Retinal safety of near infrared radiation in photovoltaic restoration of sight.
Open accessAbstract
Photovoltaic restoration of sight requires intense near-infrared light to effectively stimulate retinal neurons. We assess the retinal safety of such radiation with and without the retinal implant. Retinal damage threshold was determined in pigmented rabbits exposed to 880nm laser radiation. The 50% probability (ED50) of retinal damage during 100s exposures with 1.2mm diameter beam occurred at 175mW, corresponding to a modeled temperature rise of 12.5°C. With the implant, the same temperature was reached at 78mW, close to the experimental ED50 of 71mW. In typical use conditions, the retinal temperature rise is not expected to exceed 0.43°C, well within the safety limits for chronic use.
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- Authors
- Lorach, H., Wang, J., Lee, D. Y., Dalal, R., Huie, P., & Palanker, D.
- Affiliations
- Stanford University (US)
- Gachon University Gil Medical Center (KR)
- Corresponding author
- Lorach, H.
- Venue
- Biomedical Optics Express
- Publisher
- Optica Publishing Group
- Published
- 2015-12-04
- Volume
- 7
- Issue
- 1
- Pages
- 13
- ISSN
- 2156-7085 (ISSN-L)
- PMC
- PMC4722897
- OpenAlex
- W2255910184
- Cited by
- 33
- References
- 22
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 1 · 2020: 6 · 2019: 6 · 2018: 4 · 2017: 2 · 2016: 5
- FWCI
- 3.53
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Biomedical Optics Express (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (NIH) (R01‐EY-018608)
- Pixium Vision, Paris, France (1170660-200-UDERL)
- U.S. Department of Defense (DOD) (W81XWH‐15‐1‐0009)
- Topics
- Health Sciences › Medicine › Ophthalmology › Ocular and Laser Science Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Keywords
- retinal prosthesis, retinal neurons, photostimulation, pigmented rabbits
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