Public health implications of altered puberty timing

Golub, Mari S.; Collman, Gwen W.; Foster, Paul M.D.; Kimmel, Carole A.; Rajpert-De Meyts, Ewa; Reiter, Edward O.; Sharpe, Richard M.; Skakkebaek, Niels E.; Toppari, Jorma

doi:10.1542/peds.2007-1813g

Cited by 497Hypothalamic control of reproductive hormonesEffects and risks of endocrine disrupting chemicalsSexual Differentiation and Disorders

Public health implications of altered puberty timing

Golub, Mari S., Collman, Gwen W., Foster, Paul M.D., Kimmel, Carole A., Rajpert-De Meyts, Ewa, Reiter, Edward O., Sharpe, Richard M., Skakkebaek, Niels E. +1 more·2008·PEDIATRICS

DOI 10.1542/peds.2007-1813g

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Abstract

Changes in puberty timing have implications for the treatment of individual children, for the risk of later adult disease, and for chemical testing and risk assessment for the population. Children with early puberty are at a risk for accelerated skeletal maturation and short adult height, early sexual debut, potential sexual abuse, and psychosocial difficulties. Altered puberty timing is also of concern for the development of reproductive tract cancers later in life. For example, an early age of menarche is a risk factor for breast cancer. A low age at male puberty is associated with an increased risk for testicular cancer according to several, but not all, epidemiologic studies. Girls and, possibly, boys who exhibit premature adrenarche are at a higher risk for developing features of metabolic syndrome, including obesity, type 2 diabetes, and cardiovascular disease later in adulthood. Altered timing of puberty also has implications for behavioral disorders. For example, an early maturation is associated with a greater incidence of conduct and behavior disorders during adolescence. Finally, altered puberty timing is considered an adverse effect in reproductive toxicity risk assessment for chemicals. Recent US legislation has mandated improved chemical testing approaches for protecting children's health and screening for endocrine-disrupting agents, which has led to changes in the US Environmental Protection Agency's risk assessment and toxicity testing guidelines to include puberty-related assessments and to the validation of pubertal male and female rat assays for endocrine screening.

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Early puberty in boys is a risk factor for testicular cancer and delayed puberty can be a cause of being bullied, poor self-esteem, and psychosocial distress.
“Early puberty in boys is a risk factor for testicular cancer and delayed puberty can be a cause of being bullied, poor self-esteem, and psychosocial distress.18”
From Pubertal development and regulation (2016) · cites this paper as [18]

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Authors: Golub, M. S., Collman, G. W., Foster, P. M. D., Kimmel, C. A., Rajpert-De Meyts, E., Reiter, E. O., Sharpe, R. M., Skakkebaek, N. E., & Toppari, J.
Affiliations: California Environmental Protection Agency (US)
Division of Extramural Research and Training
National Institute of Environmental Health Sciences (US)
Environmental Protection Agency (US)
Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
Baystate Medical Center (US)
Medical Research Council (GB)
University of Turku (FI)
ORCID: Golub, Mari S.
Foster, Paul M.D.
Kimmel, Carole A.
Reiter, Edward O.
Sharpe, Richard M.
Toppari, Jorma
Venue: PEDIATRICS
Publisher: American Academy of Pediatrics (AAP)
Published: 2008-02-01
Volume: 121
Issue: Supplement_3
Pages: S218-S230
ISSN: 0031-4005 (ISSN-L)
1098-4275
DOI: 10.1542/peds.2007-1813g
OpenAlex: W2115662854
Cited by: 497
References: 152
Citations by year: 2026: 17 · 2025: 21 · 2024: 26 · 2023: 25 · 2022: 33 · 2021: 35 · 2020: 31 · 2019: 35 · 2018: 25 · 2017: 29 · 2016: 31 · 2015: 31 · 2014: 35 · 2013: 26 · 2012: 25
FWCI: 27.86
Type: journal article
Language: en
Open access: closed
Locations: PEDIATRICS (publishedVersion)
PubMed (publishedVersion)
Funders: National Center for Research Resources (P51RR000169, RR-00169)
Topics: Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
Keywords: puberty timing, precocious puberty, adult height, age at menarche, breast cancer risk, testicular cancer risk, premature adrenarche, metabolic syndrome, obesity, type 2 diabetes, cardiovascular disease, conduct disorder, behavioral disorders, reproductive toxicity, chemical risk assessment
MeSH terms: Age Factors, Animals, Child, Female, Humans, Male, Menarche, Metabolic Diseases, Puberty, Public Health, Risk Factors

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Public health implications of altered puberty timing

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