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Cited by 8Cardiovascular Function and Risk FactorsCardiovascular and exercise physiologyBlood Pressure and Hypertension Studies

Influence of Mild to Moderate Obesity on Left Ventricular Stress Filling Pattern in Hypertension.

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Seto, Shinji, Kapuku, Gaston Kakota, Kawahara, Fumitaka, Suzuki, Shin, Yano, Katsusuke·1998·Hypertension Research
DOI 10.1291/hypres.21.245
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Abstract

In resting condition, obese subjects are described as having impaired diastolic filling. To examine the effect of mild to moderate obesity on left ventricular diastolic performance during stress in hypertension, we determined the filling responses to dynamic submaximal exercise in 19 obese hypertensive patients (body mass index, 26 to 30 kg/m2) with a normal left ventricular structure, 19 age- and sex-matched, non-obese hypertensive patients, and 19 age- and sex-matched, non-obese normotensive controls (mean age, 55+/-3 yr). Doppler echocardiographic studies were performed at baseline and 1 min after exercise on a supine ergometer bicycle. At rest, systolic function and filling indices, peak velocities of early (E) and late (A) filling, and their ratio (E/A), were similar in the two hypertensive groups, while normotensive controls had higher peak velocities of E and E/A. At a maximum workload of 75 W, blood pressure and heart rate increased similarly in the two hypertensive groups. Peak velocities of E and A increased significantly after exercise. The percentage change in the peak velocity of E was greater in obese hypertensive patients than in non-obese hypertensive patients and normotensive controls (23+/-4 vs. 12+/-3 and 14+/-3%, p < 0.05). Percentage changes in A and E/A were similar in the three groups. Our study suggests that mild to moderate obesity does not further worsen left ventricular diastolic filling at rest and mitigates diastolic filling abnormalities after exercise in hypertensive patients.

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  • Some studies have found reduced early diastolic (E-wave) velocities while others have found them unchanged in obese subjects.

    “Some studies have found reduced early diastolic (E-wave) velocities (155) while others have found them to be unchanged (242, 266, 274, 279, 314).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [314]

  • Late diastolic (A-wave) velocities have been reported to be increased or unchanged in obese subjects.

    “Lastly, late diastolic (A-wave) velocities have been reported to be increased (28, 155, 242) or unchanged (266, 274, 279, 314).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [314]

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Authors
Seto, S., Kapuku, G. K., Kawahara, F., Suzuki, S., & Yano, K.
Affiliations
  • Nagasaki University Hospital (JP)
  • Nagasaki University (JP)
ORCID
Venue
Hypertension Research
Publisher
Japanese Society of Hypertension
Published
1998
Volume
21
Issue
4
Pages
245-250
ISSN
  • 0916-9636 (ISSN-L)
  • 1348-4214
DOI
10.1291/hypres.21.245
OpenAlex
W2136592021
Cited by
8
References
33
Citations by year
2022: 2 · 2016: 1
FWCI
0.00
Type
journal article
Language
en
Open access
Locations
  • Hypertension Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords
obesity, hypertension, left ventricular diastolic filling, diastolic dysfunction, exercise stress, submaximal exercise, E/A ratio, early diastolic filling velocity, left ventricular function
MeSH terms
Blood Flow Velocity, Coronary Circulation, Echocardiography, Female, Hemodynamics, Humans, Hypertension, Male, Middle Aged, Obesity, Stress, Mechanical, Exercise, Body Mass Index, Ventricular Function, Left

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