Oral administration of rac-α-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial
Abstract
Alpha-lipoic acid (ALA), a naturally occuring compound and a radical scavenger was shown to enhance glucose transport and utilization in different experimental and animal models. Clinical studies described an increase of insulin sensitivity after acute and short-term (10 d) parenteral administration of ALA. The effects of a 4-week oral treatment with alpha-lipoic acid were evaluated in a placebo-controlled, multicenter pilot study to determine see whether oral treatment also improves insulin sensitivity. Seventy-four patients with type-2 diabetes were randomized to either placebo (n = 19); or active treatment in various doses of 600 mg once daily (n = 19), twice daily (1200 mg; n = 18), or thrice daily (1800 mg; n = 18) alpha-lipoic acid. An isoglycemic glucose-clamp was done on days 0 (pre) and 29 (post). In this explorative study, analysis was done according to the number of subjects showing an improvement of insulin sensitivity after treatment. Furthermore, the effects of active vs. placebo treatment on insulin sensitivity was compared. All four groups were comparable and had a similar degree of hyperglycemia and insulin sensitivity at baseline. When compared to placebo, significantly more subjects had an increase in insulin-stimulated glucose disposal (MCR) after ALA treatment in each group. As there was no dose effect seen in the three different alpha-lipoic acid groups, all subjects receiving ALA were combined in the "active" group and then compared to placebo. This revealed significantly different changes in MCR after treatment (+27% vs. placebo; p < .01). This placebo-controlled explorative study confirms previous observations of an increase of insulin sensitivity in type-2 diabetes after acute and chronic intravenous administration of ALA. The results suggest that oral administration of alpha-lipoic acid can improve insulin sensitivity in patients with type-2 diabetes. The encouraging findings of this pilot trial need to be substantiated by further investigations.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Alloxan diabetic rats have reduced NO levels in blood.
“Indeed, alloxan diabetic rats are observed to have reduced NO levels in blood (656) , and in human subjects, acute hyperglycaemia attenuated endothelium-dependent vasodilation (657) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [656]
Cites
Glucose clamp technique: a method for quantifying insulin secretion and resistance.
DeFronzo, R. A., Tobin, J. D., & Andres, R. (1979) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1979.237.3.e214 · Cited by 7,425 · see citing works
DeFronzo, R. A., & Ferrannini, E. (1991) · Diabetes Care · doi:10.2337/diacare.14.3.173 · Cited by 4,555 · see citing works
Pathogenesis of NIDDM. A balanced overview.
DeFronzo, R. A., Bonadonna, R. C., & Ferrannini, E. (1992) · Diabetes Care · doi:10.2337/diacare.15.3.318 · Cited by 2,085 · see citing works
Physical activity and incidence of non-insulin-dependent diabetes mellitus in women
Manson, J. E., Stampfer, M. J., Colditz, G. A., Willett, W. C., Rosner, B., Hennekens, C. H., Speizer, F. E., Rimm, E. B., & Krolewski, A. S. (1991) · The Lancet · doi:10.1016/0140-6736(91)90664-b · Cited by 1,164 · see citing works
Metabolic effects of metformin in non-insulin-dependent diabetes mellitus
Stumvoll, M., Nurjhan, N., Perriello, G., Dailey, G., & Gerich, J. E. (1995) · New England Journal of Medicine · doi:10.1056/nejm199508313330903 · Cited by 1,148 · see citing works
Improvement in Glucose Tolerance and Insulin Resistance in Obese Subjects Treated with Troglitazone
Nolan, J. J., Ludvik, B. H., Beerdsen, P., Joyce, M., & Olefsky, J. M. (1994) · New England Journal of Medicine · doi:10.1056/nejm199411033311803 · Cited by 925 · see citing works
Efficacy and Metabolic Effects of Metformin and Troglitazone in Type II Diabetes Mellitus
