Role of Metformin for Weight Management in Patients Without Type 2 Diabetes

Desilets, Alicia R; Dhakal-Karki, Sushmita; Dunican, Kaelen C

doi:10.1345/aph.1k656

Cited by 111Pharmacology and Obesity TreatmentDiabetes, Cardiovascular Risks, and LipoproteinsDiabetes Treatment and Management

Role of Metformin for Weight Management in Patients Without Type 2 Diabetes

Desilets, Alicia R, Dhakal-Karki, Sushmita, Dunican, Kaelen C·2008·Annals of Pharmacotherapy

DOI 10.1345/aph.1k656

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Abstract

Objective: To evaluate the efficacy and safety of metformin for weight management in overweight and obese patients without type 2 diabetes. Data Sources: Literature was obtained through MEDLINE Ovid (1950–February week 3, 2008), EMBASE (all years), and a bibliographic review of relevant articles. Key words included metformin, obesity, overweight, and weight loss. Study Selection/Data Extraction: All studies published in the English language that evaluated the effects of metformin on weight in obese or overweight individuals were critically analyzed. Relevant articles were selected for inclusion in this review. Data Synthesis: Metformin is first-line pharmacotherapy in the treatment of overweight or obese patients with type 2 diabetes, with beneficial effects on weight in this population. Multiple trials have evaluated the effect of metformin on weight and other metabolic parameters in adults and adolescents without diabetes. Five of 12 trials in adults evaluated weight loss as a primary endpoint. Significant weight reduction was found in 4 of these studies; however, the trials were small and of weak design. Weight reduction was significant in 5 of the 6 adolescent trials; similarly, these studies were limited by weak study design and small patient population. Metabolic parameters (blood pressure, waist circumference, cholesterol parameters, insulin/glucose levels) often showed varying results. Metformin was well tolerated; gastrointestinal effects were the most frequently reported adverse effects. Conclusions: The weight loss effects of metformin in overweight or obese adults and adolescents without diabetes appear promising; however, trials have been limited by small patient populations and weak design. Metformin may also have a positive effect on metabolic parameters such as waist circumference, fasting insulin and glucose levels, and triglycerides. Further research involving large-scale trials that evaluate weight loss as a primary outcome is necessary to firmly establish the role of metformin in this population.

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In other populations, metformin prevents weight gain and appears to assist with weight loss, prevents and manages type 2 diabetes, gestational diabetes, and fatty liver, and reduces cardiovascular disease in type 2 diabetes.
“It is known in other populations to prevent weight gain and appearstoassistwithweightloss,topreventandmanageDM2,gestational diabetes, fatty liver, and reduce cardiovascular disease in DM2 (Lord et al. , 2003; Desilets et al. , 2008; Nestler, 2008; Batra et al. , 2009; NieuwenhuisRuifrok et al. , 2009; Oppelt et al. , 2010; Diabetes Prevention Program Research Group, 2012; Viollet et al. , 2012)”
From Metformin and lifestyle modification in polycystic ovary syndrome: systematic review and meta-analysis (2015) · cites this paper as Desilets et al., 2008
A meta-analysis of overweight and obese non-diabetic subjects found no significant weight loss with metformin as either a primary or secondary outcome.
“However, a meta-analysis of overweight and obese non-diabetic subjects, found no significant weight loss as either a primary or as secondary outcome [105].”
From Metformin: An Old But Still the Best Treatment for Type 2 Diabetes (2013) · cites this paper as [105]

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Authors: Desilets, A. R., Dhakal-Karki, S., & Dunican, K. C.
Affiliations: Massachusetts College of Pharmacy and Health Sciences (US)
Venue: Annals of Pharmacotherapy
Publisher: SAGE Publications
Published: 2008-04-22
Volume: 42
Issue: 6
Pages: 817-826
ISSN: 0012-6578 (ISSN-L)
1060-0280
1542-6270
DOI: 10.1345/aph.1k656
OpenAlex: W2120515445
Cited by: 111
References: 57
Citations by year: 2026: 1 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 7 · 2021: 10 · 2020: 4 · 2019: 4 · 2018: 10 · 2017: 5 · 2016: 9 · 2015: 2 · 2014: 3 · 2013: 6 · 2012: 9
FWCI: 1.18
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Annals of Pharmacotherapy (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords: metformin, weight loss, obesity, overweight, non-diabetic patients, adolescents, metabolic parameters, waist circumference, glucose and insulin, triglycerides, gastrointestinal adverse effects, drug safety
MeSH terms: Adolescent, Adult, Body Weight, Clinical Trials as Topic, Humans, Hypoglycemic Agents, Metformin, Obesity, Research Design, Weight Loss, Anti-Obesity Agents, Overweight

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Role of Metformin for Weight Management in Patients Without Type 2 Diabetes

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