Noncanonical DNA Motifs as Transactivation Targets by Wild Type and Mutant p53

WAF1, a potential mediator of p53 tumor suppression

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p53, the cellular gatekeeper for growth and division

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Surfing the p53 network

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Empirical Predictions of Protein Conformation

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Genome-Wide Mapping of in Vivo Protein-DNA Interactions

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p53: puzzle and paradigm.Preprint

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PUMA, a Novel Proapoptotic Gene, Is Induced by p53

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Conformational parameters for amino acids in helical, β-sheet, and random coil regions calculated from proteins

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Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis

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TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis

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Blinded by the Light: The Growing Complexity of p53

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Mutant p53: one name, many proteinsPreprint

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Census and evaluation of p53 target genes

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Tumor suppressor p53: Biology, signaling pathways, and therapeutic targeting

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Transcriptional Regulation by P53

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The expanding universe of p53 targets

Menendez, D., Inga, A., & Resnick, M. A. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2730 · Cited by 568

The Tumor Suppressor p53: From Structures to Drug DiscoveryPreprint

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ROS-Mediated p53 Induction of Lpin1 Regulates Fatty Acid Oxidation in Response to Nutritional Stress

Assaily, W., Rubinger, D. A., Wheaton, K., Lin, Y., Ma, W., Xuan, W., Brown‐Endres, L., Tsuchihara, K., Mak, T. W., & Benchimol, S. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.08.038 · Cited by 200

Understanding wild-type and mutant p53 activities in human cancer: new landmarks on the way to targeted therapies

Goldstein, I., Marcel, V., Olivier, M., Oren, M., Rotter, V., & Hainaut, P. L. (2010) · Cancer Gene Therapy · doi:10.1038/cgt.2010.63 · Cited by 171

An Active Role of the ΔN Isoform of p63 in Regulating Basal Keratin Genes K5 and K14 and Directing Epidermal Cell Fate

Romano, R., Ortt, K., Birkaya, B. G., Smalley, K., & Sinha, S. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005623 · Cited by 169

Diverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells

Menendez, D., Nguyen, T.-A., Freudenberg, J. M., Mathew, V. J., Anderson, C. W., Jothi, R., & Resnick, M. A. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt504 · Cited by 154

Caspase-2-Mediated Cleavage of Mdm2 Creates a p53-Induced Positive Feedback Loop

Oliver, T. G., Meylan, E., Chang, G. P., Xue, W., Burke, J. R., Humpton, T. J., Hubbard, D., Bhutkar, A. J., & Jacks, T. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.06.012 · Cited by 163

The Toll-like receptor gene family is integrated into human DNA damage and p53 networks

Menendez, D., Shatz, M., Azzam, K., Garantziotis, S., Fessler, M. B., & Resnick, M. A. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1001360 · Cited by 148

Autophagy and cardiac diseases: Therapeutic potential of natural products

Wu, X., Liu, Z., Yu, X., Xu, S., & Luo, J. (2020) · Medicinal Research Reviews · doi:10.1002/med.21733 · Cited by 137

How theTP53Family ProteinsTP63andTP73Contribute to Tumorigenesis: Regulators and Effectors

Candi, E., Agostini, M., Melino, G., & Bernassola, F. (2014) · Human Mutation · doi:10.1002/humu.22523 · Cited by 137

The Human TLR Innate Immune Gene Family Is Differentially Influenced by DNA Stress and p53 Status in Cancer Cells

Shatz, M., Menendez, D., & Resnick, M. A. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-4134 · Cited by 143

Redefining the p53 response element

Wang, B., Xiao, Z., & Ren, E. C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903284106 · Cited by 116

Interactions between the tumor suppressor p53 and immune responses

Menéndez, D., Shatz, M., & Resnick, M. A. (2012) · Current Opinion in Oncology · doi:10.1097/cco.0b013e32835b6386 · Cited by 115

p53 responsive elements in human retrotransposons

Harris, C. R., DeWan, A. T., Zupnick, A., Normart, R., Gabriel, A., Prives, C. L., Levine, A. J., & Hoh, J. (2009) · Oncogene · doi:10.1038/onc.2009.246 · Cited by 110

Sequence-dependent sliding kinetics of p53

Leith, J. S., Tafvizi, A., Huang, F. L., Uspal, W. E., Doyle, P. S., Fersht, A. R., Mirny, L. A., & van Oijen, A. M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1120452109 · Cited by 90

