The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Bisphenol A Data in NHANES Suggest Longer than Expected Half-Life, Substantial Nonfood Exposure, or Both
Open accessAbstract
BACKGROUND: It is commonly stated in the literature on human exposure to bisphenol A (BPA) that food is the predominant BPA exposure source, and that BPA is rapidly and completely cleared from the body. If this is correct, BPA levels in fasting individuals should decrease with increased fasting time. OBJECTIVES: We set out to investigate the relationship between urine BPA concentration and fasting time in a population-based sample. METHODS: We modeled log BPA urine concentration as a function of fasting time, adjusted for urine creatinine and other confounders, in 1,469 adult participants in the 2003-2004 National Health and Nutrition Examination Survey. We estimated the BPA "population-based half-life" (pop(1/2)) for a fasting time of 0-24 hr, < 4.5 hr, 4.5-8.5 hr, and > 8.5 hr. RESULTS: The overall pop(1/2) for the 0- to 24-hr interval was 43 hr [95% confidence interval (CI), 26-119 hr]. Among those reporting fasting times of 4.5-8.5 hr (n = 441), BPA declined significantly with fasting time, with a pop(1/2) of 4.1 hr (95% CI, 2.6-10.6 hr). However, within the fasting time intervals of 0-4.5 hr (n = 129) and 8.5-24 hr (n = 899), we saw no appreciable decline. Fasting time did not significantly predict highest (> 12 ng/mL) or lowest (below limit of detection) BPA levels. CONCLUSIONS: Overall, BPA levels did not decline rapidly with fasting time in this sample. This suggests substantial nonfood exposure, accumulation in body tissues such as fat, or both. Explaining these findings may require experimental pharmacokinetic studies of chronic BPA exposure, further examination of BPA levels and effects in fat, and a search for important nonfood sources.
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Self-citationExposure of the U.S. Population to Bisphenol A and 4- tertiary -Octylphenol: 2003–2004
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Adipose tissue dysfunction in obesity, diabetes, and vascular diseases
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Metabolism and Kinetics of Bisphenol A in Humans at Low Doses Following Oral Administration
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vom Saal, F. S., Akingbemi, B. T., Belcher, S. M., Birnbaum, L. S., Crain, D. A., Eriksen, M., Farabollini, F., Guillette, L. J., Hauser, R., Heindel, J. J., et al. (2007) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.07.005 · Cited by 712
Self-citationWhen drug therapy gets old: pharmacokinetics and pharmacodynamics in the elderly
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Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement
Diamanti-Kandarakis, E., Bourguignon, J.-P., Giudice, L. C., Hauser, R., Prins, G. S., Soto, A. M., Zoeller, R. T., & Gore, A. C. (2009) · Endocrine Reviews · doi:10.1210/er.2009-0002 · Cited by 4,585
Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses
Vandenberg, L. N., Colborn, T., Hayes, T. B., Heindel, J. J., Jacobs, D. R., Lee, D.-H., Shioda, T., Soto, A. M., vom Saal, F. S., Welshons, W. V., et al. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1050 · Cited by 3,209
Self-citationMetabolism disrupting chemicals and metabolic disorders
Heindel, J. J., Blumberg, B., Cave, M., Machtinger, R., Mantovani, A., Mendez, M. A., Nadal, A., Palanza, P., Panzica, G., Sargis, R., et al. (2017) · Reproductive Toxicology · doi:10.1016/j.reprotox.2016.10.001 · Cited by 1,101
Corrales, J., Kristofco, L. A., Steele, W. B., Yates, B. S., Breed, C. S., Williams, E. S., & Brooks, B. W. (2015) · Dose-Response · doi:10.1177/1559325815598308 · Cited by 771
Association of urinary bisphenol a concentration with heart disease: evidence from NHANES 2003/06
Melzer, D., Rice, N. E., Lewis, C., Henley, W. E., & Galloway, T. S. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008673 · Cited by 572
Metadata
- Authors
- Stahlhut, R. W., Welshons, W. V., & Swan, S. H.
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-05
- Volume
- 117
- Issue
- 5
- Pages
- 784-789
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- OpenAlex
- W1977726417
- Cited by
- 422
- References
- 27
- FWCI
- 21.47
- Type
- journal article
- Language
- en
- Open access
- gold
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