Cited by 268Effects and risks of endocrine disrupting chemicalsNeuroendocrine regulation and behaviorSexual Differentiation and Disorders

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Exposure to a low dose of bisphenol A during fetal life or in adulthood alters maternal behavior in mice.

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Palanza, Paola L, Howdeshell, Kembra L, Parmigiani, Stefano, vom Saal, Frederick S·2002·Environmental Health Perspectives

DOI 10.1289/ehp.02110s3415PMC PMC1241192

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Abstract

Maternal behavior in mammals is the result of a complex interaction between the lactating dam and her developing offspring. Slight perturbations of any of the components of the mother-infant interaction may result in alterations of the behavior of the mother and/or of the offspring. We studied the effects of exposure of female CD-1 mice to the estrogenic chemical bisphenol A (BPA) during fetal life and/or in adulthood during the last part of pregnancy on subsequent maternal behavior. Pregnant females were fed daily doses of corn oil (controls) or 10 microg/kg body weight BPA during gestation days 14-18. As adults, the prenatally treated female offspring were time-mated and again fed either corn oil (controls) or the same doses of BPA on gestation days 14-18, resulting in four treatment groups: controls, prenatal BPA exposure, adult BPA exposure, and both prenatal and adult BPA exposure. Maternal behavior was then observed on postnatal days 2-15 and reflex responses were examined in the offspring. Dams exposed to BPA either as fetuses or in adulthood spent less time nursing their pups and more time out of the nest compared with the control group. Females exposed to BPA both as fetuses and in adulthood did not significantly differ from controls. No alterations in postnatal reflex development were observed in the offspring of the females exposed to BPA. The changes seen in maternal behavior may be the result of a direct effect of BPA on the neuroendocrine substrates underlying the initiation of maternal behavior.

