Cited by 606Memory and Neural MechanismsSpatial Cognition and NavigationNeurogenesis and neuroplasticity mechanisms

Place cells and place recognition maintained by direct entorhinal-hippocampal circuitry

Brun, Vegard H., Otnæss, Mona K., Molden, Sturla, Steffenach, Hill-Aina, Witter, Menno P., Moser, May-Britt, Moser, Edvard I.·2002·Science

Abstract

Place cells in hippocampal area CA1 may receive positional information from the intrahippocampal associative network in area CA3 or directly from the entorhinal cortex. To determine whether direct entorhinal connections support spatial firing and spatial memory, we removed all input from areas CA3 to CA1, thus isolating the CA1 area. Pyramidal cells in the isolated CA1 area developed sharp and stable place fields. Rats with an isolated CA1 area showed normal acquisition of an associative hippocampal-dependent spatial recognition task. Spatial recall was impaired. These results suggest that the hippocampus contains two functionally separable memory circuits: The direct entorhinal-CA1 system is sufficient for recollection-based recognition memory, but recall depends on intact CA3-CA1 connectivity.

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Crossref · 10.1126/science.1071089

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  • The disynaptic circuit can account for residual hippocampal-dependent memory and high levels of CA1 place cell firing in vivo following surgical or genetic lesions of CA3.

    “Moreover, the disynaptic circuit can account for the residual hippocampal-dependent memory and high levels of CA1 place cell firing in vivo following surgical or genetic lesions of CA3 (Brun et al., 2002; Nakashiba et al., 2008).”

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Authors
Brun, V. H., Otnæss, M. K., Molden, S., Steffenach, H.-A., Witter, M. P., Moser, M.-B., & Moser, E. I.
Affiliations
  • Norwegian University of Science and Technology (NO)
  • Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
Corresponding author
Moser, Edvard I.
Venue
Science
Published
2002-06-21
Volume
296
Issue
5576
Pages
2243-2246
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2004974848
Cited by
606
References
24
Citations by year
2026: 13 · 2025: 20 · 2024: 15 · 2023: 17 · 2022: 17 · 2021: 26 · 2020: 20 · 2019: 18 · 2018: 18 · 2017: 26 · 2016: 35 · 2015: 39 · 2014: 33 · 2013: 25 · 2012: 31
FWCI
13.98
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Physical Sciences › Engineering › Automotive Engineering › Spatial Cognition and Navigation
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
place cells, entorhinal cortex, hippocampal CA1, spatial memory, recollection
MeSH terms
Action Potentials, Animals, Brain Mapping, Denervation, Electrodes, Implanted, Hippocampus, Interneurons, Memory, Nerve Net, Neural Pathways, Mental Recall, Space Perception, Pyramidal Cells, Entorhinal Cortex, Maze Learning, Rats

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