Thyrotoxic Periodic Paralysis Induced by Pulse Methylprednisolone
Open accessAbstract
We present a young Thai man who developed acute flaccid paralysis after receiving pulse methylprednisolone for chronic inflammatory demyelinating polyneuropathy. Hypokalemia from intracellular shift was confirmed by calculation of transtubular potassium gradient (TTKG). His muscle strength and serum potassium fully recovered with a small amount of potassium replacement. Graves' disease was subsequently diagnosed and treated with radioactive iodine. We suggest that acute paralysis after the use of steroids should raise a suspicion of thyrotoxic periodic paralysis (TPP). The potential mechanisms of steroid-induced TPP are discussed.
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From the literature reviews, about 10 cases have been reported regarding steroids as a precipitating factor of THPP, ranging from low dose prednisolone to pulse methylprednisolone.
“From the literature reviews, about 10 cases have been reported regarding the steroids as a precipitating factor of THPP, ranging from low dose prednisolone to pulse methylprednisolone (7,8).”
From Thyrotoxic hypokalemic periodic paralysis triggered by dexamethasone administration (2020) · cites this paper as [8]
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- Authors
- Wongraoprasert, S., Buranasupkajorn, P., Sridama, V., & Snabboon, T.
- Affiliations
- Chulalongkorn University (TH)
- ORCID
- Snabboon, Thiti
- Venue
- Internal Medicine
- Published
- 2007
- Volume
- 46
- Issue
- 17
- Pages
- 1431-1434
- ISSN
- 0918-2918 (ISSN-L)
- 1349-7235
- OpenAlex
- W2119702205
- Cited by
- 37
- References
- 11
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 3 · 2018: 2 · 2016: 2 · 2015: 1 · 2014: 4 · 2013: 3 · 2012: 4
- FWCI
- 1.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Potassium and Related Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- thyrotoxic periodic paralysis, methylprednisolone pulse therapy, acute flaccid paralysis, chronic inflammatory demyelinating polyneuropathy, transtubular potassium gradient, potassium supplementation, Graves' disease, radioiodine therapy, drug-induced hypokalemia
- MeSH terms
- Adult, Glucocorticoids, Graves Disease, Humans, Male, Methylprednisolone, Polyneuropathies, Thyrotoxicosis, Hypokalemic Periodic Paralysis, Pulse Therapy, Drug
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