Cited by 268Effects and risks of endocrine disrupting chemicalsNeuroendocrine regulation and behaviorSexual Differentiation and Disorders

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Exposure to a low dose of bisphenol A during fetal life or in adulthood alters maternal behavior in mice.

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Palanza, Paola L, Howdeshell, Kembra L, Parmigiani, Stefano, vom Saal, Frederick S·2002·Environmental Health Perspectives

DOI 10.1289/ehp.02110s3415PMC PMC1241192

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Abstract

Maternal behavior in mammals is the result of a complex interaction between the lactating dam and her developing offspring. Slight perturbations of any of the components of the mother-infant interaction may result in alterations of the behavior of the mother and/or of the offspring. We studied the effects of exposure of female CD-1 mice to the estrogenic chemical bisphenol A (BPA) during fetal life and/or in adulthood during the last part of pregnancy on subsequent maternal behavior. Pregnant females were fed daily doses of corn oil (controls) or 10 microg/kg body weight BPA during gestation days 14-18. As adults, the prenatally treated female offspring were time-mated and again fed either corn oil (controls) or the same doses of BPA on gestation days 14-18, resulting in four treatment groups: controls, prenatal BPA exposure, adult BPA exposure, and both prenatal and adult BPA exposure. Maternal behavior was then observed on postnatal days 2-15 and reflex responses were examined in the offspring. Dams exposed to BPA either as fetuses or in adulthood spent less time nursing their pups and more time out of the nest compared with the control group. Females exposed to BPA both as fetuses and in adulthood did not significantly differ from controls. No alterations in postnatal reflex development were observed in the offspring of the females exposed to BPA. The changes seen in maternal behavior may be the result of a direct effect of BPA on the neuroendocrine substrates underlying the initiation of maternal behavior.

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“Other low-dose effects of BPA that have been reported in rodents include an accelerated rate of embryonic development (35,36), accelerated growth and early puberty in females (19), and changes in the mammary gland (37), vagina (38), prostate (17,39–42), sperm production (18) [see also Sakaue et al.”
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Authors: Palanza, P. L., Howdeshell, K. L., Parmigiani, S., & vom Saal, F. S.
Affiliations: University of Parma (IT)
Department of Evolutionary and Functional Biology, Parma University, Parco Area delle Scienze 11A, 43100 Parma, Italy. palanza@biol.unipr.it
ORCID: Palanza, Paola L
Howdeshell, Kembra L
Parmigiani, Stefano
Venue: Environmental Health Perspectives
Publisher: American Chemical Society (ACS)
Published: 2002-06-01
Volume: 110
Issue: suppl 3
Pages: 415-422
ISSN: 0091-6765 (ISSN-L)
1552-9924
DOI: 10.1289/ehp.02110s3415
PMC: PMC1241192
OpenAlex: W1982546336
Cited by: 268
References: 50
Citations by year: 2026: 2 · 2025: 1 · 2024: 4 · 2023: 7 · 2022: 9 · 2021: 13 · 2020: 7 · 2019: 8 · 2018: 14 · 2017: 15 · 2016: 13 · 2015: 12 · 2014: 17 · 2013: 13 · 2012: 15
FWCI: 7.68
Type: journal article
Language: en
Open access: gold
doi.org
Licence: public-domain
creativecommons.org/licenses/by/4.0/ (vor, 5690 d)
Locations: Environmental Health Perspectives (publishedVersion, public-domain)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
MOspace Institutional Repository (University of Missouri) (submittedVersion)
Funders: Università degli Studi di Parma
National Institutes of Health (5r01es008293-04)
National Institute of Environmental Health Sciences (ES 08293)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
Keywords: bisphenol A, maternal behavior, prenatal exposure, nursing behavior, mother-infant interaction, ICR mice
MeSH terms: Bisphenol A Compounds, Administration, Oral, Animals, Benzhydryl Compounds, Estrogens, Non-Steroidal, Female, Lactation, Male, Maternal Behavior, Phenols, Pregnancy, Prenatal Exposure Delayed Effects, Reflex, Mice

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Exposure to a low dose of bisphenol A during fetal life or in adulthood alters maternal behavior in mice.

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