journal of Reproduction and Development · doi:10.1262/jrd.2013-064 · Cited by 46

Cross-talk between reproduction and energy homeostasis: central impact of estrogens, leptin and kisspeptin signaling

Nestor, C. C., Kelly, M. J., & Rønnekleiv, O. K. (2013) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2013-0050 · Cited by 49

Afferent Neuronal Control of Type-I Gonadotropin Releasing Hormone Neurons in the Human

Hrabovszky, E., & Liposits, Z. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00130 · Cited by 44

Distribution and Seasonal Variation in Hypothalamic RF‐amide Peptides in a Semi‐Desert Rodent, the Jerboa

Janati, A., Talbi, R., Klosen, P., Mikkelsen, J. D., Magoul, R., Simonneaux, V., & Ouezzani, S. E. (2013) · Journal of Neuroendocrinology · doi:10.1111/jne.12015 · Cited by 43

Actions of sex steroids on kisspeptin expression and other reproduction-related genes in the brain of the teleost fish european sea bass

Alvarado, M. V., Servili, A., Molés, G., Guéguen, M., Carrillo, M., Kah, O., & Felip, A. (2016) · Journal of Experimental Biology · doi:10.1242/jeb.137364 · Cited by 43

Evolutionary Insights into the Steroid Sensitive kiss1 and kiss2 Neurons in the Vertebrate Brain

Kanda, S., & Oka, Y. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00028 · Cited by 42

Twice-Daily Subcutaneous Injection of Kisspeptin-54 Does Not Abolish Menstrual Cyclicity in Healthy Female Volunteers

Jayasena, C. N., Comninos, A. N., Nijher, G. M. K., Abbara, A., Silva, A. D., Veldhuis, J. D., Ratnasabapathy, R., Izzi‐Engbeaya, C. N., Lim, A. K. P., Patel, D., et al. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1069 · Cited by 42

Kisspeptins and the control of gonadotrophin secretion

Dedes, I. (2012) · Systems Biology in Reproductive Medicine · doi:10.3109/19396368.2011.651555 · Cited by 43

Kisspeptin innervation of the hypothalamic paraventricular nucleus: sexual dimorphism and effect of estrous cycle in female mice

Marraudino, M., Miceli, D., Farinetti, A., Ponti, G., Panzica, G., & Gotti, S. (2017) · Journal of Anatomy · doi:10.1111/joa.12603 · Cited by 42

The roles of kisspeptin in the mechanism underlying reproductive functions in mammals

Uenoyama, Y., Inoue, N., Maeda, K., & Tsukamura, H. (2018) · Journal of Reproduction and Development · doi:10.1262/jrd.2018-110 · Cited by 44

Neuropeptides as regulators of the hypothalamus-pituitary-gonadal (HPG) axis activity and their putative roles in stress-induced fertility disorders

Gołyszny, M. J., Obuchowicz, E., & Zielinski, M. W. (2021) · Neuropeptides · doi:10.1016/j.npep.2021.102216 · Cited by 42

Kisspeptins and the neuroendocrine control of reproduction

Navarro, V. M. (2010) · Frontiers in Bioscience-Scholar · doi:10.2741/s150 · Cited by 42

The Development of Kisspeptin Circuits in the Mammalian Brain

Semaan, S. J., Tolson, K. P., & Kauffman, A. S. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-6199-9_11 · Cited by 42

Kisspeptin/Metastin: A Key Molecule Controlling Two Modes of Gonadotrophin‐Releasing Hormone/Luteinising Hormone Release in Female Rats

Uenoyama, Y., Tsukamura, H., & Maeda, K. (2009) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2009.01853.x · Cited by 40

Estradiol Membrane‐Initiated Signaling and Female Reproduction

Micevych, P. E., Wong, A., & Mittelman-Smith, M. A. (2015) · Comprehensive physiology · doi:10.1002/cphy.c140056 · Cited by 46

Hypothalamic Kisspeptin Neurons: Integral Elements of the GnRH System

Prashar, V., Arora, T., Singh, R., Sharma, A., & Parkash, J. (2022) · Reproductive Sciences · doi:10.1007/s43032-022-01027-5 · Cited by 46

