BRCA1 and CtIP Are Both Required to Recruit Dna2 at Double-Strand Breaks in Homologous Recombination
Open accessAbstract
Homologous recombination plays a key role in the repair of double-strand breaks (DSBs), and thereby significantly contributes to cellular tolerance to radiotherapy and some chemotherapy. DSB repair by homologous recombination is initiated by 5' to 3' strand resection (DSB resection), with nucleases generating the 3' single-strand DNA (3'ssDNA) at DSB sites. Genetic studies of Saccharomyces cerevisiae demonstrate a two-step DSB resection, wherein CtIP and Mre11 nucleases carry out short-range DSB resection followed by long-range DSB resection done by Dna2 and Exo1 nucleases. Recent studies indicate that CtIP contributes to DSB resection through its non-catalytic role but not as a nuclease. However, it remains elusive how CtIP contributes to DSB resection. To explore the non-catalytic role, we examined the dynamics of Dna2 by developing an immuno-cytochemical method to detect ionizing-radiation (IR)-induced Dna2-subnuclear-focus formation at DSB sites in chicken DT40 and human cell lines. Ionizing-radiation induced Dna2 foci only in wild-type cells, but not in Dna2 depleted cells, with the number of foci reaching its maximum at 30 minutes and being hardly detectable at 120 minutes after IR. Induced foci were detectable in cells in the G2 phase but not in the G1 phase. These observations suggest that Dna2 foci represent the recruitment of Dna2 to DSB sites for DSB resection. Importantly, the depletion of CtIP inhibited the recruitment of Dna2 to DSB sites in both human cells and chicken DT40 cells. Likewise, a defect in breast cancer 1 (BRCA1), which physically interacts with CtIP and contributes to DSB resection, also inhibited the recruitment of Dna2. Moreover, CtIP physically associates with Dna2, and the association is enhanced by IR. We conclude that BRCA1 and CtIP contribute to DSB resection by recruiting Dna2 to damage sites, thus ensuring the robust DSB resection necessary for efficient homologous recombination.
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ATG7, DNA2, and NBN encode DNA damage repair proteins in the DNA damage response, including homology-directed repair and non-homologous end joining for double-strand breaks.
“ATG7 is an autophagy-related protein [136] which can modulate p53-dependent cell cycle pathways during prolonged stress [78] and plays a critical role in homology-directed repair (HDR) of DSBs [46]. Similarly, DNA2 encodes a HDR DNA repair protein for repair of DSBs [62] and NBN encodes a non-homologous end joining (NHEJ) DNA repair protein for repair of DSBs [158].”
From Early onset senescence and cognitive impairment in a murine model of repeated mTBI (2021) · cites this paper as [62]
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1 retracted
RETRACTED: Human SIRT6 Promotes DNA End Resection Through CtIP Deacetylation
Kaidi, A., Weinert, B. T., Choudhary, C., & Jackson, S. P. (2010) · Science · doi:10.1126/science.1192049 · Cited by 366 · see citing works
RetractedPâques, F., & Haber, J. E. (1999) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.63.2.349-404.1999 · Cited by 2,120 · see citing works
A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage
Paull, T. T., Rogakou, E. P., Yamazaki, V., Kirchgessner, C. U., Gellert, M., & Bonner, W. M. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00610-2 · Cited by 2,098 · see citing works
Self-citationDouble-Strand Break End Resection and Repair Pathway Choice
Symington, L. S., & Gautier, J. (2011) · Annual Review of Genetics · doi:10.1146/annurev-genet-110410-132435 · Cited by 1,482 · see citing works
