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Actin-binding Proteins Coronin-1a and IBA-1 are Effective Microglial Markers for Immunohistochemistry
Abstract
This study identifies the actin-binding protein, coronin-1a, as a novel and effective immunohistochemical marker for microglia in both cell cultures and in formaldehyde-fixed, paraffin-embedded tissue. Antibodies to coronin-1a effectively immunostained microglia in human, monkey, horse, rat, and mouse tissues, even in tissues stored for long periods of time. The identity of coronin-1a-immunoreactive cells as microglia was confirmed using double immunolabeling with cell type-specific markers as well as by morphological features and the distribution of immunoreactive cells. These properties are shared by another actin-binding protein, IBA-1. Unlike IBA-1, coronin-1a immunoreactivity was also detected in lymphocytes and certain other hematopoietic cells. The results indicate that both coronin-1a and IBA-1 are robust markers for microglia that can be used in routinely processed tissue of humans and animals. Because both coronin-1a and IBA-1 are actin-binding proteins that play a role in rearrangement of the membrane cytoskeleton, it suggests that these proteins are critical to dynamic properties of microglia.
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“We used IBA-1 as a pan-macrophage marker [1].”
From Loss of homeostatic microglial phenotype in CSF1R-related Leukoencephalopathy (2020) · cites this paper as [1]
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Metadata
- Authors
- Ahmed, Z., Shaw, G., Sharma, V. P., Yang, C., McGowan, E., & Dickson, D. W.
- Affiliations
- Mayo Clinic (US)
- University of Florida Health (US)
- University of Florida (US)
- Corresponding author
- Dickson, Dennis W.
- Venue
- Journal of Histochemistry & Cytochemistry
- Publisher
- SAGE Publications
- Published
- 2007-07
- Volume
- 55
- Issue
- 7
- Pages
- 687-700
- ISSN
- 0022-1554 (ISSN-L)
- 1551-5044
- OpenAlex
- W2095733296
- Cited by
- 258
- References
- 53
- Citations by year
- 2026: 3 · 2025: 13 · 2024: 7 · 2023: 19 · 2022: 16 · 2021: 21 · 2020: 26 · 2019: 16 · 2018: 18 · 2017: 17 · 2016: 22 · 2015: 12 · 2014: 12 · 2013: 13 · 2012: 17
- FWCI
- 4.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Histochemistry & Cytochemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Mayo Clinic
- National Institutes of Health (5r01ag020216-04)
- National Institute on Aging (P50 AG25711, P50‐AG16574, R01AG022595, R01-AG20216, R01-AG22595, P01-AG-17216, P01AG03949, P01AG003949, P50AG025711, P01AG017216, P50AG016574)
- National Institute of Neurological Disorders and Stroke (P50-NS40256, P50NS040256)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Anatomy › Classical Anatomy and Histology
- Keywords
- CORO1A, Iba1, microglia, actin-binding proteins, immunohistochemical markers, paraffin-embedded tissue, formalin fixation, lymphocytes, hematopoietic cells, membrane cytoskeleton
- MeSH terms
- Actins, Animals, Calcium-Binding Proteins, Dogs, Horses, Humans, Immunohistochemistry, Macaca mulatta, Mice, Transgenic, Microfilament Proteins, Neurons, Species Specificity, Biomarkers, Microglia, Coculture Techniques, HL-60 Cells, Mice, Rats
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