A rare case of thyrotoxic periodic paralysis after epidural steroid injection: a case report and literature review
Open accessAbstract
BACKGROUND Thyrotoxic periodic paralysis (TPP) is a rare cause of acute paralysis, which if not promptly recognized and treated, can lead to significant morbidity and mortality. TPP can be precipitated by several factors, including a high carbohydrate diet and exercise. This report is of a rare case of TPP after epidural steroid injection in a young man, with a review of the literature of previous cases. CASE REPORT A 36-year-old Asian man presented to the emergency department with sudden onset of paralysis of all his limbs following epidural steroid injection for traumatic low back pain. At presentation, he was found to have severe hypokalemia of 1.8 mEq/L. Further investigations led to the diagnosis of hyperthyroidism and Graves' disease. In the process of correcting his potassium, there was an unexpected rebound hyperkalemia that was successfully corrected. He had a rapid recovery and an early discharge from hospital. CONCLUSIONS Although several factors can lead to paralysis after an epidural steroid injection, TPP should be considered in the differential diagnosis, especially in individuals who have predisposing factors of ethnicity and gender. If patients have undiagnosed hyperthyroidism on presentation, the diagnosis of TPP can be delayed or missed. In the management of patients with TPP, care should be taken when correcting potassium levels.
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Written from the paper’s full text.
TL;DR
A 36-year-old Asian man developed acute flaccid paralysis with severe hypokalemia (1.8 mEq/L) four hours after epidural steroid injection and was diagnosed with thyrotoxic periodic paralysis due to Graves’ disease. The case highlights epidural steroid injection as a rare TPP trigger and the need to anticipate rebound hyperkalemia during potassium correction.
Key findings
- Four hours after epidural steroid injection, the patient had sudden limb weakness/paralysis, with power 1/5 in both lower limbs and 4/5 in upper limbs; initial potassium was 1.8 mEq/L, and urine potassium/creatinine ratio was 7.61 mEq/g (0.81 mEq/mmol), suggesting transcellular shift rather than renal loss.
- Laboratory findings included TSH 0.100 mciu/ml one month prior, random blood glucose 176 mg/dl, HbA1c 5.1%, and elevated thyroglobulin, thyroid peroxidase, and anti-TSH receptor antibodies; ultrasonography confirmed diffusely enlarged thyroid, leading to a diagnosis of Graves’ disease and TPP.
- Potassium correction with 100 mEq IV potassium chloride overcorrected serum potassium from 1.8 mEq/L to 6.3 mEq/L; hyperkalemia was treated with calcium gluconate and insulin, and paralysis improved within three hours, with assisted ambulation within six hours and baseline potassium within nine hours.
- The literature review found no previously published case of TPP after epidural steroid injection; one prior case of hypokalemic paralysis after epidural steroid injection was not associated with thyrotoxicosis.
Methods
- Single case report with a literature review of steroid-triggered TPP and paralysis after epidural steroid injection.
- Data included clinical examination, serum and urine laboratory tests, ECG, lumbar spine MRI, thyroid function/antibodies, and thyroid ultrasonography from a 36-year-old Asian man.
- Main analysis was descriptive synthesis of the case and prior reported cases; no statistical analysis was reported.
Limitations
- Stated in the paper: the authors could not acquire external records detailing the nature and dose of the steroid used for the epidural injection.
- Evident from the text: as a single case report, it cannot establish causality or generalizability.
- Evident from the text: the literature review is narrative, with no described systematic search strategy or inclusion criteria.
Model-written summary. Check it against the paper before relying on it.
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Cites
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Claims the paper makes
0 of 41 cited sources checked · 0 supported · 0 flagged
- Findingnone given
To the authors' knowledge, this is the first case report of TPP following epidural steroid injection.
“To our knowledge, this is the first cases report of TPP following epidural steroid injection.”
Quote in the paperSubstantial claim - Findingown data
The patient had a low urine potassium to creatinine ratio of 7.61 mEq/g (0.81 mEq/mmol).
“The patient in this report had a low urine K/Cr ratio of 7.61 mEq/g (0.81 mEq/mmol), which ruled out renal loss as a possible etiology.”
Quote in the paperSubstantial claim - Findingnone given
A review of the literature identified one reported case of paralysis associated with hypokalemia following epidural steroid injection.
“A review of the literature identified one reported case of paralysis associated with hypokalemia following epidural steroid injection.”
Quote in the paperSubstantial claim - Findingnone given
The patient's laboratory investigations were diagnostic of Graves' disease.
“The patient’s laboratory investigations were diagnostic of Graves’ disease.”
Quote in the paperSubstantial claim - Findingcitation
Steroids are a relatively rarely reported trigger for TPP.
“Steroids are a relatively rarely reported trigger for TPP, and when they are involved, they are usually administered intravenously with the most common steroid being methylprednisone (Table 2).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Table 2
Not checked in the free run.
- Findingown data
At presentation, the patient had severe hypokalemia of 1.8 mEq/L.
“At presentation, he was found to have severe hypokalemia of 1.8 mEq/L.”
- Also stated in: § Case Report · plain
“Initial investigation showed severe hypokalemia of 1.8 mEq/L, magnesium of 1.8 mEq/L, sodium of 140 mEq/L, calcium of 9.9 mg/dl, random blood glucose of 176 mg/dl, and glycated hemoglobin (HbA1c) of 5.1%.”
Quote in the paperSubstantial claim - Also stated in: § Case Report · plain
- Findingreasoning
The patient had rebound hyperkalemia despite receiving just 100 mEq of potassium chloride.
“The patient had rebound hyperkalemia despite receiving just 100 mEq of potassium chloride.”
Quote in the paperSubstantial claim - Findingown data
A 36-year-old Asian man presented with sudden onset of paralysis of all his limbs following epidural steroid injection for traumatic low back pain.
“A 36-year-old Asian man presented to the emergency department with sudden onset of paralysis of all his limbs following epidural steroid injection for traumatic low back pain.”
