Cited by 820Effects and risks of endocrine disrupting chemicalsSexual Differentiation and DisordersEstrogen and related hormone effects

Exposure to bisphenol A advances puberty

Howdeshell, Kembra L., Hotchkiss, Andrew K., Thayer, Kristina A., Vandenbergh, John G., vom Saal, Frederick S.·1999·Nature

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Crossref · 10.1038/44517

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13 of 13 references verified0 citation errors · 0 not checkable

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  • In some litter-bearing species, proximity in utero of females to males can partially masculinize female siblings and alter their responsiveness to endocrine-disrupting compounds.

    “In some litter-bearing species, proximity in utero of females to males can partially masculinize female siblings and alter their responsiveness to endocrine-disrupting compounds.”
  • Failure to account for intrauterine position in EDC toxicology studies could lead to false negative results, especially when adverse alterations are produced by low doses in fetuses from only one IUP.

    “In this regard, failure to account for IUP in EDC toxicology studies could lead to false negative results, especially when adverse alterations are produced by low doses in fetuses from only one IUP (Howdeshell et al. 1999; Welshons et al. 1999).”

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Authors
Howdeshell, K. L., Hotchkiss, A. K., Thayer, K. A., Vandenbergh, J. G., & vom Saal, F. S.
Affiliations
  • University of Missouri (US)
  • North Carolina State University (US)
Venue
Nature
Published
1999-10
Volume
401
Issue
6755
Pages
763-764
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
OpenAlex
W1543950566
Cited by
820
References
13
Citations by year
2026: 10 · 2025: 7 · 2024: 12 · 2023: 12 · 2022: 16 · 2021: 19 · 2020: 27 · 2019: 27 · 2018: 29 · 2017: 34 · 2016: 40 · 2015: 30 · 2014: 40 · 2013: 49 · 2012: 29
FWCI
34.18
Type
journal article
Language
en
Open access
closed
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords
bisphenol A, endocrine disruptors, puberty onset, estrogenic activity, prenatal exposure, postnatal growth, early sexual maturation, reproductive development, environmental chemical exposure
MeSH terms
Bisphenol A Compounds, Animals, Benzhydryl Compounds, Body Weight, Estrogens, Non-Steroidal, Female, Fetus, Humans, Male, Models, Biological, Phenols, Pregnancy, Prenatal Exposure Delayed Effects, Sexual Maturation, Mice

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