Cited by 103Cancer-related Molecular PathwaysGenomics and Chromatin DynamicsProtein Structure and Dynamics

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Noncanonical DNA Motifs as Transactivation Targets by Wild Type and Mutant p53

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Jordan, Jennifer J., Menendez, Daniel, Inga, Alberto, Nourredine, Maher, Bell, Douglas, Resnick, Michael A.·2008·PLoS Genetics

DOI 10.1371/journal.pgen.1000104PMC PMC2518093

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Abstract

Sequence-specific binding by the human p53 master regulator is critical to its tumor suppressor activity in response to environmental stresses. p53 binds as a tetramer to two decameric half-sites separated by 0-13 nucleotides (nt), originally defined by the consensus RRRCWWGYYY (n = 0-13) RRRCWWGYYY. To better understand the role of sequence, organization, and level of p53 on transactivation at target response elements (REs) by wild type (WT) and mutant p53, we deconstructed the functional p53 canonical consensus sequence using budding yeast and human cell systems. Contrary to early reports on binding in vitro, small increases in distance between decamer half-sites greatly reduces p53 transactivation, as demonstrated for the natural TIGER RE. This was confirmed with human cell extracts using a newly developed, semi-in vitro microsphere binding assay. These results contrast with the synergistic increase in transactivation from a pair of weak, full-site REs in the MDM2 promoter that are separated by an evolutionary conserved 17 bp spacer. Surprisingly, there can be substantial transactivation at noncanonical (1/2)-(a single decamer) and (3/4)-sites, some of which were originally classified as biologically relevant canonical consensus sequences including PIDD and Apaf-1. p53 family members p63 and p73 yielded similar results. Efficient transactivation from noncanonical elements requires tetrameric p53, and the presence of the carboxy terminal, non-specific DNA binding domain enhanced transactivation from noncanonical sequences. Our findings demonstrate that RE sequence, organization, and level of p53 can strongly impact p53-mediated transactivation, thereby changing the view of what constitutes a functional p53 target. Importantly, inclusion of (1/2)- and (3/4)-site REs greatly expands the p53 master regulatory network.

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Authors: Jordan, J. J., Menendez, D., Inga, A., Nourredine, M., Bell, D., & Resnick, M. A.
Affiliations: University of North Carolina at Chapel Hill (US)
National Institutes of Health (US)
Corresponding author: Resnick, Michael A.
ORCID: Inga, Alberto
Bell, Douglas
Resnick, Michael A.
Venue: PLoS Genetics
Publisher: Public Library of Science (PLoS)
Published: 2008-06-27
Volume: 4
Issue: 6
Pages: e1000104
ISSN: 1553-7390 (ISSN-L)
1553-7404
DOI: 10.1371/journal.pgen.1000104
PMC: PMC2518093
OpenAlex: W2049945082
Cited by: 103
References: 113
Citations by year: 2026: 1 · 2025: 1 · 2024: 1 · 2023: 6 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 7 · 2015: 6 · 2014: 4 · 2013: 10 · 2012: 13
FWCI: 6.16
Type: journal article
Language: en
Update notices: correction (2008-10-20)
correction (2008-07-01)
correction (2008-10-20)
Open access: gold
doi.org
Licence: public-domain
creativecommons.org/publicdomain/zero/1.0/ (unspecified)
Locations: PLoS Genetics (publishedVersion, public-domain)
PubMed Central (publishedVersion, public-domain)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Figshare (submittedVersion, cc-by)
Funders: U.S. Department of Defense
Associazione Italiana per la Ricerca sul Cancro
National Institute of Environmental Health Sciences
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
Keywords: p53, transcriptional activation, response elements, p63, p73, p53 tetramer, tumor suppressor regulation
MeSH terms: Base Sequence, Binding Sites, Biological Assay, Diploidy, DNA, Humans, Molecular Sequence Data, Promoter Regions, Genetic, Saccharomyces cerevisiae, Transfection, Transcriptional Activation, Tumor Suppressor Protein p53, Consensus Sequence, Point Mutation, Protein Structure, Tertiary, Genes, Reporter, Dimerization, Response Elements, DNA, Intergenic, Cell Line, Tumor, Luciferases, Renilla, Proto-Oncogene Proteins c-mdm2

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Noncanonical DNA Motifs as Transactivation Targets by Wild Type and Mutant p53

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