The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
A Drosophila Model of High Sugar Diet-Induced Cardiomyopathy
Open accessAbstract
Diets high in carbohydrates have long been linked to progressive heart dysfunction, yet the mechanisms by which chronic high sugar leads to heart failure remain poorly understood. Here we combine diet, genetics, and physiology to establish an adult Drosophila melanogaster model of chronic high sugar-induced heart disease. We demonstrate deterioration of heart function accompanied by fibrosis-like collagen accumulation, insulin signaling defects, and fat accumulation. The result was a shorter life span that was more severe in the presence of reduced insulin and P38 signaling. We provide evidence of a role for hexosamine flux, a metabolic pathway accessed by glucose. Increased hexosamine flux led to heart function defects and structural damage; conversely, cardiac-specific reduction of pathway activity prevented sugar-induced heart dysfunction. Our data establish Drosophila as a useful system for exploring specific aspects of diet-induced heart dysfunction and emphasize enzymes within the hexosamine biosynthetic pathway as candidate therapeutic targets.
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Cites
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Cited by
Methods for studying metabolism in Drosophila
Tennessen, J. M., Barry, W. E., Cox, J., & Thummel, C. S. (2014) · Methods · doi:10.1016/j.ymeth.2014.02.034 · Cited by 445
Gut microbiota dictates the metabolic response of Drosophila to diet
Wong, A. C.-N., Dobson, A. J., & Douglas, A. E. (2014) · Journal of Experimental Biology · doi:10.1242/jeb.101725 · Cited by 305
Arble, D. M., Bass, J., Behn, C. D., Butler, M. P., Challet, E., Czeisler, C., Depner, C. M., Elmquist, J., Franken, P., Grandner, M. A., et al. (2015) · Sleep · doi:10.5665/sleep.5226 · Cited by 173
Time‐restricted feeding for prevention and treatment of cardiometabolic disorders
Melkani, G. C., & Panda, S. (2017) · The Journal of Physiology · doi:10.1113/jp273094 · Cited by 155
Coupled sensing of hunger and thirst signals balances sugar and water consumption
Jourjine, N., Mullaney, B. C., Mann, K., & Scott, K. (2016) · Cell · doi:10.1016/j.cell.2016.06.046 · Cited by 154
Metadata
- Authors
- Na, J., Musselman, L. P., Pendse, J., Baranski, T. J., Bodmer, R., Ocorr, K., & Cagan, R.
- Venue
- PLoS Genetics
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-01-10
- Volume
- 9
- Issue
- 1
- Pages
- e1003175
- ISSN
- 1553-7390 (ISSN-L)
- 1553-7404
- OpenAlex
- W2062222375
- Cited by
- 252
- References
- 8
- FWCI
- 13.35
- Type
- journal article
- Language
- en
- Open access
- gold
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- Na, J., Musselman, L. P., Pendse, J., Baranski, T. J., Bodmer, R., Ocorr, K., & Cagan, R. (2013). A Drosophila Model of High Sugar Diet-Induced Cardiomyopathy. PLoS Genetics. https://doi.org/10.1371/journal.pgen.1003175
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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