Human CtIP promotes DNA end resection
Sartori, A. A., Lukas, C., Coates, J., Mistrik, M., Fu, S., Bartek, J., Baer, R., Lukas, J., & Jackson, S. P. (2007) · Nature · doi:10.1038/nature06337 · Cited by 1,362 · see citing works
Sgs1 Helicase and Two Nucleases Dna2 and Exo1 Resect DNA Double-Strand Break Ends
Zhu, Z., Chung, W.-H., Shim, E. Y., Lee, S. E., & Ira, G. (2008) · Cell · doi:10.1016/j.cell.2008.08.037 · Cited by 1,041 · see citing works
Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing
Mimitou, E. P., & Symington, L. S. (2008) · Nature · doi:10.1038/nature07312 · Cited by 1,009 · see citing works
Escribano‐Diaz, C., Orthwein, A., Fradet‐Turcotte, A., Xing, M., Young, J. T. F., Tkáč, J., Cook, M. A., Rosebrock, A. P., Munro, M., Canny, M. D., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.01.001 · Cited by 903 · see citing works
The MRE11 complex: at the crossroads of DNA repair and checkpoint signalling
D'Amours, D., & Jackson, S. P. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm805 · Cited by 874 · see citing works
Rad51‐deficient vertebrate cells accumulate chromosomal breaks prior to cell death
Sonoda, E., Sasaki, M., Buerstedde, J., Bezzubova, O., Shinohara, A., Ogawa, H., Takata, M., Yamaguchi-Iwai, Y., & Takeda, S. (1998) · EMBO Journal · doi:10.1093/emboj/17.2.598 · Cited by 860 · see citing works
Self-citationNimonkar, A. V., Genschel, J., Kinoshita, E., Polaczek, P., Campbell, J. L., Wyman, C., Modrich, P. L., & Kowalczykowski, S. C. (2011) · Genes & Development · doi:10.1101/gad.2003811 · Cited by 767 · see citing works
Abraxas and RAP80 Form a BRCA1 Protein Complex Required for the DNA Damage Response
Wang, B., Matsuoka, S., Ballif, B. A., Zhang, D., Smogorzewska, A., Gygi, S. P., & Elledge, S. J. (2007) · Science · doi:10.1126/science.1139476 · Cited by 695 · see citing works
CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle
Yun, M. H., & Hiom, K. (2009) · Nature · doi:10.1038/nature07955 · Cited by 556 · see citing works
Increased ratio of targeted to random integration after transfection of chicken B cell lines
Buerstedde, J.-M., & Takeda, S. (1991) · Cell · doi:10.1016/0092-8674(91)90581-i · Cited by 543 · see citing works
Self-citationSonoda, E., Hochegger, H., Saberi, A., Taniguchi, Y., & Takeda, S. (2006) · DNA repair · doi:10.1016/j.dnarep.2006.05.022 · Cited by 527 · see citing works
Self-citationTruong, L. N., Li, Y., Shi, L. Z., Hwang, P. Y.-H., He, J. N., Wang, H., Razavian, N. B., Berns, M. W., & Wu, X. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1213431110 · Cited by 513 · see citing works
Bidirectional resection of DNA double-strand breaks by Mre11 and Exo1
Garcia, V., Phelps, S. E. L., Gray, S., & Neale, M. J. (2011) · Nature · doi:10.1038/nature10515 · Cited by 461 · see citing works
Yu, X., Wu, L. C., Bowcock, A. M., Aronheim, A., & Baer, R. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.39.25388 · Cited by 389 · see citing works
Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae
Niu, H., Chung, W.-H., Zhu, Z., Kwon, Y., Zhao, W., Chi, P., Prakash, R., Seong, C., Liu, D., Lu, L., et al. (2010) · Nature · doi:10.1038/nature09318 · Cited by 378 · see citing works
53BP1 Mediates Productive and Mutagenic DNA Repair through Distinct Phosphoprotein Interactions
Callén, E., Virgilio, M. D., Kruhlak, M. J., Nieto-Soler, M., Wong, N., Chen, H. T., Faryabi, R. B., Polato, F., Santos, M. A., Starnes, L. M., et al. (2013) · Cell · doi:10.1016/j.cell.2013.05.023 · Cited by 346 · see citing works
BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIPPreprint
Yu, X., Fu, S., Lai, M., Baer, R. J., & Chen, J. (2006) · Genes & Development · doi:10.1101/gad.1431006 · Cited by 283 · see citing works