Characterization of the p53 Cistrome – DNA Binding Cooperativity Dissects p53's Tumor Suppressor Functions

Schlereth, K., Heyl, C., Krampitz, A.-M., Mernberger, M., Finkernagel, F., Scharfe, M., Jarek, M., Leich, E., Rosenwald, A., & Stiewe, T. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003726 · Cited by 87

Distinct p53 genomic binding patterns in normal and cancer-derived human cells

Botcheva, K., McCorkle, S., McCombie, W. R., Dunn, J. J., & Anderson, C. W. (2011) · Cell Cycle · doi:10.4161/cc.10.24.18383 · Cited by 84

Altered-Function p53 Missense Mutations Identified in Breast Cancers Can Have Subtle Effects on Transactivation

Jordan, J. J., Inga, A., Conway, K., Edmiston, S. N., Carey, L., Wu, L., & Resnick, M. A. (2010) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0442 · Cited by 77

Conservation of DNA-binding specificity and oligomerisation properties within the p53 family

Brandt, T., Petrovich, M., Joerger, A. C., & Veprintsev, D. B. (2009) · BMC Genomics · doi:10.1186/1471-2164-10-628 · Cited by 77

Cancer therapeutic approach based on conformational stabilization of mutant p53 protein by small peptides

Tal, P., Eizenberger, S., Cohen, E., Goldfinger, N., Pietrokovski, S., Oren, M., & Rotter, V. (2016) · Oncotarget · doi:10.18632/oncotarget.7857 · Cited by 73

Whole-genome cartography of p53 response elements ranked on transactivation potential

Tebaldi, T., Zaccara, S., Alessandrini, F., Bisio, A., Ciribilli, Y., & Inga, A. (2015) · BMC Genomics · doi:10.1186/s12864-015-1643-9 · Cited by 72

A Comprehensive and High-Resolution Genome-wide Response of p53 to Stress

Chang, G. S., Chen, X. A., Park, B., Rhee, H. S., Li, P., Han, K. H., Mishra, T., Chan-Salis, K. Y., Li, Y., Hardison, R. C., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.06.030 · Cited by 73

Methylation and deamination of CpGs generate p53-binding sites on a genomic scale

Żemojtel, T., Kiełbasa, S. M., Arndt, P. F., Chung, H., & Vingron, M. (2008) · Trends in Genetics · doi:10.1016/j.tig.2008.11.005 · Cited by 66

Structural and Drug Targeting Insights on Mutant p53

Gomes, A. S., Ramos, H., Inga, A., Sousa, E., & Saraiva, L. (2021) · Cancers · doi:10.3390/cancers13133344 · Cited by 63

More targets, more pathways and more clues for mutant p53

Garritano, S., Inga, A., Gemignani, F., & Landi, S. (2013) · Oncogenesis · doi:10.1038/oncsis.2013.15 · Cited by 64

To repress or not to repress: This is the guardian's question

Rinn, J. L., & Huarte, M. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.04.002 · Cited by 60

Identification of new p53 target microRNAs by bioinformatics and functional analysis

Bisio, A., Sanctis, V. D., Vescovo, V. D., Denti, M. A., Jegga, A. G., Inga, A., & Ciribilli, Y. (2013) · BMC Cancer · doi:10.1186/1471-2407-13-552 · Cited by 56

Interactions of Chromatin Context, Binding Site Sequence Content, and Sequence Evolution in Stress-Induced p53 Occupancy and Transactivation

Su, D., Wang, X., Campbell, M. R., Song, L., Safi, A., Crawford, G. E., & Bell, D. A. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1004885 · Cited by 54

Sequence-dependent cooperative binding of p53 to DNA targets and its relationship to the structural properties of the DNA targets

Beno, I., Rosenthal, K., Levitine, M., Shaulov, L., & Haran, T. E. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq1044 · Cited by 51

Determinants of p53 DNA binding, gene regulation, and cell fate decisions

Fischer, M., & Sammons, M. A. (2024) · Cell Death and Differentiation · doi:10.1038/s41418-024-01326-1 · Cited by 59