Immunofluorescent histochemical and ultrastructural studies on the innervation of kisspeptin/neurokinin B neurons to tuberoinfundibular dopaminergic neurons in the arcuate nucleus of rats

Sawai, N., Iijima, N., Takumi, K., Matsumoto, K. T., & Ozawa, H. (2012) · Neuroscience Research · doi:10.1016/j.neures.2012.05.011 · Cited by 41

Endocrinology of the Testis and Male Reproduction

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Involvement of gonadotropin-inhibitory hormone in pubertal disorders induced by thyroid status

Kiyohara, M., Son, Y. L., & Tsutsui, K. (2017) · Scientific Reports · doi:10.1038/s41598-017-01183-8 · Cited by 42

High-Fat, High-Sugar Diet Disrupts the Preovulatory Hormone Surge and Induces Cystic Ovaries in Cycling Female Rats

Volk, K. M., Pogrebna, V. V., Roberts, J. A., Zachry, J. E., Blythe, S. G., & Toporikova, N. (2017) · Journal of the Endocrine Society · doi:10.1210/js.2017-00305 · Cited by 42

Progesterone Receptors in AVPV Kisspeptin Neurons Are Sufficient for Positive Feedback Induction of the LH Surge

Mohr, M. A., Esparza, L. A., Steffen, P., Micevych, P. E., & Kauffman, A. S. (2021) · Endocrinology · doi:10.1210/endocr/bqab161 · Cited by 38

Aging-related changes in RP3V kisspeptin neurons predate the reduced activation of GnRH neurons during the early reproductive decline in female mice

Zhang, J., Yang, L., Lin, N., Pan, X., Zhu, Y., & Chen, X. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.08.038 · Cited by 40

GLP-1 increases Kiss-1 mRNA expression in kisspeptin-expressing neuronal cells†

Oride, A., Kanasaki, H., Mijiddorj, T., Sukhbaatar, U., Hara, T., Tumurbaatar, T., & Kyo, S. (2017) · Biology of Reproduction · doi:10.1093/biolre/iox087 · Cited by 38

Impact of Triclosan on Female Reproduction through Reducing Thyroid Hormones to Suppress Hypothalamic Kisspeptin Neurons in Mice

Cao, X., Xu, H., Xiong, J., Zhu, W., Zhang, J., & Chen, L. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00006 · Cited by 39

ESR2 Is Essential for Gonadotropin-Induced Kiss1 Expression in Granulosa Cells

Chakravarthi, V. P., Khristi, V., Ghosh, S., Yerrathota, S., Dai, E., Roby, K. F., Wolfe, M. W., & Rumi, M. A. K. (2018) · Endocrinology · doi:10.1210/en.2018-00608 · Cited by 38

Hypothalamic kisspeptin and kisspeptin receptors: Species variation in reproduction and reproductive behaviours

Sivalingam, M., & Parhar, I. S. (2021) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2021.100951 · Cited by 40

Gonadal Steroid Induction of Kisspeptin Peptide Expression in the Rostral Periventricular Area of the Third Ventricle During Postnatal Development in the Male Mouse

Clarkson, J., Shamas, S., Mallinson, S., & Herbison, A. E. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02294.x · Cited by 39

Peripheral action of kisspeptin at reproductive tissues—role in ovarian function and embryo implantation and relevance to assisted reproductive technology in livestock: a review

D’Occhio, M. J., Campanile, G., & Baruselli, P. S. (2020) · Biology of Reproduction · doi:10.1093/biolre/ioaa135 · Cited by 41

Age-related alterations in hypothalamic kisspeptin, neurokinin B, and dynorphin neurons and in pulsatile LH release in female and male rats

Kunimura, Y., Iwata, K., Ishigami, A., & Ozawa, H. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.10.018 · Cited by 37

Neurochemical Characterization of Neurons Expressing Estrogen Receptor β in the Hypothalamic Nuclei of Rats Using in Situ Hybridization and Immunofluorescence

Kanaya, M., Higo, S., & Ozawa, H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms21010115 · Cited by 38

Sexual differentiation of kisspeptin neurons responsible for sex difference in gonadotropin release in rats

Tsukamura, H., Homma, T., Tomikawa, J., Uenoyama, Y., & Maeda, K. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05645.x · Cited by 37

