Gestational exposure to bisphenol A and cross-fostering affect behaviors in juvenile mice.
Open accessAbstract
Bisphenol-A (BPA) is a component of polycarbonate resins, and, lately, concern has been raised about its potential negative effects on human health. BPA is an estrogen analog and, in addition, it can act as a DNA hypomethylator. We examined the effects of gestational exposure to BPA on several behaviors in C57BL/6J mice. Because BPA affects maternal care, which, may have long-lasting effects on offspring behavior, we tested mice raised by either biological or fostered dams. Both diet and dam affected behavior in juvenile mice in a social novelty task and the elevated plus maze (EPM). In a social novelty task, the amount of time spent interacting with an adult male was affected by sex and gestational diet, but only in juveniles raised by a foster dam. Control females spent less time sniffing a novel adult than did control males or females exposed to BPA during gestation. In the EPM, juveniles reared by foster dams and exposed to BPA during gestation spent less time in the distal half of the open arm as compared with juveniles gestated on a control diet. Adult offspring raised by their biological dams showed the same response pattern; gestational BPA increased anxiety as compared with control diet. Our results show that prenatal BPA exposure affects social behavior and anxiety in the EPM. Moreover, some facet(s) of the infant-maternal interaction may modify these effects.
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A 40-fold higher BPA dose decreased male social preference in the identical task.
“However a 40-fold higher BPA dose decreased male social preference in the identical task [16].”
From Gestational Exposure to Low Dose Bisphenol A Alters Social Behavior in Juvenile Mice (2011) · cites this paper as [16]
The Results (Social Novelty; page unavailable) report a diet-by-sex interaction in foster-reared juveniles, but identify increased investigation by BPA-exposed females rather than a decrease in male social preference. The Discussion (BPA Exposure Counteracts Sex Differences in Juvenile Social Behavior; page unavailable) describes BPA-exposed males as intermediate, not as showing a demonstrated decrease from control males. The Methods confirm a social-novelty task and a BPA dose, but the paper alone cannot establish the claimed 40-fold comparison. (LLM, conf=0.85)
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Experimental — accuracy not yet measuredExposure to a 40-fold higher BPA dose decreased time in the middle, increased time in the closed arm, and tended to decrease time in the outermost portion of the open arm, indicating increased anxiety-related behaviors in the plus maze.
“Yet again, exposure to the 40-fold higher BPA dose decreased time in the middle, increased time in the closed arm, and tended to decrease time in the outer most portion of the open arm [16], indicating that BPA at this high dose increased anxiety-related behaviors in the plus maze.”
From Gestational Exposure to Low Dose Bisphenol A Alters Social Behavior in Juvenile Mice (2011) · cites this paper as [16]
The Results (Elevated Plus Maze; page unavailable) report that BPA-exposed juveniles spent less time in the middle and more time in the closed arms. They also report less time in the distal open arm, particularly among males. The Methods and Results give the administered dose but do not establish the claimed 40-fold comparison; the plus-maze effects also varied by sex and rearing condition. (LLM, conf=0.86)
Experimental — accuracy not yet measuredBPA can influence social interactions and anxiety in rodents.
“BPA can also influence social interactions and anxiety in rodents [7], [15], [16], [17].”
From Gestational Exposure to Low Dose Bisphenol A Alters Social Behavior in Juvenile Mice (2011) · cites this paper as [16]
Pups were fostered to a control dam because differences in maternal behavior caused by BPA might affect behavior.
“We did this to limit offspring exposure to BPA to the gestational period and because differences in maternal behavior caused by BPA might affect behavior [16], [39].”
From Gestational Exposure to Low Dose Bisphenol A Alters Social Behavior in Juvenile Mice (2011) · cites this paper as [16]
Pups were fostered to a control dam to limit offspring exposure to BPA to the gestational period.
“We did this to limit offspring exposure to BPA to the gestational period and because differences in maternal behavior caused by BPA might affect behavior [16], [39].”
From Gestational Exposure to Low Dose Bisphenol A Alters Social Behavior in Juvenile Mice (2011) · cites this paper as [16]
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“N IH -PA Author M anuscript N IH -PA Author M anuscript N IH -PA Author M anuscript The time spent in each chamber, the time spent sniffing each jail cell, and the numbers of entries into each side were all scored (adapted from (Moy et al., 2004; Moy et al., 2009).”
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- Authors
- Cox, K. H., Gatewood, J. D., Howeth, C., & Rissman, E. F.
- Affiliations
- University of Virginia (US)
- Corresponding author
- Rissman, Emilie F.
- Venue
- Hormones and Behavior
- Publisher
- Elsevier BV
- Published
- 2010-11
- Volume
- 58
- Issue
- 5
- Pages
- 754-761
- ISSN
- 0018-506X (ISSN-L)
- PMC
- PMC2982867
- OpenAlex
- W2148428145
- Cited by
- 127
- References
- 7
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 2 · 2022: 8 · 2021: 10 · 2020: 8 · 2019: 3 · 2018: 10 · 2017: 10 · 2016: 10 · 2015: 13 · 2014: 13 · 2013: 12 · 2012: 11
- FWCI
- 8.33
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Hormones and Behavior (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Autism Speaks
- National Institutes of Health
- National Institute of Mental Health (R01MH086711)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (T32HD007323, U54HD028934, U54-HD-28934)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- bisphenol A, prenatal exposure, cross-fostering, maternal care, youth behavior, anxiety, social novelty, elevated plus maze, sex differences, developmental programming, endocrine disruptors, DNA hypomethylation
- MeSH terms
- Bisphenol A Compounds, Air Pollutants, Animals, Animal Husbandry, Animals, Newborn, Anxiety, Behavior, Animal, Benzhydryl Compounds, Exploratory Behavior, Female, Male, Maternal Deprivation, Mice, Inbred C57BL, Phenols, Pregnancy, Prenatal Exposure Delayed Effects, Maze Learning, Maternal Exposure, Mice
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