Structure of p73 DNA-binding domain tetramer modulates p73 transactivation

Ethayathulla, A. S., Tse, P. W., Monti, P., Nguyen, S., Inga, A., Fronza, G., & Viadiu, H. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1115463109 · Cited by 51

Gain-of-function p53 mutants have widespread genomic locations partially overlapping with p63

Martynova, E., Pozzi, S., Basile, V., Dolfini, D., Zambelli, F., Imbriano, C., Pavesi, G., & Mantovani, R. (2012) · Oncotarget · doi:10.18632/oncotarget.447 · Cited by 49

p53 Binding to Nucleosomal DNA Depends on the Rotational Positioning of DNA Response Element

Sahu, G., Wang, D., Chen, C. B., Zhurkin, V. B., Harrington, R. E., Appella, E., Hager, G. L., & Nagaich, A. K. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.081182 · Cited by 48

Estrogen receptor acting in cis enhances WT and mutant p53 transactivation at canonical and noncanonical p53 target sequences

Menéndez, D., Inga, A., & Resnick, M. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909129107 · Cited by 49

Probing the Functional Impact of Sequence Variation on p53-DNA Interactions Using a Novel Microsphere Assay for Protein-DNA Binding with Human Cell Extracts

Noureddine, M., Menéndez, D., Campbell, M. R., Bandele, O. J., Horvath, M. M., Wang, X., Pittman, G. S., Chorley, B. N., Resnick, M. A., & Bell, D. A. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000462 · Cited by 45

TP53 Mutants in the Tower of Babel of Cancer Progression

Bisio, A., Ciribilli, Y., Fronza, G., Inga, A., & Monti, P. (2014) · Human Mutation · doi:10.1002/humu.22514 · Cited by 44

Diverse p53/DNA binding modes expand the repertoire of p53 response elements

Vyas, P., Beno, I., Xi, Z., Stein, Y., Golovenko, D., Kessler, N., Rotter, V., Shakked, Z., & Haran, T. E. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1618005114 · Cited by 45

Transactivation specificity is conserved among p53 family proteins and depends on a response element sequence code

Ciribilli, Y., Monti, P., Bisio, A., Nguyen, H. T., Ethayathulla, A. S., Ramos, A., Foggetti, G., Menichini, P., Menéndez, D., Resnick, M. A., et al. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt657 · Cited by 42

p53 Transactivation and the Impact of Mutations, Cofactors and Small Molecules Using a Simplified Yeast-Based Screening System

Andreotti, V., Ciribilli, Y., Monti, P., Bisio, A., Lion, M., Jordan, J., Fronza, G., Menichini, P., Resnick, M. A., & Inga, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020643 · Cited by 43

Two p53 tetramers bind one consensus DNA response element

Kearns, S., Lurz, R., Orlova, E. V., & Okorokov, A. L. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw215 · Cited by 37

p53 dynamics upon response element recognition explored by molecular simulations

Terakawa, T., & Takada, S. (2015) · Scientific Reports · doi:10.1038/srep17107 · Cited by 34

Recognition of Local DNA Structures by p53 Protein

Brázda, V., & Coufal, J. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18020375 · Cited by 41

Low-level p53 expression changes transactivation rules and reveals superactivating sequences

Jordan, J. J., Menéndez, D., Sharav, J., Beno, I., Rosenthal, K., Resnick, M. A., & Haran, T. E. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1205971109 · Cited by 33

P53 Family Members Modulate the Expression of PRODH, but Not PRODH2, via Intronic p53 Response Elements

Raimondi, I., Ciribilli, Y., Monti, P., Bisio, A., Pollegioni, L., Fronza, G., Inga, A., & Campomenosi, P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069152 · Cited by 32

Transglutaminase 2 contributes to a TP53-induced autophagy program to prevent oncogenic transformation

Yeo, S. Y., Itahana, Y., Guo, A. K., Han, R., Iwamoto, K., Nguyen, T., Bao, Y., Kleiber, K., Wu, Y., Bay, B., et al. (2016) · eLife · doi:10.7554/elife.07101 · Cited by 32

TP53-inducible putative long noncoding RNAs encode functional polypeptides that suppress cell proliferationPreprint

Xu, W., Liu, C., Deng, B., Lin, P., Sun, Z., Liu, A., Xuan, J., Li, Y., Zhou, K., Zhang, X., et al. (2022) · Genome Research · doi:10.1101/gr.275831.121 · Cited by 30