Socially regulated reproductive development: Analysis of GnRH‐1 and kisspeptin neuronal systems in cooperatively breeding naked mole‐rats (Heterocephalus glaber)

Zhou, S., Holmes, M. M., Forger, N. G., Goldman, B. D., Lovern, M. B., Caraty, A., Kalló, I., Faulkes, C. G., & Coen, C. W. (2013) · The Journal of Comparative Neurology · doi:10.1002/cne.23327 · Cited by 36

Effects of estradiol on kisspeptin neurons during puberty

Clarkson, J. (2013) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.02.002 · Cited by 38

Immunohistochemical Evidence for the Presence of Various Kisspeptin Isoforms in the Mammalian Brain

Franceschini, I., Yeo, S., Beltramo, M., Desroziers, E., Okamura, H., Herbison, A. E., & Caraty, A. (2013) · Journal of Neuroendocrinology · doi:10.1111/jne.12069 · Cited by 37

Central distribution of kiss2 neurons and peri-pubertal changes in their expression in the brain of male and female red seabream Pagrus major

Shimizu, Y., Tomikawa, J., Hirano, K., Nanikawa, Y., Akazome, Y., Kanda, S., Kazeto, Y., Okuzawa, K., Uenoyama, Y., Ohkura, S., et al. (2011) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2011.11.038 · Cited by 35

Hypothalamic Expression of KiSS1 and RFamide-related Peptide-3 mRNAs during The Estrous Cycle of Rats.

Salehi, M. S., Shirazi, M. R. J., Zamiri, M. J., Pazhoohi, F., Namavar, M. R., Niazi‎, A., Ramezani, A., Tanideh, N., Tamadon, A., & Zarei, A. (2013) · Europe PMC (PubMed Central) · Cited by 35

Daily rhythms count for female fertility

Simonneaux, V., Bahougne, T., & Angelopoulou, E. (2017) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2017.10.012 · Cited by 41

Kisspeptin neurons as an integration center of reproductive regulation: Observation of reproductive function based on a new concept of reproductive regulatory nervous system

Ozawa, H. (2021) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12419 · Cited by 36

Heterozygous Deletion of Ventral Anterior Homeobox (Vax1) Causes Subfertility in Mice

Hoffmann, H. M., Tamrazian, A., Xie, H., Millan, M. I. P., Kauffman, A. S., & Mellon, P. L. (2014) · Endocrinology · doi:10.1210/en.2014-1277 · Cited by 34

Effect of androgen on Kiss1 expression and luteinizing hormone release in female rats

Iwata, K., Kunimura, Y., Matsumoto, K. T., & Ozawa, H. (2017) · Journal of Endocrinology · doi:10.1530/joe-16-0568 · Cited by 36

Hypothalamic Astrocyte Development and Physiology for Neuroprogesterone Induction of the Luteinizing Hormone Surge

Sinchak, K., Mohr, M. A., & Micevych, P. E. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00420 · Cited by 35

Nitric oxide resets kisspeptin-excited GnRH neurons via PIP2 replenishment

Constantin, S., Reynolds, D., Oh, A., Pizano, K., & Wray, S. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2012339118 · Cited by 36

Emerging concepts on the epigenetic and transcriptional regulation of the Kiss1 gene

Semaan, S. J., & Kauffman, A. S. (2013) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2013.03.006 · Cited by 33

Does the KNDy Model for the Control of Gonadotropin-Releasing Hormone Pulses Apply to Monkeys and Humans?

Lehman, M. N., He, W., Coolen, L. M., Levine, J. E., & Goodman, R. L. (2019) · Seminars in Reproductive Medicine · doi:10.1055/s-0039-3400254 · Cited by 35

Environmental disruption of reproductive rhythms

Moralia, M.-A., Quignon, C., Simonneaux, M., & Simonneaux, V. (2022) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2022.100990 · Cited by 35

Kisspeptin Antagonists

Roseweir, A. K., & Millar, R. P. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-6199-9_8 · Cited by 32

KNDy neurones and GnRH / LH pulse generation: Current understanding and future aspects

Uenoyama, Y., & Tsukamura, H. (2023) · Journal of Neuroendocrinology · doi:10.1111/jne.13285 · Cited by 32