Inzucchi, S. E., Maggs, D. G., Spollett, G. R., Page, S. L., Rife, F. S., Walton, V., & Shulman, G. I. (1998) · New England Journal of Medicine · doi:10.1056/nejm199803263381303 · Cited by 794 · see citing works
Nagi, D. K., & Yudkin, J. S. (1993) · Diabetes Care · doi:10.2337/diacare.16.4.621 · Cited by 353 · see citing works
Jacob, S., Kristian, R. E. T. T., WICKLMAYR, M., Agrawal, B., Hj, A., & Dietze, G. J. (1996) · PubMed · Cited by 228 · see citing works
Self-citationSplanchnic and renal metabolism of insulin in human subjects: a dose-response study
Ferrannini, E., Wahren, J., FABER, O. K., Felig, P., Binder, C., & DeFronzo, R. A. (1983) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1983.244.6.e517 · Cited by 214 · see citing works
ESTRADA, D. E., Ewart, H. S., Tsakiridis, T. K., Volchuk, A., Ramlal, T., Tritschler, H., & Klip, A. (1996) · Diabetes · doi:10.2337/diab.45.12.1798 · Cited by 199 · see citing works
Self-citationKonrad, T., Vicini, P., Kusterer, K., Höflich, A., Assadkhani, A., Böhles, H. J., Sewell, A., Tritschler, H., Cobelli, C., & Usadel, K. H. (1999) · Diabetes Care · doi:10.2337/diacare.22.2.280 · Cited by 189 · see citing works
Self-citationDifferential effect of chronic treatment with two beta-blocking agents on insulin sensitivity
Jacob, S., Kristian, R. E. T. T., WICKLMAYR, M., Agrawal, B., Augustin, H. J., & Dietze, G. N.-J. (1996) · Journal of Hypertension · doi:10.1097/00004872-199604000-00012 · Cited by 183 · see citing works
Self-citationEnhancement of glucose disposal in patients with type 2 diabetes by alpha-lipoic acid.
Jacob, S., Henriksen, E. J., Schiemann, A.-L., Simón, I., Clancy, D. E., Tritschler, H., Jung, W.-I., Hj, A., & Dietze, G. (1995) · PubMed · Cited by 182 · see citing works
Self-citationJacob, S., Streeper, R. S., Fogt, D. L., Hokama, J. Y., Henriksen, E. J., Dietze, G., & Tritschler, H. (1996) · Diabetes · doi:10.2337/diab.45.8.1024 · Cited by 181 · see citing works
Self-citationDel Prato, S., Bonadonna, R. C., Bonora, E., Gulli, G., Solini, A., Shank, M., & DeFronzo, R. A. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116226 · Cited by 170 · see citing works
The Effect of Acarbose on Insulin Sensitivity in Subjects With Impaired Glucose Tolerance
Chiasson, J., Josse, R. G., Leiter, L. A., Mihic, M., Nathan, D. M., Palmason, C., Cohen, R. M., & Wolever, T. M. S. (1996) · Diabetes Care · doi:10.2337/diacare.19.11.1190 · Cited by 168 · see citing works
Prevention of non???insulin-dependent diabetes mellitus with physical activity
Helmrich, S. P., Ragland, D. R., & Paffenbarger, R. S. (1994) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199407000-00003 · Cited by 138 · see citing works
Jacob, S., Henriksen, E. J., Tritschler, H., Hj, A., & Dietze, G. (2009) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0029-1211455 · Cited by 134 · see citing works
Self-citationLipoic acid reduces glycemia and increases muscle GLUT4 content in streptozotocin-diabetic rats
Khamaisi, M., Potashnik, R., Tirosh, A., Demshchak, E., Rudich, A., Trischler, H., Wessel, K., & Bashan, N. (1997) · Metabolism · doi:10.1016/s0026-0495(97)90120-7 · Cited by 124 · see citing works
Henriksen, E. J., Jacob, S., Streeper, R. S., Fogt, D. L., Hokama, J. Y., & Tritschler, H. (1997) · Life Sciences · doi:10.1016/s0024-3205(97)00562-6 · Cited by 112 · see citing works
Self-citationStreeper, R. S., Henriksen, E. J., Jacob, S., Hokama, J. Y., Fogt, D. L., & Tritschler, H. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.1.e185 · Cited by 106 · see citing works
Self-citationWaldh�usl, W. K. (2015) · Frontiers in diabetes · doi:10.1159/000422655 · Cited by 91 · see citing works
Stimulation of glucose utilization by thioctic acid in rat diaphragm incubated in vitro
Haugaard, N., & Haugaard, E. S. (1970) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(70)90183-2 · Cited by 88 · see citing works