Human single-nucleotide polymorphisms alter p53 sequence-specific binding at gene regulatory elements

Bandele, O. J., Wang, X., Campbell, M. R., Pittman, G. S., & Bell, D. A. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq764 · Cited by 30

Preferential binding of p53 tumor suppressor to p21 promoter sites that contain inverted repeats capable of forming cruciform structure

Coufal, J., Jagelská, E. B., Liao, J. C. C., & Brázda, V. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.10.015 · Cited by 27

Modulation of immune responses by the tumor suppressor p53

Lowe, J. M., Shatz, M., Resnick, M. A., & Menéndez, D. (2013) · Biodiscovery · doi:10.7750/biodiscovery.2013.8.2 · Cited by 30

New Therapeutic Strategies for Cancer and Neurodegeneration Emerging from Yeast Cell-based Systems

Pereira, C., Leao, M., Soares, J., Bessa, C., & Saraiva, L. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212802430422 · Cited by 28

The Coordinated P53 and Estrogen Receptor Cis-Regulation at an FLT1 Promoter SNP Is Specific to Genotoxic Stress and Estrogenic Compound

Ciribilli, Y., Andreotti, V., Menéndez, D., Langen, J.-S., Schönfelder, G., Resnick, M. A., & Inga, A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010236 · Cited by 26

Functional four-base A/T gap core sequence CATTAG of P53 response elements specifically bound tetrameric P53 differently than two-base A/T gap core sequence CATG bound both dimeric and tetrameric P53

Cai, B., Chen, J.-Y., Lu, M.-H., Chang, L.-T., Lin, H.-C., Chang, Y.-M., & Chao, C.-F. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp033 · Cited by 26

ΔN-P63α and TA-P63α exhibit intrinsic differences in transactivation specificities that depend on distinct features of DNA target sites

Monti, P., Ciribilli, Y., Bisio, A., Foggetti, G., Raimondi, I., Campomenosi, P., Menichini, P., Fronza, G., & Inga, A. (2014) · Oncotarget · doi:10.18632/oncotarget.1845 · Cited by 26

The complex architecture of p53 binding sites

Senitzki, A., Safieh, J., Sharma, V., Golovenko, D., Danin‐Poleg, Y., Inga, A., & Haran, T. E. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa1283 · Cited by 25

A p53-dependent promoter associated with polymorphic tandem repeats controls the expression of a viral transcript encoding clustered microRNAs

Stik, G., Laurent, S., Coupeau, D., Coutaud, B., Dambrine, G., Rasschaert, D., & Muylkens, B. (2010) · RNA · doi:10.1261/rna.2121210 · Cited by 32

Interferon regulatory factor 4 binding protein is a novel p53 target gene and suppresses cisplatin-induced apoptosis of breast cancer cells

Yang, M., Yuan, F., Li, P., Chen, Z., Chen, A., Li, S., & Hu, C. (2012) · Molecular Cancer · doi:10.1186/1476-4598-11-54 · Cited by 23

Cooperativity Dominates the Genomic Organization of p53-Response Elements: A Mechanistic View

Pan, Y., & Nussinov, R. (2009) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000448 · Cited by 22

Roles of p53 Family Structure and Function in Non-Canonical Response Element Binding and Activation

Cai, B., Chao, C., Huang, H., Lee, H.-Y., Kannagi, R., & Chen, J.-Y. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20153681 · Cited by 21

Lysine120 Interactions with p53 Response Elements can Allosterically Direct p53 Organization

Pan, Y., & Nussinov, R. (2010) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000878 · Cited by 21

The structure formed by inverted repeats in p53 response elements determines the transactivation activity of p53 protein

Brázda, V., Čechová, J., Battistin, M., Coufal, J., Jagelská, E. B., Raimondi, I., & Inga, A. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.12.113 · Cited by 20

Single-Molecule Studies of Unlabeled Full-Length p53 Protein Binding to DNA

Nuttall, P., Lee, K., Ciccarella, P., Carminati, M., Ferrari, G., Kim, K. B., & Albrecht, T. (2016) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.5b11076 · Cited by 19

Making Connections: p53 and the Cathepsin Proteases as Co-Regulators of Cancer and Apoptosis

