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Dynamic Endothelial Cell Rearrangements Drive Developmental Vessel Regression
Open accessAbstract
Patterning of functional blood vessel networks is achieved by pruning of superfluous connections. The cellular and molecular principles of vessel regression are poorly understood. Here we show that regression is mediated by dynamic and polarized migration of endothelial cells, representing anastomosis in reverse. Establishing and analyzing the first axial polarity map of all endothelial cells in a remodeling vascular network, we propose that balanced movement of cells maintains the primitive plexus under low shear conditions in a metastable dynamic state. We predict that flow-induced polarized migration of endothelial cells breaks symmetry and leads to stabilization of high flow/shear segments and regression of adjacent low flow/shear segments.
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Citations
Cites
Angiogenesis in life, disease and medicine
Carmeliet, P. (2005) · Nature · doi:10.1038/nature04478 · Cited by 3,482
Basic and Therapeutic Aspects of Angiogenesis
Potente, M., Gerhardt, H., & Carmeliet, P. (2011) · Cell · doi:10.1016/j.cell.2011.08.039 · Cited by 2,771
Self-citationCollective cell migration in morphogenesis, regeneration and cancer
Friedl, P., & Gilmour, D. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2720 · Cited by 2,712
In Vivo Imaging of Embryonic Vascular Development Using Transgenic Zebrafish
Lawson, N. D., & Weinstein, B. M. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0711 · Cited by 2,151
Alon, T., Hemo, I., Itin, A., Pe'er, J., Stone, J., & Keshet, E. (1995) · Nature Medicine · doi:10.1038/nm1095-1024 · Cited by 1,604
Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting
Jakobsson, L., Franco, C. A., Bentley, K., Collins, R. T., Ponsioen, B., Aspalter, I. M., Rosewell, I., Busse, M., Thurston, G., Medvinsky, A., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2103 · Cited by 971
Self-citationFluid Shear Stress on Endothelial Cells Modulates Mechanical Tension across VE-Cadherin and PECAM-1
Conway, D. E., Breckenridge, M. T., Hinde, E., Gratton, E., Chen, C. S., & Schwartz, M. A. (2013) · Current Biology · doi:10.1016/j.cub.2013.04.049 · Cited by 506
Flow regulates arterial-venous differentiation in the chick embryo yolk sac
le Noble, F., Moyon, D., Pardanaud, L., Yuan, L., Djonov, V., Matthijsen, R., Bréant, C., Fleury, V., & Eichmann, A. (2004) · Development · doi:10.1242/dev.00929 · Cited by 483
WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature
Lobov, I. B., Rao, S., Carroll, T. J., Vallance, J. E., Ito, M., Ondr, J. K., Kurup, S., Glass, D. A., Patel, M. S., Shu, W., et al. (2005) · Nature · doi:10.1038/nature03928 · Cited by 430
Disruption of acvrl1 increases endothelial cell number in zebrafish cranial vessels
Roman, B. L., Pham, V. N., Lawson, N. D., Kulik, M., Childs, S., Lekven, A. C., Garrity, D. M., Moon, R. T., Fishman, M. C., Lechleider, R. J., et al. (2002) · Development · doi:10.1242/dev.129.12.3009 · Cited by 365
The role of differential VE-cadherin dynamics in cell rearrangement during angiogenesis
Bentley, K., Franco, C. A., Philippides, A., Blanco, R., Dierkes, M., Gebala, V., Stanchi, F., Jones, M., Aspalter, I. M., Cagna, G., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb2926 · Cited by 364
Self-citationNrarp Coordinates Endothelial Notch and Wnt Signaling to Control Vessel Density in Angiogenesis
Phng, L.-K., Potente, M., Leslie, J. D., Babbage, J., Nyqvist, D., Lobov, I., Ondr, J. K., Rao, S., Lang, R. A., Thurston, G., et al. (2009) · Developmental Cell · doi:10.1016/j.devcel.2008.12.009 · Cited by 349
Self-citationModular control of endothelial sheet migration
Vitorino, P., & Meyer, T. (2008) · Genes & Development · doi:10.1101/gad.1725808 · Cited by 282
Haemodynamics-Driven Developmental Pruning of Brain Vasculature in Zebrafish
Chen, Q., Jiang, L., Li, C., Hu, D., Bu, J.-W., Cai, D., & Du, J.-L. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001374 · Cited by 250
Distinct Cellular Mechanisms of Blood Vessel Fusion in the Zebrafish Embryo
Herwig, L., Blum, Y., Krudewig, A., Ellertsdottir, E., Lenard, A., Belting, H.-G., & Affolter, M. (2011) · Current Biology · doi:10.1016/j.cub.2011.10.016 · Cited by 248
Notch controls retinal blood vessel maturation and quiescence
Ehling, M., Adams, S., Benedito, R., & Adams, R. H. (2013) · Development · doi:10.1242/dev.093351 · Cited by 231
Arteries are formed by vein-derived endothelial tip cells
Xu, C., Hasan, S. S., Schmidt, I., Rocha, S. F., Pitulescu, M. E., Bussmann, J., Meyen, D., Raz, E., Adams, R. H., & Siekmann, A. F. (2014) · Nature Communications · doi:10.1038/ncomms6758 · Cited by 224
