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Exposure to a low dose of bisphenol A during fetal life or in adulthood alters maternal behavior in mice.
Open accessAbstract
Maternal behavior in mammals is the result of a complex interaction between the lactating dam and her developing offspring. Slight perturbations of any of the components of the mother-infant interaction may result in alterations of the behavior of the mother and/or of the offspring. We studied the effects of exposure of female CD-1 mice to the estrogenic chemical bisphenol A (BPA) during fetal life and/or in adulthood during the last part of pregnancy on subsequent maternal behavior. Pregnant females were fed daily doses of corn oil (controls) or 10 microg/kg body weight BPA during gestation days 14-18. As adults, the prenatally treated female offspring were time-mated and again fed either corn oil (controls) or the same doses of BPA on gestation days 14-18, resulting in four treatment groups: controls, prenatal BPA exposure, adult BPA exposure, and both prenatal and adult BPA exposure. Maternal behavior was then observed on postnatal days 2-15 and reflex responses were examined in the offspring. Dams exposed to BPA either as fetuses or in adulthood spent less time nursing their pups and more time out of the nest compared with the control group. Females exposed to BPA both as fetuses and in adulthood did not significantly differ from controls. No alterations in postnatal reflex development were observed in the offspring of the females exposed to BPA. The changes seen in maternal behavior may be the result of a direct effect of BPA on the neuroendocrine substrates underlying the initiation of maternal behavior.
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“We did this to limit offspring exposure to BPA to the gestational period and because differences in maternal behavior caused by BPA might affect behavior [16], [39].”
From Gestational Exposure to Low Dose Bisphenol A Alters Social Behavior in Juvenile Mice (2011) · cites this paper as [39]
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“We did this to limit offspring exposure to BPA to the gestational period and because differences in maternal behavior caused by BPA might affect behavior [16], [39].”
From Gestational Exposure to Low Dose Bisphenol A Alters Social Behavior in Juvenile Mice (2011) · cites this paper as [39]
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Cites
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Exposure to bisphenol A advances puberty
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“Other low-dose effects of BPA that have been reported in rodents include an accelerated rate of embryonic development (35,36), accelerated growth and early puberty in females (19), and changes in the mammary gland (37), vagina (38), prostate (17,39–42), sperm production (18) [see also Sakaue et al.”
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Bisphenol Analogues Other Than BPA: Environmental Occurrence, Human Exposure, and Toxicity—A Review
Chen, D., Kannan, K., Tan, H., Zheng, Z., Feng, Y.-L., Wu, Y., & Widelka, M. (2016) · Environmental Science & Technology · doi:10.1021/acs.est.5b05387 · Cited by 1,704
Bisphenol-A and the Great Divide: A Review of Controversies in the Field of Endocrine Disruption
Vandenberg, L. N., Maffini, M. V., Sonnenschein, C., Rubin, B. S., & Soto, A. M. (2009) · Endocrine Reviews · doi:10.1210/er.2008-0021 · Cited by 1,407
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Huang, Y., Wong, C. K. C., Zheng, J., Bouwman, H., Barra, R. O., Wahlström, B. A., Neretin, L. N., & Wong, M. H. (2011) · Environment International · doi:10.1016/j.envint.2011.04.010 · Cited by 1,148
In vivo effects of bisphenol A in laboratory rodent studies
Richter, C. A., Birnbaum, L. S., Farabollini, F., Newbold, R. R., Rubin, B. S., Talsness, C. E., Vandenbergh, J. G., Walser-Kuntz, D. R., & vom Saal, F. S. (2007) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.06.004 · Cited by 1,147
Metadata
- Authors
- Palanza, P. L., Howdeshell, K. L., Parmigiani, S., & vom Saal, F. S.
- Affiliations
- University of Parma (IT)
- Department of Evolutionary and Functional Biology, Parma University, Parco Area delle Scienze 11A, 43100 Parma, Italy. palanza@biol.unipr.it
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 2002-06-01
- Volume
- 110
- Issue
- suppl 3
- Pages
- 415-422
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- PMC
- PMC1241192
- OpenAlex
- W1982546336
- Cited by
- 268
- References
- 50
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 4 · 2023: 7 · 2022: 9 · 2021: 13 · 2020: 7 · 2019: 8 · 2018: 14 · 2017: 15 · 2016: 13 · 2015: 12 · 2014: 17 · 2013: 13 · 2012: 15
- FWCI
- 7.68
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- public-domain
- creativecommons.org/licenses/by/4.0/ (vor, 5690 d)
- Locations
- Environmental Health Perspectives (publishedVersion, public-domain)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- MOspace Institutional Repository (University of Missouri) (submittedVersion)
- Funders
- Università degli Studi di Parma
- National Institutes of Health (5r01es008293-04)
- National Institute of Environmental Health Sciences (ES 08293)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Keywords
- bisphenol A, maternal behavior, prenatal exposure, nursing behavior, mother-infant interaction, ICR mice
- MeSH terms
- Bisphenol A Compounds, Administration, Oral, Animals, Benzhydryl Compounds, Estrogens, Non-Steroidal, Female, Lactation, Male, Maternal Behavior, Phenols, Pregnancy, Prenatal Exposure Delayed Effects, Reflex, Mice
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