Estrada, D. E., Ewart, H. S., Tsakiridis, T., Volchuk, A., Ramlal, T., Tritschler, H., & Klip, A. (1996) · Diabetes · doi:10.2337/diabetes.45.12.1798 · Cited by 74 · see citing works
Self-citationJacob, S., Streeper, R. S., Fogt, D. L., Hokama, J. Y., Tritschler, H., Dietze, G., & Henriksen, E. J. (1996) · Diabetes · doi:10.2337/diabetes.45.8.1024 · Cited by 64 · see citing works
Self-citationDorella, M., Giusto, M., Tos, V. D., Campagnolo, M., Palatini, P., Rossi, G., Ceolotto, G., Felice, M., Semplicini, A., & Prato, S. D. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.4.8636369 · Cited by 45 · see citing works
The influence of thioctic acid on metabolism and function of the diabetic heart
Strödter, D., Lehmann, E., Lehmann, U., Tritschler, H., Bretzel, R. G., & Federlin, K. (1995) · Diabetes Research and Clinical Practice · doi:10.1016/0168-8227(95)01118-w · Cited by 42 · see citing works
Self-citationOral Antidiabetic Drugs: an Overview
Melander, A. (1996) · Diabetic Medicine · doi:10.1002/dme.1996.13.s6.143 · Cited by 41 · see citing works
Baron, A., Eckel, R. H., Schmeiser, L., & Kolterman, O. (1987) · Metabolism · doi:10.1016/0026-0495(87)90035-7 · Cited by 38 · see citing works
Singh, H., & Bowman, R. H. (1970) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(70)90048-3 · Cited by 35 · see citing works
Scheen, A. J., Letiexhe, M. R., & Lefèbvre, P. J. (1995) · Diabetic Medicine · doi:10.1111/j.1464-5491.1995.tb00410.x · Cited by 27 · see citing works
Prigeon, R. L., Jacobson, R. K., Porte, D., & Kahn, S. E. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.9.8784086 · Cited by 21 · see citing works
Gliclazide and insulin action in human muscle
Bak, J. F., & Pedersen, O. B. (1991) · Diabetes Research and Clinical Practice · doi:10.1016/0168-8227(91)90009-3 · Cited by 10 · see citing works
ChemInform Abstract: The Thiazolidinediones — A Novel Approach for the Treatment of Type‐2 Diabetes
Bethge, H., & Haering, H.-U. (1998) · ChemInform · doi:10.1002/chin.199823260 · Cited by 2 · see citing works
Flagged first, then by citations
1 of the 36 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Increased oxidative stress in obesity and its impact on metabolic syndrome
Furukawa, S., Fujita, T., Shimabukuro, M., Iwaki, M., Yamada, Y., Nakajima, Y., Nakayama, O., Makishima, M., Matsuda, M., & Shimomura, I. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21625 · Cited by 5,508 · see citing works
Oxidative Stress and Stress-Activated Signaling Pathways: A Unifying Hypothesis of Type 2 Diabetes
Evans, J. L., Goldfine, I. D., Maddux, B. A., & Grodsky, G. M. (2002) · Endocrine Reviews · doi:10.1210/er.2001-0039 · Cited by 2,232 · see citing works
Evans, J. L., Goldfine, I. D., Maddux, B. A., & Grodsky, G. M. (2003) · Diabetes · doi:10.2337/diabetes.52.1.1 · Cited by 1,482 · see citing works
Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098 · see citing works
Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential
Shay, K. P., Moreau, R. F., Smith, E. J., Smith, A. R., & Hagen, T. M. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.07.026 · Cited by 976 · see citing works
R�sen, P., Nawroth, P., King, G. L., M�ller, W., Tritschler, H., & Packer, L. (2001) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.196 · Cited by 881 · see citing works
Self-citationInsulin Resistance and Chronic Cardiovascular Inflammatory Syndrome
Fernández-Real, J. M., & Ricart, W. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0010 · Cited by 886 · see citing works
Systematic Review of Herbs and Dietary Supplements for Glycemic Control in Diabetes
Yeh, G. Y., Eisenberg, D. M., Kaptchuk, T. J., & Phillips, R. S. (2003) · Diabetes Care · doi:10.2337/diacare.26.4.1277 · Cited by 864 · see citing works
Mechanisms of obesity-associated insulin resistance: many choices on the menuPreprint
