The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
The Interaction of CtIP and Nbs1 Connects CDK and ATM to Regulate HR–Mediated Double-Strand Break Repair
Open accessAbstract
CtIP plays an important role in homologous recombination (HR)-mediated DNA double-stranded break (DSB) repair and interacts with Nbs1 and BRCA1, which are linked to Nijmegen breakage syndrome (NBS) and familial breast cancer, respectively. We identified new CDK phosphorylation sites on CtIP and found that phosphorylation of these newly identified CDK sites induces association of CtIP with the N-terminus FHA and BRCT domains of Nbs1. We further showed that these CDK-dependent phosphorylation events are a prerequisite for ATM to phosphorylate CtIP upon DNA damage, which is important for end resection to activate HR by promoting recruitment of BLM and Exo1 to DSBs. Most notably, this CDK-dependent CtIP and Nbs1 interaction facilitates ATM to phosphorylate CtIP in a substrate-specific manner. These studies reveal one important mechanism to regulate cell-cycle-dependent activation of HR upon DNA damage by coupling CDK- and ATM-mediated phosphorylation of CtIP through modulating the interaction of CtIP with Nbs1, which significantly helps to understand how DSB repair is regulated in mammalian cells to maintain genome stability.
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Self-citationA Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1
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The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway
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A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase
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DNA double-strand breaks: signaling, repair and the cancer connection
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Double-Strand Break End Resection and Repair Pathway Choice
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Self-citationHuman CtIP promotes DNA end resection
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Cited by
Repair Pathway Choices and Consequences at the Double-Strand Break
Ceccaldi, R., Rondinelli, B., & D’Andrea, A. D. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.07.009 · Cited by 1,499
The control of DNA repair by the cell cycle
Hustedt, N., & Durocher, D. (2017) · Nature Cell Biology · doi:10.1038/ncb3452 · Cited by 738
Ionizing Radiation-Induced DNA Damage, Response, and Repair
Santivasi, W. L., & Xia, F. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5668 · Cited by 593
Hereditary breast and ovarian cancer: new genes in confined pathways
Nielsen, F. C., van Overeem Hansen, T., & Sørensen, C. S. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.72 · Cited by 367
BRCA1 and CtIP Are Both Required to Recruit Dna2 at Double-Strand Breaks in Homologous Recombination
Hoa, N. N., Kobayashi, J., Omura, M., Hirakawa, M., Yang, S.-H., Komatsu, K., Paull, T. T., Takeda, S., & Sasanuma, H. (2015) · PLOS ONE · doi:10.1371/journal.pone.0124495 · Cited by 38
Metadata
- Authors
- Wang, H., Shi, L. Z., Wong, C. C. L., Han, X., Hwang, P. Y.-H., Truong, L. N., Zhu, Q., Shao, Z., Chen, D. J., Berns, M. W., Yates, J. R., Chen, L., & Wu, X.
- Venue
- PLoS Genetics
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-02-28
- Volume
- 9
- Issue
- 2
- Pages
- e1003277
- ISSN
- 1553-7390 (ISSN-L)
- 1553-7404
- OpenAlex
- W1970038285
- Cited by
- 259
- References
- 66
- FWCI
- 8.20
- Type
- journal article
- Language
- en
- Open access
- gold
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- Wang, H., Shi, L. Z., Wong, C. C. L., Han, X., Hwang, P. Y.-H., Truong, L. N., Zhu, Q., Shao, Z., Chen, D. J., Berns, M. W., Yates, J. R., Chen, L., & Wu, X. (2013). The Interaction of CtIP and Nbs1 Connects CDK and ATM to Regulate HR–Mediated Double-Strand Break Repair. PLoS Genetics. https://doi.org/10.1371/journal.pgen.1003277
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