Impact of sleep and circadian disruption on energy balance and diabetes: a summary of workshop discussions
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A workshop was held at the National Institute for Diabetes and Digestive and Kidney Diseases with a focus on the impact of sleep and circadian disruption on energy balance and diabetes. The workshop identified a number of key principles for research in this area and a number of specific opportunities. Studies in this area would be facilitated by active collaboration between investigators in sleep/circadian research and investigators in metabolism/diabetes. There is a need to translate the elegant findings from basic research into improving the metabolic health of the American public. There is also a need for investigators studying the impact of sleep/circadian disruption in humans to move beyond measurements of insulin and glucose and conduct more in-depth phenotyping. There is also a need for the assessments of sleep and circadian rhythms as well as assessments for sleep-disordered breathing to be incorporated into all ongoing cohort studies related to diabetes risk. Studies in humans need to complement the elegant short-term laboratory-based human studies of simulated short sleep and shift work etc. with studies in subjects in the general population with these disorders. It is conceivable that chronic adaptations occur, and if so, the mechanisms by which they occur needs to be identified and understood. Particular areas of opportunity that are ready for translation are studies to address whether CPAP treatment of patients with pre-diabetes and obstructive sleep apnea (OSA) prevents or delays the onset of diabetes and whether temporal restricted feeding has the same impact on obesity rates in humans as it does in mice.
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Chronic sleep fragmentation promotes obesity in young adult mice
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Self-citationAge-related cardiac disease model of Drosophila
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Sympatho-adrenal activation by chronic intermittent hypoxia
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Absence of Detectable Melatonin and Preservation of Cortisol and Thyrotropin Rhythms in Tetraplegia1
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Self-citationSex differences in the circadian control of hamster wheel-running activity
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Indirect sensing of insulin‐induced hypoglycaemia by the carotid body in the rat
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Homeostatic and circadian contribution to EEG and molecular state variables of sleep regulation
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Self-citationRepeated light-dark shifts speed up body weight gain in male F344 rats
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Influence of the Circadian System on Disease Severity
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Self-citationAbsence of Detectable Melatonin and Preservation of Cortisol and Thyrotropin Rhythms in Tetraplegia
Zeitzer, J. M. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.6.2189 · Cited by 83 · see citing works
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Free fatty acids and the metabolic syndrome in patients with obstructive sleep apnoea
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Carotid body denervation prevents fasting hyperglycemia during chronic intermittent hypoxia
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Self-citationCombined effects of high-fat feeding and circadian desynchronization
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Self-citationRethinking the central causes of diabetes
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Self-citationCircadian desynchronization triggers premature cellular aging in a diurnal rodent
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Self-citationDo Sleep Disorders and Associated Treatments Impact Glucose Metabolism?
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Self-citationHypoxia-inducible factors and hypertension: lessons from sleep apnea syndrome
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Rhythmic Leptin Is Required for Weight Gain from Circadian Desynchronized Feeding in the Mouse
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Self-citationCirculating adhesion molecules in obstructive sleep apnea and cardiovascular disease
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Self-citationMangia, S., Tesfaye, N., Martino, F. D., Kumar, A. F., Kollasch, P., Moheet, A. A., Eberly, L. E., & Seaquist, E. R. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.117 · Cited by 42 · see citing works
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Self-citationSetting the main circadian clock of a diurnal mammal by hypocaloric feeding
Mendoza, J., Gourmelen, S., Dumont, S., Ciocca, D., Pévet, P., & Challet, É. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.230300 · Cited by 35 · see citing works
Self-citationA Novel Link Between Circadian Clocks and Adipose Tissue Energy Metabolism
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What can blood biomarkers tell us about cardiovascular risk in obstructive sleep apnea?