Quote in the paperSubstantial claim - Findingown data
Ultrasonography confirmed a diffusely enlarged thyroid gland.
“Ultrasonography confirmed a diffusely enlarged thyroid gland.”
Quote in the paperNot a substantial claim - Findingown data
The patient had diffuse thyroid enlargement without any further stigmata of thyrotoxicosis.
“He had diffuse thyroid enlargement without any further stigmata of thyrotoxicosis.”
Quote in the paperNot a substantial claim - Findingown data
Further investigation of his thyroid function showed elevated levels of antibodies to thyroglobulin, a thyroid peroxidase antibody, and an anti-TSH receptor antibody.
“Further investigation of his thyroid function showed elevated levels of antibodies to thyroglobulin, a thyroid peroxidase antibody, and an anti-TSH receptor antibody.”
Quote in the paperSubstantial claim - Findingown data
Hypokalemia was rapidly overcorrected with the serum potassium rising from 1.8 mEq/L to 6.3 mEq/L after receiving 100 mEq of potassium.
“Hypokalemia was rapidly overcorrected with the serum potassium rising from 1.8 mEq/L to 6.3 mEq/L after receiving 100 mEq of potassium.”
Quote in the paperNot a substantial claim - Findingown data
His flaccid paralysis rapidly improved within three hours of potassium correction.
“His flaccid paralysis rapidly improved within three hours of potassium correction.”
Quote in the paperNot a substantial claim - Findingown data
The patient had a thyroid stimulating hormone (TSH) level of 0.100 mciu/ml one month prior.
“Laboratory results at that time showed a thyroid stimulating hormone (TSH) level of 0.100 mciu/ml and a testosterone level of 784 ng/dl.”
Quote in the paperSubstantial claim - Findingown data
Additional history after recovery revealed a recent weight loss of 30 lb in the previous six months despite a good appetite.
“Additional history after his recovery revealed that he had a recent history of weight loss of 30 lb in the previous six months, despite having a good appetite.”
Quote in the paperNot a substantial claim - Premisecitation
Severe hypokalemia of any cause can lead to muscle paralysis.
“Severe hypokalemia of any cause can lead to muscle paralysis [1–3].”
Quote in the paperSubstantial claim0 of 3 sources checked- cites [1] Lin S-H Yang S-S Chau T A practical approach to genetic hypokalemia Electrolyte Blood Press 2010 8 1 38 50 21468196 PMC3041498
Not checked in the free run.
- cites [2] Hegde S Shaikh MA Gummadi T Hypokalaemic periodic paralysis in a patient with subclinical hyperthyroidism: A rare case J Clin Diagn Res 2016 10 1 OD14 15 PMC4740643 26894115
Not checked in the free run.
- cites [3] Weber F Lehmann-Horn F Hypokalemic periodic paralysis. 2002 4 30 Adam MP Ardinger HH Pagon RA GeneReviews® [Internet] Seattle (WA) University of Washington Seattle; 1993–2018. Available from: URL: https://www.ncbi.nlm.nih.gov/books/NBK1338/ 20301512
Not checked in the free run.
- Premisecitation
Thyrotoxic periodic paralysis (TPP) is a rare cause of acute paralysis.
“Thyrotoxic periodic paralysis (TPP) is a rare cause of acute paralysis, which is reported to be more common in Asian males [4,6].”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites [4] Patel H Wilches LV Guerrero J Thyrotoxic periodic paralysis: Diversity in America J Emerg Med 2014 46 6 760 62 24315723
Not checked in the free run.
- cites [6] Kelley DE Gharib H Kennedy FP Thyrotoxic periodic paralysis: Report of 10 cases and review of electromyographic findings Arch Intern Med 1989 149 11 2597 600 2818118
Not checked in the free run.
- Interpretationcitation
The patient's low urine K/Cr ratio ruled out renal loss as a possible etiology.
“The patient in this report had a low urine K/Cr ratio of 7.61 mEq/g (0.81 mEq/mmol), which ruled out renal loss as a possible etiology.”
Quote in the paperSubstantial claim0 of 2 sources checked- cites [5] Vijayakumar A Ashwath G Thimmappa D Thyrotoxic periodic paralysis: Clinical challenges J Thyroid Res 2014 2014 649502 24695373 PMC3945080
Not checked in the free run.
- cites [13] Lin S-H Lin Y-F Chen D-T Laboratory tests to determine the cause of hypokalemia and paralysis Arch Intern Med 2004 164 14 1561 66 15277290
Not checked in the free run.
- Premisecitation
Steroids can facilitate intracellular potassium shift indirectly by inducing hyperglycemia that induces insulin release.
“Steroids can also facilitate intracellular potassium shift indirectly by inducing hyperglycemia that induces insulin release [24].”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [24] Toschi E Camastra S Sironi AM Effect of acute hyperglycemia on insulin secretion in humans Diabetes 2002 51 Suppl. 1 S130 33 11815471
Not checked in the free run.
- Premisecitation
Hypokalemia with paralysis has been reported after epidural steroid injection.
“Although rare, hypokalemia with paralysis has been reported after epidural steroid injection [17].”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [17] Tahmasbi Sohi M Sullivan WJ Anderson DJM Transient hypokalemic quad-riplegia after a lumbar transforaminal epidural dexamethasone injection: A case report PM R 2018 10 5 544 47 29074369
Not checked in the free run.
- Interpretationreasoning
The patient's vomiting occurred after developing flaccid paralysis and was likely a symptom rather than a cause of his hypokalemic state.
“The patient reported vomiting that occurred after developing flaccid paralysis, which was likely to be a symptom rather than a cause of his hypokalemic state.”
Quote in the paperNot a substantial claim - Premisecitation
Overcorrection of potassium is not an uncommon problem during the management of TPP.
“Overcorrection of potassium is not an uncommon problem during the management of TPP.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [13] Lin S-H Lin Y-F Chen D-T Laboratory tests to determine the cause of hypokalemia and paralysis Arch Intern Med 2004 164 14 1561 66 15277290
Not checked in the free run.
