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Mechanism of action of organophosphorus and carbamate insecticides.
Open accessAbstract
Organophosphorus and carbamate insecticides are toxic to insects and mammals by virtue of their ability to inactivate the enzyme acetylcholinesterase. This review addresses the mechanism of inhibition of acetylcholinesterase by organophosphorus and carbamate esters, focusing on structural requirements necessary for anticholinesterase activity. The inhibition of acetylcholinesterase by these compounds is discussed in terms of reactivity and steric effects. The role of metabolic activation or degradation in the overall intoxication process is also discussed.
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Cited by
Ahmad, M. F., Ahmad, F. A., Alsayegh, A. A., Zeyaullah, M., AlShahrani, A. M., Muzammil, K., Saati, A. A., Wahab, S., Elbendary, E. Y., Kambal, N., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e29128 · Cited by 624
RetractedAcetylcholinesterase inhibitors as Alzheimer therapy: from nerve toxins to neuroprotection
Singh, M., Kaur, M., Kukreja, H., Chugh, R., Silakari, O., & Singh, D. (2013) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2013.09.050 · Cited by 364
Nkya, T. E., Akhouayri, I., Poupardin, R., Batengana, B., Mosha, F., Magesa, S., Kisinza, W., & David, J.-P. (2014) · Malaria Journal · doi:10.1186/1475-2875-13-28 · Cited by 195
Silva, A. P. B., Santos, J. M. M., & Martins, A. J. (2014) · Parasites & Vectors · doi:10.1186/1756-3305-7-450 · Cited by 160
Praegnatio Perturbatio—Impact of Endocrine-Disrupting Chemicals
Padmanabhan, V., Song, W., & Puttabyatappa, M. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnaa035 · Cited by 103
Metadata
- Authors
- Fukuto, T. R.
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 1990-07
- Volume
- 87
- Pages
- 245-254
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- OpenAlex
- W2128446165
- Cited by
- 1,003
- References
- 0
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- gold
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- Fukuto, T. R. (1990). Mechanism of action of organophosphorus and carbamate insecticides. Environmental Health Perspectives. https://doi.org/10.1289/ehp.9087245
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
