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Pervasive Sharing of Genetic Effects in Autoimmune Disease
Open accessAbstract
Genome-wide association (GWA) studies have identified numerous, replicable, genetic associations between common single nucleotide polymorphisms (SNPs) and risk of common autoimmune and inflammatory (immune-mediated) diseases, some of which are shared between two diseases. Along with epidemiological and clinical evidence, this suggests that some genetic risk factors may be shared across diseases-as is the case with alleles in the Major Histocompatibility Locus. In this work we evaluate the extent of this sharing for 107 immune disease-risk SNPs in seven diseases: celiac disease, Crohn's disease, multiple sclerosis, psoriasis, rheumatoid arthritis, systemic lupus erythematosus, and type 1 diabetes. We have developed a novel statistic for Cross Phenotype Meta-Analysis (CPMA) which detects association of a SNP to multiple, but not necessarily all, phenotypes. With it, we find evidence that 47/107 (44%) immune-mediated disease risk SNPs are associated to multiple-but not all-immune-mediated diseases (SNP-wise P(CPMA)<0.01). We also show that distinct groups of interacting proteins are encoded near SNPs which predispose to the same subsets of diseases; we propose these as the mechanistic basis of shared disease risk. We are thus able to leverage genetic data across diseases to construct biological hypotheses about the underlying mechanism of pathogenesis.
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“many loci were associated with multiple diseases and that the genes encoded in those loci fall into distinct immune pathways.69, 70”
From Genome‐wide association studies of multiple sclerosis (2018) · cites this paper as [70]
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“These results suggest that perturbations to key immune processes mediate risk to multiple diseases.”
From Genome‐wide association studies of multiple sclerosis (2018) · cites this paper as [70]
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“Some of these relationships are expected, such as the impact of obesity variants on risk of hepatic steatosis and type 2 diabetes84 or variants that influence multiple autoimmune conditions85.”
From A brief history of human disease genetics (2020) · cites this paper as [85]
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Cites
R: A Language and Environment for Statistical Computing
R Core Team (2000) · doi:10.32614/r.manuals · Cited by 355,893
Hierarchical Grouping to Optimize an Objective Function
Ward, J. H. (1963) · Journal of the American Statistical Association · doi:10.1080/01621459.1963.10500845 · Cited by 21,341
A General Coefficient of Similarity and Some of Its Properties
Gower, J. C. (1971) · Biometrics · doi:10.2307/2528823 · Cited by 5,517
Hindorff, L. A., Sethupathy, P., Junkins, H. A., Ramos, E. M., Mehta, J. P., Collins, F. S., & Manolio, T. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903103106 · Cited by 4,013
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
the NIDDK IBD Genetics Consortium, Barrett, J. C., the Belgian-French IBD Consortium, the Wellcome Trust Case Control Consortium, Hansoul, S., Nicolae, D. L., Cho, J. H., Duerr, R. H., Rioux, J. D., Brant, S. R., et al. (2008) · Nature Genetics · doi:10.1038/ng.175 · Cited by 2,593
Self-citationThe Type 1 Diabetes Genetics Consortium, Barrett, J. C., Clayton, D. G., Concannon, P., Akolkar, B., Cooper, J. D., Erlich, H. A., Julier, C., Morahan, G., Nerup, J., et al. (2009) · Nature Genetics · doi:10.1038/ng.381 · Cited by 1,746
Self-citationGenome-wide scan reveals association of psoriasis with IL-23 and NF-κB pathways