- Interpretationown data
Hyperaldosteronism as an underlying factor in this case presentation was ruled out by a normal serum aldosterone level and the absence of hypertension.
“Hyperaldosteronism as an underlying factor in this case presentation was ruled out by a normal serum aldosterone level and the absence of hypertension.”
Quote in the paperNot a substantial claim - Premisecitation
Tahmasbi Sohi et al. reported a case of a 30-year-old man who developed hypokalemia, hyperglycemia with quadriplegia 4 hours after intrathecal steroid injection.
“Recently, Tahmasbi Sohi et al. reported a case of a 30-year-old man who developed hypokalemia, hyperglycemia with quadriplegia 4 hours after intrathecal steroid injection [17].”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [17] Tahmasbi Sohi M Sullivan WJ Anderson DJM Transient hypokalemic quad-riplegia after a lumbar transforaminal epidural dexamethasone injection: A case report PM R 2018 10 5 544 47 29074369
Not checked in the free run.
- Interpretationreasoning
The rebound hyperkalemia observed in the patient was likely due to a transient reversal of sodium-potassium ATPase stimulation.
“The rebound hyperkalemia observed in the patient was likely to have been due to a transient reversal of sodium-potassium ATPase stimulation.”
Quote in the paperSubstantial claim - Interpretationcitation
Hypokalemic paralysis in the patient presented in this report could be explained by systemic effects of steroids from the epidural steroid injection he received.
“Hypokalemic paralysis in the patient presented in this report could be explained by systemic effects of steroids from the epidural steroid injection he received.”
Quote in the paperSubstantial claim - Premisecitation
Hyperthyroidism can cause hypokalemia by activating Na/K ATPases and thus driving potassium intracellularly.
“Hyperthyroidism can cause hypokalemia by activating Na/K ATPases and thus driving potassium intracellularly [29].”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [29] Lin S-H Huang C-L Mechanism of thyrotoxic periodic paralysis J Am Soc Nephrol 2012 23 6 985 88 22460532 PMC3358768
Not checked in the free run.
- Interpretationown data
The patient's low K/Cr ratio made the mineralocorticoid effect possibility unlikely.
“However, the K/Cr ratio of the patient was low, making this possibility unlikely.”
Quote in the paperSubstantial claim - Interpretationreasoning
Epidural steroid injection is a rare precipitant of TPP in genetically predisposed individuals who have subclinical hyperthyroidism.
“Epidural steroid injection is a rare precipitant of thyrotoxic periodic paralysis (TPP) in genetically predisposed individuals who have subclinical hyperthyroidism but should be considered in patients who develop paralysis after this procedure.”
Quote in the paperSubstantial claim - Premisecitation
Steroids can directly induce the expression of Na/K ATPase to facilitate intracellular potassium shifts.
“First, steroids can directly induce the expression of Na/K ATPase to facilitate intracellular potassium shifts [23].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [23] Kaji DM Thakkar U Kahn T Glucocorticoid-induced alterations in the sodium-potassium pump of the human erythrocyte J Clin Invest 1981 68 2 422 30 6267104 PMC370814
Not checked in the free run.
- Premisecitation
Iatrogenic overcorrection of potassium in hypokalemic periodic paralysis has been reported.
“Iatrogenic overcorrection of potassium in hypokalemic periodic paralysis has been reported [13].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [13] Lin S-H Lin Y-F Chen D-T Laboratory tests to determine the cause of hypokalemia and paralysis Arch Intern Med 2004 164 14 1561 66 15277290
Not checked in the free run.
- Interpretationown data
Evidence for a steroid-induced hyperglycemia/insulin mechanism in this case report was indicated by a high blood glucose level with a normal HbA1c.
“Evidence for such a mechanism in this case report was indicated by a high blood glucose level with a normal HbA1c.”
Quote in the paperNot a substantial claim - Premisecitation
Transient hyperinsulinemia and hyperglycemia lead to activation of Na/K ATPase, which drives potassium into the cells.
“Transient hyperinsulinemia and hyperglycemia then lead to activation of Na/K ATPase, which drives potassium into the cells [25].”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [25] Düfer M Haspel D Krippeit-Drews P Activation of the Na+/K+-ATPase by insulin and glucose as a putative negative feedback mechanism in pancreatic beta-cells Pflugers Arch 2009 457 6 1351 60 18836740
Not checked in the free run.
- Premisecitation
Triggers are usually required to induce the extent of hypokalemia required for TPP.
“However, triggers are usually required to induce the extent of hypokalemia required for TPP [30,31].”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites [30] Amblee A Gulati S Thyrotoxic periodic paralysis: Eight cases in males of Hispanic origin from a single hospital AACE Clin Case Rep 2015 2 1 e58 64
Not checked in the free run.
- cites [31] Chang C-C Cheng C-J Sung C-C A 10-year analysis of thyrotoxic periodic paralysis in 135 patients: focus on symptomatology and precipitants Eur J Endocrinol 2013 169 5 529 36 23939916 PMC3789562
Not checked in the free run.
- Interpretationreasoning
The likely trigger of his TPP was the epidural steroid injection with its systemic effects facilitated by an environment of hypertestosteronemia.
“The likely trigger of his TPP was the epidural steroid injection with its systemic effects facilitated by an environment of hypertestosteronemia.”
Quote in the paperSubstantial claim- Rests on an assumption: The patient's serum testosterone level of 784 ng/dl represents hypertestosteronemia (elevated testosterone).
- Interpretationown data
When correcting hypokalemia related to TPP, rebound hyperkalemia is a potential complication that should be anticipated.
“When correcting hypokalemia related to TPP, rebound hyperkalemia is a potential complication that should be anticipated.”
Quote in the paperSubstantial claim - Interpretationown data
The rapid correction of potassium was significantly out of proportion to the expected increase in potassium levels.