Fellow travellers: emergent properties of collective cell migration
Rørth, P. (2012) · EMBO reports · doi:10.1038/embor.2012.149 · Cited by 200
Angiogenic morphogenesis driven by dynamic and heterogeneous collective endothelial cell movement
Arima, S., Nishiyama, K., Ko, T., Arima, Y., Hakozaki, Y., Sugihara, K., Koseki, H., Uchijima, Y., Kurihara, Y., & Kurihara, H. (2011) · Development · doi:10.1242/dev.068023 · Cited by 187
Udan, R. S., Vadakkan, T. J., & Dickinson, M. E. (2013) · Development · doi:10.1242/dev.096255 · Cited by 161
Endothelial basement membrane limits tip cell formation by inducing Dll4/Notch signalling in vivo
Stenzel, D., Franco, C. A., Estrach, S., Mettouchi, A., Sauvaget, D., Rosewell, I. R., Schertel, A., Armer, H. E. J., Domogatskaya, A., Rodin, S., et al. (2011) · EMBO Reports · doi:10.1038/embor.2011.194 · Cited by 160
Self-citationDynamic Analysis of Vascular Morphogenesis Using Transgenic Quail Embryos
Sato, Y., Poynter, G., Huss, D. J., Filla, M. B., Czirók, A., Rongish, B. J., Little, C. D., Fraser, S. E., & Lansford, R. D. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012674 · Cited by 158
VEGF deprivation-induced apoptosis is a component of programmed capillary regression
Meeson, A. P., Argilla, M., Ko, K. A., Witte, L., & Lang, R. A. (1999) · Development · doi:10.1242/dev.126.7.1407 · Cited by 149
Derivation of mouse embryonic stem cells
Bryja, V., Bonilla, S., & Arenas, E. (2006) · Nature Protocols · doi:10.1038/nprot.2006.355 · Cited by 142
Covassin, L., Siekmann, A. F., Kacergis, M. C., Laver, E., Moore, J. C., Villefranc, J. A., Weinstein, B. M., & Lawson, N. D. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.02.031 · Cited by 139
Lobov, I. B., Cheung, E., Wudali, R., Cao, J., Halász, G., Wei, Y., Economides, A. N., Lin, H. C., Papadopoulos, N. J., Yancopoulos, G. D., et al. (2011) · Blood · doi:10.1182/blood-2010-08-302067 · Cited by 125
Obligatory participation of macrophages in an angiopoietin 2-mediated cell death switch
Rao, S., Lobov, I. B., Vallance, J. E., Tsujikawa, K., Shiojima, I., Akunuru, S., Walsh, K. X., Benjamin, L. E., & Lang, R. A. (2007) · Development · doi:10.1242/dev.012187 · Cited by 116
Kochhan, E., Lenard, A., Ellertsdóttir, E., Herwig, L., Affolter, M., Belting, H., & Siekmann, A. F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075060 · Cited by 116
Bernabéu, M. O., Jones, M. L., Nielsen, J. H., Krüger, T., Nash, R. W., Groen, D., Schmieschek, S., Hetherington, J., Gerhardt, H., Franco, C. A., et al. (2014) · Journal of The Royal Society Interface · doi:10.1098/rsif.2014.0543 · Cited by 102
Self-citationHughes, S., & Chan‐Ling, T. (2000) · Microcirculation · doi:10.1111/j.1549-8719.2000.tb00131.x · Cited by 82
SRF selectively controls tip cell invasive behavior in angiogenesis
Franco, C. A., Blanc, J., Parlakian, A., Blanco, R., Aspalter, I. M., Kazakova, N., Diguet, N., Mylonas, E., Gao-Li, J., Vaahtokari, A., et al. (2013) · Development · doi:10.1242/dev.091074 · Cited by 74
Self-citationMartin, M., Geudens, I., Bruyr, J., Potente, M., Bleuart, A., Lebrun, M., Simonis, N., Deroanne, C., Twizere, J., Soubeyran, P., et al. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.187 · Cited by 49
Self-citation
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Vascular heterogeneity and specialization in development and disease
Potente, M., & Mäkinen, T. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.36 · Cited by 653
Vascular endothelial cell development and diversity
Trimm, E., & Red-Horse, K. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00770-1 · Cited by 537
Vascular Tissue Engineering: Progress, Challenges, and Clinical Promise
Song, H.-H. G., Rumma, R. T., Ozaki, C. K., Edelman, E. R., & Chen, C. S. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.02.009 · Cited by 476
Diabetic retinopathy: hyperglycaemia, oxidative stress and beyond
Hammes, H.-P. (2018) · Diabetologia · doi:10.1007/s00125-017-4435-8 · Cited by 357
Interpericyte tunnelling nanotubes regulate neurovascular coupling
Alarcon-Martinez, L., Villafranca-Baughman, D., Quintero, H., Kacerovsky, J. B., Dotigny, F., Murai, K. K., Prat, A., Drapeau, P., & Di Polo, A. (2020) · Nature · doi:10.1038/s41586-020-2589-x · Cited by 312
Metadata
- Authors
- Franco, C. A., Jones, M. L., Bernabeu, M. O., Geudens, I., Mathivet, T., Rosa, A., Lopes, F. M., Lima, A. P., Ragab, A., Collins, R. T., Phng, L.-K., Coveney, P. V., & Gerhardt, H.
- Venue
- PLOS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2015-04-17
- Volume
- 13
- Issue
- 4
- Pages
- e1002125
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- OpenAlex
- W2049681345
- Cited by
- 295
- References
- 32
- FWCI
- 9.39
- Type
- journal article
- Language
- en
- Open access
- gold
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