A meta-analysis of the past 25 years of weight loss research using diet, exercise or diet plus exercise intervention
Abstract
Objective The therapeutic effectiveness of diet, exercise, and diet plus exercise for weight loss in obesity was determined. Data sources All human research reported in English, published in peer-reviewed scientific journals within the past 25 y was reviewed. Study selection Acceptance criteria (n = 493 from > 700 studies) were that a therapeutic intervention of diet, exercise or diet plus exercise was employed, specifically for weight reduction in obese adult humans and that weight change was reported numerically. Only aerobic exercise studies were included, while drug, hormone and surgical treatments were excluded. Data extraction All data were extracted by the same investigator from the original research report. Except for gender and program type, all extracted data were numerical. Data synthesis ANOVA, with a Newman-Keuls post hoc test, was used to determine differences among programs (P < 0.05). One analysis was performed on the group mean data and one based on effect sizes. Analyses were repeated using initial body weight, initial percent body fat and program length, as covariates. Results Primarily, subjects aged 40 y have been studied (39.5 +/- 0.4 y, mean +/- s.e.m.) who are only moderately obese (92.7 +/- 0.9 kg, 33.2 +/- 0.5 body mass index (BMI), 33.4 +/- 0.7% body fat); for short durations (15.6 +/- 0.6 weeks). Exercise studies were of a shorter duration, used younger subjects who weighed less, had lower BMI and percentage body fat values, than diet or diet plus exercise studies. Despite these differences, weight lost through diet, exercise and diet plus exercise was 10.7 +/- 0.5, 2.9 +/- 0.4* and 11.0 +/- 0.6 kg, respectively. However, at one-year follow-up, diet plus exercise tended to be the superior program. Effect size and covariate analyses revealed similar program differences. Conclusion Weight loss research over the past 25 y has been very narrowly focused on a middle age population that is only moderately obese, while the interventions lasted for only short periods of time. The data shows, however, that a 15-week diet or diet plus exercise program, produces a weight loss of about 11 kg, with a 6.6 +/- 0.5 and 8.6 +/- 0.8 kg maintained loss after one year, respectively.
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Exercise has been shown to help offset some of the changes in lean body mass experienced with weight loss.
“Exercise has been shown to help offset some of the changes in LBM experienced with weight loss [29,30].”
From Body Composition Changes in Weight Loss: Strategies and Supplementation for Maintaining Lean Body Mass, a Brief Review (2018) · cites this paper as [30]
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Brown, R. E., Sharma, A. M., Ardern, C. I., Mirdamadi, P., Mirdamadi, P., & Kuk, J. L. (2015) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2015.08.007 · Cited by 105 · see citing works
Physical Inactivity and Mortality Risk
Kokkinos, P. F., Sheriff, H. M., & Kheirbek, R. (2011) · Cardiology Research and Practice · doi:10.4061/2011/924945 · Cited by 106 · see citing works
Trying to Lose Weight: Diet Strategies among Americans with Overweight or Obesity in 1996 and 2003
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Creating a Robust Public Health Infrastructure for Physical Activity Promotion
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Fatmax : A new concept to optimize fat oxidation during exercise?
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Influence of Running and Walking on Hormonal Regulators of Appetite in Women
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Healthy Behavior Change of Adults With Mental Retardation: Attendance in a Health Promotion Program
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- Authors
- Miller, W., Koceja, D., & Hamilton, E.
- Affiliations
- Indiana University Bloomington (US)
- Venue
- International Journal of Obesity
- Published
- 1997-10
- Volume
- 21
- Issue
- 10
- Pages
- 941-947
- ISSN
- 0307-0565 (ISSN-L)
- 1476-5497
- OpenAlex
- W2140653847
- Semantic Scholar
- 8d5ccf66cb397dd184b954e7877e2a3f95fdd57e
- Cited by
- 686
- References
- 9
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 14 · 2023: 18 · 2022: 12 · 2021: 21 · 2020: 22 · 2019: 27 · 2018: 18 · 2017: 27 · 2016: 24 · 2015: 37 · 2014: 28 · 2013: 27 · 2012: 31
- FWCI
- 2.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- International Journal of Obesity (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- obesity, weight loss, dietary intervention, aerobic exercise, weight loss maintenance, long-term weight loss, body mass index, body fat percentage, intervention duration, effect size
- MeSH terms
- Adult, Body Composition, Combined Modality Therapy, Diet, Reducing, Humans, Obesity, Weight Loss, Exercise
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