Correction: Cryptococcal Cell Morphology Affects Host Cell Interactions and Pathogenicity
Open accessAbstract
Cryptococcus neoformans is a common life-threatening human fungal pathogen.The size of cryptococcal cells is typically 5 to 10 mm.Cell enlargement was observed in vivo, producing cells up to 100 mm.These morphological changes in cell size affected pathogenicity via reducing phagocytosis by host mononuclear cells, increasing resistance to oxidative and nitrosative stress, and correlated with reduced penetration of the central nervous system.Cell enlargement was stimulated by coinfection with strains of opposite mating type, and ste3aD pheromone receptor mutant strains had reduced cell enlargement.Finally, analysis of DNA content in this novel cell type revealed that these enlarged cells were polyploid, uninucleate, and produced daughter cells in vivo.These results describe a novel mechanism by which C. neoformans evades host phagocytosis to allow survival of a subset of the population at early stages of infection.Thus, morphological changes play unique and specialized roles during infection.
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Research suggests that either mis-segregation of chromosomes or compromised nuclear division leads to the formation of aneuploid cells under azole stress.
“research suggests that either mis-segregation of chromosomes or compromised nuclear division leads to the formation of aneuploid cells under azole stress27–29.”
From Treatment strategies for cryptococcal infection: challenges, advances and future outlook (2021) · cites this paper as [29]
During cryptococcal infection of mouse lungs, ~20% of fungal cells transform from haploid yeast into polyploid titan cells.
“During cryptococcal infection of mouse lungs, ~20% of fungal cells transform from haploid yeast into polyploid titan cells29,147, making up a substantial subset of the population.”
From Treatment strategies for cryptococcal infection: challenges, advances and future outlook (2021) · cites this paper as [29]
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- Authors
- Okagaki, L. H., Strain, A. K., Nielsen, J. N., Charlier, C., Baltes, N. J., Chrétien, F., Heitman, J., Dromer, F., & Nielsen, K.
- Affiliations
- University of Minnesota (US)
- University of North Carolina at Chapel Hill (US)
- Centre National de la Recherche Scientifique (FR)
- Duke University (US)
- Corresponding author
- Nielsen, Judith N.
- Venue
- PLoS Pathogens
- Publisher
- Public Library of Science (PLoS)
- Published
- 2010-06-23
- Volume
- 6
- Issue
- 6
- ISSN
- 1553-7366 (ISSN-L)
- 1553-7374
- PMC
- PMC2890777
- OpenAlex
- W2000414956
- Cited by
- 71
- References
- 49
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 7 · 2023: 5 · 2022: 7 · 2021: 7 · 2020: 7 · 2019: 10 · 2018: 6 · 2017: 6 · 2016: 3 · 2014: 2 · 2012: 1
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS Pathogens (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- University of Minnesota
- National Institute of Allergy and Infectious Diseases (AI50113)
- Topics
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- Cryptococcus neoformans, cell expansion, cell morphology, pathogenicity, phagocytosis evasion, oxidative stress resistance, CNS penetration, polyploidy, host-pathogen interaction
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