Nair, R. P., Duffin, K. C., Helms, C., Ding, J., Stuart, P. E., Goldgar, D. E., Gudjonsson, J. E., Li, Y., Tejasvi, T., Feng, B., et al. (2009) · Nature Genetics · doi:10.1038/ng.311 · Cited by 1,433
Self-citationSNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap
Johnson, A. D., Handsaker, R. E., Pulit, S. L., Nizzari, M. M., O’Donnell, C. J., & de Bakker, P. I. W. (2008) · Bioinformatics · doi:10.1093/bioinformatics/btn564 · Cited by 1,339
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci
BIRAC Consortium, Stahl, E. A., YEAR Consortium, Raychaudhuri, S., Remmers, E. F., Xie, G., Eyre, S., Thomson, B. P., Li, Y., Kurreeman, F. A. S., et al. (2010) · Nature Genetics · doi:10.1038/ng.582 · Cited by 1,253
Self-citationSTAT4 and the Risk of Rheumatoid Arthritis and Systemic Lupus Erythematosus
Remmers, E. F., Plenge, R. M., Lee, A. T., Graham, R., Hom, G., Behrens, T. W., de Bakker, P. I. W., Le, J. M., Lee, H., Batliwalla, F., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa073003 · Cited by 1,055
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Iakovliev, A., McGurnaghan, S. J., Hayward, C., Colombo, M., Lipschutz, D., Spiliopoulou, A., Colhoun, H. M., & McKeigue, P. (2023) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2023.04.003 · Cited by 18
Fine points in mapping autoimmunity
Polychronakos, C. (2011) · Nature Genetics · doi:10.1038/ng.1015 · Cited by 17
Kawai, V. K., Shi, M., Feng, Q., Chung, C. P., Liu, G., Cox, N. J., Jarvik, G. P., Lee, M. T. M., Hebbring, S. J., Harley, J. B., et al. (2020) · Arthritis & Rheumatology · doi:10.1002/art.41291 · Cited by 17
Maintenance of Complex Trait Variation: Classic Theory and Modern Data
Koch, E. M., & Sunyaev, S. R. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.763363 · Cited by 18
López-Rivera, J. J., Rodríguez-Salazar, L., Soto-Ospina, A., Estrada-Serrato, C., Serrano, D., Chaparro-Solano, H. M., Londoño, O., Rueda, P. A., Ardila, G., Villegas-Lanau, A., et al. (2022) · Brain Sciences · doi:10.3390/brainsci12070871 · Cited by 17
Zemedikun, D. T., Gokhale, K. M., Chandan, J. S., Cooper, J. M., Lord, J. M., Filer, A. D., Falahee, M., Nirantharakumar, K., & Raza, K. (2021) · Rheumatology · doi:10.1093/rheumatology/keab148 · Cited by 16
Axisa, P., Yoshida, T. M., Lucca, L. E., Kasler, H. G., Lincoln, M. R., Pham, G. H., Priore, D. D., Carpier, J.-M., Lucas, C. L., Verdin, E. M., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abl3651 · Cited by 18
Self-citationFinding Genetic Overlaps Among Diseases Based on Ranked Gene Lists
Chen, Q., Zhou, X. J., & Sun, F. (2015) · Journal of Computational Biology · doi:10.1089/cmb.2014.0149 · Cited by 16
Seventeen in Crohn's disease: less prime than we thought?
Raine, T., & Kaser, A. (2012) · Gut · doi:10.1136/gutjnl-2012-302525 · Cited by 16
General Features of Autoimmune Disease
Davidson, A., & Diamond, B. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-384929-8.00003-4 · Cited by 16
Bearoff, F. M., del Río, R., Case, L. K., Dragon, J. A., Nguyen-Vu, T., Lin, C.-Y., Blankenhorn, E. P., Teuscher, C., & Krementsov, D. N. (2016) · Genes and Immunity · doi:10.1038/gene.2016.37 · Cited by 16
General Features of Autoimmune Disease
Davidson, A., & Diamond, B. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-812102-3.00003-8 · Cited by 16
Wu, G. F., Harp, C. R. P., & Shindler, K. S. (2015) · Current Immunology Reviews · doi:10.2174/1573395511666150707181644 · Cited by 17
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Deng, Y., & Pan, W. (2020) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1007778 · Cited by 15
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Brown, R. L., & Ciciurkaite, G. (2017) · Cambridge University Press eBooks · doi:10.1017/9781316471289.014 · Cited by 15
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Schizophrenia at a Genetics Crossroads: Where to Now?
