The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
Low Doses of Bisphenol A and Diethylstilbestrol Impair Ca 2+ Signals in Pancreatic α-Cells through a Nonclassical Membrane Estrogen Receptor within Intact Islets of Langerhans
Open accessAbstract
Glucagon, secreted from pancreatic alpha-cells integrated within the islets of Langerhans, is involved in the regulation of glucose metabolism by enhancing the synthesis and mobilization of glucose in the liver. In addition, it has other extrahepatic effects ranging from lipolysis in adipose tissue to the control of satiety in the central nervous system. In this article, we show that the endocrine disruptors bisphenol A (BPA) and diethylstilbestrol (DES), at a concentration of 10(-9) M, suppressed low-glucose-induced intracellular calcium ion ([Ca2+]i) oscillations in alpha-cells, the signal that triggers glucagon secretion. This action has a rapid onset, and it is reproduced by the impermeable molecule estradiol (E2) conjugated to horseradish peroxidase (E-HRP). Competition studies using E-HRP binding in immunocytochemically identified alpha-cells indicate that 17beta-E2, BPA, and DES share a common membrane-binding site whose pharmacologic profile differs from the classical ER. The effects triggered by BPA, DES, and E2 are blocked by the G alpha i- and G alpha o-protein inhibitor pertussis toxin, by the guanylate cyclase-specific inhibitor 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one, and by the nitric oxide synthase inhibitor N-nitro-L-arginine methyl ester. The effects are reproduced by 8-bromo-guanosine 3',5'-cyclic monophosphate and suppressed in the presence of the cGMP-dependent protein kinase inhibitor KT-5823. The action of E2, BPA, and DES in pancreatic alpha-cells may explain some of the effects elicited by endocrine disruptors in the metabolism of glucose and lipid.
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A review of the environmental fate, effects, and exposures of bisphenol A
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Bisphenol-A: an estrogenic substance is released from polycarbonate flasks during autoclaving
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Identity of an Estrogen Membrane Receptor Coupled to a G Protein in Human Breast Cancer Cells
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Glucagon and regulation of glucose metabolism
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Welshons, W. V., Thayer, K. A., Judy, B. M., Taylor, J. A., Curran, E. M., & vom Saal, F. S. (2003) · Environmental Health Perspectives · doi:10.1289/ehp.5494 · Cited by 905
Cited by
Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement
Diamanti-Kandarakis, E., Bourguignon, J.-P., Giudice, L. C., Hauser, R., Prins, G. S., Soto, A. M., Zoeller, R. T., & Gore, A. C. (2009) · Endocrine Reviews · doi:10.1210/er.2009-0002 · Cited by 4,585
EDC-2: the endocrine society's second scientific statement on endocrine-disrupting chemicals
Gore, A. C., Chappell, V. A., Fenton, S. E., Flaws, J. A., Nadal, A., Prins, G. S., Toppari, J., & Zoeller, R. T. (2015) · Endocrine Reviews · doi:10.1210/er.2015-1010 · Cited by 2,407
In vivo effects of bisphenol A in laboratory rodent studies
Richter, C. A., Birnbaum, L. S., Farabollini, F., Newbold, R. R., Rubin, B. S., Talsness, C. E., Vandenbergh, J. G., Walser-Kuntz, D. R., & vom Saal, F. S. (2007) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.06.004 · Cited by 1,147
Metabolism disrupting chemicals and metabolic disorders
Heindel, J. J., Blumberg, B., Cave, M., Machtinger, R., Mantovani, A., Mendez, M. A., Nadal, A., Palanza, P., Panzica, G., Sargis, R., et al. (2017) · Reproductive Toxicology · doi:10.1016/j.reprotox.2016.10.001 · Cited by 1,101
Self-citationLa Merrill, M. A., Vandenberg, L. N., Smith, M. T., Goodson, W., Browne, P., Patisaul, H. B., Guyton, K. Z., Kortenkamp, A., Cogliano, V. J., Woodruff, T. J., et al. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0273-8 · Cited by 1,005
Metadata
- Authors
- Alonso-Magdalena, P., Laribi, O., Ropero, A. B., Fuentes, E., Ripoll, C., Soria, B., & Nadal, A.
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-08
- Volume
- 113
- Issue
- 8
- Pages
- 969-977
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- OpenAlex
- W1975204728
- Cited by
- 276
- References
- 73
- FWCI
- 5.89
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Low Doses of Bisphenol A and Diethylstilbestrol Impair Ca 2+ Signals in Pancreatic α-Cells through a Nonclassical Membrane Estrogen Receptor within Intact Islets of Langerhans. https://app.cochat.ai/papers/10.1289/ehp.8002
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- Alonso-Magdalena, P., Laribi, O., Ropero, A. B., Fuentes, E., Ripoll, C., Soria, B., & Nadal, A. (2005). Low Doses of Bisphenol A and Diethylstilbestrol Impair Ca 2+ Signals in Pancreatic α-Cells through a Nonclassical Membrane Estrogen Receptor within Intact Islets of Langerhans. Environmental Health Perspectives. https://doi.org/10.1289/ehp.8002
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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