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Cited by 64Phytochemical Studies and BioactivitiesSteroid Chemistry and BiochemistryPlant biochemistry and biosynthesis

The Ecdysones

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Nakanishi, Koji·1971·Pure and Applied Chemistry
DOI 10.1351/pac197125010167
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Abstract

The discovery of ecdysones, moulting hormones of insects and crustaceans, from plants in late 1966 has resulted in subsequent isolationsofatotal of about 40 new phytoecdysones.This has contributed a great deal to the understanding of the chemistry and physicochemical data of ecdysones.A general account of these aspects is given, together with results of preliminary bio-organic studies concerning the metabolic fate of exogenaus ecdysones and the site of biosynthesis of ecdysones in the silkworm.Finally, very recently several plants have been discovered to contain substances which inhibit the moulting as bioassayed by the topical dipping method.The structure of the first to be elucidated, ajugalactone, is discussed.The second inhibitor to be isolated is.interesting because it is a non-steroid.Another intriguing aspect of these inhibitors is their specificity towards the ecdysone structure.* Since the discovery of ecdysone-active hydroxy steroids from plants, it is convenient, in some cases, to differentiate those with the prefix phytofrom those isolated from insects ;and Crustacea (zooecdysones ).However, most zooecdysones are present in plants as weil.

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  • Phytoecdysteroids are bioactive molecules produced by plants as a defense against herbivorous insects.

    “Phytoecdysteroids are a class of bioactive molecules produced by plants as a defense against herbivorous insects [7].”

    From Ecdysterone and Turkesterone—Compounds with Prominent Potential in Sport and Healthy Nutrition (2024) · cites this paper as [7]

    The Abstract identifies phytoecdysones as ecdysone-active compounds found in plants, and the discussion of ponasterones describes their moulting activity in insects. The paper does not say plants produce them as a defense against herbivorous insects; the Introduction's suggestion of pest control concerns a different class of compounds that antagonize ecdysones. (LLM, conf=0.88)

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Research works printed but not linked: 62

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Authors
Nakanishi, K.
Affiliations
Columbia University (US)
Corresponding author
Nakanishi, Koji
ORCID
Nakanishi, Koji
Venue
Pure and Applied Chemistry
Publisher
Walter de Gruyter GmbH
Published
1971-01-01
Volume
25
Issue
1
Pages
167-196
ISSN
  • 0033-4545 (ISSN-L)
  • 1365-3075
DOI
10.1351/pac197125010167
OpenAlex
W4245161909
Cited by
64
References
0
Citations by year
2024: 2 · 2021: 1 · 2020: 1 · 2017: 3 · 2016: 1 · 2013: 1
FWCI
2.35
Type
journal article
Language
en
Open access
Locations
  • Pure and Applied Chemistry (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institutes of Health
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical Studies and Bioactivities
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Steroid Chemistry and Biochemistry
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
Keywords
ecdysone, phytoecdysone, insect molting, crustacean molting, ecdysone metabolism, structure-activity relationship
MeSH terms
Biological Assay, Chromatography, Ecdysone, Insecta, Magnetic Resonance Spectroscopy

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