Effects and Therapeutic Potentials of Kisspeptin Analogs: Regulation of the Hypothalamic-Pituitary-Gonadal Axis

Matsui, H., & Asami, T. (2014) · Neuroendocrinology · doi:10.1159/000357809 · Cited by 32

Rola sygnalizacji kisspeptyny w osi podwzgórze–przysadka–nadnercza — aktualna perspektywa

Javed, Z., Qamar, U., & Sathyapalan, T. (2015) · Endokrynologia Polska · doi:10.5603/ep.2015.0066 · Cited by 30

Genetic Deletion of Esr1 in the Mouse Preoptic Area Disrupts the LH Surge and Estrous Cyclicity

Porteous, R. W., & Herbison, A. E. (2019) · Endocrinology · doi:10.1210/en.2019-00284 · Cited by 31

Aromatase Knockout Mice Show Normal Steroid‐Induced Activation of Gonadotrophin‐Releasing Hormone Neurones and Luteinising Hormone Surges With a Reduced Population of Kisspeptin Neurones in the Rostral Hypothalamus

Szymanski, L. A., & Bakker, J. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02334.x · Cited by 31

Circadian Regulation of Kisspeptin in Female Reproductive Functioning

Kriegsfeld, L. J. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-6199-9_18 · Cited by 30

Significance of serum neurokinin B and kisspeptin levels in the differential diagnosis of premature thelarche and idiopathic central precocious puberty

Abacı, A., Çatlı, G., Anık, A., Küme, T., Çalan, Ö. G., Dündar, B. N., & Böber, E. (2015) · Peptides · doi:10.1016/j.peptides.2014.12.011 · Cited by 30

Menstrual cyclic change of metastin/GPR54 in endometrium

Baba, T., Kang, H., Hosoe, Y., Kharma, B., Abiko, K., Matsumura, N., Hamanishi, J., Yamaguchi, K. D., Yoshioka, Y., Koshiyama, M., et al. (2014) · Medical Molecular Morphology · doi:10.1007/s00795-014-0081-0 · Cited by 30

KNDy neuron as a gatekeeper of puberty onset

Uenoyama, Y., Tsukamura, H., & Maeda, K. (2014) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.12398 · Cited by 29

Characterization of Kisspeptin Neurons in the Human Rostral Hypothalamus

Rumpler, É., Skrapits, K., Takács, S., Göcz, B., Trinh, S. H., Rácz, G. A., Matolcsy, A., Kozma, Z., Ciofi, P., Dhillo, W. S., et al. (2020) · Neuroendocrinology · doi:10.1159/000507891 · Cited by 29

The role of the hypothalamus and pituitary epigenomes in central activation of the reproductive axis at puberty

Shalev, D., & Melamed, P. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.111031 · Cited by 29

Opioidergic pathways and kisspeptin in the regulation of female reproduction in mammals

Uenoyama, Y., Tsuchida, H., Nagae, M., Inoue, N., & Tsukamura, H. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.958377 · Cited by 30

Oestrogen‐Dependent Suppression of Pulsatile Luteinising Hormone Secretion andKiss1mRNA Expression in the Arcuate Nucleus During Late Lactation in Rats

Yamada, S., Uenoyama, Y., Deura, C., Minabe, S., Naniwa, Y., Iwata, K., Kawata, M., Maeda, K., & Tsukamura, H. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02330.x · Cited by 29

Estrogen Receptors: Their Actions and Functional Roles in Health and Disease

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Chronic exposure to low dose of bisphenol A causes follicular atresia by inhibiting kisspeptin neurons in anteroventral periventricular nucleus in female mice

Tang, C., Jia, Z., Liu, P., Zhou, Y., Hu, Q., Zhong, Y., Wang, X., & Chen, L. (2020) · NeuroToxicology · doi:10.1016/j.neuro.2020.04.011 · Cited by 28

Estrous Cycle Plasticity in the Central Clock Output to Kisspeptin Neurons: Implications for the Preovulatory Surge

Jamieson, B. B., Bouwer, G. T., Campbell, R. E., & Piet, R. (2021) · Endocrinology · doi:10.1210/endocr/bqab071 · Cited by 28