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Colborn, T., Saal, F. S. V., & Soto, A. M. (1993) · Environmental Health Perspectives · doi:10.1289/ehp.93101378 · Cited by 3,570
Maternal Care, Hippocampal Glucocorticoid Receptors, and Hypothalamic-Pituitary-Adrenal Responses to Stress
Liu, D., Diorio, J., Tannenbaum, B., Caldji, C., Francis, D., Freedman, A., Sharma, S., Pearson, D., Plotsky, P. M., & Meaney, M. J. (1997) · Science · doi:10.1126/science.277.5332.1659 · Cited by 3,170
Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations
Meaney, M. J. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1161 · Cited by 2,708
Nongenomic Transmission Across Generations of Maternal Behavior and Stress Responses in the Rat
Francis, D., Diorio, J., Liu, D., & Meaney, M. J. (1999) · Science · doi:10.1126/science.286.5442.1155 · Cited by 1,965
Maternal care during infancy regulates the development of neural systems mediating the expression of fearfulness in the rat
Caldji, C., Tannenbaum, B., Sharma, S., Francis, D., Plotsky, P. M., & Meaney, M. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.5335 · Cited by 1,437
Intellectual impairment in children exposed to polychlorinated biphenyls in utero
Jacobson, J. L., & Jacobson, S. W. (1996) · New England Journal of Medicine · doi:10.1056/nejm199609123351104 · Cited by 1,132
The Inheritance of Epigenetic Defects
Holliday, R. (1987) · Science · doi:10.1126/science.3310230 · Cited by 1,096
Exposure to bisphenol A advances puberty
Howdeshell, K. L., Hotchkiss, A. K., Thayer, K. A., Vandenbergh, J. G., & vom Saal, F. S. (1999) · Nature · doi:10.1038/44517 · Cited by 820 · cited 1×
“Other low-dose effects of BPA that have been reported in rodents include an accelerated rate of embryonic development (35,36), accelerated growth and early puberty in females (19), and changes in the mammary gland (37), vagina (38), prostate (17,39–42), sperm production (18) [see also Sakaue et al.”
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Relative Binding Affinity-Serum Modified Access (RBA-SMA) Assay Predicts the Relative In Vivo Bioactivity of the Xenoestrogens Bisphenol A and Octylphenol
Nagel, S. C., Saal, F. S. V., Thayer, K. A., Dhar, M., Boechler, M., & Welshons, W. V. (1997) · Environmental Health Perspectives · doi:10.1289/ehp.9710570 · Cited by 793
A Physiologically Based Approach To the Study of Bisphenol a and Other Estrogenic Chemicals On the Size of Reproductive Organs, Daily Sperm Production, and Behavior
Saal, F. S. V., Cooke, P. S., Buchanan, D. L., Palanza, P., Thayer, K. A., Nagel, S. C., Parmigiani, S., & Welshons, W. V. (1998) · Toxicology and Industrial Health · doi:10.1177/074823379801400115 · Cited by 757
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Saal, F. S. V., & Hughes, C. L. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.7713 · Cited by 1,174
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Huang, Y., Wong, C. K. C., Zheng, J., Bouwman, H., Barra, R. O., Wahlström, B. A., Neretin, L. N., & Wong, M. H. (2011) · Environment International · doi:10.1016/j.envint.2011.04.010 · Cited by 1,148
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Richter, C. A., Birnbaum, L. S., Farabollini, F., Newbold, R. R., Rubin, B. S., Talsness, C. E., Vandenbergh, J. G., Walser-Kuntz, D. R., & vom Saal, F. S. (2007) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.06.004 · Cited by 1,147
Components of plastic: experimental studies in animals and relevance for human health
Talsness, C. E., Martino‐Andrade, A. J., Kuriyama, S. N., Taylor, J. A., & Saal, F. S. V. (2009) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2008.0281 · Cited by 663
NTP‐CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A
Chapin, R. E., Adams, J., Boekelheide, K., Gray, L. E., Hayward, S. W., Lees, P. S. J., Mcintyre, B., Portier, K. M., Schnorr, T. M., Selevan, S. G., et al. (2008) · Birth Defects Research Part B Developmental and Reproductive Toxicology · doi:10.1002/bdrb.20147 · Cited by 514
Sex-specific epigenetic disruption and behavioral changes following low-dose in utero bisphenol A exposure
Kundakovic, M., Gudsnuk, K., Franks, B., Madrid, J., Miller, R. L., Perera, F. P., & Champagne, F. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1214056110 · Cited by 490
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Bisphenol A and human chronic diseases: Current evidences, possible mechanisms, and future perspectives
Rezg, R., El‐Fazâa, S., Gharbi, N., & Mornagui, B. (2014) · Environment International · doi:10.1016/j.envint.2013.12.007 · Cited by 450
Endocrine disruptor bisphenol A strongly binds to human estrogen-related receptor γ (ERRγ) with high constitutive activity
Takayanagi, S., Tokunaga, T., Liu, X., Okada, H., Matsushima, A., & Shimohigashi, Y. (2006) · Toxicology Letters · doi:10.1016/j.toxlet.2006.08.012 · Cited by 407
