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Cited by 169Regulation of Appetite and ObesityGenetic Associations and EpidemiologyAdipokines, Inflammation, and Metabolic Diseases

The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.

Unraveling the Genetics of Human Obesity

Open access
Mutch, David M., Clément, Karine·2006·PLoS Genetics
DOI 10.1371/journal.pgen.0020188PMC PMC1756898
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Abstract

The use of modern molecular biology tools in deciphering the perturbed biochemistry and physiology underlying the obese state has proven invaluable. Identifying the hypothalamic leptin/melanocortin pathway as critical in many cases of monogenic obesity has permitted targeted, hypothesis-driven experiments to be performed, and has implicated new candidates as causative for previously uncharacterized clinical cases of obesity. Meanwhile, the effects of mutations in the melanocortin-4 receptor gene, for which the obese phenotype varies in the degree of severity among individuals, are now thought to be influenced by one's environmental surroundings. Molecular approaches have revealed that syndromes (Prader-Willi and Bardet-Biedl) previously assumed to be controlled by a single gene are, conversely, regulated by multiple elements. Finally, the application of comprehensive profiling technologies coupled with creative statistical analyses has revealed that interactions between genetic and environmental factors are responsible for the common obesity currently challenging many Westernized societies. As such, an improved understanding of the different "types" of obesity not only permits the development of potential therapies, but also proposes novel and often unexpected directions in deciphering the dysfunctional state of obesity.

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Metadata

Authors
Mutch, D. M., & Clément, K.
Affiliations
  • Inserm (FR)
  • University College London (GB)
Corresponding author
Clément, Karine
ORCID
Venue
PLoS Genetics
Publisher
Public Library of Science (PLoS)
Published
2006
Volume
2
Issue
12
Pages
e188
ISSN
  • 1553-7390 (ISSN-L)
  • 1553-7404
DOI
10.1371/journal.pgen.0020188
PMC
PMC1756898
OpenAlex
W1977583120
Cited by
169
References
74
Citations by year
2026: 1 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 6 · 2019: 8 · 2018: 7 · 2017: 10 · 2016: 12 · 2015: 7 · 2014: 11 · 2013: 13 · 2012: 13
FWCI
1.43
Type
journal article
Language
en
Open access
Licence
Locations
  • PLoS Genetics (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords
human obesity, monogenic obesity, leptin, melanocortin pathway, melanocortin-4 receptor, Prader-Willi syndrome, Bardet-Biedl syndrome, gene-environment interaction, obesity phenotypes, obesity treatment
MeSH terms
Animals, Chromosome Mapping, Environment, Humans, Hypothalamus, Mutation, Obesity, Phenotype, Syndrome, Gene Expression Profiling

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