Parp‐1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells
Hochegger, H., Dejsuphong, D., Fukushima, T., Morrison, C. G., Sonoda, E., Schreiber, V., Zhao, G., Saberi, A., Masutani, M., Adachi, N., et al. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601015 · Cited by 276 · see citing works
Self-citationMre11 is essential for the maintenance of chromosomal DNA in vertebrate cells
Yamaguchi‐Iwai, Y., Sonoda, E., Sasaki, M. S., Morrison, C., Haraguchi, T., Hiraoka, Y., Yamashita, Y. M., Yagi, T., Takata, M., Price, C., et al. (1999) · The EMBO Journal · doi:10.1093/emboj/18.23.6619 · Cited by 276 · see citing works
Self-citationWang, H., Shi, L. Z., Wong, C. C. L., Han, X., Hwang, P. Y.-H., Truong, L. N., Zhu, Q., Shao, Z., Chen, D. J., Berns, M. W., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003277 · Cited by 254 · see citing works
Whitfield, M. L., Zheng, L.-X., Baldwin, A. E., Ohta, T., Hurt, M. M., & Marzluff, W. F. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.12.4188-4198.2000 · Cited by 250 · see citing works
Multiple roles of Rev3, the catalytic subunit of polζ in maintaining genome stability in vertebrates
Sonoda, E., Okada, T., Zhao, G. Y., Tateishi, S., Araki, K., Yamaizumi, M., Yagi, T., Verkaik, N. S., van Gent, D. C., Takata, M., et al. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg308 · Cited by 204 · see citing works
Self-citationCatalytic and Noncatalytic Roles of the CtIP Endonuclease in Double-Strand Break End Resection
Makharashvili, N., Tubbs, A., Yang, S.-H., Wang, H., Barton, O., Zhou, Y., Deshpande, R. A., Lee, J., Löbrich, M., Sleckman, B. P., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.04.011 · Cited by 179 · see citing works
Self-citationNakamura, K. M., Kogame, T., Oshiumi, H., Shinohara, A., Sumitomo, Y., Agama, K., Pommier, Y. G., Tsutsui, K., Tsutsui, K., Hartsuiker, E., et al. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000828 · Cited by 149 · see citing works
Self-citationWang, H., Li, Y., Truong, L. N., Shi, L. Z., Hwang, P. Y.-H., He, J. N., Do, J. P. H., Cho, M. J., Li, H., Negrete, A., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.04.012 · Cited by 141 · see citing works
Activation of DSB Processing Requires Phosphorylation of CtIP by ATR
Peterson, S., Li, Y., Wu-Baer, F., Chait, B. T., Baer, R. J., Yan, H., Gottesman, M. E., & Gautier, J. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.11.020 · Cited by 131 · see citing works
DNA end resection by CtIP and exonuclease 1 prevents genomic instability
Eid, W., Steger, M., El‐Shemerly, M., Ferretti, L. P., Peña-Dı́az, J., König, C., Valtorta, E., Sartori, A. A., & Ferrari, S. M. (2010) · EMBO Reports · doi:10.1038/embor.2010.157 · Cited by 126 · see citing works
Delia, D. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh221 · Cited by 120 · see citing works
Nakamura, K. M., Sakai, W., Kawamoto, T., Bree, R. T., Lowndes, N. F., Takeda, S., & Taniguchi, Y. (2006) · DNA repair · doi:10.1016/j.dnarep.2006.03.008 · Cited by 111 · see citing works
Self-citationBiochemical analysis of human Dna2
Masuda-Sasa, T. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl070 · Cited by 97 · see citing works
Human Nuclease/Helicase DNA2 Alleviates Replication Stress by Promoting DNA End Resection
Peng, G., Dai, H., Zhang, W., Hsieh, H.-J., Pan, M., Park, Y., Tsai, R. Y. L., Bedrosian, I., Lee, J., Ira, G., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-3152 · Cited by 74 · see citing works
CtIP-dependent DNA resection is required for DNA damage checkpoint maintenance but not initiation
Kousholt, A. N., Fugger, K., Hoffmann, S., Larsen, B. D., Menzel, T., Sartori, A. A., & Sørensen, C. S. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201111065 · Cited by 72 · see citing works