Evaluation of Immortalized AVPV- and Arcuate-Specific Neuronal Kisspeptin Cell Lines to Elucidate Potential Mechanisms of Estrogen Responsiveness and Temporal Gene Expression in Females

Jacobs, D. C., Veitch, R. E., & Chappell, P. E. (2016) · Endocrinology · doi:10.1210/en.2016-1294 · Cited by 28

Regulation of kisspeptin and gonadotropin-releasing hormone expression in rat placenta: study using primary cultures of rat placental cells

Oride, A., Kanasaki, H., Mijiddorj, T., Sukhbaatar, U., Ishihara, T., & Kyo, S. (2015) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-015-0083-3 · Cited by 27

Delayed Adverse Effects of Neonatal Exposure to Diethylstilbestrol and Their Dose Dependency in Female Rats

Yoshida, M., Takahashi, M., Inoue, K., Hayashi, S., Maekawa, A., & Nishikawa, A. (2011) · Toxicologic Pathology · doi:10.1177/0192623311413785 · Cited by 28

Negative effects of endocrine disruptor bisphenol A on ovarian granulosa cells and the protective role of folic acid

Šturm, D. C., & Virant‐Klun, I. (2023) · Reproduction · doi:10.1530/rep-22-0257 · Cited by 27

Circadian and kisspeptin regulation of the preovulatory surge

Piet, R. (2023) · Peptides · doi:10.1016/j.peptides.2023.170981 · Cited by 29

Distribution and regulation of gonadotropin-releasing hormone, kisspeptin, RF-amide related peptide-3, and dynorphin in the bovine hypothalamus

Tanco, V. M., Whitlock, B. K., Jones, M. A., Wilborn, R. R., Brandebourg, T. D., & Foradori, C. D. (2016) · PeerJ · doi:10.7717/peerj.1833 · Cited by 29

Delayed effects of single neonatal subcutaneous exposure of low-dose 17α-ethynylestradiol on reproductive function in female rats

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Molecular and Epigenetic Mechanism Regulating Hypothalamic Kiss1 Gene Expression in Mammals

Uenoyama, Y., Tomikawa, J., Inoue, N., Goto, T., Minabe, S., Ieda, N., Nakamura, S., Watanabe, Y., Ikegami, K., Matsuda, F., et al. (2016) · Neuroendocrinology · doi:10.1159/000445207 · Cited by 28

Ad libitum feeding triggers puberty onset associated with increases in arcuate Kiss1 and Pdyn expression in growth-retarded rats

Majarune, S., Nima, P., Sugimoto, A., Nagae, M., Inoue, N., Tsukamura, H., & Uenoyama, Y. (2019) · Journal of Reproduction and Development · doi:10.1262/jrd.2019-048 · Cited by 26

Effects of low energy availability on female reproductive function

Iwasa, T., Minato, S., Imaizumi, J., Yoshida, A., Kawakita, T., Yoshida, K., & Yamamoto, Y. (2021) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12414 · Cited by 32

Sexual Dimorphism in Kisspeptin Signaling

Lee, E. B., Dilower, I., Marsh, C. A., Wolfe, M. W., Masumi, S., Upadhyaya, S., & Rumi, M. A. K. (2022) · Cells · doi:10.3390/cells11071146 · Cited by 27

Differential Effects of Hypothalamic IGF-I on Gonadotropin Releasing Hormone Neuronal Activation During Steroid-Induced LH Surges in Young and Middle-Aged Female Rats

Sun, Y., Todd, B. J., Thornton, K. M., Etgen, A. M., & Neal-Perry, G. S. (2011) · Endocrinology · doi:10.1210/en.2011-1051 · Cited by 26

Gpr54 −/− mice show more pronounced defects in spermatogenesis than Kiss1 −/− mice and improved spermatogenesis with age when exposed to dietary phytoestrogens

Mei, H., Walters, C., Carter, R., & Colledge, W. H. (2010) · Reproduction · doi:10.1530/rep-10-0432 · Cited by 26

KISS1 Is Down-Regulated by 17β-Estradiol in MDA-MB-231 Cells through a Nonclassical Mechanism and Loss of Ribonucleic Acid Polymerase II Binding at the Proximal Promoter

Huijbregts, L., & de Roux, N. (2010) · Endocrinology · doi:10.1210/en.2010-0260 · Cited by 25

