Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 378

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Hypertenion: Sensitivity of Patient Outcomes to Pharmacist Interventions. Part II: Systematic Review and Meta-Analysis in Hypertension Management

Machado, Márcio, Bajcar, Jana, Guzzo, Giovanni C, Einarson, Thomas R·2007·Annals of Pharmacotherapy
DOI 10.1345/aph.1k311
Open this paper in CoChat — free account

Abstract

Background: Hypertension is a major health concern worldwide due to its deleterio us impact. Few studies have quantitatively assessed pharmacists’ interventions in hypertensive patients. Objectives: To identify and quantify outcomes sensitive to pharmacists’ interventions. Methods: International Pharmaceutical Abstracts, MEDLINE, Cochrane Central, and EMBASE were searched from inception through December 2006. Two independent reviewers identified articles; results were compared and resolved through consensus. Data extracted included intervention type, patient numbers, demographics, study characteristics, instruments used, data compared, and outcomes reported. A random effects meta-analysis was used to combine data. Study quality was assessed using the Downs–Black scale. Results: Of 203 potential articles identified, 98 were selected and their abstracts were read. Nine of these were reviewed full-text and 19 more were identified from references, resulting in a total of 28 articles. Research designs included 18 randomized controlled trials, 6 single-arm clinical trials, 3 nonrandomized comparative trials, and 1 database study. Average quality score was 66% ± 12% (fair). Medication management (82%) and hypertension education (68%) were the interventions most used. Thirty-nine study results (57% of all outcomes evaluated) were sensitive to pharmacists’ interventions. Meta-analysis of 2246 patients in 13 studies found that pharmacists’ interventions significantly reduced systolic blood pressure (10.7 ± 11.6 mm Hg; p = 0.002), while controls remained unchanged (3.2 ± 12.1 mm Hg; p = 0.361). Pharmacists’ interventions further reduced systolic blood pressure (6.9 ± 12.1 mm Hg;p = 0.047) over controls. Nonsensitive results included further reduction in diastolic blood pressure (3.6 ± 3.7 mm Hg; p = 0.06), quality of life (1 of 8 significant), and adherence (5 of 13 significant). Conclusions: Systolic blood pressure is sensitive to pharmacists’ interventions. Other outcomes may also be sensitive; however, more high-quality studies are needed for a comprehensive quantitative assessment