Soond, S. M., Savvateeva, L. V., Makarov, V. A., Gorokhovets, N. V., Townsend, P. A., & Zamyatnin, A. A. (2020) · Cancers · doi:10.3390/cancers12113476 · Cited by 18

P53 protein and the diseases in central nervous system

Lei, L., Lu, Q., Gui-fang, M., Li, T., Deng, J., & Li, W. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2022.1051395 · Cited by 18

A Regulatory Loop Composed of RAP80-HDM2-p53 Provides RAP80-enhanced p53 Degradation by HDM2 in Response to DNA Damage

Yan, J., Menéndez, D., Yang, X.-P., Resnick, M. A., & Jetten, A. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.013102 · Cited by 16

Formation of stress-specific p53 binding patterns is influenced by chromatin but not by modulation of p53 binding affinity to response elements †

Millau, J., Bandele, O. J., Perron, J., Bastien, N., Bouchard, É. F., Gaudreau, L. R., Bell, D. A., & Drouin, R. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq1209 · Cited by 14

Expression of Micro-RNA-492 (MiR-492) in Human Cervical Cancer Cell Lines is Upregulated by Transfection with Wild-Type P53, Irradiation, and 5-Fluorouracil Treatment In Vitro

Liu, M., Wang, Z., Liu, Q., Zhu, H., & Xu, N. (2018) · Medical Science Monitor · doi:10.12659/msm.911585 · Cited by 14

Evolution of p53 Transactivation Specificity through the Lens of a Yeast-Based Functional Assay

Lion, M., Raimondi, I., Donati, S., Jousson, O., Ciribilli, Y., & Inga, A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0116177 · Cited by 17

Molecular Basis for Modulation of the p53 Target Selectivity by KLF4

Brandt, T., Townsley, F. M., Teufel, D. P., Freund, S. M. V., & Veprintsev, D. B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048252 · Cited by 14

Functional analyses of human DNA repair proteins important for aging and genomic stability using yeast genetics

Aggarwal, M., & Brosh, R. M. (2012) · DNA repair · doi:10.1016/j.dnarep.2012.01.013 · Cited by 13

TLR2∆22 (-196-174) significantly increases the risk of breast cancer in females carrying proline allele at codon 72 of TP53 gene: a case–control study from four ethnic groups of North Eastern region of India

Devi, K. R., Chenkual, S., Majumdar, G., Ahmed, J., Kaur, T., Zonunmawia, J. C., Mukherjee, K., Phukan, R. K., Mahanta, J., Rajguru, S. K., et al. (2015) · Tumor Biology · doi:10.1007/s13277-015-3795-2 · Cited by 11

Identification of human guanylate-binding protein 1 gene (hGBP1) as a direct transcriptional target gene of p53

Zhu, Z., Wei, J., Shi, Z., Yang, Y., Shao, D., Li, B., Wang, X., & Ma, Z. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.05.074 · Cited by 11

The Influence of Quadruplex Structure in Proximity to P53 Target Sequences on the Transactivation Potential of P53 Alpha Isoforms

Porubiaková, O., Bohálová, N., Inga, A., Vadovičová, N., Coufal, J., Fojta, M., & Brázda, V. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms21010127 · Cited by 11

Selective functional inhibition of a tumor-derived p53 mutant by cytosolic chaperones identified using split-YFP in budding yeast

Denney, A. S., Weems, A. D., & McMurray, M. A. (2021) · G3 Genes Genomes Genetics · doi:10.1093/g3journal/jkab230 · Cited by 11

p53 regulates katanin-p60 promoter in HCT 116 cells

Kırımtay, K., Selçuk, E., Kelle, D., Erman, B., & Karabay, A. (2019) · Gene · doi:10.1016/j.gene.2019.144241 · Cited by 10

Optimisation of TP53 reporters by systematic dissection of synthetic TP53 response elements

Trauernicht, M., Rastogi, C., Manzo, S. G., Bussemaker, H., & van Steensel, B. (2023) · bioRxiv · doi:10.1093/nar/gkad718 · Cited by 8

Progesterone up-regulates p27 through an increased binding of the progesterone receptor-A-p53 protein complex onto the non-canonical p53 binding motif in HUVEC

Hsu, S., Lin, P., Chou, C., & Lee, W. (2018) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2018.08.011 · Cited by 9

