Cited by 2,205Heavy Metal Exposure and ToxicityHeavy metals in environmentMercury impact and mitigation studies

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Low-Level Environmental Lead Exposure and Children’s Intellectual Function: An International Pooled Analysis

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Lanphear, Bruce P., Hornung, Richard, Khoury, Jane, Yolton, Kimberly, Baghurst, Peter, Bellinger, David C., Canfield, Richard L., Dietrich, Kim N., Bornschein, Robert, Greene, Tom, Rothenberg, Stephen J., Needleman, Herbert L., Schnaas, Lourdes, Wasserman, Gail, Graziano, Joseph, Roberts, Russell·2005·Environmental Health Perspectives

DOI 10.1289/ehp.7688PMC PMC1257652

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Abstract

Lead is a confirmed neurotoxin, but questions remain about lead-associated intellectual deficits at blood lead levels < 10 μg/dL and whether lower exposures are, for a given change in exposure, associated with greater deficits. The objective of this study was to examine the association of intelligence test scores and blood lead concentration, especially for children who had maximal measured blood lead levels < 10 μg/dL. We examined data collected from 1,333 children who participated in seven international population-based longitudinal cohort studies, followed from birth or infancy until 5–10 years of age. The full-scale IQ score was the primary outcome measure. The geometric mean blood lead concentration of the children peaked at 17.8 μg/dL and declined to 9.4 μg/dL by 5–7 years of age; 244 (18%) children had a maximal blood lead concentration < 10 μg/dL, and 103 (8%) had a maximal blood lead concentration < 7.5 μg/dL. After adjustment for covariates, we found an inverse relationship between blood lead concentration and IQ score. Using a log-linear model, we found a 6.9 IQ point decrement [95% confidence interval (CI), 4.2–9.4] associated with an increase in concurrent blood lead levels from 2.4 to 30 μg/dL. The estimated IQ point decrements associated with an increase in blood lead from 2.4 to 10 μg/dL, 10 to 20 μg/dL, and 20 to 30 μg/dL were 3.9 (95% CI, 2.4–5.3), 1.9 (95% CI, 1.2–2.6), and 1.1 (95% CI, 0.7–1.5), respectively. For a given increase in blood lead, the lead-associated intellectual decrement for children with a maximal blood lead level < 7.5 μg/dL was significantly greater than that observed for those with a maximal blood lead level ≥7.5 μg/dL (p = 0.015). We conclude that environmental lead exposure in children who have maximal blood lead levels < 7.5 μg/dL is associated with intellectual deficits.

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Figure 1 Restricted cubic splines and log-linear model for concurrent blood lead concentration. The dotted lines are the 95% CIs for the restricted cubic splines.CC0 · PubMed Central

Figure 2 Linear models for each cohort study in the pooled analysis, adjusted for maternal IQ, HOME score, maternal education, and birth weight. The figure represents the 5th to 95th percentile of the concurrent blood lead level at the time of IQ testing.CC0 · PubMed Central

Figure 3 Log-linear model (95% CIs shaded) for concurrent blood lead concentration, adjusted for HOME score, maternal education, maternal IQ, and birth weight. The mean IQ (95% CI) for the intervals < 5 μg/dL, 5–10 μg/dL, 10–15 μg/dL, 15–20 μg/dL, and > 20 μg/dL are shown.CC0 · PubMed Central

Figure 4 Log-linear model for concurrent blood lead concentration along with linear models for concurrent blood lead levels among children with peak blood lead levels above and below 10 μg/dL.CC0 · PubMed Central

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Authors: Lanphear, B. P., Hornung, R., Khoury, J., Yolton, K., Baghurst, P., Bellinger, D. C., Canfield, R. L., Dietrich, K. N., Bornschein, R., Greene, T., Rothenberg, S. J., Needleman, H. L., Schnaas, L., Wasserman, G., Graziano, J., & Roberts, R.
Affiliations: Cincinnati Children's Hospital Medical Center (US)
Women's and Children's Hospital (AU)
Boston Children's Hospital (US)
Cornell University (US)
University of Cincinnati (US)
Cleveland Clinic (US)
Instituto Nacional de Salud Pública (MX)
University of Pittsburgh (US)
Instituto Nacional de Perinatología (MX)
Columbia University (US)
Griffith University (AU)
ORCID: Lanphear, Bruce P.
Khoury, Jane
Yolton, Kimberly
Canfield, Richard L.
Greene, Tom
Rothenberg, Stephen J.
Schnaas, Lourdes
Roberts, Russell
Venue: Environmental Health Perspectives
Publisher: American Chemical Society (ACS)
Published: 2005-03-18
Volume: 113
Issue: 7
Pages: 894-899
ISSN: 0091-6765 (ISSN-L)
1552-9924
DOI: 10.1289/ehp.7688
PMC: PMC1257652
OpenAlex: W2126489758
Cited by: 2,205
References: 54
Citations by year: 2026: 112 · 2025: 83 · 2024: 95 · 2023: 77 · 2022: 131 · 2021: 112 · 2020: 125 · 2019: 132 · 2018: 114 · 2017: 128 · 2016: 108 · 2015: 110 · 2014: 131 · 2013: 133 · 2012: 111
FWCI: 49.30
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor, 4669 d)
Locations: Environmental Health Perspectives (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, public-domain)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion, public-domain)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion, other-oa)
Griffith Research Online (submittedVersion)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
Physical Sciences › Environmental Science › Pollution › Heavy metals in environment
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Mercury impact and mitigation studies
Keywords: lead exposure, blood lead levels, child intelligence, IQ, neurotoxicity, low-level lead exposure, dose-response relationship, children, environmental lead
MeSH terms: Child, Child, Preschool, Environmental Exposure, Female, Humans, Infant, Infant, Newborn, Intelligence, Intelligence Tests, Lead, Longitudinal Studies, Male, Cohort Studies

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Low-Level Environmental Lead Exposure and Children’s Intellectual Function: An International Pooled Analysis

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