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Management of the insulin resistance syndrome
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Circadian physiology of metabolism
Panda, S. (2016) · Science · doi:10.1126/science.aah4967 · Cited by 1,092 · see citing works
Self-citationFasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan
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Self-citationMetabolically healthy obesity: facts and fantasies
Smith, G. I., Mittendorfer, B., & Klein, S. (2019) · Journal of Clinical Investigation · doi:10.1172/jci129186 · Cited by 655 · see citing works
Self-citationThe role of insufficient sleep and circadian misalignment in obesity
Chaput, J., McHill, A. W., Cox, R. C., Broussard, J. L., Dutil, C., da Costa, B. G. G., Sampasa‐Kanyinga, H., & Wright, K. P. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00747-7 · Cited by 691 · see citing works
Self-citationMeal timing regulates the human circadian system
Wehrens, S. M. T., Christou, S., Isherwood, C., Middleton, B., Gibbs, M. A., Archer, S. N., Skene, D. J., & Johnston, J. D. (2017) · Current Biology · doi:10.1016/j.cub.2017.04.059 · Cited by 596 · see citing works
“As sleep disruption is known to modulate metabolic physiology [15], we assessed subjective sleepiness throughout each constant routine using the Karolinska Sleepiness Scale (KSS).”
MethodThe circadian regulation of food intake
Challet, E. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0210-x · Cited by 428 · see citing works
Self-citationCircadian disruption: what do we actually mean?
Vetter, C. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14255 · Cited by 333 · see citing works
“In their review on the consequences of circadian disruption on metabolic outcomes, Arble et al. (Arble et al., 2015) describe widely used jetlag, shift work, and non-24h models in animal research.”
BackgroundMcHill, A. W., & Wright, K. P. (2017) · Obesity Reviews · doi:10.1111/obr.12503 · Cited by 316 · see citing works
Self-citationThe Role of Microbiome in Insomnia, Circadian Disturbance and Depression
Li, Y., Hao, Y., Fan, F., & Zhang, B. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00669 · Cited by 294 · see citing works
Merikangas, K. R., Swendsen, J., Hickie, I. B., Cui, L., Shou, H., Merikangas, A. K., Zhang, J., Lamers, F., Crainiceanu, C., Volkow, N. D., et al. (2019) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2018.3546 · Cited by 231 · see citing works
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Self-citationBody composition and cardiometabolic health across the menopause transition
Marlatt, K. L., Pitynski, D., Gavin, K. M., Moreau, K. L., Melanson, E. L., Santoro, N. F., & Kohrt, W. M. (2021) · Obesity · doi:10.1002/oby.23289 · Cited by 227 · see citing works
The origins and evolution of sleep
Keene, A. C., & Duboué, E. R. (2018) · Journal of Experimental Biology · doi:10.1242/jeb.159533 · Cited by 224 · see citing works
Self-citationDepner, C. M., Melanson, E. L., Eckel, R. H., Snell-Bergeon, J. K., Perreault, L., Bergman, B. C., Higgins, J. A., Guerin, M. K., Stothard, E. R., Morton, S. J., et al. (2019) · Current Biology · doi:10.1016/j.cub.2019.01.069 · Cited by 203 · see citing works
Self-citationSmolensky, M. H., Hermida, R. C., Reinberg, A., Sackett-Lundeen, L., & Portaluppi, F. (2016) · Chronobiology International · doi:10.1080/07420528.2016.1184678 · Cited by 197 · see citing works
“Epidemiologic, clinical and laboratory animal investigations reveal evidence of increased risk for a broad array of medical conditions, including obesity; metabolic syndrome; diabetes; hypertension; cardiovascular disease; and breast, prostate, colorectal and other cancers (Arble et al., 2015; Cho et al., 2015; Cuesta…”
BackgroundInfluentialSleep Duration and Diabetes Risk: Population Trends and Potential Mechanisms
Grandner, M. A., Seixas, A. A., Shetty, S., & Shenoy, S. (2016) · Current Diabetes Reports · doi:10.1007/s11892-016-0805-8 · Cited by 188 · see citing works
Self-citationAnderson, J. R., Carroll, I. M., Azcárate-Peril, M. A., Rochette, A. D., Heinberg, L. J., Peat, C. M., Steffen, K. J., Manderino, L. M., Mitchell, J. E., & Gunstad, J. (2017) · Sleep Medicine · doi:10.1016/j.sleep.2017.07.018 · Cited by 171 · see citing works
Human resting energy expenditure varies with circadian phase
Zitting, K.-M., Vujovic, N., Yuan, R. K., Isherwood, C. M., Medina, J. E., Wang, W., Buxton, O. M., Williams, J. S., Czeisler, C. A., & Duffy, J. F. (2018) · Current Biology · doi:10.1016/j.cub.2018.10.005 · Cited by 164 · see citing works
Self-citationSleep: important considerations for the prevention of cardiovascular disease
Grandner, M. A., Alfonso-Miller, P., Fernandez-Mendoza, J., Shetty, S., Shenoy, S., & Combs, D. (2016) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000000324 · Cited by 166 · see citing works
Self-citationReynolds, A. C., Paterson, J. L., Ferguson, S. A., Stanley, D., Wright, K. P., & Dawson, D. E. (2016) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2016.06.009 · Cited by 169 · see citing works
Self-citationMolecular Mechanisms of Sleep Homeostasis in Flies and MammalsPreprint
Allada, R., Cirelli, C., & Sehgal, A. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a027730 · Cited by 155 · see citing works
BaHammam, A. S., & Pirzada, R. (2023) · Clocks & Sleep · doi:10.3390/clockssleep5030034 · Cited by 138 · see citing works
“However, more research is needed in the general population as well as long-term studies to investigate the potential for adaptation to long-term disruption of the circadian rhythm [47].”
