The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Emergence of Noise-Induced Oscillations in the Central Circadian Pacemaker
Open accessAbstract
Bmal1 is an essential transcriptional activator within the mammalian circadian clock. We report here that the suprachiasmatic nucleus (SCN) of Bmal1-null mutant mice, unexpectedly, generates stochastic oscillations with periods that overlap the circadian range. Dissociated SCN neurons expressed fluctuating levels of PER2 detected by bioluminescence imaging but could not generate circadian oscillations intrinsically. Inhibition of intercellular communication or cyclic-AMP signaling in SCN slices, which provide a positive feed-forward signal to drive the intracellular negative feedback loop, abolished the stochastic oscillations. Propagation of this feed-forward signal between SCN neurons then promotes quasi-circadian oscillations that arise as an emergent property of the SCN network. Experimental analysis and mathematical modeling argue that both intercellular coupling and molecular noise are required for the stochastic rhythms, providing a novel biological example of noise-induced oscillations. The emergence of stochastic circadian oscillations from the SCN network in the absence of cell-autonomous circadian oscillatory function highlights a previously unrecognized level of circadian organization.
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Mammalian circadian biology: elucidating genome-wide levels of temporal organization
Lowrey, P. L., & Takahashi, J. S. (2004) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.5.061903.175925 · Cited by 976
Self-citationUnderstanding circuit dynamics using the stomatogastric nervous system of lobsters and crabs.
Marder, E., & Bucher, D. (2007) · Annual Review of Physiology · doi:10.1146/annurev.physiol.69.031905.161516 · Cited by 681
cAMP-dependent signaling as a core component of the mammalian circadian pacemaker
O'Neill, J. S., Maywood, E. S., Chesham, J. E., Takahashi, J. S., & Hastings, M. H. (2008) · Science · doi:10.1126/science.1152506 · Cited by 418
Self-citationReal-time luminescence reporting of circadian gene expression in mammals
Yamazaki, S., & Takahashi, J. S. (2005) · Methods in Enzymology · doi:10.1016/s0076-6879(05)93012-7 · Cited by 200
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Cited by
Central and Peripheral Circadian Clocks in Mammals
Mohawk, J. A., Green, C. B., & Takahashi, J. S. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-060909-153128 · Cited by 2,265
Self-citationCircadian integration of metabolism and energetics
Bass, J., & Takahashi, J. S. (2010) · Science · doi:10.1126/science.1195027 · Cited by 1,910
Self-citationMolecular components of the mammalian circadian clock
Buhr, E. D., & Takahashi, J. S. (2013) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-25950-0_1 · Cited by 738
Self-citationRey, G., Cesbron, F., Rougemont, J., Reinke, H., Brunner, M., & Naef, F. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1000595 · Cited by 474
Maywood, E. S., Chesham, J. E., O'Brien, J. A., & Hastings, M. H. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1101767108 · Cited by 287
Metadata
- Authors
- Ko, C. H., Yamada, Y. R., Welsh, D. K., Buhr, E. D., Liu, A. C., Zhang, E. E., Ralph, M. R., Kay, S. A., Forger, D. B., & Takahashi, J. S.
- Venue
- PLoS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2010-10-12
- Volume
- 8
- Issue
- 10
- Pages
- e1000513
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- OpenAlex
- W2048893195
- Cited by
- 212
- References
- 5
- FWCI
- 6.70
- Type
- journal article
- Language
- en
- Open access
- gold
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- Ko, C. H., Yamada, Y. R., Welsh, D. K., Buhr, E. D., Liu, A. C., Zhang, E. E., Ralph, M. R., Kay, S. A., Forger, D. B., & Takahashi, J. S. (2010). Emergence of Noise-Induced Oscillations in the Central Circadian Pacemaker. PLoS Biology. https://doi.org/10.1371/journal.pbio.1000513
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
