The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Green Coffee Bean Extract and Its Metabolites Have a Hypotensive Effect in Spontaneously Hypertensive Rats
Open accessAbstract
The effects of a water-soluble green coffee bean extract (GCE) on blood pressure were investigated using spontaneously hypertensive rats (SHR). There was a dose-dependent reduction in blood pressure after a single ingestion (180 to 720 mg/kg, p.o.) or long-term ingestion (0.25 to 1% diet for 6 weeks) of GCE. A single oral ingestion (50 to 200 mg/kg) of 5-caffeoylquinic acid (5-CQA), the major component of GCE, dose-dependently decreased blood pressure, suggesting that 5-CQA is involved in the hypotensive effect of GCE in SHR. Because significant increases in caffeic acid (CA) or ferulic acid (FA) were detected in plasma after oral ingestion of 5-CQA in SHR, these acids (2.5, 5,10 micromol/kg) were intravenously injected into SHR under anesthesia and the carotid arterial pressure was measured. Of the two components, FA had a stronger depressor effect than CA. The depressor effect of FA (50 mg/kg, p.o.) was attenuated by the concurrent injection of atropine sulfate (5 mg/kg, s.c.), suggesting that the hypotensive effect of FA in SHR might be mediated via the muscarinic acetylcholine receptors. These findings indicate that oral ingestion of GCE or 5-CQA decreases blood pressure in SHR, and that FA, which is a metabolite of 5-CQA, is a candidate hypotensive component.
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Effect of green tea rich in ?-aminobutyric acid on blood pressure of Dahl salt-sensitive rats
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Metadata
- Authors
- SUZUKI, A., KAGAWA, D., OCHIAI, R., TOKIMITSU, I., & SAITO, I.
- Venue
- Hypertension Research
- Publisher
- Japanese Society of Hypertension
- Published
- 2002
- Volume
- 25
- Issue
- 1
- Pages
- 99-107
- ISSN
- 0916-9636 (ISSN-L)
- OpenAlex
- W2000285435
- Cited by
- 174
- References
- 8
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- bronze
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- SUZUKI, A., KAGAWA, D., OCHIAI, R., TOKIMITSU, I., & SAITO, I. (2002). Green Coffee Bean Extract and Its Metabolites Have a Hypotensive Effect in Spontaneously Hypertensive Rats. Hypertension Research. https://doi.org/10.1291/hypres.25.99
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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