BackgroundYurgel, M. E., Kakad, P. P., Zandawala, M., Nässel, D. R., Godenschwege, T. A., & Keene, A. C. (2019) · PLoS Biology · doi:10.1371/journal.pbio.2006409 · Cited by 132 · see citing works
Self-citationArora, T., Grey, I., Östlundh, L., Alamoodi, A., Omar, O. M., Hubert Lam, K.-B., & Grandner, M. (2022) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2022.101593 · Cited by 109 · see citing works
Self-citationGupta, N. J., Kumar, V., & Panda, S. (2017) · PLOS ONE · doi:10.1371/journal.pone.0172852 · Cited by 100 · see citing works
Self-citationTruong, K. K., Lam, M. T. Y., Grandner, M. A., Sassoon, C. S. H., & Malhotra, A. (2016) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201602-125fr · Cited by 102 · see citing works
Self-citationUsing the tools of genetic epidemiology to understand sex differences in neuropsychiatric disorders
Merikangas, A. K., & Almasy, L. (2020) · Genes, Brain and Behavior · doi:10.1111/gbb.12660 · Cited by 82 · see citing works
“toms are similar in males and females and steady across development.(17) Sex differences in onset and course of disorders of mid and late life have been extensively documented for several neurologic”
BackgroundChronomedicine and type 2 diabetes: shining some light on melatonin
Forrestel, A. C., Miedlich, S. U., Yurcheshen, M. E., Wittlin, S. D., & Sellix, M. T. (2016) · Diabetologia · doi:10.1007/s00125-016-4175-1 · Cited by 80 · see citing works
Repeated evolution of circadian clock dysregulation in cavefish populations
Mack, K. L., Jaggard, J. B., Persons, J. L., Roback, E. Y., Passow, C. N., Stanhope, B. A., Ferrufino, E., Tsuchiya, D., Smith, S. E., Slaughter, B. D., et al. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009642 · Cited by 72 · see citing works
Self-citationBaHammam, A. S., & Almeneessier, A. S. (2020) · Frontiers in Nutrition · doi:10.3389/fnut.2020.00028 · Cited by 80 · see citing works
“Moreover, long-term studies are needed to explore the possibility of adaptation to the changes of chronic circadian misalignment (16).”
BackgroundNagare, R., Woo, M. K., MacNaughton, P., Plitnick, B., Tinianov, B. D., & Figueiro, M. G. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18199980 · Cited by 85 · see citing works
Sex differences in frailty among older adults
Zeidan, R. S., McElroy, T., Rathor, L., Martenson, M. S., Lin, Y., & Mankowski, R. T. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112333 · Cited by 77 · see citing works
“Good quality of sleep (with > 80 % sleep efficiency) is indispensable for overall health and longevity and can help prevent a range of health conditions, including obesity, diabetes, and cardiovascular disease as well as an increase in mortality rate (Arble et al., 2015; He et al., 2020).”