Qatanani, M., & Lazar, M. A. (2007) · Genes & Development · doi:10.1101/gad.1550907 · Cited by 780 · see citing works
Oxidative stress and the etiology of insulin resistance and type 2 diabetes
Henriksen, E. J., Diamond-Stanic, M. K., & Marchionne, E. M. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.12.005 · Cited by 600 · see citing works
The Molecular Basis for Oxidative Stress-Induced Insulin Resistance
Evans, J. L., Maddux, B. A., & Goldfine, I. D. (2005) · Antioxidants & Redox Signaling · doi:10.1089/ars.2005.7.1040 · Cited by 587 · see citing works
Role of Reactive Oxygen Species in the Progression of Type 2 Diabetes and Atherosclerosis
Kaneto, H., Katakami, N., Matsuhisa, M., & Matsuoka, T. (2010) · Mediators of Inflammation · doi:10.1155/2010/453892 · Cited by 578 · see citing works
Molecular aspects of lipoic acid in the prevention of diabetes complications
Packer, L., Kraemer, K., & Rimbach, G. (2001) · Nutrition · doi:10.1016/s0899-9007(01)00658-x · Cited by 556 · see citing works
Positive and Negative Regulation of Insulin Signaling by Reactive Oxygen and Nitrogen Species
Bashan, N., Kovsan, J., Kachko, I., Ovadia, H., & Rudich, A. (2009) · Physiological Reviews · doi:10.1152/physrev.00014.2008 · Cited by 542 · see citing works
Impact of postprandial glycaemia on health and prevention of disease
Blaak, E. E., Antoine, J. M., Benton, D., Björck, I., Bozzetto, L., Brouns, F. J. P. H., Diamant, M., Dye, L., Hulshof, T. G., Holst, J. J., et al. (2012) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.01011.x · Cited by 487 · see citing works
Modification of Brain Aging and Neurodegenerative Disorders by Genes, Diet, and Behavior
Mattson, M. P., Chan, S. L., & Duan, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00004.2002 · Cited by 438 · see citing works
Oxidative Stress Is Associated with Adiposity and Insulin Resistance in Men
Urakawa, H., Katsuki, A., Sumida, Y., Gabazza, E. C., Murashima, S., Morioka, K., Maruyama, N., Kitagawa, N., Tanaka, T., Hori, Y., et al. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030202 · Cited by 416 · see citing works
Maddux, B. A., See, W., Lawrence, J. C., Goldfine, A. L., Goldfine, I. D., & Evans, J. L. (2001) · Diabetes · doi:10.2337/diabetes.50.2.404 · Cited by 405 · see citing works
Oxidative Stress in Diabetes: Implications for Vascular and Other Complications
Pitocco, D., Tesauro, M., Rizzi, A., Ghirlanda, G., & Cardillo, C. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141121525 · Cited by 409 · see citing works
Proposed mechanisms for the induction of insulin resistance by oxidative stress
Bloch-Damti, A., & Bashan, N. (2005) · Antioxidants & Redox Signaling · doi:10.1089/ars.2005.7.1553 · Cited by 388 · see citing works
Lipoic acid - the drug of the future?
Bilska‐Wilkosz, A., & Włodek, L. B. (2005) · PubMed · Cited by 349 · see citing works
Involvement of Oxidative Stress in the Pathogenesis of Diabetes
Kaneto, H., Katakami, N., Kawamori, D., Miyatsuka, T., Sakamoto, K., Matsuoka, T., Matsuhisa, M., & Yamasaki, Y. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.1465 · Cited by 264 · see citing works
Bajaj, S., & Khan, A. A. (2012) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/2230-8210.104057 · Cited by 262 · see citing works
A Drosophila Model of High Sugar Diet-Induced Cardiomyopathy
Na, J., Musselman, L. P., Pendse, J., Baranski, T., Bodmer, R., Ocorr, K. A., & Cagan, R. L. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003175 · Cited by 252 · see citing works
Kandhare, A. D., Raygude, K. S., Ghosh, P., Ghule, A. E., & Bodhankar, S. L. (2012) · Fitoterapia · doi:10.1016/j.fitote.2012.01.010 · Cited by 243 · see citing works
Tibullo, D., Volti, G. L., Giallongo, C., Grasso, S., Tomassoni, D., Anfuso, C. D., Lupo, G., Amenta, F., Avola, R., & Bramanti, V. (2017) · Inflammation Research · doi:10.1007/s00011-017-1079-6 · Cited by 240 · see citing works
