The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Cancer and developmental exposure to endocrine disruptors.
Open accessAbstract
Developing organisms have increased susceptibility to cancer if they are exposed to environmental toxicants during rapid growth and differentiation. Human studies have demonstrated clear increases in cancer after prenatal exposure to ionizing radiation, and there is suggestive evidence that brain tumors and leukemia are associated with parental exposures to chemicals. Animal experiments have demonstrated increased tumor formation induced by prenatal or neonatal exposure to a variety of chemicals, including direct-acting carcinogens and drugs. Recently, natural estrogens have been classified as known human carcinogens. Prenatal exposure to natural and synthetic estrogens is associated with increases in breast and vaginal tumors in humans as well as uterine tumors in animals. Synthetic halogenated chemicals increase liver tumors after early life-stage exposure. Recently, a prototypical endocrine-disrupting compound, 2,3,7,8-tetrachlorodibenzo-p-dioxin, has been shown to be a developmental toxicant of the mammary gland in rodents. Dioxin alters multiple endocrine systems, and its effects on the developing breast involve delayed proliferation and differentiation of the mammary gland, as well as an elongation of the window of sensitivity to potential carcinogens. Implications of these new findings suggest that causes of endocrine-related cancers or susceptibility to cancer may be a result of developmental exposures rather than exposures existing at or near the time of tumor detection.
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Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife.
Van den Berg, M., Birnbaum, L., Bosveld, A. T., Brunström, B., Cook, P., Feeley, M., Giesy, J. P., Hanberg, A., Hasegawa, R., Kennedy, S. W., et al. (1998) · Environmental Health Perspectives · doi:10.1289/ehp.98106775 · Cited by 3,301
Self-citationHerbst, A. L., Ulfelder, H., & Poskanzer, D. C. (1971) · New England Journal of Medicine · doi:10.1056/nejm197104222841604 · Cited by 2,520
Skakkebæk, N. E., Rajpert-De Meyts, E., & Main, K. M. (2001) · Human Reproduction · doi:10.1093/humrep/16.5.972 · Cited by 2,260
Kociba, R. J., Keyes, D. G., Beyer, J. E., Carreon, R. M., Wade, C. E., Dittenber, D. A., Kalnins, R. P., Frauson, L. E., Park, C. N., Barnard, S. D., et al. (1978) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(78)90075-3 · Cited by 1,057
Risk of childhood cancer from fetal irradiation.
Doll, R., & Wakeford, R. (1997) · The British Journal of Radiology · doi:10.1259/bjr.70.830.9135438 · Cited by 680
Greaves, M. (1997) · The Lancet · doi:10.1016/s0140-6736(96)09412-3 · Cited by 504
Markey, C. M., Luque, E. H., Munoz de Toro, M., Sonnenschein, C., & Soto, A. M. (2001) · Biology of Reproduction · doi:10.1093/biolreprod/65.4.1215 · Cited by 412
Atrazine Disrupts the Hypothalamic Control of Pituitary-Ovarian Function
Cooper, R. L. (2000) · Toxicological Sciences · doi:10.1093/toxsci/53.2.297 · Cited by 365
Anderson, L. M., Diwan, B. A., Fear, N. T., & Roman, E. (2000) · Environmental Health Perspectives · doi:10.1289/ehp.00108s3573 · Cited by 363
McLachlan, J. A., Newbold, R. R., & Bullock, B. C. (1980) · PubMed · Cited by 360
Cited by
In vivo effects of bisphenol A in laboratory rodent studies
Richter, C. A., Birnbaum, L. S., Farabollini, F., Newbold, R. R., Rubin, B. S., Talsness, C. E., Vandenbergh, J. G., Walser-Kuntz, D. R., & vom Saal, F. S. (2007) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.06.004 · Cited by 1,147
Self-citationEffect of Endocrine Disruptor Pesticides: A Review
Mnif, W., Hassine, A. I. H., Bouaziz, A., Bartegi, A., Thomas, O., & Roig, B. (2011) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph8062265 · Cited by 1,012
Ho, S.-M., Tang, W.-Y., Belmonte de Frausto, J., & Prins, G. S. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0516 · Cited by 796
Public health implications of altered puberty timing
Golub, M. S., Collman, G. W., Foster, P. M. D., Kimmel, C. A., Rajpert-De Meyts, E., Reiter, E. O., Sharpe, R. M., Skakkebaek, N. E., & Toppari, J. (2008) · PEDIATRICS · doi:10.1542/peds.2007-1813g · Cited by 497
The Impact of Nutrition and Environmental Epigenetics on Human Health and Disease
Tiffon, C. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113425 · Cited by 499
Metadata
- Authors
- Birnbaum, L. S., & Fenton, S. E.
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 2003-04
- Volume
- 111
- Issue
- 4
- Pages
- 389-394
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- OpenAlex
- W2027109773
- Cited by
- 458
- References
- 57
- FWCI
- 12.03
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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