KISS1 Gene Expression in the Developing Brain of Female Pigs in Pre- and Peripubertal Periods

Ieda, N., Uenoyama, Y., TAJIMA, Y., Nakata, T., Masatoshi, K. A. N. O., Naniwa, Y., Watanabe, Y., Minabe, S., Tomikawa, J., Inoue, N., et al. (2014) · Journal of Reproduction and Development · doi:10.1262/jrd.2013-129 · Cited by 25

Enhancement of the luteinising hormone surge by male olfactory signals is associated with anteroventral periventricular Kiss1 cell activation in female rats

Watanabe, Y., Ikegami, K., ISHIGAKI, R., Ieda, N., Uenoyama, Y., Maeda, K., Tsukamura, H., & Inoue, N. (2017) · Journal of Neuroendocrinology · doi:10.1111/jne.12505 · Cited by 25

GnRH(1-5), a metabolite of gonadotropin-releasing hormone, enhances luteinizing hormone release via activation of kisspeptin neurons in female rats

Ieda, N., Assadullah, Minabe, S., Ikegami, K., Watanabe, Y., Sugimoto, Y., Sugimoto, A., Kawai, N., Ishii, H., Inoue, N., et al. (2020) · Endocrine Journal · doi:10.1507/endocrj.ej19-0444 · Cited by 25

Identification of Hypothalamic Arcuate Nucleus-Specific Enhancer Region of Kiss1 Gene in Mice

Goto, T., Tomikawa, J., Ikegami, K., Minabe, S., Abe, H., Fukanuma, T., Imamura, T., Takase, K., Sanbo, M., Tomita, K., et al. (2014) · Molecular Endocrinology · doi:10.1210/me.2014-1289 · Cited by 25

Conditional kisspeptin neuron-specific Kiss1 knockout with newly generated Kiss1-floxed and Kiss1-Cre mice replicates a hypogonadal phenotype of global Kiss1 knockout mice

Ikegami, K., Goto, T., Nakamura, S., Watanabe, Y., Sugimoto, A., Majarune, S., Horihata, K., Nagae, M., Tomikawa, J., Imamura, T., et al. (2020) · Journal of Reproduction and Development · doi:10.1262/jrd.2020-026 · Cited by 24

The impact of inflammatory stress on hypothalamic kisspeptin neurons: Mechanisms underlying inflammation-associated infertility in humans and domestic animals

Magata, F., Tsukamura, H., & Matsuda, F. (2023) · Peptides · doi:10.1016/j.peptides.2023.170958 · Cited by 27

Modulation of Gonadotrophin‐Releasing Hormone Secretion by an Endogenous Circadian Clock

Chappell, P. E., Goodall, C. P., Tonsfeldt, K. J., White, R. S., Bredeweg, E., & Latham, K. L. (2009) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2009.01845.x · Cited by 24

Circadian transcriptional factor DBP regulates expression of Kiss1 in the anteroventral periventricular nucleus

Xu, Z., Kaga, S., Tsubomizu, J., Fujisaki, J., Mochiduki, A., Sakai, T., Tsukamura, H., Maeda, K., Inoue, K., & Adachi, A. A. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.03.020 · Cited by 25

Neurons that co-localize aromatase- and kisspeptin-like immunoreactivity may regulate the HPG axis of the Mallard drake (Anas platyrhynchos)

Saldanha, C. J., Walters, B. J., & Fraley, G. S. (2010) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2010.01.007 · Cited by 24

Development and Aging of the Kisspeptin–GPR54 System in the Mammalian Brain: What are the Impacts on Female Reproductive Function?