The role of vitamin E and oxidative stress in diabetes complications
Pazdro, R., & Burgess, J. R. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.03.005 · Cited by 236 · see citing works
α-Lipoic acid increases insulin sensitivity by activating AMPK in skeletal muscle
Lee, W. J., Song, K., Koh, E. H., Won, J. C., Kim, H. S., Park, H., Kim, M.-S., Kim, S., Lee, K., & Park, J. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.05.035 · Cited by 232 · see citing works
Evans, J. L., & Goldfine, I. (2000) · Diabetes Technology & Therapeutics · doi:10.1089/15209150050194279 · Cited by 183 · see citing works
Haber, C. A., Lam, T. K. T., Yu, Z., Gupta, N., Goh, T. T., Bogdanovic, E., Giacca, A., & Fantus, I. G. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00355.2002 · Cited by 225 · see citing works
Konrad, D., Somwar, R., Sweeney, G., Yaworsky, K., Hayashi, M., Ramlal, T., & Klip, A. (2001) · Diabetes · doi:10.2337/diabetes.50.6.1464 · Cited by 217 · see citing works
Kaneto, H., Nakatani, Y., Kawamori, D., Miyatsuka, T., Matsuoka, T., Matsuhisa, M., & Yamasaki, Y. (2006) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2006.01.004 · Cited by 203 · see citing works
Natural Products Used for Diabetes
Shapiro, K., & Gong, W. C. (2002) · Journal of the American Pharmaceutical Association (1996) · doi:10.1331/108658002763508515 · Cited by 195 · see citing works
Nobili, V., Manco, M., Vito, R. D., Ciampalini, P., Piemonte, F., & Marcellini, M. (2006) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.03161.x · Cited by 183 · see citing works
Park, K., Min, A.-K., Koh, E. H., Kim, H. S., Kim, M., Park, H., Kim, Y.-D., Yoon, T.-S., Jang, B. K., Hwang, J. S., et al. (2008) · Hepatology · doi:10.1002/hep.22496 · Cited by 178 · see citing works
Inflammation and NF-κB in Alzheimer's Disease and Diabetes
Granic, I., Dolga, A. M., Nijholt, I. M., van Dijk, G., & Eisel, U. L. M. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-0976 · Cited by 175 · see citing works
Nitric Oxide Dysfunction in the Pathophysiology of Preeclampsia
Lowe, D. T. (2000) · Nitric Oxide · doi:10.1006/niox.2000.0296 · Cited by 174 · see citing works
Shay, K. P., Moreau, R. F., Smith, E. J., & Hagen, T. M. (2008) · IUBMB Life · doi:10.1002/iub.40 · Cited by 170 · see citing works
Prevention of Hypertension, Insulin Resistance, and Oxidative Stress by α-Lipoic Acid
Midaoui, A. E., & de Champlain, J. (2002) · Hypertension · doi:10.1161/hy0202.104345 · Cited by 161 · see citing works
Effect of High-Dose Vitamin E on Insulin Resistance and Associated Parameters in Overweight Subjects
Manning, P. J., Sutherland, W. H. F., Walker, R. J., Williams, S., de Jong, S. A., Ryalls, A. R., & Berry, E. A. (2004) · Diabetes Care · doi:10.2337/diacare.27.9.2166 · Cited by 159 · see citing works
The Role of Antioxidant Micronutrients in the Prevention of Diabetic Complications
Bonnefont‐Rousselot, D. (2004) · Treatments in Endocrinology · doi:10.2165/00024677-200403010-00005 · Cited by 152 · see citing works
BROWN, M., Evans, J. L., & LUO, Y. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.10.017 · Cited by 152 · see citing works
Role of phytochemicals in the management of metabolic syndrome
Cicero, A. F. G., & Colletti, A. (2015) · Phytomedicine · doi:10.1016/j.phymed.2015.11.009 · Cited by 151 · see citing works
Complementary Therapies for Diabetes: The Case for Chromium, Magnesium, and Antioxidants
Guerrero‐Romero, F., & Rodríguez‐Morán, M. (2005) · Archives of Medical Research · doi:10.1016/j.arcmed.2005.01.004 · Cited by 147 · see citing works
Midaoui, A. E. (2003) · American Journal of Hypertension · doi:10.1016/s0895-7061(02)03253-3 · Cited by 144 · see citing works
Henriksen, E. J. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.04.002 · Cited by 136 · see citing works
Nitrosative Stress and Pathogenesis of Insulin Resistance