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1345/aph.1k311

Cites

6 of 6 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 6 references

Research works printed but not linked: 53

  1. 10.1001/jama.289.19.2560 · DOI · Paper page
  2. Hepler C, Strand L. Opportunities and responsibilities in pharmaceutical care. Am J Hosp Pharm 1990; 47: 533-43.
  3. Strand L. Re-visioning the profession. J Am Pharm Assoc 1997; 37: 474-8.
  4. 10.1345/aph.1D094 · DOI
  5. 10.1177/106002809803200101 · DOI
  6. 10.1592/phco.22.15.1294.33476 · DOI
  7. 10.1592/phco.24.4.389.33169 · DOI
  8. 10.1177/106002809603000305 · DOI · Paper page
  9. 10.1592/phco.20.19.1508.34852 · DOI
  10. 10.1016/S1086-5802(16)31061-0 · doi:10.1016/s1086-5802(16)31061-0
  11. Bucci C, Jackevicius C, McFarlane K, Liu P. Pharmacist's contribution in a heart function clinic: patient perception and medication appropriateness. Can J Cardiol 2003; 19: 391-6.
  12. 10.1093/ageing/30.3.205 · DOI · Paper page
  13. 10.1592/phco.20.15.1149.34590 · DOI
  14. 10.1097/00005650-200102000-00002 · doi:10.1097/00005650-200102000-00002
  15. 10.1592/phco.25.1.110.55619 · DOI
  16. 10.1016/S0140-6736(76)91737-2 · DOI · Paper page
  17. 10.1001/jama.1975.03260030032016 · doi:10.1001/jama.1975.03260030032016
  18. 10.1097/00005650-198102000-00002 · doi:10.1097/00005650-198102000-00002
  19. 10.1016/S0149-2918(97)80078-1 · DOI · Paper page
  20. 10.1023/A:1008631926100 · DOI
  21. 10.1177/106002809302700917 · DOI
  22. 10.1177/106002809302700118 · DOI
  23. Gonzales ME, Thompson ST, Vilme MC, . Design, implementation, and impact of a pharmacist-managed hypertension clinic: an 8-month evaluation (abstract). Pharmacotherapy 2004; 24:1426.
  24. 10.1111/j.2042-7174.2000.tb01002.x · DOI
  25. 10.1046/j.1525-1497.1998.00225.x · DOI
  26. 10.1592/phco.23.2.209.32096 · DOI · Paper page
  27. 10.1093/milmed/165.2.106 · doi:10.1093/milmed/165.2.106
  28. 10.1345/aph.1C267 · DOI
  29. 10.1111/j.1365-2710.2005.00663.x · doi:10.1111/j.1365-2710.2005.00663.x
  30. 10.1016/j.amjhyper.2005.11.009 · DOI
  31. 10.1016/j.puhe.2004.11.009 · DOI
  32. 10.1002/j.1875-9114.1997.tb03687.x · DOI
  33. 10.1331/108658002762063691 · DOI
  34. 10.1093/ajhp/60.6.554 · doi:10.1093/ajhp/60.6.554
  35. 10.1016/S1086-5802(16)30372-2 · DOI
  36. Hawkins DW, Fiedler FP, Douglas HL, Eschbach RC. Evaluation of a clinical pharmacist caring for hypertensive and diabetic patients. Am J Hosp Pharm 1979; 36: 1321-5.
  37. 10.1592/phco.26.9.1342 · DOI
  38. 10.1592/phco.26.9.1333 · doi:10.1592/phco.26.9.1333
  39. McKenney JM, Brown ED, Necsary R, Reavis HL. Effect of pharmacist drug monitoring and patient education on hypertensive patients. Contemp Pharm Pract 1978; 1: 50-6.
  40. McKenney JM, Witherspoon JM. The impact of outpatient hospital pharmacists on patients receiving antihypertensive and anticoagulant therapy. Hosp Pharm 1985; 20: 408-15.
  41. 10.1592/phco.20.17.1384.34891 · DOI · Paper page
  42. Menard PJ, Kirshner BS, Kloth DD, Pyka RS, Hill LR, Venkataraman K. Management of the hypertensive patient by the pharmacist prescriber. Hosp Pharm 1986; 21: 20-34.
  43. Morse GD, Douglas JH, Stewart R, Gal P. Effect of pharmacist intervention on control of resistant hypertension. Am J Hosp Pharm 1986; 43: 905-9.
  44. 10.1592/phco.24.4.324.33173 · DOI
  45. 10.1592/phco.21.17.1337.34424 · DOI
  46. 10.1016/S1086-5802(16)30099-7 · DOI
  47. 10.1007/s11096-004-2563-y · DOI
  48. 10.1016/S1086-5802(16)30371-0 · DOI
  49. 10.1345/aph.1D605 · DOI
  50. 10.1592/phco.22.17.1533.34127 · DOI · Paper page
  51. 10.1111/j.1525-1497.2005.0226.x · DOI
  52. 10.1592/phco.20.3.119.34778 · doi:10.1592/phco.20.3.119.34778
  53. 10.1023/A:1012227018705 · doi:10.1023/a:1012227018705

Cited by

See all 378

Metadata

Authors
Machado, M., Bajcar, J., Guzzo, G. C., & Einarson, T. R.
Venue
Annals of Pharmacotherapy
Publisher
SAGE Publications
Published
2007-11
Volume
41
Issue
11
Pages
1770-1781
ISSN
  • 0012-6578 (ISSN-L)
  • 1060-0280
  • 1542-6270
DOI
10.1345/aph.1k311
OpenAlex
W2123895995
Cited by
378
References
6
FWCI
3.19
Type
journal article
Language
en
Open access
closed
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Hypertenion: Sensitivity of Patient Outcomes to Pharmacist Interventions. Part II: Systematic Review and Meta-Analysis in Hypertension Management. https://app.cochat.ai/papers/10.1345/aph.1k311
The paper
Machado, M., Bajcar, J., Guzzo, G. C., & Einarson, T. R. (2007). Hypertenion: Sensitivity of Patient Outcomes to Pharmacist Interventions. Part II: Systematic Review and Meta-Analysis in Hypertension Management. Annals of Pharmacotherapy. https://doi.org/10.1345/aph.1k311

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.