Understanding the context of health for persons with multiple chronic conditions: Moving from what is the matter to what matters
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PURPOSE: An isolated focus on 1 disease at a time is insufficient to generate the scientific evidence needed to improve the health of persons living with more than 1 chronic condition. This article explores how to bring context into research efforts to improve the health of persons living with multiple chronic conditions (MCC). METHODS: Forty-five experts, including persons with MCC, family and friend caregivers, researchers, policy makers, funders, and clinicians met to critically consider 4 aspects of incorporating context into research on MCC: key contextual factors, needed research, essential research methods for understanding important contextual factors, and necessary partnerships for catalyzing collaborative action in conducting and applying research. RESULTS: Key contextual factors involve complementary perspectives across multiple levels: public policy, community, health care systems, family, and person, as well as the cellular and molecular levels where most research currently is focused. Needed research involves moving from a disease focus toward a person-driven, goal-directed research agenda. Relevant research methods are participatory, flexible, multilevel, quantitative and qualitative, conducive to longitudinal dynamic measurement from diverse data sources, sufficiently detailed to consider what works for whom in which situation, and generative of ongoing communities of learning, living and practice. Important partnerships for collaborative action include cooperation among members of the research enterprise, health care providers, community-based support, persons with MCC and their family and friend caregivers, policy makers, and payers, including government, public health, philanthropic organizations, and the business community. CONCLUSION: Consistent attention to contextual factors is needed to enhance health research for persons with MCC. Rigorous, integrated, participatory, multimethod approaches to generate new knowledge and diverse partnerships can be used to increase the relevance of research to make health care more sustainable, safe, equitable and effective, to reduce suffering, and to improve quality of life.
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A panel of comorbidity experts recently identified understanding contextual factors, such as patients' relationships, values, and goals, as a vital paradigm shift in the treatment of patients with multiple chronic conditions.
“Indeed, a panel of comorbidity experts recently identified understanding contextual factors, such as patients ' relationships, values, and goals, as a vital paradigm shift in the treatment of patients with multiple chronic conditions [77].”
From Acceptance and Commitment Therapy: A Transdiagnostic Behavioral Intervention for Mental Health and Medical Conditions. (2017) · cites this paper as [77]
The Key Contextual Factors section identifies patients’ goals, preferences, social connections, and family relationships as relevant context. The Discussion calls understanding context vital and describes a paradigm shift, but specifies that the shift concerns how knowledge is generated and research is conducted, not directly how patients are treated. Page numbers are not available in our copy. (LLM, conf=0.85)
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Bensken, W. P., Dong, W., Gullett, H., Etz, R., & Stange, K. C. (2021) · The Journal of the American Board of Family Medicine · doi:10.3122/jabfm.2021.02.200145 · Cited by 10 · see citing works
Self-citationAarønes, T. R., Taraldsen, K., & Kvæl, L. A. H. (2025) · BMC Health Services Research · doi:10.1186/s12913-024-12185-4 · Cited by 9 · see citing works
Managing Complexity in Older Patients with CKD
Weiss, J. W., & Boyd, C. M. (2017) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.02340317 · Cited by 9 · see citing works
Self-citationSzanton, S. L., Han, H., Campbell, J. C., Reynolds, N. R., Himmelfarb, C. D., Perrin, N., & Davidson, P. M. (2019) · Journal of Clinical Nursing · doi:10.1111/jocn.15145 · Cited by 9 · see citing works
Carolane, T., Coulombe, V., & Briand, C. (2017) · International Journal of Mental Health Systems · doi:10.1186/s13033-016-0111-5 · Cited by 8 · see citing works
Limiting and Promoting Resident Self-Care in Assisted Living
Morgan, J. C., Kemp, C. L., Barmon, C., Fitzroy, A. F., & Ball, M. M. (2021) · The Journals of Gerontology Series B · doi:10.1093/geronb/gbab016 · Cited by 8 · see citing works
- Authors
- Bayliss, E. A., Bonds, D. E., Boyd, C. M., Davis, M. M., Finke, B., Fox, M. H., Glasgow, R. E., Goodman, R. A., Heurtin-Roberts, S., Lachenmayr, S., Lind, C., Madigan, E. A., Meyers, D. S., Mintz, S., Nilsen, W. J., Okun, S., Ruiz, S., Salive, M. E., & Stange, K. C.
- Affiliations
- Centers for Disease Control and Prevention (US)
- ORCID
- Venue
- The Annals of Family Medicine
- Publisher
- Annals of Family Medicine
- Published
- 2014-05-01
- Volume
- 12
- Issue
- 3
- Pages
- 260-269
- ISSN
- 1544-1709 (ISSN-L)
- 1544-1717
- PMC
- PMC4018375
- OpenAlex
- W2149582914
- Cited by
- 225
- References
- 106
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 6 · 2023: 15 · 2022: 16 · 2021: 25 · 2020: 64 · 2019: 17 · 2018: 11 · 2017: 17 · 2016: 13 · 2015: 15 · 2014: 14
- FWCI
- 14.86
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- The Annals of Family Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Cancer Society
- Centers for Disease Control and Prevention
- Agency for Healthcare Research and Quality
- Topics
- Health Sciences › Medicine › Epidemiology › Chronic Disease Management Strategies
- Health Sciences › Health Professions › General Health Professions › Health Policy Implementation Science
- Health Sciences › Health Professions › General Health Professions › Health, psychology, and well-being
- Keywords
- multimorbidity, research collaboration, participatory research, research agenda, health care system, health policy, learning communities, research relevance, quality of life
- MeSH terms
- Chronic Disease, Cooperative Behavior, Health Services Research, Humans, Research, Comorbidity, Biomedical Research
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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