“The rapid correction of potassium was significantly out of proportion to the expected increase in potassium levels.”
Quote in the paperNot a substantial claim
- May combine two claims. 19
- Classified as probably not a substantial claim. 20
May combine two claims.
FindingcitationThere has been one reported case of hypokalemic paralysis following epidural steroid injection, but this was not associated with thyrotoxicosis.
“However, there has been one reported case of hypokalemic paralysis following epidural steroid injection, but this was not associated with thyrotoxicosis, and there have been other reports of paralysis following epidural steroid injection, including trauma and hemorrhage [7,8].”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataOn examination, power was 1/5 in both lower limbs and 4/5 in his upper limbs.
“Power was 1/5 in both lower limbs and 4/5 in his upper limbs.”
Quote in the paperNot a substantial claimMay combine two claims.
FindingreasoningThe patient in this report had some risk factors for the development of TPP, including hyperglycemia, hypertestosteronemia, steroid injection, and being a young adult male of Asian origin.
“The patient in this report had some risk factors for the development of TPP, including hyperglycemia, hypertestosteronemia, steroid injection, and being a young adult male of Asian origin.”
Quote in the paperSubstantial claim- Rests on an assumption: The patient's serum testosterone level of 784 ng/dl represents hypertestosteronemia (elevated testosterone).
Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Findingnone givenIn the process of correcting his potassium, there was an unexpected rebound hyperkalemia that was successfully corrected.
“In the process of correcting his potassium, there was an unexpected rebound hyperkalemia that was successfully corrected.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataFour hours after the epidural steroid injection, the patient noticed that his legs became weak, and he collapsed.
“Four hours after the epidural steroid injection, the patient noticed that his legs became weak, and he collapsed to the floor while urinating in the bathroom at his home.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Findingnone givenThe patient had a rapid recovery and an early discharge from hospital.
“He had a rapid recovery and an early discharge from hospital.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataThe weakness in the legs was more severe than that in his upper extremities.
“The weakness in the legs was more severe than that in his upper extremities, which allowed him to crawl back to his bedroom.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
FindingcitationWhen steroids trigger TPP, they are usually administered intravenously, most commonly methylprednisone.
“Steroids are a relatively rarely reported trigger for TPP, and when they are involved, they are usually administered intravenously with the most common steroid being methylprednisone (Table 2).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Table 2
Not checked in the free run.
May combine two claims.
Findingnone givenFurther investigations led to the diagnosis of hyperthyroidism and Graves' disease.
“Further investigations led to the diagnosis of hyperthyroidism and Graves’ disease.”
Quote in the paperSubstantial claimMay combine two claims.
FindingcitationThe case reported by Tahmasbi Sohi et al. was similar to ours regarding gender, latency of symptom development, and patient management.
“This case was similar to ours regarding gender, the latency of symptom development, and patient management [17].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [17] Tahmasbi Sohi M Sullivan WJ Anderson DJM Transient hypokalemic quad-riplegia after a lumbar transforaminal epidural dexamethasone injection: A case report PM R 2018 10 5 544 47 29074369
Not checked in the free run.
May combine two claims.
Findingown dataHe was able to ambulate with assistance within six hours of treatment and was back to baseline potassium levels within nine hours of treatment.
“He was able to ambulate with assistance within six hours of treatment and was back to baseline potassium levels within nine hours of treatment.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataThe patient had a testosterone level of 784 ng/dl one month prior.
“Laboratory results at that time showed a thyroid stimulating hormone (TSH) level of 0.100 mciu/ml and a testosterone level of 784 ng/dl.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataThe patient's potassium level one month prior was 3.7 mEq/L.
“His potassium level at the time was 3.7 mEq/L.”
Quote in the paperNot a substantial claimMay combine two claims.
FindingreasoningHe was discharged with a diagnosis of TPP secondary to Graves' disease and treated with propranolol.
“He was discharged from hospital with a diagnosis of thyrotoxic periodic paralysis (TPP) secondary to Graves’ disease and treated with propranolol.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataAldosterone was 9.5 ng/dl.
“Aldosterone was 9.5 ng/dl, urine potassium was 12.8 mEq/L, urine creatinine was 168.22 mg/dL (14.87 mmol/L) and the urine potassium to creatinine ratio was 7.61 mEq/g (0.81 mEq/mmol).”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataThe patient was unaware of the test results, as he was awaiting a follow-up visit at the time of the episode of paralysis.
“The patient was unaware of the test results, as he was awaiting a follow-up visit at the time of the episode of paralysis that resulted in his hospital admission.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataMRI of the lumbar spine showed bulging intervertebral discs but no nerve impingement or other causes for his paraplegia.
“Magnetic resonance imaging (MRI) of his lumbar spine showed bulging intervertebral discs but no nerve impingement or other causes for his paraplegia.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationThe incidence of TPP in the United States is unknown.
“Although the incidence of TPP in the United States is unknown, published reviews and case report indicate that the incidence may be on the rise due to changing demographics [4,6].”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites [4] Patel H Wilches LV Guerrero J Thyrotoxic periodic paralysis: Diversity in America J Emerg Med 2014 46 6 760 62 24315723
Not checked in the free run.
- cites [6] Kelley DE Gharib H Kennedy FP Thyrotoxic periodic paralysis: Report of 10 cases and review of electromyographic findings Arch Intern Med 1989 149 11 2597 600 2818118
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationOther reports of paralysis following epidural steroid injection include trauma and hemorrhage.
“However, there has been one reported case of hypokalemic paralysis following epidural steroid injection, but this was not associated with thyrotoxicosis, and there have been other reports of paralysis following epidural steroid injection, including trauma and hemorrhage [7,8].”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites [7] Manchikanti L Hirsch JA Neurological complications associated with epidural steroid injections Curr Pain Headache Rep 2015 19 5 482 25795154
Not checked in the free run.