Circadian rhythms affect bone reconstruction by regulating bone energy metabolism
Luo, B., Zhou, X., Tang, Q., Yin, Y., Feng, G., Li, S., & Chen, L. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-03068-x · Cited by 69 · see citing works
Pediatric sleep: current knowledge, gaps, and opportunities for the future
Reynolds, A., Spaeth, A. M., Hale, L. E., Williamson, A. A., LeBourgeois, M. K., Wong, S. D., Hartstein, L. E., Levenson, J. C., Kwon, M., Hart, C. N., et al. (2023) · SLEEP · doi:10.1093/sleep/zsad060 · Cited by 70 · see citing works
“Experimental studies with adults lend further support to disturbances in glucose regulation and insulin sensitivity that result from short sleep [105, 106], and also demonstrate that sleep restriction leads to increased caloric intake that predisposes to weight gain [107]—a finding also observed in…”
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Self-citationAssociation Between Outdoor Light-at-night Exposure and Colorectal Cancer in Spain
García-Saenz, A., de Miguel, A. S., Espinosa, A., Costas, L., Aragonés, N., Tonne, C. C., Moreno, V. R., Pérez‐Gómez, B., Valentín, A., Pollán, M., et al. (2020) · Epidemiology · doi:10.1097/ede.0000000000001226 · Cited by 68 · see citing works
Ding, C., Lim, L., Li, X., & Kong, A. P. S. (2018) · Journal of Obesity & Metabolic Syndrome · doi:10.7570/jomes.2018.27.1.4 · Cited by 75 · see citing works
The Effect of Circadian and Sleep Disruptions on Obesity Risk
Noh, J. H. (2018) · Journal of Obesity & Metabolic Syndrome · doi:10.7570/jomes.2018.27.2.78 · Cited by 60 · see citing works
The multiple roles of salt-inducible kinases in regulating physiology
Jagannath, A., Taylor, L., Ru, Y., Wakaf, Z., Akpobaro, K., Vasudevan, S. R., & Foster, F. (2023) · Physiological Reviews · doi:10.1152/physrev.00023.2022 · Cited by 58 · see citing works
Nagai, N., Ayaki, M., Yanagawa, T., Hattori, A., Negishi, K., Mori, T., Nakamura, T. J., & Tsubota, K. (2019) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.19-27195 · Cited by 60 · see citing works
Brown, M., Sen, S., Mazzone, A., Her, T. K., Xiong, Y., Lee, J., Javeed, N., Colwell, C. S., Rakshit, K., LeBrasseur, N. K., et al. (2021) · Science Advances · doi:10.1126/sciadv.abg6856 · Cited by 55 · see citing works
“Most notably, chronic circadian rhythm disruptions (CDs) are associated with increased incidence of metabolic diseases such as type 2 diabetes mellitus (T2DM) ( 14 – 17 ).”
Palmisano, B. T., Stafford, J. M., & Pendergast, J. S. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00044 · Cited by 54 · see citing works
“For example, restricting eating to specific times of day, called time-restricted feeding, is gaining traction as a plausible behavioral strategy to reduce obesity (50).”
MECHANISMS OF CIRCADIAN CLOCK INTERACTIONS WITH ARYL HYDROCARBON RECEPTOR SIGNALING
Tischkau, S. A. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14361 · Cited by 55 · see citing works
“Disruption of coordinated timing between the SCN and peripheral oscillators located in every organ system may upset the intricate homeostatic balance necessary for health and contribute to numerous pathologies, including cardiovascular disease, metabolic disease, cancer and others (Arble et al., 2015; Bass, 2017).”
