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Cited by 165Optical Coherence Tomography ApplicationsCutaneous Melanoma Detection and ManagementNonmelanoma Skin Cancer Studies

Advances in optical coherence tomography in dermatology—a review

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Olsen, Jonas, Holmes, Jon, Jemec, Gregor B. E.·2018·Journal of Biomedical Optics
DOI 10.1117/1.jbo.23.4.040901
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Abstract

Optical coherence tomography (OCT) was introduced as an imaging system, but like ultrasonography, other measures, such as blood perfusion and polarization of light, have enabled the technology to approach clinical utility. This review aims at providing an overview of the advances in clinical research based on the improving technical aspects. OCT provides cross-sectional and en face images down to skin depths of 0.4 to 2.00 mm with optical resolution of 3 to 15 μm. Dynamic optical coherence tomography (D-OCT) enables the visualization of cutaneous microvasculature via detection of rapid changes in the interferometric signal of blood flow. Nonmelanoma skin cancer (NMSC) is the most comprehensively investigated topic, resulting in improved descriptions of morphological features and diagnostic criteria. A refined scoring system for diagnosing NMSC, taking findings from conventional and D-OCT into account, is warranted. OCT diagnosis of melanoma is hampered by the resolution and the optical properties of melanin. D-OCT may be of value in diseases characterized with dynamic changes in the vasculature of the skin and the addition of functional measures is strongly encouraged. In conclusion, OCT in dermatology is still an emerging technology that has great potential for improving further in the future.

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  36. Jonas Olsen is an MD and PhD student at the Department of Dermatology, Zealand University Hospital, Denmark. He has auth- ored several manuscripts in the clinical field of OCT in dermatology and is teaching applied medical statistics at the PhD-school at faculty of health sciences, University of Copenhagen. Currently, he is writing a PhD-thesis on the nonsurgical treatment effects on the microvascu- lature of nonmelanoma skin cancer assessed with OCT. Jon Holmes has more than 30 years' experience in optical imaging, both in industrial manufacturing and in diagnostics for medicine, and in 2006 cofounded Michelson Diagnostics Ltd. and became the com- pany's first CEO. Specializing in optical coherence tomography, he was elected a fellow of the Institute of Physics in November 2017. He is author of multiple patents and publications in peer-reviewed journals in the field of OCT.
  37. Gregor B. E. Jemec is the founding chairman at the Department of Dermatology, Zealand University Hospital, and tenured professor at the University of Copenhagen, Denmark. He has broad academic interests in many fields of dermatology and publishes broadly with 450+ scientific publications, 10 books and 130+ invited lectures at international conferences. Currently, he heads a research group dedicated the clinical use of OCT. Journal of Biomedical Optics 040901-10 April 2018 • Vol. 23
  38. Olsen, Holmes, and Jemec: Advances in optical coherence tomography. . . Downloaded From: https://www.spiedigitallibrary.org/journals/Journal-of-Biomedical-Optics on 14 Jun 2019 Terms of Use: https://www.spiedigitallibrary.org/terms-of-use

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Authors
Olsen, J., Holmes, J., & Jemec, G. B. E.
Affiliations
  • University of Copenhagen (DK)
  • VivoSight (United Kingdom) (GB)
ORCID
Venue
Journal of Biomedical Optics
Publisher
SPIE-Intl Soc Optical Eng
Published
2018-04-26
Volume
23
Issue
04
Pages
1-10
ISSN
  • 1083-3668 (ISSN-L)
  • 1560-2281
DOI
10.1117/1.jbo.23.4.040901
OpenAlex
W2799929571
Cited by
165
References
72
Citations by year
2026: 12 · 2025: 20 · 2024: 20 · 2023: 28 · 2022: 21 · 2021: 30 · 2020: 20 · 2019: 12 · 2018: 2
FWCI
1.30
Type
journal article
Language
en
Open access
Locations
  • Journal of Biomedical Optics (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, other-oa)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Optical Coherence Tomography Applications
  • Health Sciences › Medicine › Oncology › Cutaneous Melanoma Detection and Management
  • Health Sciences › Medicine › Epidemiology › Nonmelanoma Skin Cancer Studies
Keywords
optical coherence tomography, dermatology, dynamic optical coherence tomography, skin microcirculation, blood perfusion, polarization imaging, non-melanoma skin cancer, melanoma diagnosis, skin imaging, functional imaging
MeSH terms
Aged, Female, Humans, Interferometry, Male, Middle Aged, Skin, Tomography, Optical Coherence

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