- cites [8] Abram SE O’Connor TC Complications associated with epidural steroid injections Reg Anesth 1996 21 2 149 62 8829408
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationA mineralocorticoid effect of the injected steroid can lead to hypokalemia via increased urinary excretion.
“The third possible mechanism is a mineralocorticoid effect of the injected steroid leading to hypokalemia via increased urinary excretion [26].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [26] van Buren M Rabelink TJ Koppeschaar HPF Koomans HA Role of glucocorticoid in excretion of an acute potassium load in patients with Addison’s disease and panhypopituitarism Kidney Int 1993 44 5 1130 38 8264146
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationIn the case reported by Tahmasbi Sohi et al., epidural steroid injection was performed with dexamethasone.
“In the case reported by Tahmasbi Sohi et al., epidural steroid injection was performed with dexamethasone [17].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [17] Tahmasbi Sohi M Sullivan WJ Anderson DJM Transient hypokalemic quad-riplegia after a lumbar transforaminal epidural dexamethasone injection: A case report PM R 2018 10 5 544 47 29074369
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
PremisecitationOther potential causes of paralysis in this patient could have included conus medullaris syndrome from infarction, or an epidural hematoma.
“Other potential causes of paralysis in this patient could have included conus medullaris syndrome from infarction [28], or an epidural hematoma, all of which have been reported as causes of paralysis after epidural steroid injection [7,8].”
Quote in the paperNot a substantial claim0 of 3 sources checked- cites [28] Tackla RD Keller JT Ernst RJ Conus medullaris syndrome after epidural steroid injection: Case report Int J Spine Surg 2012 6 29 33 25694868 PMC4300874
Not checked in the free run.
- cites [7] Manchikanti L Hirsch JA Neurological complications associated with epidural steroid injections Curr Pain Headache Rep 2015 19 5 482 25795154
Not checked in the free run.
- cites [8] Abram SE O’Connor TC Complications associated with epidural steroid injections Reg Anesth 1996 21 2 149 62 8829408
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationThe most common triggers for TPP are high carbohydrate diet, alcohol, and exercise.
“Many triggers for TPP have been identified, with the most common being high carbohydrate diet, alcohol, and exercise [30,31].”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites [30] Amblee A Gulati S Thyrotoxic periodic paralysis: Eight cases in males of Hispanic origin from a single hospital AACE Clin Case Rep 2015 2 1 e58 64
Not checked in the free run.
- cites [31] Chang C-C Cheng C-J Sung C-C A 10-year analysis of thyrotoxic periodic paralysis in 135 patients: focus on symptomatology and precipitants Eur J Endocrinol 2013 169 5 529 36 23939916 PMC3789562
Not checked in the free run.
May combine two claims.
PremisecitationHypertestosteronemia creates an environment for the development of TPP as it increases muscle bulk and can induce the expression of Na/K ATPase in muscles, thereby explaining the increased incidence of TPP in men, although women have a higher incidence of Graves' disease.
“Hypertestosteronemia also creates an environment for the development of TPP as it increases muscle bulk and can induce the expression of Na/K ATPase in muscles, thereby explaining the increased incidence of TPP in men, although women have a higher incidence of Graves’ disease [29,31].”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites [29] Lin S-H Huang C-L Mechanism of thyrotoxic periodic paralysis J Am Soc Nephrol 2012 23 6 985 88 22460532 PMC3358768
Not checked in the free run.
- cites [31] Chang C-C Cheng C-J Sung C-C A 10-year analysis of thyrotoxic periodic paralysis in 135 patients: focus on symptomatology and precipitants Eur J Endocrinol 2013 169 5 529 36 23939916 PMC3789562
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationTPP is reported to be more common in Asian males.
“Thyrotoxic periodic paralysis (TPP) is a rare cause of acute paralysis, which is reported to be more common in Asian males [4,6].”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites [4] Patel H Wilches LV Guerrero J Thyrotoxic periodic paralysis: Diversity in America J Emerg Med 2014 46 6 760 62 24315723
Not checked in the free run.
- cites [6] Kelley DE Gharib H Kennedy FP Thyrotoxic periodic paralysis: Report of 10 cases and review of electromyographic findings Arch Intern Med 1989 149 11 2597 600 2818118
Not checked in the free run.
May combine two claims.
PremisecitationThe case reported by Tahmasbi Sohi et al. differed from ours by the absence of thyrotoxicosis, with hypokalemia solely attributed to direct effects of steroids and hyperglycemia.
“What distinguishes the case presented in this report from the case reported by Tahmasbi Sohi et al. is the absence of thyrotoxicosis, with the hypokalemia in their case solely attributed to the direct effects of the steroids and hyperglycemia [17].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [17] Tahmasbi Sohi M Sullivan WJ Anderson DJM Transient hypokalemic quad-riplegia after a lumbar transforaminal epidural dexamethasone injection: A case report PM R 2018 10 5 544 47 29074369
Not checked in the free run.
May combine two claims.
InterpretationreasoningIn this patient, conus medullaris syndrome and epidural hematoma were unlikely given the time course of his symptoms and the resolution of paralysis after potassium replacement.
“However, in this patient, these diagnoses were unlikely given the time course of his symptoms and the resolution of paralysis after potassium replacement.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Study design and conductown dataThe procedure in the case reported here was done at another hospital, and external records of the nature and dose of steroid used were unavailable.
“Unfortunately, the procedure in the case reported here was done at another hospital, and we were unable to acquire external records of the details of the nature of the steroid used and the dose administered.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S4 (based).
Interpretationnone givenIf patients have undiagnosed hyperthyroidism on presentation, the diagnosis of TPP can be delayed or missed.
“If patients have undiagnosed hyperthyroidism on presentation, the diagnosis of TPP can be delayed or missed.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
InterpretationreasoningThis patient had an initial overcorrection of his potassium, which supports that caution is needed during potassium correction in TPP.
“This patient had an initial overcorrection of his potassium, which supports that caution is needed during potassium correction in TPP.”
Quote in the paperNot a substantial claimMay combine two claims.
