Cited by 390Cholinesterase and Neurodegenerative DiseasesAlzheimer's disease research and treatmentsPesticide Exposure and Toxicity

Acetylcholinesterase inhibitors as Alzheimer therapy: from nerve toxins to neuroprotection

Singh, Manjinder, Kaur, Maninder, Kukreja, Hitesh, Chugh, Rajan, Silakari, Om, Singh, Dhandeep·2013·European Journal of Medicinal Chemistry

Abstract

Acetylcholinesterase is a member of the α/β hydrolase protein super family, with a significant role in acetylcholine-mediated neurotransmission. Research in the modulators of AChEs has moved from a potent poison (Sarin, Soman) in war times to the potent medicine (physostigmine) in peaceful times. Natural anti-AChE includes carbamates, glycoalkaloids, anatoxins derived from green algae; synthetic anti-AChE includes highly poisonous organophosphates used as nerve gases and insecticides. Recently, the role of anti-AChE was reassessed from neurotoxins to neuron-protective in the diseases characterized by impaired acetylcholine-mediated neurotransmission like Alzheimer's disease (AD). So, the AChE has been proven to be the most viable therapeutic target for the symptomatic treatment of AD. This review article gives a spectrum of strategies to design AChE inhibitors used in the Alzheimer therapy.

Integrity signals

Registry

Crossref · 10.1016/j.ejmech.2013.09.050

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203 of 203 references verified0 citation errors · 0 not checkable

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Authors
Singh, M., Kaur, M., Kukreja, H., Chugh, R., Silakari, O., & Singh, D.
Affiliations
Panjab University (IN)
Corresponding author
Singh, Dhandeep
Venue
European Journal of Medicinal Chemistry
Publisher
Elsevier BV
Published
2013-12
Volume
70
Pages
165-188
ISSN
0223-5234 (ISSN-L)
OpenAlex
W1994264985
Cited by
364
References
210
Citations by year
2026: 12 · 2025: 30 · 2024: 31 · 2023: 34 · 2022: 35 · 2021: 29 · 2020: 32 · 2019: 36 · 2018: 30 · 2017: 31 · 2016: 21 · 2015: 23 · 2014: 17 · 2013: 1
FWCI
2.90
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Medicinal Chemistry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Pesticide Exposure and Toxicity
Keywords
acetylcholinesterase inhibitors, Alzheimer's disease, acetylcholinesterase, cholinergic neurotransmission, organophosphorus nerve agents, carbamate insecticides, physostigmine, glycoalkaloids, anatoxin, neuroprotection, drug design strategies, alpha/beta hydrolase superfamily
MeSH terms
Acetylcholinesterase, Alzheimer Disease, Animals, Cholinesterase Inhibitors, Humans, Drug Design, Molecular Structure

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