Corvin, A. P. (2013) · Schizophrenia Bulletin · doi:10.1093/schbul/sbt041 · Cited by 14
Bogers, L., Kuiper, K. L., Smolders, J., Rip, J., & van Luijn, M. M. (2023) · Immunology Letters · doi:10.1016/j.imlet.2023.07.006 · Cited by 14
Comorbid autoimmune disorders in people with multiple sclerosis: A retrospective cohort study
Rato, M. L., Santos, M. L. P. D. L., de Sá, J., & Ferreira, J. (2023) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2023.578226 · Cited by 16
Søgaard, K. L., Ellervik, C., Svensson, J., & Thorsen, S. U. (2017) · The Review of Diabetic Studies · doi:10.1900/rds.2017.14.269 · Cited by 15
Lahue, K. G., Lara, M. K., Linton, A. A., Lavoie, B. A., Fang, Q., McGill, M. M., Crothers, J. W., Teuscher, C., Mawe, G. M., Tyler, A. L., et al. (2020) · Genes and Immunity · doi:10.1038/s41435-020-00110-8 · Cited by 14
Chiaroni-Clarke, R. C., Munro, J. E., Chavez, R. A., Pezic, A., Allen, R. C., Akikusa, J., Piper, S. E., Saffery, R., Ponsonby, A., & Ellis, J. A. (2014) · Pediatric Rheumatology · doi:10.1186/1546-0096-12-53 · Cited by 14
Harsini, S., & Rezaei, N. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-818006-8.00001-3 · Cited by 13
Coordinating GWAS results with gene expression in a systems immunologic paradigm in autoimmunity
Stranger, B. E., & Jager, P. L. D. (2012) · Current Opinion in Immunology · doi:10.1016/j.coi.2012.09.002 · Cited by 13
Evaluation of a DLA-79 allele associated with multiple immune-mediated diseases in dogs
Friedenberg, S. G., Buhrman, G., Chdid, L., Olby, N. J., Olivry, T., Guillaumin, J., O’Toole, T., Goggs, R. A. N., Kennedy, L. J., Rose, R. B., et al. (2015) · Immunogenetics · doi:10.1007/s00251-015-0894-6 · Cited by 13
Testing Genetic Pleiotropy with GWAS Summary Statistics for Marginal and Conditional Analyses
Deng, Y., & Pan, W. (2017) · Genetics · doi:10.1534/genetics.117.300347 · Cited by 13
Zhang, X., Veturi, Y., Verma, S. S., Bone, W. P., Verma, A., Lucas, A., Hebbring, S. J., Denny, J. C., Stanaway, I. B., Jarvik, G. P., et al. (2018) · Pacific Symposium on Biocomputing (PSB) · doi:10.1142/9789813279827_0025 · Cited by 13
Rich, S. S., & CONCANNON, P. J. (2015) · Diabetes Care · doi:10.2337/dcs15-2001 · Cited by 13
Self-citationAtaş, P. K. (2025) · Health Information Science and Systems · doi:10.1007/s13755-025-00350-w · Cited by 12
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Gururajan, M., Sindhava, V. J., & Bondada, S. (2014) · Antibodies · doi:10.3390/antib3010116 · Cited by 12
Tsoi, L. C., Elder, J. T., & Abecasis, G. R. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu799 · Cited by 12
Self-citationAyala‐Ramirez, M., MacNell, N., McNamee, L. E., McGrath, J. A., Akhtari, F. S., Curry, M. D., Dunnon, A. K., Fessler, M. B., Garantziotis, S., Parks, C. G., et al. (2022) · Environment International · doi:10.1016/j.envint.2022.107687 · Cited by 12
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Hosack, T., Thomas, T. R., Ravindran, R. P., Uhlig, H. H., Travis, S. P. L., & Buckley, C. D. (2023) · Nature Reviews Rheumatology · doi:10.1038/s41584-023-01007-2 · Cited by 12
Topaloudi, A., Jain, P., Martinez, M. B., Bryant, J. K., Reynolds, G., Zagoriti, Z., Lagoumintzis, G., Zamba‐Papanicolaou, E., Tzartos, J. S., Poulas, K. A., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1147573 · Cited by 12
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Díaz-Gallo, L.-M., & Martin, J. J. (2012) · Expert Review of Clinical Immunology · doi:10.1586/eci.11.90 · Cited by 12
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Santori, F. R. (2015) · Immunology Letters · doi:10.1016/j.imlet.2015.06.002 · Cited by 15
