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Cited by 699

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Speckle variance detection of microvasculature using swept-source optical coherence tomography

Mariampillai, Adrian, Standish, Beau A., Moriyama, Eduardo H., Khurana, Mamta, Munce, Nigel R., Leung, Michael K. K., Jiang, James, Cable, Alex, Wilson, Brian C., Vitkin, I. Alex, Yang, Victor X. D.·2008·Optics Letters

Abstract

We report on imaging of microcirculation by calculating the speckle variance of optical coherence tomography (OCT) structural images acquired using a Fourier domain mode-locked swept-wavelength laser. The algorithm calculates interframe speckle variance in two-dimensional and three-dimensional OCT data sets and shows little dependence to the Doppler angle ranging from 75 degrees to 90 degrees . We demonstrate in vivo detection of blood flow in vessels as small as 25 microm in diameter in a dorsal skinfold window chamber model with direct comparison with intravital fluorescence confocal microscopy. This technique can visualize vessel-size-dependent vascular shutdown and transient vascular occlusion during Visudyne photodynamic therapy and may provide opportunities for studying therapeutic effects of antivascular treatments without on exogenous contrast agent.

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Metadata

Authors
Mariampillai, A., Standish, B. A., Moriyama, E. H., Khurana, M., Munce, N. R., Leung, M. K. K., Jiang, J., Cable, A., Wilson, B. C., Vitkin, I. A., & Yang, V. X. D.
Venue
Optics Letters
Published
2008-06-30
Volume
33
Issue
13
Pages
1530
ISSN
  • 0146-9592 (ISSN-L)
  • 1539-4794
OpenAlex
W2012407707
Cited by
699
References
7
FWCI
12.58
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Speckle variance detection of microvasculature using swept-source optical coherence tomography. https://app.cochat.ai/papers/10.1364/ol.33.001530
The paper
Mariampillai, A., Standish, B. A., Moriyama, E. H., Khurana, M., Munce, N. R., Leung, M. K. K., Jiang, J., Cable, A., Wilson, B. C., Vitkin, I. A., & Yang, V. X. D. (2008). Speckle variance detection of microvasculature using swept-source optical coherence tomography. Optics Letters. https://doi.org/10.1364/ol.33.001530

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