BackgroundPalermo, J., Chesi, A., Zimmerman, A. J., Sonti, S., Pahl, M. C., Lasconi, C., Brown, E., Pippin, J. A., Wells, A. D., Doldur-Balli, F., et al. (2023) · Science Advances · doi:10.1126/sciadv.abq0844 · Cited by 47 · see citing works
Self-citationGrandner, M. A. (2017) · Sleep Health · doi:10.1016/j.sleh.2017.07.014 · Cited by 48 · see citing works
“search into signaling molecules secreted by adipose tissue from both population and laboratory studies implicates sleep-dependent changes in adipose tissue as well.(55) In addition to studies of acute sleep loss, another emerging litera-”
BackgroundSelf-citationHogenboom, R., Kalsbeek, M. J. T., Korpel, N. L., de Goede, P., Koenen, M., Buijs, R. M., Romijn, J. A., Swaab, D. F., Kalsbeek, A., & Yi, C. (2019) · Diabetologia · doi:10.1007/s00125-019-4953-7 · Cited by 49 · see citing works
“Introduction deprivation, and profound disruptions in blood glucose and insulin levels [6].”
BackgroundInterorgan rhythmicity as a feature of healthful metabolism
Bass, J. T. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.01.009 · Cited by 49 · see citing works
Self-citationSmit, A. N., Broesch, T., Siegel, J. M., & Mistlberger, R. E. (2019) · Scientific Reports · doi:10.1038/s41598-019-53635-y · Cited by 45 · see citing works
Sleep, Circadian Rhythms, and Fertility
Goldstein, C. A., & Smith, Y. R. (2016) · Current Sleep Medicine Reports · doi:10.1007/s40675-016-0057-9 · Cited by 41 · see citing works
Zhou, M. Y., Lalani, C. S. P., Banda, J. A., & Robinson, T. N. (2018) · Obesity Science & Practice · doi:10.1002/osp4.303 · Cited by 40 · see citing works
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Sleep Restriction With Circadian Disruption Negatively Alter Bone Turnover Markers in Women
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“Interruptions to sleep likely cause weight gain and obesity owing to the influence of poor sleep quality on leptin secretion, whereby reduced leptin concentrations in the blood stimulate appetite and thus increase food intake (Arble et al. 2015; Figueiro et al. 2012; Hagen et al. 2015).”
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“This point was highlighted in a workshop convened by the National Institute for Diabetes and Digestive and Kidney Diseases which showcased emerging research on the role of sleep and circadian disruption in affecting metabolism, energy balance and diabetes risk (Arble et al., 2015).”
BackgroundPioneering new frontiers in circadian medicine chronotherapies for cardiovascular health
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Eating Habits and Sleep Quality during the COVID-19 Pandemic in Adult Population of Ecuador
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“…studies in rodents and humans have shown that circadian misalignment of food intake and sleep may have adverse effects on energy balance, glucose metabolism and appetite regulation, 14–17 suggesting a great therapeutic potential of aligning food intake to circadian rhythms of metabolism.”
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“) can also exacerbate cardiovascular disease risk and metabolic dysfunction during menopause [6-9].”
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“It has been observed that short sleep could lead to an increase in food intake, due to behavioural and hormonal changes, a greater propensity towards unhealthy eating habits and a reduction in physical activity (Peuhkuri et al. 2012; Arble et al. 2015; St-Onge 2017; Godos, Ferri, et al. 2020).”
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“Time-restricted feeding is a novel and promising approach for obesity and related disease management; however, it is largely untested in humans, to a great extent due to the challenges of helping individuals modify their behavior to a shorter window of eating [15,58,59].”
Tianwang Buxin Granules Influence the Intestinal Flora in Perimenopausal Insomnia
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“By contrast, sleep, fasting, inactivity, and restorative processes occur during the biological night-time (when levels of melatonin are high) [34].”
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“Misalignment of food timing with circadian rhythms contributes to adiposity and impaired glucose homeostasis in experimental models (3 – 5), raising the possibility that changing the timing of eating could be a viable intervention for obesity.”
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The Effects of Sleep on the Commensal Microbiota
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“are high in fat is thought to promote increased feeding and contributes to sleep-related disorders.(16,17) Food is comprised of complex macronutrients including sugars, proteins and fats.”
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“…the available evidence is beginning to support a causal relationship between sleep complaints and selected health problems including psychiatric disorders and cardiometabolic risk (Breslau et al. 1996; Mullington et al. 2009; Davies et al. 2014; Arble et al. 2015; Briancon-Marjollet et al. 2015).”
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“Therefore, as a pivotal function of the circadian clock, the liver governs metabolic output [35].”