Lin, J., Tabassum, R., Ripatti, S., & Pirinen, M. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.00431 · Cited by 12
Jia, X., Shi, X., Xia, Z., Feng, Y., Li, Y., Tan, J., Xu, F., Wang, W., Sun, C., Deng, H., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00030 · Cited by 12
McGeachie, M. J., Clemmer, G. L., Lasky-Su, J. A., Dahlin, A., Raby, B. A., & Weiss, S. T. (2014) · Genomics Data · doi:10.1016/j.gdata.2014.04.004 · Cited by 11
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Yin, X., Cheng, H., Lin, Y., Fan, X., Cui, Y., Zhou, F., Shen, C., Zuo, X., Zheng, X., Zhang, W., et al. (2014) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2014.07.007 · Cited by 11
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Venkataraman, G. R., DeBoever, C., Tanigawa, Y., Aguirre, M., Ioannidis, A. G., Mostafavi, H., Spencer, C. C. A., Poterba, T., Bustamante, C. D., Daly, M. J., et al. (2021) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2021.11.005 · Cited by 11
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Tabarés‐Seisdedos, R., & Valderas, J. M. (2013) · Journal of Comorbidity · doi:10.15256/joc.2013.3.19 · Cited by 11
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Cifuentes, R., Restrepo-Montoya, D., & Anaya, J. (2012) · Autoimmune Diseases · doi:10.1155/2012/792106 · Cited by 10
Gene signature-based mapping of immunological systems and diseases
Liu, H., Liu, J., Toups, M., Soos, T. J., & Arendt, C. (2016) · BMC Bioinformatics · doi:10.1186/s12859-016-1012-y · Cited by 10
Meta‐MultiSKAT: Multiple phenotype meta‐analysis for region‐based association test
Dutta, D., Taliun, S. A. G., Weinstock, J. S., Zawistowski, M., Sidore, C., Fritsche, L. G., Cucca, F., Schlessinger, D., Abecasis, G. R., Brummett, C. M., et al. (2019) · Genetic Epidemiology · doi:10.1002/gepi.22248 · Cited by 10
Self-citationTopic modeling identifies novel genetic loci associated with multimorbidities in UK Biobank
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Reuschlé, Q., van Heddegem, L., Bosteels, V., Moncan, M., Depauw, S., Wadier, N., Maréchal, S., Nolf, C. D., Delgado, V., Messai, Y., et al. (2023) · Journal of Autoimmunity · doi:10.1016/j.jaut.2023.103152 · Cited by 10
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Shiina, T., Suzuki, S., & Kulski, J. K. (2016) · InTech eBooks · doi:10.5772/61842 · Cited by 10
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Jalkanen, A., Saraste, M., Gfeller, A., Surcel, H.-M., & Airas, L. M. (2013) · Multiple Sclerosis Journal · doi:10.1177/1352458513485148 · Cited by 10
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Viscardi, L. H., Paixão‐Côrtes, V. R., Comas, D., Salzano, F. M., Rovaris, D. L., Bau, C. H. D., Amorim, C. E. G., & Bortolini, M. C. (2018) · Genetics and Molecular Biology · doi:10.1590/1678-4685-gmb-2017-0308 · Cited by 10
Parnell, G. P., Schibeci, S. D., Fewings, N., Afrasiabi, A., Law, S. P. L., Samaranayake, S., Kh’ng, J. H., Fong, Y. H., Brown, D. A., Liddle, C., et al. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy324 · Cited by 10
Mavroudi, I., & Papadaki, H. Α. (2012) · Clinical and Developmental Immunology · doi:10.1155/2012/123789 · Cited by 10
Anaya, J., Shoenfeld, Y., & Cervera, R. (2011) · Autoimmunity Reviews · doi:10.1016/j.autrev.2011.10.001 · Cited by 9
Sams, A. J., & Hawks, J. D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070564 · Cited by 9
Link, B. G., & Phelan, J. C. (2017) · Cambridge University Press eBooks · doi:10.1017/9781316471289.024 · Cited by 11