PremisecitationSystemic effects of steroids after epidural steroid injections are not uncommon and can have significant effects on metabolism.
“Systemic effects of steroids after epidural steroid injections are not uncommon and can have significant effects on metabolism [14–16].”
Quote in the paperSubstantial claim0 of 3 sources checked- cites [14] Abdul AJ Ghai B Bansal D Hypothalamic pituitary adrenocortical axis suppression following a single epidural injection of methylprednisolone acetate Pain Physician 2017 20 7 E991 1001 29149147
Not checked in the free run.
- cites [15] Goel AP Nguyen VH Hamill-Ruth R Use of a risk-stratification tool in identification of potential adrenal suppression preceding steroid injection therapy in chronic pain patients Pain Med 2015 16 12 2226 34 26243057
Not checked in the free run.
- cites [16] Horani MH Silverberg AB Secondary Cushing’s syndrome after a single epidural injection of a corticosteroid Endocr Pract 2005 11 6 408 10 16638729
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationThe incidence of TPP may be on the rise in the United States due to changing demographics.
“Although the incidence of TPP in the United States is unknown, published reviews and case report indicate that the incidence may be on the rise due to changing demographics [4,6].”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites [4] Patel H Wilches LV Guerrero J Thyrotoxic periodic paralysis: Diversity in America J Emerg Med 2014 46 6 760 62 24315723
Not checked in the free run.
- cites [6] Kelley DE Gharib H Kennedy FP Thyrotoxic periodic paralysis: Report of 10 cases and review of electromyographic findings Arch Intern Med 1989 149 11 2597 600 2818118
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing), S4 (based).
Interpretationnone givenIt is likely that the paralysis from TPP is mediated by sudden and transient hypokalemia.
“It is likely that the paralysis from TPP is mediated by sudden and transient hypokalemia.”
Quote in the paperNot a substantial claim
The paper relies on this without support.
The patient's serum testosterone level of 784 ng/dl represents hypertestosteronemia (elevated testosterone).
“The patient in this report had some risk factors for the development of TPP, including hyperglycemia, hypertestosteronemia, steroid injection, and being a young adult male of Asian origin.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
There are few published cases of glucocorticoid administration prior to TPP.
“There are few published cases of glucocorticoid administration prior to TPP, thus the possibility that glucocorticoids may precipitate TPP requires further investigation.”
From Thyrotoxic Periodic Paralysis With Hypokalemia: A Case Study (2023) · cites this paper as [16]
From the current review of the literature, there are at least 13 cases of TPP associated with glucocorticoid use.
“From the current review of the literature, there are at least 13 cases of TPP associated with glucocorticoid use [13-16].”
From Thyrotoxic Periodic Paralysis With Hypokalemia: A Case Study (2023) · cites this paper as [16]
Glucocorticoid treatment for Graves' ophthalmopathy or thyroid storm may precipitate TPP via a negative feedback mechanism.
“Glucocorticoid treatment for Graves’ ophthalmopathy or thyroid storm may precipitate TPP via a negative feedback mechanism [16].”
From Thyrotoxic Periodic Paralysis With Hypokalemia: A Case Study (2023) · cites this paper as [16]
Cites
1 retracted
Thyrotoxic Periodic Paralysis: Clinical Challenges
Vijayakumar, A., Ashwath, G., & Thimmappa, D. (2014) · Journal of Thyroid Research · doi:10.1155/2014/649502 · Cited by 88 · cited 2× · see citing works
“5 mEq/mmol) in the setting of hypokalemia is indicative of potassium loss from the gut, or transcellular shift [5,13].”
BackgroundRetractedKelley, D. E. (1989) · Archives of Internal Medicine · doi:10.1001/archinte.149.11.2597 · Cited by 227 · cited 2× · see citing works
“Although the incidence of TPP in the United States is unknown, published reviews and case report indicate that the incidence may be on the rise due to changing demographics [4,6].”
BackgroundPotassium Disorders: Hypokalemia and Hyperkalemia.
Viera, A. J., & Wouk, N. (2015) · PubMed · Cited by 191 · see citing works
Mechanism of Thyrotoxic Periodic Paralysis
Lin, S.-H., & Huang, C.-L. (2012) · Journal of the American Society of Nephrology · doi:10.1681/asn.2012010046 · Cited by 174 · cited 3× · see citing works
“Hypertestosteronemia also creates an environment for the development of TPP as it increases muscle bulk and can induce the expression of Na/K ATPase in muscles, thereby explaining the increased incidence of TPP in men, although women have a higher incidence of Graves’ disease [29,31].”
BackgroundLin, S.-H. (2001) · QJM · doi:10.1093/qjmed/94.3.133 · Cited by 173 · see citing works
Laboratory Tests to Determine the Cause of Hypokalemia and Paralysis
Lin, S.-H., Lin, Y.-F., Chen, D.-T., Chu, P., Hsu, C.-W., & Halperin, M. L. (2004) · Archives of Internal Medicine · doi:10.1001/archinte.164.14.1561 · Cited by 167 · cited 3× · see citing works
“5 mEq/mmol) in the setting of hypokalemia is indicative of potassium loss from the gut, or transcellular shift [5,13].”
BackgroundMethodComplications Associated With Epidural Steroid Injections
Abram, S. E., & O’Connor, T. C. (1996) · Regional Anesthesia The Journal of Neural Blockade in Obstetrics Surgery & Pain Control · doi:10.1136/rapm-00115550-199621020-00012 · Cited by 160 · cited 2× · see citing works
“Other potential causes of paralysis in this patient could have included conus medullaris syndrome from infarction [28], or an epidural hematoma, all of which have been reported as causes of paralysis after epidural steroid injection [7,8].”
BackgroundPotassium Disorders: Hypokalemia and Hyperkalemia.
