Cited by 173Circadian rhythm and melatoninSleep and Work-Related FatigueSleep and related disorders

Impact of sleep and circadian disruption on energy balance and diabetes: a summary of workshop discussions

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Arble, Deanna M., Bass, Joseph, Behn, Cecilia Diniz, Butler, Matthew P., Challet, Etienne, Czeisler, Charles, Depner, Christopher M., Elmquist, Joel +20 more·2015·Sleep

Abstract

A workshop was held at the National Institute for Diabetes and Digestive and Kidney Diseases with a focus on the impact of sleep and circadian disruption on energy balance and diabetes. The workshop identified a number of key principles for research in this area and a number of specific opportunities. Studies in this area would be facilitated by active collaboration between investigators in sleep/circadian research and investigators in metabolism/diabetes. There is a need to translate the elegant findings from basic research into improving the metabolic health of the American public. There is also a need for investigators studying the impact of sleep/circadian disruption in humans to move beyond measurements of insulin and glucose and conduct more in-depth phenotyping. There is also a need for the assessments of sleep and circadian rhythms as well as assessments for sleep-disordered breathing to be incorporated into all ongoing cohort studies related to diabetes risk. Studies in humans need to complement the elegant short-term laboratory-based human studies of simulated short sleep and shift work etc. with studies in subjects in the general population with these disorders. It is conceivable that chronic adaptations occur, and if so, the mechanisms by which they occur needs to be identified and understood. Particular areas of opportunity that are ready for translation are studies to address whether CPAP treatment of patients with pre-diabetes and obstructive sleep apnea (OSA) prevents or delays the onset of diabetes and whether temporal restricted feeding has the same impact on obesity rates in humans as it does in mice.

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Crossref · 10.5665/sleep.5226

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Authors
Arble, D. M., Bass, J., Behn, C. D., Butler, M. P., Challet, E., Czeisler, C., Depner, C. M., Elmquist, J., Franken, P., Grandner, M. A., Hanlon, E. C., Keene, A. C., Joyner, M. J., Karatsoreos, I., Kern, P. A., Klein, S., Morris, C. J., Pack, A. I., Panda, S., Ptacek, L. J., Punjabi, N. M., Sassone-Corsi, P., Scheer, F. A., Saxena, R., Seaquest, E. R., Thimgan, M. S., Van Cauter, E., & Wright, K. P.
Affiliations
  • University of Michigan (US)
  • Northwestern University (US)
  • Colorado School of Mines (US)
  • Oregon Health & Science University (US)
  • Institute for Cellular and Integrative Neuroscience, CNRS, University of Strasbourg, France
  • Brigham and Women's Hospital (US)
  • University of Colorado Boulder (US)
  • The University of Texas Southwestern Medical Center (US)
  • University of Lausanne (CH)
  • University of Arizona (US)
  • University of Chicago (US)
  • University of Nevada, Reno (US)
  • Mayo Clinic (US)
  • Washington State University (US)
  • University of Kentucky (US)
  • Washington University in St. Louis (US)
  • University of Pennsylvania (US)
  • Salk Institute for Biological Studies (US)
  • Department of Neurology, Howard Hughes Medical Institute, University of California, San Francisco, CA
  • Johns Hopkins University (US)
  • Center for Epigenetics and Metabolism, School of Medicine, University of California, Irvine, CA
  • Harvard University (US)
  • University of Minnesota (US)
  • Missouri University of Science and Technology (US)
  • Sleep, Metabolism and Health Center, The University of Chicago, Chicago, IL
Corresponding author
Pack, Allan I.
Venue
Sleep
Published
2015-12-01
Volume
38
Issue
12
Pages
1849-1860
ISSN
  • 0161-8105 (ISSN-L)
  • 1550-9109
OpenAlex
W2396565630
Cited by
173
References
126
Citations by year
2026: 10 · 2025: 21 · 2024: 23 · 2023: 16 · 2022: 9 · 2021: 16 · 2020: 17 · 2019: 15 · 2018: 14 · 2017: 17 · 2016: 14 · 2015: 1
FWCI
8.50
Type
journal article
Language
en
Open access
Locations
  • SLEEP (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • e-Publications@Marquette (Marquette University) (submittedVersion)
  • UKnowledge (University of Kentucky) (submittedVersion)
  • HAL (submittedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
  • IRIS (submittedVersion)
  • SERVAL (Université de Lausanne) (submittedVersion)
Funders
  • Eli Lilly and Company
  • AstraZeneca
  • Boston Scientific Corporation
  • Sleep Research Society
  • ResMed
  • National Institutes of Health (UL1TR000430, KL2TR000431)
  • National Heart, Lung, and Blood Institute (K23HL110216)
  • National Cancer Institute (P30CA014195)
  • National Institute of Diabetes and Digestive and Kidney Diseases (P30DK098722)
  • National Institute of Neurological Disorders and Stroke (R01NS085152, R15NS080155)
  • National Center for Advancing Translational Sciences
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords
circadian rhythm disruption, energy balance, diabetes mellitus, sleep-disordered breathing, obstructive sleep apnea, prediabetes, continuous positive airway pressure, obesity, shift work, short sleep duration, glucose and insulin, metabolic health, chronic adaptation
MeSH terms
Animals, Circadian Rhythm, Diabetes Mellitus, Energy Metabolism, Fasting, Food Deprivation, Glucose, Homeostasis, Humans, Insulin, Obesity, Sleep, Time Factors, Age of Onset, Sleep Disorders, Circadian Rhythm, Sleep Apnea, Obstructive, Metabolic Syndrome, Mice, Endophenotypes

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