van Amerongen, B. M., & Feron, F. P. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms131013461 · Cited by 9
Isobe, N., & Oksenberg, J. R. (2014) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.12078 · Cited by 9
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Sams, A. J., & Hawks, J. D. (2014) · Human Biology · doi:10.3378/027.086.0102 · Cited by 9
Hansen, P. R., Isaksen, J. L., Jemec, G. B. E., Ellervik, C., & Kanters, J. K. (2019) · British Journal of Dermatology · doi:10.1111/bjd.17622 · Cited by 9
Rosenfield, S., Kato, K., & Smith, D. T. (2017) · Cambridge University Press eBooks · doi:10.1017/9781316471289.017 · Cited by 9
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Self-citationCampa, D., Barrdahl, M., Tsilidis, K. K., Severi, G., Diver, W. R., Siddiq, A., Chanock, S. J., Hoover, R. N., Ziegler, R. G., Berg, C. D., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085955 · Cited by 8
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Zhou, H., Qi, Y., Xu, Y., Qi, X., & Qi, H. (2024) · Scientific Reports · doi:10.1038/s41598-024-58182-9 · Cited by 8
Dhattarwal, N., Mahajan, V. K., Mehta, K. S., Chauhan, P. S., Yadav, R. S., Sharma, S. B., Sharma, A., Sharma, R., Rana, A., & Sondhi, M. (2020) · Australasian Journal of Dermatology · doi:10.1111/ajd.13308 · Cited by 8
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Pouladi, N., Achour, L., Li, H., Berghout, J., Kenost, C., Gonzalez‐Garay, M. L., & Lussier, Y. A. (2016) · Yearbook of Medical Informatics · doi:10.15265/iy-2016-040 · Cited by 8
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Safi, M.-A. A. (2019) · Saudi Medical Journal · doi:10.15537/smj.2019.7.24293 · Cited by 8
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Martínez-Nava, G. A., Zamudio-Cuevas, Y., Terrazas-Ontiveros, N. A., Martínez-Flores, K., Espinosa-Morales, R., Mijares-Díaz, F., Juárez-Barreto, S. M., Lozada-Pérez, C., Valdés-Flores, M., Sánchez-Sánchez, R., et al. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06801-3 · Cited by 6
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Mirowsky, J., & Ross, C. E. (2017) · Cambridge University Press eBooks · doi:10.1017/9781316471289.021 · Cited by 8
Horwitz, A. V. (2017) · Cambridge University Press eBooks · doi:10.1017/9781316471289.004 · Cited by 8
Keith, V. M., & Brown, D. R. (2017) · Cambridge University Press eBooks · doi:10.1017/9781316471289.019 · Cited by 9
Yu, Y., Xia, L., Lee, S., Zhou, X., Stringham, H. M., Boehnke, M., & Mukherjee, B. (2018) · Human Heredity · doi:10.1159/000496867 · Cited by 8
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Maiti, A. K., & Nath, S. K. (2012) · Autoimmunity Reviews · doi:10.1016/j.autrev.2012.09.001 · Cited by 7
Joo, J., Lim, K., Yang, S., Kim, S.-H., Cocco, L., & Suh, P. (2021) · Advances in Biological Regulation · doi:10.1016/j.jbior.2021.100833 · Cited by 7
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Florez, J. C. (2016) · Diabetes Care · doi:10.2337/dci15-0029 · Cited by 8
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Li, J. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i3.949 · Cited by 7
Lv, W., Zhang, X., Fan, K., Xia, X., Zhang, Q., Li, H., Jiang, B.-Y., Zhang, W., & Deng, H. (2018) · European Journal of Human Genetics · doi:10.1038/s41431-018-0180-9 · Cited by 7
Kiel, C., Strunz, T., Graßmann, F., & Weber, B. H. F. (2020) · Cells · doi:10.3390/cells9102257 · Cited by 7
YILMAZ, F., & Söyük, S. (2020) · Sosyal Guvence · doi:10.21441/sosyalguvence.823636 · Cited by 7
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Whooley, O. (2017) · Cambridge University Press eBooks · doi:10.1017/9781316471289.006 · Cited by 7