Kim, M. J., Valerio, C., & Knobloch, G. (2023) · PubMed · Cited by 121 · see citing works
Hormonal and pharmacological modification of plasma potassium homeostasis
Clausen, T. (2010) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2010.00859.x · Cited by 116 · cited 1× · see citing works
“Factors that enhance intracellular potassium shift include alkalosis, hyperthyroidism, beta-adrenergic activity [9], elevated levels of testosterone and insulin [10].”
BackgroundChang, C.-C., Cheng, C.-J., Sung, C.-C., Chiueh, T.-S., Lee, C.-H., Chau, T., & Lin, S.-H. (2013) · European Journal of Endocrinology · doi:10.1530/eje-13-0381 · Cited by 114 · cited 4× · see citing works
“However, triggers are usually required to induce the extent of hypokalemia required for TPP [30,31].”
BackgroundInfluentialEffect of Acute Hyperglycemia on Insulin Secretion in Humans
Toschi, E., Camastra, S., Sironi, A. M., Masoni, A., Gastaldelli, A., Mari, A., Ferrannini, E., & Natali, A. (2002) · Diabetes · doi:10.2337/diabetes.51.2007.s130 · Cited by 82 · cited 1× · see citing works
“Steroids can also facilitate intracellular potassium shift indirectly by inducing hyperglycemia that induces insulin release [24].”
BackgroundNeurological Complications Associated with Epidural Steroid Injections
Manchikanti, L., & Hirsch, J. A. (2015) · Current Pain and Headache Reports · doi:10.1007/s11916-015-0482-3 · Cited by 68 · cited 2× · see citing works
“Other potential causes of paralysis in this patient could have included conus medullaris syndrome from infarction [28], or an epidural hematoma, all of which have been reported as causes of paralysis after epidural steroid injection [7,8].”
BackgroundGlucocorticoid-induced alterations in the sodium potassium pump of the human erythrocyte.
Kaji, D. M., Thakkar, U., & Kahn, T. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110271 · Cited by 54 · cited 1× · see citing works
“First, steroids can directly induce the expression of Na/K ATPase to facilitate intracellular potassium shifts [23].”
Background(2017) · PubMed · Cited by 43 · see citing works
Thyrotoxic Periodic Paralysis Induced by Pulse Methylprednisolone
Wongraoprasert, S., Buranasupkajorn, P., Sridama, V., & Snabboon, T. (2007) · Internal Medicine · doi:10.2169/internalmedicine.46.0044 · Cited by 37 · see citing works
Secondary Cushing’s Syndrome After A Single Epidural Injection Of A Corticosteroid
Horani, M. H., & Silverberg, A. B. (2005) · Endocrine Practice · doi:10.4158/ep.11.6.408 · Cited by 24 · see citing works
Düfer, M., Haspel, D., Krippeit‐Drews, P., Aguilar‐Bryan, L., Bryan, J., & Drews, G. (2008) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-008-0592-4 · Cited by 24 · cited 1× · see citing works
“Transient hyperinsulinemia and hyperglycemia then lead to activation of Na/K ATPase, which drives potassium into the cells [25].”
BackgroundTigas, S. K., Papachilleos, P., Ligkros, N., Andrikoula, M., & Tsatsoulis, A. A. (2011) · HORMONES · doi:10.14310/horm.2002.1323 · Cited by 20 · cited 1× · see citing works
“, 2011 [22] Methylprednisolone 1 g IV Table 2.”
BackgroundYao, Y., Fan, L., Zhang, X., Xiao, Z., Long, Y., & Tian, H. (2013) · Thyroid · doi:10.1089/thy.2011.0493 · Cited by 19 · see citing works
Thyrotoxic periodic paralysis: diversity in America
Patel, H., Wilches, L. V., & Guerrero, J. (2014) · The Journal of Emergency Medicine · doi:10.1016/j.jemermed.2013.08.104 · Cited by 19 · cited 3× · see citing works
“Although the incidence of TPP in the United States is unknown, published reviews and case report indicate that the incidence may be on the rise due to changing demographics [4,6].”
BackgroundA Practical Approach to Genetic Hypokalemia
Lin, S., Yang, S.-S., & Chau, T. (2010) · Electrolytes & Blood Pressure · doi:10.5049/ebp.2010.8.1.38 · Cited by 19 · cited 1× · see citing works
“High 24-hour urine potassium is an indication of renal loss, which could be due to loop diuretic or thiazide diuretic use, or hereditary renal channelopathies, such as Bartter syndrome, Gitelman syndrome, and Liddle syndrome [1], hyperaldosteronism or renal tubular acidosis [3].”
BackgroundA Case of Trigger-Point Injection-Induced Hypokalemic Paralysis
Soriano, P. K., Bhattarai, M., Vogler, C. N., & Hudali, T. H. (2017) · American Journal of Case Reports · doi:10.12659/ajcr.903139 · Cited by 13 · see citing works
Conus medullaris syndrome after epidural steroid injection: Case report
Tackla, R. D., Keller, J. T., Ernst, R. J., et al. (2012) · The International Journal of Spine Surgery · doi:10.1016/j.ijsp.2011.10.002 · Cited by 12 · cited 1× · see citing works
“Other potential causes of paralysis in this patient could have included conus medullaris syndrome from infarction [28], or an epidural hematoma, all of which have been reported as causes of paralysis after epidural steroid injection [7,8].”
Backgroundvan Buren, M., Rabelink, T. J., Koppeschaar, H. P. F., et al. (1993) · Kidney International · doi:10.1038/ki.1993.359 · Cited by 10 · cited 1× · see citing works
“The third possible mechanism is a mineralocorticoid effect of the injected steroid leading to hypokalemia via increased urinary excretion [26].”
BackgroundHsiao, Y., Fang, Y., Leu, J., & Tsai, M. (2017) · American Journal of Case Reports · doi:10.12659/ajcr.901793 · Cited by 8 · cited 1× · see citing works
“Hyperaldosteronism with hypokalemic paralysis via renal salt wasting has previously been reported in a patient with hyperthyroidism, emphasizing the need to rule out secondary causes [27].”
