The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
Components of Coated Vesicles and Nuclear Pore Complexes Share a Common Molecular Architecture
Open accessAbstract
Numerous features distinguish prokaryotes from eukaryotes, chief among which are the distinctive internal membrane systems of eukaryotic cells. These membrane systems form elaborate compartments and vesicular trafficking pathways, and sequester the chromatin within the nuclear envelope. The nuclear pore complex is the portal that specifically mediates macromolecular trafficking across the nuclear envelope. Although it is generally understood that these internal membrane systems evolved from specialized invaginations of the prokaryotic plasma membrane, it is not clear how the nuclear pore complex could have evolved from organisms with no analogous transport system. Here we use computational and biochemical methods to perform a structural analysis of the seven proteins comprising the yNup84/vNup107-160 subcomplex, a core building block of the nuclear pore complex. Our analysis indicates that all seven proteins contain either a beta-propeller fold, an alpha-solenoid fold, or a distinctive arrangement of both, revealing close similarities between the structures comprising the yNup84/vNup107-160 subcomplex and those comprising the major types of vesicle coating complexes that maintain vesicular trafficking pathways. These similarities suggest a common evolutionary origin for nuclear pore complexes and coated vesicles in an early membrane-curving module that led to the formation of the internal membrane systems in modern eukaryotes.
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Molecular mechanism of the nuclear protein import cycle
Stewart, M. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2114 · Cited by 919
Integrated Structural Analysis of the Human Nuclear Pore Complex Scaffold
Bui, K. H., von Appen, A., DiGuilio, A. L., Ori, A., Sparks, L., Mackmull, M.-T., Bock, T., Hagen, W., Andrés-Pons, A., Glavy, J. S., et al. (2013) · Cell · doi:10.1016/j.cell.2013.10.055 · Cited by 357
AI-based structure prediction empowers integrative structural analysis of human nuclear pores
Mosalaganti, S., Obarska-Kosinska, A., Siggel, M., Taniguchi, R., Turoňová, B., Zimmerli, C. E., Buczak, K., Schmidt, F. H., Margiotta, E., Mackmull, M.-T., et al. (2022) · Science · doi:10.1126/science.abm9506 · Cited by 355
Endocytosis and signaling: Cell logistics shape the eukaryotic cell plan
Sigismund, S., Confalonieri, S., Ciliberto, A., Polo, S., Scita, G., & Di Fiore, P. P. (2012) · Physiological Reviews · doi:10.1152/physrev.00005.2011 · Cited by 338
Metadata
- Authors
- Devos, D., Dokudovskaya, S., Alber, F., Williams, R., Chait, B. T., Sali, A., & Rout, M. P.
- Venue
- PLoS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2004-11-02
- Volume
- 2
- Issue
- 12
- Pages
- e380
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- OpenAlex
- W2046115216
- Cited by
- 391
- References
- 70
- FWCI
- 7.11
- Type
- journal article
- Language
- en
- Open access
- gold
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- Devos, D., Dokudovskaya, S., Alber, F., Williams, R., Chait, B. T., Sali, A., & Rout, M. P. (2004). Components of Coated Vesicles and Nuclear Pore Complexes Share a Common Molecular Architecture. PLoS Biology. https://doi.org/10.1371/journal.pbio.0020380
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