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Zheng, N., Tsepilov, Y. A., Sharapov, S., Wang, Z., Grishenko, A. K., Feng, X., Shirali, M., Joshi, P. K., Wilson, J. F., Yudi Pawitan, Y., et al. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.627989 · Cited by 7
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Wakefield, J. C., & Schmitz, M. F. (2017) · Cambridge University Press eBooks · doi:10.1017/9781316471289.005 · Cited by 7
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Self-citation
Metadata
- Authors
- Cotsapas, C., Voight, B. F., Rossin, E., Lage, K., Neale, B. M., Wallace, C., Abecasis, G. R., Barrett, J. C., Behrens, T., Cho, J., De Jager, P. L., Elder, J. T., Graham, R. R., Gregersen, P., Klareskog, L., Siminovitch, K. A., van Heel, D. A., Wijmenga, C., Worthington, J., Todd, J. A., Hafler, D. A., Rich, S. S., Daly, M. J., & on behalf of the FOCiS Network of Consortia
- Affiliations
- Massachusetts General Hospital (US)
- Broad Institute (US)
- University of Cambridge (GB)
- University of Michigan (US)
- Wellcome Sanger Institute (GB)
- Genentech (US)
- Yale University (US)
- Northwell Health (US)
- Karolinska Institutet (SE)
- Mount Sinai Hospital (CA)
- University Medical Center Groningen (NL)
- Manchester Academic Health Science Centre (GB)
- University of Virginia (US)
- Corresponding author
- Daly, Mark J.
- ORCID
- Cotsapas, Chris
- Voight, Benjamin F.
- Rossin, Elizabeth
- Lage, Kasper
- Neale, Benjamin M.
- Wallace, Chris
- Abecasis, Gonçalo R.
- Barrett, Jeffrey C.
- Behrens, Timothy
- Cho, Judy
- Elder, James T.
- Graham, Robert R.
- Gregersen, Peter
- Klareskog, Lars
- Wijmenga, Cisca
- Worthington, Jane
- Todd, John A.
- Hafler, David A.
- Rich, Stephen S.
- Daly, Mark J.
- Venue
- PLoS Genetics
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-08-10
- Volume
- 7
- Issue
- 8
- Pages
- e1002254
- ISSN
- 1553-7390 (ISSN-L)
- 1553-7404
- PMC
- PMC3154137
- OpenAlex
- W1859891932
- Cited by
- 606
- References
- 30
- Citations by year
- 2026: 18 · 2025: 18 · 2024: 21 · 2023: 26 · 2022: 26 · 2021: 27 · 2020: 40 · 2019: 37 · 2018: 40 · 2017: 77 · 2016: 40 · 2015: 54 · 2014: 57 · 2013: 63 · 2012: 52
- FWCI
- 6.01
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS Genetics (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
- Figshare (submittedVersion, cc-by)
- Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU) (submittedVersion, other-oa)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, cc-by)
- Queen Mary Research Online (Queen Mary University of London) (submittedVersion, cc-by)
- PLoS eBooks
- Funders
- Wellcome Trust (091157, 089989)
- National Institute for Health and Care Research (NF-SI-0508-10275)
- Versus Arthritis (/17552)
- National Institute of General Medical Sciences (T32GM007753)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK043351)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR050511, R01AR042742, R01AR054966)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Keywords
- autoimmune disease, shared genetic risk, immune-mediated diseases, single nucleotide polymorphisms, celiac disease, Crohn's disease, multiple sclerosis, psoriasis, rheumatoid arthritis, systemic lupus erythematosus, type 1 diabetes, protein-protein interaction network, pathogenesis, MHC locus
- MeSH terms
- Autoimmune Diseases, Humans, Phenotype, Comorbidity, Cluster Analysis, Polymorphism, Single Nucleotide, Genome-Wide Association Study, Genetic Loci, Protein Interaction Maps
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