Franceschini, I., & Desroziers, E. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00022 · Cited by 27

Kisspeptin: a new marker for human pre-ovulation

Zhai, J., Ding, L., Zhao, S., Li, W., Sun, Y., Su, S., Zhang, J., Zhao, H., & Chen, Z. (2017) · Gynecological Endocrinology · doi:10.1080/09513590.2017.1296129 · Cited by 24

Testing the Critical Window Hypothesis of Timing and Duration of Estradiol Treatment on Hypothalamic Gene Networks in Reproductively Mature and Aging Female Rats

Yin, W., Maguire, S. M., Pham, B., Garcia, A. N., Dang, N.-V., Liang, J., Wolfe, A., Hofmann, H. A., & Gore, A. C. (2015) · Endocrinology · doi:10.1210/en.2015-1032 · Cited by 23

Inducible Kiss1 knockdown in the hypothalamic arcuate nucleus suppressed pulsatile secretion of luteinizing hormone in male mice

Minabe, S., Nakamura, S., Fukushima, E., Sato, M., Ikegami, K., Goto, T., Sanbo, M., Hirabayashi, M., Tomikawa, J., Imamura, T., et al. (2020) · Journal of Reproduction and Development · doi:10.1262/jrd.2019-164 · Cited by 23

The effects of gonadal steroid manipulation on the expression of Kiss1 mRNA in rat arcuate nucleus during postnatal development

Takumi, K., Iijima, N., Iwata, K., Higo, S., & Ozawa, H. (2012) · The Journal of Physiological Sciences · doi:10.1007/s12576-012-0222-y · Cited by 23

Modulation of Gonadotrophin‐Releasing Hormone Pulse Generator Activity by the Pheromone in Small Ruminants

Murata, K., Wakabayashi, Y., Kitago, M., Ohara, H., Watanabe, H., Tamogami, S., Warita, Y., Yamagishi, K., Ichikawa, M., Takeuchi, Y., et al. (2009) · Journal of neuroendocrinology · doi:10.1111/j.1365-2826.2009.01836.x · Cited by 25

Reproductive neuropeptides: Prevalence of GnRH and KNDy neural signalling components in a model avian, gallus gallus

Joseph, N. T., Tello, J. A., Bédécarrats, G. Y., & Millar, R. P. (2013) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2013.05.018 · Cited by 23

Electrophysiology of Kisspeptin Neurons

Alreja, M. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-6199-9_16 · Cited by 21

Hypothalamic but not pituitary or ovarian defects underlie the reproductive abnormalities in Axl/Tyro3 null mice

Pierce, A. M., Xu, M., Bliesner, B., Liu, Z., Richards, J. S., Tobet, S. A., & Wierman, M. E. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.04.007 · Cited by 23

Dicer ablation in Kiss1 neurons impairs puberty and fertility preferentially in female mice

Roa, J., Ruiz-Cruz, M., Ruiz-Pino, F., Onieva, R., Vazquez, M. J., Sanchez-Tapia, M. J., Ruiz-Rodriguez, J. M., Sobrino, V., Barroso, A., Heras, V., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-32347-4 · Cited by 22

Metastin/Kisspeptin-GPR54 System Regulating Reproductive Functions in Mammals.

Tsukamura, H., Yamada, S., Homma, T., Inamoto, Y., Uenoyama, Y., Ohkura, S., Inoue, N., & Maeda, K. (2008) · Biology of Reproduction · doi:10.1093/biolreprod/78.s1.280a · Cited by 1

Involvement of central metastin in the regulation of preovulatory luteinizing hormone surge and estrous cyclicity in female rats

Kinoshita, M., Tsukamura, H., Adachi, S., Matsui, H., Uenoyama, Y., Iwata, K., Yamada, S., Inoue, K., Ohtaki, T., Matsumoto, H., et al. (2005) · Endocrinology · doi:10.1210/en.2005-0195 · Cited by 507

Physiological role of metastin/kisspeptin in regulating gonadotropin-releasing hormone (GnRH) secretion in female rats

Ohkura, S., Uenoyama, Y., Yamada, S., Homma, T., Takase, K., Inoue, N., Maeda, K.-I., & Tsukamura, H. (2009) · Peptides · doi:10.1016/j.peptides.2008.08.004 · Cited by 80

Evidence that estrogen mediates the positive feedback effect on GnRH.

Shirazi, M. R. J. (2009) · Adelaide Research & Scholarship (AR&S) (University of Adelaide)

Kisspeptin Is Essential for the Full Preovulatory LH Surge and Stimulates GnRH Release from the Isolated Ovine Median Eminence

Smith, J. T., Li, Q., Yap, K. S., Shahab, M., Roseweir, A. K., Millar, R. P., & Clarke, I. J. (2011) · Endocrinology · doi:10.1210/en.2010-1225 · Cited by 254