The Epistatic Relationship between BRCA2 and the Other RAD51 Mediators in Homologous Recombination
Qing, Y., Yamazoe, M., Hirota, K., Dejsuphong, D., Sakai, W., Yamamoto, K. N., Bishop, D. K., Wu, X., & Takeda, S. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002148 · Cited by 72 · see citing works
Self-citationRAP80 Acts Independently of BRCA1 in Repair of Topoisomerase II Poison-Induced DNA Damage
Iijima, J., Zeng, Z., Takeda, S., & Taniguchi, Y. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0267 · Cited by 11 · see citing works
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Flagged first, then by citations
1 of the 39 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Mechanism and regulation of DNA end resection in eukaryotes
Symington, L. S. (2016) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2016.1172552 · Cited by 368 · see citing works
Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes
Hoa, N. N., Shimizu, T., Zhou, Z., Wang, Z., Deshpande, R. A., Paull, T. T., Akter, S., Tsuda, M., Furuta, R., Tsutsui, K., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.10.011 · Cited by 181 · see citing works
Self-citationMultiple roles of DNA2 nuclease/helicase in DNA metabolism, genome stability and human diseases
Zheng, L., Meng, Y., Campbell, J. L., & Shen, B. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz1101 · Cited by 108 · see citing works
Platinum-based systematic therapy in triple-negative breast cancer
Zhu, Y., Hu, Y., Tang, C., Guan, X., & Zhang, W. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188678 · Cited by 90 · see citing works
A Selective Small Molecule DNA2 Inhibitor for Sensitization of Human Cancer Cells to Chemotherapy
Liu, W., Zhou, M., Li, Z., Li, H., Polaczek, P., Dai, H., Wu, Q., Liu, C., Karanja, K. K., Popuri, V., et al. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.02.043 · Cited by 89 · see citing works
CtIP promotes the motor activity of DNA2 to accelerate long-range DNA end resection
Ceppi, I., Howard, S. M., Kasaciunaite, K., Pinto, C., Anand, R., Seidel, R., & Ćejka, P. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2001165117 · Cited by 79 · see citing works
Mechanism of BRCA1–BARD1 function in DNA end resection and DNA protection
Ceppi, I., Stritto, M. R. D., Mütze, M., Braunshier, S., Mengoli, V., Reginato, G., Võ, H. M. P., Jimeno, S., Acharya, A., Roy, M. M., et al. (2024) · Nature · doi:10.1038/s41586-024-07909-9 · Cited by 68 · see citing works
Inhibition of DNA2 nuclease as a therapeutic strategy targeting replication stress in cancer cells
Kumar, S., Peng, X., Daley, J. M., Yang, L., Shen, J., Nguyen, N. C., Bae, G., Niu, H., Peng, Y., Hsieh, H.-J., et al. (2017) · Oncogenesis · doi:10.1038/oncsis.2017.15 · Cited by 63 · see citing works
Hoa, N. N., Akagawa, R., Yamasaki, T., Hirota, K., Sasa, K., Natsume, T., Kobayashi, J., Sakuma, T., Yamamoto, T., Komatsu, K., et al. (2015) · Genes to Cells · doi:10.1111/gtc.12310 · Cited by 49 · see citing works
Self-citationMijnes, J., Veeck, J., Gaisa, N. T., Burghardt, E., de Ruijter, T. C., Gostek, S., Dahl, E., Pfister, D. J. K. P., Schmid, S. C., Knüchel, R., et al. (2018) · Clinical Epigenetics · doi:10.1186/s13148-018-0447-6 · Cited by 49 · see citing works
Yu, T.-Y., Kimble, M. T., & Symington, L. S. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1816539115 · Cited by 47 · see citing works
EXO1 protects BRCA1-deficient cells against toxic DNA lesions
van de Kooij, B., Schreuder, A., Pavani, R., Garzero, V., Uruci, S., Wendel, T. J., van Hoeck, A., Alonso, M. S. M., Everts, M., Koerse, D., et al. (2024) · Molecular Cell · doi:10.1016/j.molcel.2023.12.039 · Cited by 46 · see citing works