Exposure to Bisphenol A and Other Phenols in Neonatal Intensive Care Unit Premature Infants
Calafat, A. M., Weuve, J., Ye, X., Jia, L. T., Hu, H., Ringer, S., Huttner, K., & Hauser, R. (2009) · Environmental Health Perspectives · doi:10.1289/ehp.0800265 · Cited by 374
Gestational Exposure to Bisphenol A Produces Transgenerational Changes in Behaviors and Gene Expression
Wolstenholme, J. T., Edwards, M., Shetty, S. R. J., Gatewood, J. D., Taylor, J. A., Rissman, E. F., & Connelly, J. J. (2012) · Endocrinology · doi:10.1210/en.2012-1195 · Cited by 319
The role of bisphenol A in shaping the brain, epigenome and behavior
Wolstenholme, J. T., Rissman, E. F., & Connelly, J. J. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.10.001 · Cited by 309
Transfer of bisphenol A across the human placenta
Balakrishnan, B., Henare, K., Thorstensen, E. B., Ponnampalam, A. P., & Mitchell, M. D. (2010) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2010.01.025 · Cited by 304
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Howdeshell, K. L., Peterman, P. H., Judy, B. M., Taylor, J. A., Orazio, C. E., Ruhlen, R. L., Saal, F. S. V., & Welshons, W. V. (2003) · Environmental Health Perspectives · doi:10.1289/ehp.5993 · Cited by 300
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Schecter, A. J., Malik, N., Haffner, D. N., Smith, S., Harris, T. R., Paepke, O., & Birnbaum, L. S. (2010) · Environmental Science & Technology · doi:10.1021/es102785d · Cited by 297
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Aiken, C., & Ozanne, S. E. (2013) · Human Reproduction Update · doi:10.1093/humupd/dmt043 · Cited by 295
Minireview: Endocrine disruptors: Past lessons and future directions
Schug, T. T., Johnson, A. F., Birnbaum, L. S., Colborn, T., Guillette, L. J., Crews, D. P., Collins, T., Soto, A. M., vom Saal, F. S., McLachlan, J. A., et al. (2016) · Molecular Endocrinology · doi:10.1210/me.2016-1096 · Cited by 282
Effects of developmental exposure to bisphenol A on brain and behavior in mice
Palanza, P., Gioiosa, L., Saal, F. S. V., & Parmigiani, S. (2008) · Environmental Research · doi:10.1016/j.envres.2008.07.023 · Cited by 283
Self-citation
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Kundaković, M., & Champagne, F. A. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.02.005 · Cited by 280
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Rubin, B. S., Lenkowski, J. R., Schaeberle, C. M., Vandenberg, L. N., Ronsheim, P. M., & Soto, A. M. (2006) · Endocrinology · doi:10.1210/en.2006-0189 · Cited by 311
Current Knowledge on Endocrine Disrupting Chemicals (EDCs) from Animal Biology to Humans, from Pregnancy to Adulthood: Highlights from a National Italian Meeting
Street, M. E., Angelini, S., Bernasconi, S., Burgio, E., Cassio, A., Catellani, C., Cirillo, F., Deodati, A., Fabbrizi, E., Fanos, V., et al. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061647 · Cited by 272
Self-citation
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Saal, F. S. V., & Welshons, W. V. (2005) · Environmental Research · doi:10.1016/j.envres.2005.09.001 · Cited by 257
Endocrine disruptors: from Wingspread to environmental developmental biology
Markey, C. M., Rubin, B. S., Soto, A. M., & Sonnenschein, C. (2002) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(02)00272-8 · Cited by 212
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Willhite, C. C., Ball, G. L., & McLellan, C. J. (2008) · Journal of Toxicology and Environmental Health Part B · doi:10.1080/10937400701724303 · Cited by 198
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Saili, K. S., Corvi, M. M., Weber, D. N., Patel, A. U., Das, S. R., Przybyla, J., Anderson, K. A., & Tanguay, R. L. (2011) · Toxicology · doi:10.1016/j.tox.2011.11.001 · Cited by 204
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Yolton, K. A., Xu, Y. Y., Strauss, D., Altaye, M., Calafat, A. M., & Khoury, J. C. (2011) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2011.08.003 · Cited by 199
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Grumetto, L., Montesano, D., Seccia, S., Albrizio, S., & Barbato, F. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf802297z · Cited by 187
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Huang, R.-P., Liu, Z., Yin, H., Dang, Z., Wu, P., Zhu, N., & Lin, Z. (2018) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2018.01.144 · Cited by 184
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Jašarević, E., Sieli, P. T., Twellman, E. E., Welsh, T. H., Schachtman, T. R., Roberts, R. M., Geary, D. C., & Rosenfeld, C. S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1107958108 · Cited by 183
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“We did so not only to limit the exposure time but also to remove the complicating effects that BPA may have on maternal behavior [16,39].”
Background
