Cited by 258Neuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology ResearchClassical Anatomy and Histology

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Actin-binding Proteins Coronin-1a and IBA-1 are Effective Microglial Markers for Immunohistochemistry

Ahmed, Zeshan, Shaw, Gerry, Sharma, Ved P., Yang, Cui, McGowan, Eileen, Dickson, Dennis W.·2007·Journal of Histochemistry & Cytochemistry

DOI 10.1369/jhc.6a7156.2007

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Abstract

This study identifies the actin-binding protein, coronin-1a, as a novel and effective immunohistochemical marker for microglia in both cell cultures and in formaldehyde-fixed, paraffin-embedded tissue. Antibodies to coronin-1a effectively immunostained microglia in human, monkey, horse, rat, and mouse tissues, even in tissues stored for long periods of time. The identity of coronin-1a-immunoreactive cells as microglia was confirmed using double immunolabeling with cell type-specific markers as well as by morphological features and the distribution of immunoreactive cells. These properties are shared by another actin-binding protein, IBA-1. Unlike IBA-1, coronin-1a immunoreactivity was also detected in lymphocytes and certain other hematopoietic cells. The results indicate that both coronin-1a and IBA-1 are robust markers for microglia that can be used in routinely processed tissue of humans and animals. Because both coronin-1a and IBA-1 are actin-binding proteins that play a role in rearrangement of the membrane cytoskeleton, it suggests that these proteins are critical to dynamic properties of microglia.

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Authors: Ahmed, Z., Shaw, G., Sharma, V. P., Yang, C., McGowan, E., & Dickson, D. W.
Affiliations: Mayo Clinic (US)
University of Florida Health (US)
University of Florida (US)
Corresponding author: Dickson, Dennis W.
ORCID: Shaw, Gerry
Sharma, Ved P.
McGowan, Eileen
Dickson, Dennis W.
Venue: Journal of Histochemistry & Cytochemistry
Publisher: SAGE Publications
Published: 2007-07
Volume: 55
Issue: 7
Pages: 687-700
ISSN: 0022-1554 (ISSN-L)
1551-5044
DOI: 10.1369/jhc.6a7156.2007
OpenAlex: W2095733296
Cited by: 258
References: 53
Citations by year: 2026: 3 · 2025: 13 · 2024: 7 · 2023: 19 · 2022: 16 · 2021: 21 · 2020: 26 · 2019: 16 · 2018: 18 · 2017: 17 · 2016: 22 · 2015: 12 · 2014: 12 · 2013: 13 · 2012: 17
FWCI: 4.45
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Journal of Histochemistry & Cytochemistry (publishedVersion)
PubMed (publishedVersion)
Funders: Mayo Clinic
National Institutes of Health (5r01ag020216-04)
National Institute on Aging (P50 AG25711, P50‐AG16574, R01AG022595, R01-AG20216, R01-AG22595, P01-AG-17216, P01AG03949, P01AG003949, P50AG025711, P01AG017216, P50AG016574)
National Institute of Neurological Disorders and Stroke (P50-NS40256, P50NS040256)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Anatomy › Classical Anatomy and Histology
Keywords: CORO1A, Iba1, microglia, actin-binding proteins, immunohistochemical markers, paraffin-embedded tissue, formalin fixation, lymphocytes, hematopoietic cells, membrane cytoskeleton
MeSH terms: Actins, Animals, Calcium-Binding Proteins, Dogs, Horses, Humans, Immunohistochemistry, Macaca mulatta, Mice, Transgenic, Microfilament Proteins, Neurons, Species Specificity, Biomarkers, Microglia, Coculture Techniques, HL-60 Cells, Mice, Rats

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Actin-binding Proteins Coronin-1a and IBA-1 are Effective Microglial Markers for Immunohistochemistry

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