Kaneki, M., Shimizu, N., Yamada, D., & Chang, K. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.1464 · Cited by 133 · see citing works
Use of Antioxidant Nutrients in the Prevention and Treatment of Type 2 Diabetes
Ruhe, R. C., & McDonald, R. B. (2001) · Journal of the American College of Nutrition · doi:10.1080/07315724.2001.10719169 · Cited by 133 · see citing works
Thioctic Acid for Patients with Symptomatic Diabetic Polyneuropathy
Ziegler, D. (2004) · Treatments in Endocrinology · doi:10.2165/00024677-200403030-00005 · Cited by 133 · see citing works
Two Tales of Antioxidant Enzymes on β Cells and Diabetes
Lei, X. G., & Vatamaniuk, M. Z. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3416 · Cited by 130 · see citing works
Lacroix, I. M. E., & Li‐Chan, E. C. Y. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300223 · Cited by 125 · see citing works
Hays, N. P., Galassetti, P. R., & Coker, R. H. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.02.003 · Cited by 122 · see citing works
Melhem, M. F., Craven, P. A., Liachenko, J., & DeRubertis, F. R. (2002) · Journal of the American Society of Nephrology · doi:10.1681/asn.v131108 · Cited by 117 · see citing works
Shen, Q. W., Zhu, M. J., Tong, J., Ren, J. T., & Du, . (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00115.2007 · Cited by 111 · see citing works
Tatsumi, C., Kudo, M., Ueshima, K., Kitai, S., Takahashi, S., Inoue, T., Minami, Y., Chung, H., Maekawa, K., Fujimoto, K., et al. (2008) · Intervirology · doi:10.1159/000122602 · Cited by 109 · see citing works
Kamenova, P. (2006) · HORMONES · doi:10.14310/horm.2002.11191 · Cited by 108 · see citing works
Moini, H., Tirosh, O., Park, Y. C., Cho, K., & Packer, L. (2002) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2001.2680 · Cited by 108 · see citing works
Nutritional supplementation for type 2 diabetes: a systematic review
Bartlett, H., & Eperjesi, F. (2008) · Ophthalmic & physiological optics · doi:10.1111/j.1475-1313.2008.00595.x · Cited by 106 · see citing works
Wang, Y., Li, X., Guo, Y., Chan, L., & Guan, X. (2009) · Metabolism · doi:10.1016/j.metabol.2009.10.018 · Cited by 105 · see citing works
Kidd, P. M. (2005) · PubMed · Cited by 104 · see citing works
Dietary cysteine alleviates sucrose-induced oxidative stress and insulin resistance
Blouet, C., Mariotti, F., Azzout‐Marniche, D., Mathé, V., Mikogami, T., Tomé, D., & Huneau, J. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.01.006 · Cited by 101 · see citing works
Antioxidants: do they have a role in the treatment of insulin resistance?
Evans, J. L. (2007) · PubMed · Cited by 99 · see citing works
Biological Complementary Therapies: A Focus on Botanical Products in Diabetes
Shane‐McWhorter, L. (2001) · Diabetes Spectrum · doi:10.2337/diaspect.14.4.199 · Cited by 96 · see citing works
Sancheti, H., Akopian, G. K., Yin, F., Brinton, R. D., Walsh, J. P., & Cadenas, E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069830 · Cited by 95 · see citing works
Capece, U., Moffa, S., Improta, I., Giuseppe, G. D., Nista, E. C., CEFALO, C. M. A., Cinti, F., Pontecorvi, A., Gasbarrini, A., Giaccari, A., et al. (2022) · Nutrients · doi:10.3390/nu15010018 · Cited by 96 · see citing works
Micronutrient Status in Type 2 Diabetes
Kaur, B., & Henry, C. J. (2014) · Advances in food and nutrition research · doi:10.1016/b978-0-12-800270-4.00002-x · Cited by 91 · see citing works
de Oliveira, A. M., Rondó, P. H. D. C., Luzia, L. A., D’Abronzo, F. H., & Illison, V. K. (2011) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2011.02.010 · Cited by 90 · see citing works
Carlson, D. A., SMITH, A. R. W., Fischer, S. J., Young, K. L., & Packer, L. (2007) · PubMed · Cited by 86 · see citing works
Fogacci, F., Rizzo, M., Krogager, C., Kennedy, C., Georges, C. M. G., Knežević, T., Liberopoulos, E. N., Vallée, A., Pérez‐Martínez, P., Wenstedt, E. F. E., et al. (2020) · Antioxidants · doi:10.3390/antiox9101011 · Cited by 84 · see citing works
