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Ensemble-Based Computational Approach Discriminates Functional Activity of p53 Cancer and Rescue Mutants
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“Second site suppressor mutations could help correct the conformation of mutant p53, improve the stability of p53-DNA binding, and provide a theoretical basis for the reactivation of mutant p53 (Table 4).531–545”
From Targeting p53 pathways: mechanisms, structures, and advances in therapy (2023) · cites this paper as [540]
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“Second site suppressor mutations could help correct the conformation of mutant p53, improve the stability of p53-DNA binding, and provide a theoretical basis for the reactivation of mutant p53 (Table 4).531–545”
From Targeting p53 pathways: mechanisms, structures, and advances in therapy (2023) · cites this paper as [540]
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Cites
Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations
Cho, Y., Gorina, S., Jeffrey, P. D., & Pavletich, N. P. (1994) · Science · doi:10.1126/science.8023157 · Cited by 2,551 · cited 2×
“These mutations may cause partial or global protein destabilization, loss of zinc coordination, or disruption of DNA contacts, and thus inactivate the tumor suppressor function of p53 (www-p53.iarc.fr) [4].”
BackgroundRestoration of p53 function leads to tumour regression in vivo
Ventura, A., Kirsch, D. G., McLaughlin, M. E., Tuveson, D. A., Grimm, J., Lintault, L., Newman, J., Reczek, E. E., Weissleder, R., & Jacks, T. (2007) · Nature · doi:10.1038/nature05541 · Cited by 1,820 · cited 1×
“Recently, two independent studies on transgenic mice demonstrated that restoration of p53 activity enables tumor regression in vivo [6,7]. p53 reactivation is especially promising in regression of advanced stage cancers [8,9].”
BackgroundRestoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound
Bykov, V. J. N., Issaeva, N., Shilov, A., Hultcrantz, M., Pugacheva, E., Chumakov, P., Bergman, J., Wiman, K. G., & Selivanova, G. (2002) · Nature Medicine · doi:10.1038/nm0302-282 · Cited by 1,067
Modeling the Therapeutic Efficacy of p53 Restoration in Tumors
Martins, C. P., Brown-Swigart, L., & Evan, G. I. (2006) · Cell · doi:10.1016/j.cell.2006.12.007 · Cited by 600 · cited 1×
“Recently, two independent studies on transgenic mice demonstrated that restoration of p53 activity enables tumor regression in vivo [6,7]. p53 reactivation is especially promising in regression of advanced stage cancers [8,9].”
BackgroundSolution structure of p53 core domain: Structural basis for its instability
Cañadillas, J. M. P., Tidow, H., Freund, S. M. V., Rutherford, T. J., Ang, H. C., & Fersht, A. R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510941103 · Cited by 174
Pang, Y.-P. (1999) · Journal of Molecular Modeling · doi:10.1007/s008940050119 · Cited by 161
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Cited by
Targeting p53 pathways: mechanisms, structures, and advances in therapy
Wang, H., Guo, M., Wei, H., & Chen, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01347-1 · Cited by 1,016
Structural Evolution and Dynamics of the p53 Proteins
Chillemi, G., Kehrloesser, S., Bernassola, F., Desideri, A., Dötsch, V., Levine, A. J., & Melino, G. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a028308 · Cited by 65
Metadata
- Authors
- Demir, Ö., Baronio, R., Salehi, F., Wassman, C. D., Hall, L., Hatfield, G. W., Chamberlin, R., Kaiser, P., Lathrop, R. H., & Amaro, R. E.
- Venue
- PLoS Computational Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-10-20
- Volume
- 7
- Issue
- 10
- Pages
- e1002238
- ISSN
- 1553-7358
- Cited by
- 39
- References
- 6
- Language
- en
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- Demir, Ö., Baronio, R., Salehi, F., Wassman, C. D., Hall, L., Hatfield, G. W., Chamberlin, R., Kaiser, P., Lathrop, R. H., & Amaro, R. E. (2011). Ensemble-Based Computational Approach Discriminates Functional Activity of p53 Cancer and Rescue Mutants. PLoS Computational Biology. https://doi.org/10.1371/journal.pcbi.1002238
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