The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Video-rate confocal scanning laser microscope for imaging human tissues in vivo
Abstract
We have built a video-rate confocal scanning laser microscope for reflectance imaging of human skin and oral mucosa in vivo. Design and imaging parameters were determined for optimum resolution and contrast. Mechanical skin-holding fixtures and oral tissue clamps were made for stable objective lens-to-tissue contact such that gross tissue motion relative to the microscope was minimized. Confocal imaging was possible to maximum depths of 350 microm in human skin and 450 microm in oral mucosa, with measured lateral resolution of 0.5-1 microm and axial resolution (section thickness) of 3-5 microm at the 1064-nm wavelength. This resolution is comparable with that of conventional microscopy of excised biopsies (histology). Normal and abnormal tissue morphology and dynamic processes were observed.
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Cites
Handbook Of Biological Confocal Microscopy
(2006) · Springer eBooks · doi:10.1007/978-0-387-45524-2 · Cited by 3,637
A review of the optical properties of biological tissues
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Anderson, R. R., & Parrish, J. A. (1981) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12479191 · Cited by 2,456
Self-citationPeli, E. (1990) · Journal of the Optical Society of America A · doi:10.1364/josaa.7.002032 · Cited by 1,298
Light scattering in lntralipid-10% in the wavelength range of 400–1100 nm
van Staveren, H. J., Moes, C. J. M., van Marie, J., Prahl, S. A., & van Gemert, M. J. C. (1991) · Applied Optics · doi:10.1364/ao.30.004507 · Cited by 1,106
In Vivo Confocal Scanning Laser Microscopy of Human Skin: Melanin Provides Strong Contrast
Rajadhyaksha, M., Grossman, M., Esterowitz, D., Webb, R. H., & Rox Anderson, R. (1995) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12606215 · Cited by 1,093
Self-citationPeli, E. (1988) · Annual Meeting Optical Society of America · doi:10.1364/oam.1988.fd8 · Cited by 937
Van Gemert, M. J. C., Jacques, S. L., Sterenborg, H. J. C. M., & Star, W. M. (1989) · IEEE Transactions on Biomedical Engineering · doi:10.1109/10.42108 · Cited by 807
Aberrations in confocal fluorescence microscopy induced by mismatches in refractive index
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Confocal scanning laser ophthalmoscope
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Cited by
Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy
Evans, C. L., Potma, E. O., Puoris'haag, M., Côté, D., Lin, C. P., & Xie, X. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508282102 · Cited by 957
Rajadhyaksha, M., González, S., Zavislan, J. M., Rox Anderson, R., & Webb, R. H. (1999) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1999.00690.x · Cited by 834
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Metadata
- Authors
- Rajadhyaksha, M., Anderson, R. R., & Webb, R. H.
- Venue
- Applied Optics
- Publisher
- Optica Publishing Group
- Published
- 1999-04-01
- Volume
- 38
- Issue
- 10
- Pages
- 2105
- ISSN
- 0003-6935 (ISSN-L)
- 1539-4522
- OpenAlex
- W2093516870
- Cited by
- 300
- References
- 25
- FWCI
- 7.08
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