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Schug, T. T., Abagyan, R. A., Blumberg, B., Collins, T. J., Crews, D. P., deFur, P. L., Dickerson, S. M., Edwards, T. M., Gore, A. C., Guillette, L. J., et al. (2012) · Green Chemistry · doi:10.1039/c2gc35055f · Cited by 148
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Braunrath, R., Podlipna, D., Padlesak, S., & Cichna‐Markl, M. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf051525j · Cited by 138
Gestational exposure to bisphenol A and cross-fostering affect behaviors in juvenile mice.
Cox, K. H., Gatewood, J. D., Howeth, C., & Rissman, E. F. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.07.008 · Cited by 127
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Berger, A., Ziv‐Gal, A., Cudiamat, J., Wang, W., Zhou, C., & Flaws, J. A. (2015) · Reproductive Toxicology · doi:10.1016/j.reprotox.2015.12.004 · Cited by 121
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Rosenfeld, C. S. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00057 · Cited by 125
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Porrini, S., Belloni, V., Seta, D. D., Farabollini, F., Giannelli, G., & Dessì-Fulgheri, F. (2005) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2004.11.014 · Cited by 114
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Seta, D. D., Minder, I., Dessì-Fulgheri, F., & Farabollini, F. (2005) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2004.11.017 · Cited by 107
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Golub, M. S., Wu, K. L., Kaufman, F. L., Li, L., Moran, F. M., Zeise, L. A., Alexeeff, G. V., & Donald, J. M. (2010) · Birth Defects Research Part B Developmental and Reproductive Toxicology · doi:10.1002/bdrb.20275 · Cited by 106
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Self-citation
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Kim, M. E., Park, H. R., Gong, E. J., Choi, S. Y., Kim, H. S., & Lee, J. (2011) · Food and Chemical Toxicology · doi:10.1016/j.fct.2011.09.017 · Cited by 95
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Sobolewski, M., Conrad, K., Allen, J. L., Weston, H., Martin, K., Lawrence, B. P., & Cory-Slechta, D. A. (2014) · NeuroToxicology · doi:10.1016/j.neuro.2014.09.008 · Cited by 91
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Mita, L., Bianco, M., Viggiano, E., Zollo, F., Bencivenga, U., Sica, V., Monaco, G., Portaccio, M., Diano, N., A, C., et al. (2010) · Chemosphere · doi:10.1016/j.chemosphere.2010.09.071 · Cited by 88
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Adewale, H. B., Todd, K. L., Mickens, J. A., & Patisaul, H. B. (2011) · NeuroToxicology · doi:10.1016/j.neuro.2010.07.008 · Cited by 86
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Johnson, S. A., Javurek, A. B., Painter, M. S., Ellersieck, M. R., Welsh, T. H., Camacho, L., Lewis, S. M., Vanlandingham, M. M., Ferguson, S. A., & Rosenfeld, C. S. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.09.005 · Cited by 90
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Authors: Palanza, P. L., Howdeshell, K. L., Parmigiani, S., & vom Saal, F. S.
Affiliations: University of Parma (IT)
Department of Evolutionary and Functional Biology, Parma University, Parco Area delle Scienze 11A, 43100 Parma, Italy. palanza@biol.unipr.it
ORCID: Palanza, Paola L
Howdeshell, Kembra L
Parmigiani, Stefano
Venue: Environmental Health Perspectives
Publisher: American Chemical Society (ACS)
Published: 2002-06-01
Volume: 110
Issue: suppl 3
Pages: 415-422
ISSN: 0091-6765 (ISSN-L)
1552-9924
DOI: 10.1289/ehp.02110s3415
PMC: PMC1241192
OpenAlex: W1982546336
Cited by: 268
References: 50
Citations by year: 2026: 2 · 2025: 1 · 2024: 4 · 2023: 7 · 2022: 9 · 2021: 13 · 2020: 7 · 2019: 8 · 2018: 14 · 2017: 15 · 2016: 13 · 2015: 12 · 2014: 17 · 2013: 13 · 2012: 15
FWCI: 7.68
Type: journal article
Language: en
Open access: gold
doi.org
Licence: public-domain
creativecommons.org/licenses/by/4.0/ (vor, 5690 d)
Locations: Environmental Health Perspectives (publishedVersion, public-domain)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
MOspace Institutional Repository (University of Missouri) (submittedVersion)
Funders: Università degli Studi di Parma
National Institutes of Health (5r01es008293-04)
National Institute of Environmental Health Sciences (ES 08293)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
Keywords: bisphenol A, maternal behavior, prenatal exposure, nursing behavior, mother-infant interaction, ICR mice
MeSH terms: Bisphenol A Compounds, Administration, Oral, Animals, Benzhydryl Compounds, Estrogens, Non-Steroidal, Female, Lactation, Male, Maternal Behavior, Phenols, Pregnancy, Prenatal Exposure Delayed Effects, Reflex, Mice

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Exposure to a low dose of bisphenol A during fetal life or in adulthood alters maternal behavior in mice.

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