BackgroundGoel, A. P., Nguyen, V. H., & Hamill-Ruth, R. J. (2015) · Pain Medicine · doi:10.1111/pme.12855 · Cited by 7 · see citing works
Hypokalaemic Periodic Paralysis in a Patient with Subclinical Hyperthyroidism: A Rare Case
Hegde, S. (2016) · JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH · doi:10.7860/jcdr/2016/15489.7131 · Cited by 7 · see citing works
Sohi, M. T., Sullivan, W. J., & Anderson, D. (2017) · PM&R · doi:10.1016/j.pmrj.2017.10.003 · Cited by 7 · cited 6× · see citing works
“is the absence of thyrotoxicosis, with the hypokalemia in their case solely attributed to the direct effects of the steroids and hyperglycemia [17].”
BackgroundMethodResultInfluentialHypokalemia and muscle paralysis after low-dose methylprednisolone
Büyükçam, F., Çalık, M., Erkuran, M. K., & Akay, H. (2010) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2010.05.008 · Cited by 6 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- [3]Weber F Lehmann-Horn F Hypokalemic periodic paralysis. 2002 4 30 Adam MP Ardinger HH Pagon RA GeneReviews® [Internet] Seattle (WA) University of Washington Seattle; 1993–2018. Available from: URL: https://www.ncbi.nlm.nih.gov/books/NBK1338/ 20301512
- [20]Genek DG Huddam B Karakuş V Glucocorticoid-induced hypokalemic periodic paralysis in subclinical hyperthyroidism: Case report Medical Journal of Mugla Sitki Kocman University 2016 3 3 32 34
Cited by
Sorted by citations
Lin, Y.-Y., & Hsieh, Y.-S. (2021) · Cureus · doi:10.7759/cureus.15880 · Cited by 6 · see citing works
Murashita, M., Wada, N., Baba, S., Sugawara, H., Miyoshi, A., & Obara, S. (2022) · Endocrinology Diabetes and Metabolism Case Reports · doi:10.1530/edm-22-0236 · Cited by 5 · see citing works
Gendron, A.-A., Marquis, A., Mongeon, C., Statie, A., Bouchard, A., & Khazaka, M. (2022) · The Canadian Journal of Hospital Pharmacy · doi:10.4212/cjhp.3145 · Cited by 3 · see citing works
Scheive, M., Patel, N., & Saeed, Z. I. (2023) · Endocrinology Diabetes and Metabolism Case Reports · doi:10.1530/edm-22-0358 · Cited by 3 · see citing works
Sahebi, K., Foroozand, H., Bahmei, M., Taghizadeh, R., Zare, S., & Inaloo, S. (2025) · Heliyon · doi:10.1016/j.heliyon.2025.e41675 · Cited by 2 · see citing works
Thyrotoxic Periodic Paralysis With Hypokalemia: A Case Study
Mebane, N. B., Khan, A., Bevinal, M., & Davis, E. (2023) · Cureus · doi:10.7759/cureus.40757 · Cited by 3 · see citing works
“Glucocorticoid treatment for Graves’ ophthalmopathy or thyroid storm may precipitate TPP via a negative feedback mechanism [16].”
BackgroundGlucocorticoid-induced Thyrotoxic Periodic Paralysis Following Lumbar Nerve Root Block
Uda, S., Shimizu, H., & Nishioka, H. (2025) · Internal Medicine · doi:10.2169/internalmedicine.5987-25 · Cited by 1 · see citing works
Thyrotoxic Periodic Paralysis- An Uncommon Disease in the Western World: A Case Report
Samad, S., Samuel Joshua, M., & Popilevsky, F. (2021) · International Journal of Critical Care and Emergency Medicine · doi:10.23937/2474-3674/1510117
Hiccups as a Rare Presentation of Thyrotoxicosis Triaged by an Epidural Steroid Injection
Al-Radideh, O., Farouji, I., DaCosta, T. R., Abed, H., & Baranestky, N. (2021) · Cureus · doi:10.7759/cureus.16438
Thyrotoxic Periodic Paralysis: A Review and Suggestions for Treatment
Krasnova, S. L., Topilow, A. A., Calissendorff, J., & Falhammar, H. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-76097-3.00006-5
(2019) · Reactions Weekly · doi:10.1007/s40278-019-61093-4
Contreras-García, C., Salgado-Gómez, E., & Ochoa-Magdaleno, J. (2023) · Revista Mexicana de Endocrinología Metabolismo y Nutrición · doi:10.24875/rme.23000014
- Authors
- Affram, K. O., Reddy, T. L., & Osei, K. M.
- Affiliations
- Piedmont Athens Regional (US)
- Corresponding author
- Osei, Kofi M.
- ORCID
- Affram, Kwame Ofori
- Venue
- American Journal of Case Reports
- Published
- 2018-12-08
- Volume
- 19
- Pages
- 1453-1458
- ISSN
- 1941-5923 (ISSN-L)
- PMC
- PMC6293861
- OpenAlex
- W2903792611
- Semantic Scholar
- 26d646b91f52b0484ef0e5f5eeb3a9554aba17d5
- Cited by
- 13
- References
- 29
- Citations by year
- 2025: 2 · 2023: 3 · 2022: 2 · 2021: 5 · 2019: 1
- FWCI
- 1.19
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- American Journal of Case Reports (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Potassium and Related Disorders
- Health Sciences › Medicine › Surgery › Medical Case Reports and Studies
- Keywords
- thyrotoxic periodic paralysis, epidural steroid injection complications, hypokalemia, hyperthyroidism, Graves' disease, potassium correction
- MeSH terms
- Adult, Glucocorticoids, Graves Disease, Humans, Hypokalemia, Injections, Epidural, Male, Paralysis, Thyrotoxicosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Claims read by deepseek-v4.1-flash under definition version 3 (extract-v3) on 2026-10-09.
Classified by jev-1.13-20260917 (gold-guideline-v0.2) on 2026-10-09.
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