Ecdysteroids from the flowers of Aerva javanica
Abstract
Four new ecdysteroids (1-4), along with three known steroids, β-ecdysone (5), 5-β-2-deoxyintegristerone A (6) and 24-epi-makisterone A (7) (Fig. 1), were isolated from the methanolic extract of the flowers of Aerva javanica by using normal and reverse phase chromatography. The structures of the new compounds (1-4) were determined due to 1D ((1)H and (13)C), 2D NMR (HSQC, HMBC, COSY, NOESY) techniques and high resolution mass spectrometry (HREIMS). The known compounds (5-7) were characterized based on the 1D NMR spectroscopy and mass spectrometry and by comparison with the literature values. All isolates were evaluated for their inhibitory activities against enzymes acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and lipoxygenase (LOX).
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Aervecdysteroids A-D showed no significant inhibition of AChE, BChE, and LOX in vitro.
“Evaluated enzyme inhibitory activities against AChE, BChE and LOX and no significant effect have been observed.”
From The Phytochemical, Biological, and Medicinal Attributes of Phytoecdysteroids: An Updated Review (2021) · cites this paper as [51]
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The Phytochemical, Biological, and Medicinal Attributes of Phytoecdysteroids: An Updated Review
Das, N., Mishra, S. K., Bishayee, A., Ali, E. S., & Bishayee, A. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.10.012 · Cited by 115 · see citing works
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Ecdysteroids: Isolation, Chemical Transformations, and Biological Activity
Savchenko, R. G., Veskina, N. A., Odinokov, V. N., Benkovskaya, G. V., & Parfenova, L. V. (2022) · Phytochemistry Reviews · doi:10.1007/s11101-021-09792-y · Cited by 39 · see citing works
- Authors
- Saleem, M., Musaddiq, S., Riaz, N., Zubair, M., Ashraf, M., Nasar, R., & Jabbar, A.
- Affiliations
- Islamia University of Bahawalpur (PK)
- Venue
- Steroids
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 78
- Issue
- 11
- Pages
- 1098-1102
- ISSN
- 0039-128X (ISSN-L)
- OpenAlex
- W2014720478
- Cited by
- 17
- References
- 14
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 1 · 2022: 3 · 2021: 2 · 2020: 3 · 2017: 2 · 2016: 1 · 2014: 1
- FWCI
- 0.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Steroids (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Alexander von Humboldt-Stiftung
- University of Karachi
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical Studies and Bioactivities
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive natural compounds
- Keywords
- ecdysteroids, Aerva javanica, flowers, natural product isolation, structure elucidation, 20-hydroxyecdysone, acetylcholinesterase inhibition, butyrylcholinesterase inhibition, lipoxygenase inhibition, steroidal alkaloids
- MeSH terms
- Ecdysteroids, Amaranthaceae, Flowers
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