Puf-A promotes cancer progression by interacting with nucleophosmin in nucleolus

Cho, H.-C., Huang, Y., Hung, J., Hung, T., Cheng, K., Liu, Y., Kuo, M.-W., Wang, S.-H., Yu, A. L.-T., & Yu, J. (2022) · Oncogene · doi:10.1038/s41388-021-02138-0 · Cited by 9

p53: Balancing tumour suppression and implications for the clinic

Buganim, Y., & Rotter, V. (2009) · European Journal of Cancer · doi:10.1016/s0959-8049(09)70037-1 · Cited by 9

Sequence Properties of an Intramolecular Interaction that Inhibits p53 DNA Binding

Gregory, E., & Daughdrill, G. W. (2022) · Biomolecules · doi:10.3390/biom12111558 · Cited by 8

Regression based predictor for p53 transactivation

Gowrisankar, S., & Jegga, A. G. (2009) · BMC Bioinformatics · doi:10.1186/1471-2105-10-215 · Cited by 7

MOCCS: Clarifying DNA-binding motif ambiguity using ChIP-Seq data

Ozaki, H., & Iwasaki, W. (2016) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2016.01.014 · Cited by 6

A Protein in the Yeast Saccharomyces cerevisiae Presents DNA Binding Homology to the p53 Checkpoint Protein and Tumor Suppressor

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Transactivation by low and high levels of human p53 reveals new physical rules of engagement and novel super-transactivation sequences

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A/T gap tolerance in the core sequence and flanking sequence requirements of non-canonical p53 response elements

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Quantitative Analysis of NF-κB Transactivation Specificity Using a Yeast-Based Functional Assay

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p53-dependent cell cycle checkpoint after DNA damage and its relevance to PARP1

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Involvement of p53 in the S-phase Checkpoint during Nucleotide Deficiencies

Heyer, C. L. (2011) · VCU Scholars Compass (Virginia Commonwealth University) · doi:10.25772/4zf5-2439

Modulation of p53's transcriptional function by small molecules

Nikulenkov, F. (2011) · Figshare

Predicting Functional Impact of Coding and Non-Coding Single Nucleotide Polymorphisms

Gowrisankar, S. (2008) · OhioLink ETD Center (Ohio Library and Information Network)

OPINION Interactions between the tumor suppressor p53 and immune responses

Menéndez, D., Shatz, M., & Resnick, M. A. (2013)

Data from Altered-Function p53 Missense Mutations Identified in Breast Cancers Can Have Subtle Effects on Transactivation

Jordan, J. J., Inga, A., Conway, K., Edmiston, S. N., Carey, L., Wu, L., & Resnick, M. A. (2023) · doi:10.1158/1541-7786.c.6542128

Data from Altered-Function p53 Missense Mutations Identified in Breast Cancers Can Have Subtle Effects on Transactivation

Jordan, J. J., Inga, A., Conway, K., Edmiston, S. N., Carey, L., Wu, L., & Resnick, M. A. (2023) · doi:10.1158/1541-7786.c.6542128.v1

Optimisation of TP53 reporters by systematic dissection of synthetic TP53 response elementsPreprint

Trauernicht, M., Rastogi, C., Manzo, S. G., Bussemaker, H. J., & van Steensel, B. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.24.549988

Molecular characterization of FOX factors and Wnt signalling interplay in human cancers

Pizzolato, G. (2023) · Linköping University medical dissertations · doi:10.3384/9789180753364

Novel therapeutic interventions to overcome drug resistance in cancer: targeting key regulators of the apoptotic pathway

Kanwar, N., Kumar, A. H. S., Gupta, N., Gagneja, G., & Kanwal, A. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-33343-9.00008-9

Diversity Within the Master Regulatory p53 Transcriptional Network: Impact of Sequence, Binding Motifs and Mutations

Jordan, J. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/bz4n-sq62 · Cited by 2

Potentiating the p53 network.

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Transactivation specificity is conserved among p53 family proteins and depends on a response element sequence code

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The p53 Master Regulator and Rules of Engagement with Target Sequences

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60 Binding and transactivation by the tumor suppression protein p53 are encoded in the differential structural properties of its response elements

Haran, T. E., Senitzki, A., Sharav, J., Beno, I., Rosenthal, K., Jordan, J. J., Menéndez, D., & Resnick, M. A. (2013) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2013.786494