Abdul-Ghani, M. A., Jani, R., Chavez, A., Molina-Carrion, M., Tripathy, D., & DeFronzo, R. A. (2009) · Diabetologia · doi:10.1007/s00125-009-1264-4 · Cited by 83 · see citing works
Metabolic dysfunction in obstructive sleep apnea: A critical examination of underlying mechanisms
Mesarwi, O. A., Sharma, E. V., Jun, J. C., & Polotsky, V. Y. (2014) · Sleep and Biological Rhythms · doi:10.1111/sbr.12078 · Cited by 81 · see citing works
Zhang, Y., & Chen, X. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00380.2010 · Cited by 82 · see citing works
α-Lipoic acid prevents diabetes mellitus in diabetes-prone obese rats
Song, K., Lee, W. J., Koh, J., Kim, H. S., Youn, J. Y., Park, H., Koh, E. H., Kim, M., Youn, J. H., Lee, K., et al. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.10.213 · Cited by 81 · see citing works
Kaneto, H., Nakatani, Y., Kawamori, D., Miyatsuka, T., Matsuoka, T., Matsuhisa, M., & Yamasaki, Y. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2005.04.003 · Cited by 81 · see citing works
Role of Pyruvate Dehydrogenase Kinase 4 in Regulation of Blood Glucose Levels
Jeoung, N. H., & Harris, R. A. (2010) · Korean Diabetes Journal · doi:10.4093/kdj.2010.34.5.274 · Cited by 78 · see citing works
Visnagri, A., Kandhare, A. D., Kumar, V. S., Rajmane, A. R., Mohammad, A., Ghosh, P., Ghule, A. E., & Bodhankar, S. L. (2012) · Biomedicine & Aging Pathology · doi:10.1016/j.biomag.2012.10.006 · Cited by 78 · see citing works
Nierenberg, A. A., Kansky, C., Brennan, B. P., Shelton, R. C., Perlis, R. H., & Iosifescu, D. V. (2012) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867412449303 · Cited by 76 · see citing works
Lipoic acid effects on established atherosclerosis
Ying, Z., Kherada, N. I., Farrar, B., Kampfrath, T., Chung, Y., Simonetti, O. P., Deiuliis, J. A., Desikan, R., Khan, B. V., Villamena, F. A., et al. (2009) · Life Sciences · doi:10.1016/j.lfs.2009.11.009 · Cited by 74 · see citing works
The oxidative damage and inflammation caused by pesticides are reverted by lipoic acid in rat brain
Astiz, M., de Alaniz, M. J. T., & Marra, C. A. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.09.003 · Cited by 74 · see citing works
Mechanick, J. I., Brett, E. M., Chausmer, A. B., Dickey, R. A., Wallach, S., Bergman, D. A., Garber, J. R., Hamilton, C. R., Handelsman, Y., Holdy, K. E., et al. (2003) · Endocrine Practice · doi:10.4158/ep.9.5.417 · Cited by 73 · see citing works
Insulin resistance: lifestyle and nutritional interventions.
Kelly, G. S. (2000) · PubMed · Cited by 71 · see citing works
Porasuphatana, S., Suddee, S., Nartnampong, A., Konsil, J., Harnwong, B., & Santaweesuk, A. (2012) · PubMed · Cited by 67 · see citing works
Remely, M., Ferk, F., Sterneder, S., Setayesh, T., Kepčija, T., Roth, S., Noorizadeh, R., Greunz, M., Rebhan, I., Wagner, K., et al. (2017) · Nutrients · doi:10.3390/nu9060607 · Cited by 67 · see citing works
Saengsirisuwan, V., Kinnick, T. R., Schmit, M. B., & Henriksen, E. J. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.1.145 · Cited by 67 · see citing works
The Effect of Lipoic Acid Therapy on Cognitive Functioning in Patients with Alzheimer's Disease
Fava, A., Pirritano, D., Plastino, M., Cristiano, D., Puccio, G., Colica, C., Ermio, C., Bartolo, M. D., Mauro, G. F., & Bosco, D. (2013) · Journal of Neurodegenerative Diseases · doi:10.1155/2013/454253 · Cited by 65 · see citing works
Induction of heat shock proteins may combat insulin resistance
McCarty, M. F. (2005) · Medical Hypotheses · doi:10.1016/j.mehy.2004.08.033 · Cited by 65 · see citing works
Medicinal plants and secondary metabolites for diabetes mellitus control
Bahmani, M., Golshahi, H., Saki, K., Rafieian‐Kopaei, M., Delfan, B., & Mohammadi, T. (2014) · Asian Pacific Journal of Tropical Disease · doi:10.1016/s2222-1808(14)60708-8 · Cited by 64 · see citing works