- Authors
- Arble, D. M., Bass, J., Behn, C. D., Butler, M. P., Challet, E., Czeisler, C., Depner, C. M., Elmquist, J., Franken, P., Grandner, M. A., Hanlon, E. C., Keene, A. C., Joyner, M. J., Karatsoreos, I., Kern, P. A., Klein, S., Morris, C. J., Pack, A. I., Panda, S., Ptacek, L. J., Punjabi, N. M., Sassone-Corsi, P., Scheer, F. A., Saxena, R., Seaquest, E. R., Thimgan, M. S., Van Cauter, E., & Wright, K. P.
- Affiliations
- University of Michigan (US)
- Northwestern University (US)
- Colorado School of Mines (US)
- Oregon Health & Science University (US)
- Institute for Cellular and Integrative Neuroscience, CNRS, University of Strasbourg, France
- Brigham and Women's Hospital (US)
- University of Colorado Boulder (US)
- The University of Texas Southwestern Medical Center (US)
- University of Lausanne (CH)
- University of Arizona (US)
- University of Chicago (US)
- University of Nevada, Reno (US)
- Mayo Clinic (US)
- Washington State University (US)
- University of Kentucky (US)
- Washington University in St. Louis (US)
- University of Pennsylvania (US)
- Salk Institute for Biological Studies (US)
- Department of Neurology, Howard Hughes Medical Institute, University of California, San Francisco, CA
- Johns Hopkins University (US)
- Center for Epigenetics and Metabolism, School of Medicine, University of California, Irvine, CA
- Harvard University (US)
- University of Minnesota (US)
- Missouri University of Science and Technology (US)
- Sleep, Metabolism and Health Center, The University of Chicago, Chicago, IL
- Corresponding author
- Pack, Allan I.
- ORCID
- Arble, Deanna M.
- Bass, Joseph
- Behn, Cecilia Diniz
- Butler, Matthew P.
- Czeisler, Charles
- Depner, Christopher M.
- Elmquist, Joel
- Franken, Paul
- Grandner, Michael A.
- Keene, Alex C.
- Joyner, Michael J.
- Karatsoreos, Ilia
- Kern, Philip A.
- Klein, Samuel
- Pack, Allan I.
- Panda, Satchidananda
- Punjabi, Naresh M.
- Scheer, Frank A.
- Saxena, Richa
- Wright, Kenneth P.
- Venue
- Sleep
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-12-01
- Volume
- 38
- Issue
- 12
- Pages
- 1849-1860
- ISSN
- 0161-8105 (ISSN-L)
- 1550-9109
- PMC
- PMC4667373
- OpenAlex
- W2396565630
- Cited by
- 173
- References
- 126
- Citations by year
- 2026: 10 · 2025: 21 · 2024: 23 · 2023: 16 · 2022: 9 · 2021: 16 · 2020: 17 · 2019: 15 · 2018: 14 · 2017: 17 · 2016: 14 · 2015: 1
- FWCI
- 8.50
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- SLEEP (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- e-Publications@Marquette (Marquette University) (submittedVersion)
- UKnowledge (University of Kentucky) (submittedVersion)
- HAL (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Funders
- Eli Lilly and Company
- AstraZeneca
- Boston Scientific Corporation
- Sleep Research Society
- ResMed
- National Institutes of Health (UL1TR000430, KL2TR000431)
- National Heart, Lung, and Blood Institute (K23HL110216)
- National Cancer Institute (P30CA014195)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK098722)
- National Institute of Neurological Disorders and Stroke (R01NS085152, R15NS080155)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- circadian rhythm disruption, energy balance, diabetes mellitus, sleep-disordered breathing, obstructive sleep apnea, prediabetes, continuous positive airway pressure, obesity, shift work, short sleep duration, glucose and insulin, metabolic health, chronic adaptation
- MeSH terms
- Animals, Circadian Rhythm, Diabetes Mellitus, Energy Metabolism, Fasting, Food Deprivation, Glucose, Homeostasis, Humans, Insulin, Obesity, Sleep, Time Factors, Age of Onset, Sleep Disorders, Circadian Rhythm, Sleep Apnea, Obstructive, Metabolic Syndrome, Mice, Endophenotypes
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