Sancheti, H., Kanamori, K., Patil, I., Diaz-Brinton, R., Ross, B., & Cadenas, E. (2014) · Journal of Cerebral Blood Flow and Metabolism · doi:10.1038/jcbfm.2013.196 · Cited by 60 · see citing works
Stabilization of α-lipoic acid by complex formation with chitosan
Kofuji, K., Nakamura, M., Isobe, T., Murata, Y., & Kawashima, S. (2008) · Food Chemistry · doi:10.1016/j.foodchem.2007.11.078 · Cited by 60 · see citing works
Rahimlou, M., Asadi, M., Banaei-Jahromi, N., & Mansoori, A. (2019) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2019.03.015 · Cited by 60 · see citing works
Effects of alpha lipoic acid on metabolic syndrome: A comprehensive review
Najafi, N., Mehri, S., Rahbardar, M. G., & Hosseinzadeh, H. (2022) · Phytotherapy Research · doi:10.1002/ptr.7406 · Cited by 57 · see citing works
Bitar, M. S., Al‐Saleh, E., & Al‐Mulla, F. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.01.033 · Cited by 57 · see citing works
The effect of lipoic acid and vitamin E therapies in individuals with the metabolic syndrome
Manning, P. J., Sutherland, W. H. F., Williams, S., Walker, R. J., Berry, E. A., de Jong, S. A., & Ryalls, A. R. (2012) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2011.11.006 · Cited by 55 · see citing works
Cummings, B. P., Stanhope, K. L., Graham, J. L., Evans, J. L., Baskin, D. G., Griffen, S. C., & Havel, P. J. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00468.2009 · Cited by 55 · see citing works
Evans, J. L., Heymann, C. J., Goldfine, I. D., & Gavin, L. A. (2002) · Endocrine Practice · doi:10.4158/ep.8.1.29 · Cited by 53 · see citing works
Are antioxidants useful for treating skeletal muscle atrophy?
Bonetto, A., Penna, F., Muscaritoli, M., Minero, V. G., Fanelli, F. R., Baccino, F. M., & Costelli, P. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.07.002 · Cited by 52 · see citing works
Alpha-Lipoic Acid for the Prevention of Diabetic Macular Edema
Haritoglou, C., Gerß, J., Hammes, H. P., Kampik, A., ULBIG, M. W., & for the RETIPON Study Group (2011) · Ophthalmologica · doi:10.1159/000329470 · Cited by 52 · see citing works
Dicter, N., Madar, Z., & Tirosh, O. (2002) · Journal of Nutrition · doi:10.1093/jn/131.10.3001 · Cited by 52 · see citing works
Mohammadi, V., Khalili, M., Eghtesadi, S., Dehghani, S., Jazayeri, S., Aghababaee, S. K., Sabour, H., Saberi, H., Eghtesadi, M., & Gohari, M. R. (2015) · Spinal Cord · doi:10.1038/sc.2015.35 · Cited by 51 · see citing works
Chronic insulin treatment causes insulin resistance in 3T3-L1 adipocytes through oxidative stress
Ge, X., Yu, Q., Qi, W., Shi, X., & Zhai, Q. (2008) · Free Radical Research · doi:10.1080/10715760802158448 · Cited by 47 · see citing works
- Authors
- Jacob, S., Ruus, P., Hermann, R., Tritschler, H. J., Maerker, E., Renn, W., Augustin, H. J., Dietze, G. J., & Rett, K.
- Affiliations
- Max Grundig Klinik (DE)
- University of Tübingen (DE)
- Corresponding author
- Jacob, S
- ORCID
- Rett, K
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 1999-08
- Volume
- 27
- Issue
- 3-4
- Pages
- 309-314
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W2088208009
- Cited by
- 280
- References
- 36
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 7 · 2023: 4 · 2022: 4 · 2021: 4 · 2020: 10 · 2019: 9 · 2018: 7 · 2017: 5 · 2016: 4 · 2015: 7 · 2014: 15 · 2013: 23 · 2012: 14
- FWCI
- 4.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Biochemical Acid Research Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- alpha-lipoic acid, type 2 diabetes, insulin sensitivity, oral administration, glucose disposal, dose comparison
- MeSH terms
- Administration, Oral, Anthropometry, Diabetes Mellitus, Type 2, Female, Humans, Insulin Resistance, Thioctic Acid, Male, Middle Aged, Pilot Projects, Stereoisomerism, Glucose Clamp Technique, Free Radical Scavengers
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