DNA end resection during homologous recombination
Gnügge, R., & Symington, L. S. (2021) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2021.07.004 · Cited by 43 · see citing works
Kruspe, S., Dickey, D. D., Urak, K. T., Blanco, G. N., Miller, M. J., Clark, K. C., Burghardt, E. L., Gutierrez, W. R., Phadke, S. D., Kamboj, S., et al. (2017) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2017.08.004 · Cited by 40 · see citing works
Early onset senescence and cognitive impairment in a murine model of repeated mTBI
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Isobe, S.-Y., Hiraga, S., Nagao, K., Sasanuma, H., Donaldson, A. D., & Obuse, C. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109383 · Cited by 28 · see citing works
Self-citation“Back to a false normality”: new intriguing mechanisms of resistance to PARP inhibitors
Incorvaia, L., Passiglia, F., Rizzo, S., Galvano, A., Listì, A., Barraco, N., Maragliano, R., Calò, V., Natoli, C., Ciaccio, M., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.14409 · Cited by 26 · see citing works
Tomasini, P. P., Guecheva, T. N., Leguisamo, N. M., Péricart, S., Brunac, A., Hoffmann, J., & Saffi, J. (2021) · Cancers · doi:10.3390/cancers13133130 · Cited by 24 · see citing works
Role of human DNA2 (hDNA2) as a potential target for cancer and other diseases: A systematic review
Jia, P., Junaid, M., Ma, Y., Ahmad, F., Jia, Y., Li, W., & Pei, D. (2017) · DNA repair · doi:10.1016/j.dnarep.2017.09.001 · Cited by 23 · see citing works
Liu, W., Polaczek, P., Roubal, I., Meng, Y., Choe, W., Caron, M., Sedgeman, C. A., Yu, X., Liu, C., Wu, Q., et al. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad624 · Cited by 22 · see citing works
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Falquet, B., Ölmezer, G., Enkner, F., Klein, D., Challa, K., Appanah, R., Gasser, S. M., & Rass, U. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa524 · Cited by 15 · see citing works
Nakano, T., Akamatsu, K., Kohzaki, M., Tsuda, M., Hirayama, R., Sassa, A., Yasui, M., Shoulkamy, M. I., Hiromoto, T., Tamada, T., et al. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae1077 · Cited by 12 · see citing works
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Cybulla, E., Wallace, S., Meroni, A., Jackson, J., Agashe, S., Tennakoon, M., Limbu, M., Quinet, A., Lomonosova, E. E., Noia, H. M., et al. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae563 · Cited by 11 · see citing works
Sasanuma, H., Yamada, S., Tsuda, M., & Takeda, S. (2020) · DNA repair · doi:10.1016/j.dnarep.2020.102913 · Cited by 10 · see citing works
Self-citationHu, X., Wu, X., Liu, H., Cheng, Z., Zhao, Z., Xiang, C., Feng, X., Takeda, S., & Qing, Y. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.27082 · Cited by 9 · see citing works
Self-citationMohanad, M., Yousef, H. F., & Bahnassy, A. A. (2022) · Molecular Genetics and Genomics · doi:10.1007/s00438-022-01950-x · Cited by 8 · see citing works
Shimizu, N., Akagawa, R., Takeda, S., & Sasanuma, H. (2020) · Genome Instability & Disease · doi:10.1007/s42764-020-00015-w · Cited by 7 · see citing works
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Mojumdar, A., Adam, N., & Cobb, J. A. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.101937 · Cited by 7 · see citing works
Xiang, C., Wu, X., Zhao, Z., Feng, X., Bai, X., Liu, X., Zhao, J., Takeda, S., & Qing, Y. (2020) · Toxicology in Vitro · doi:10.1016/j.tiv.2020.104825 · Cited by 7 · see citing works
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van de Kooij, B., Schreuder, A., Pavani, R., Garzero, V., van Hoeck, A., Alonso, M. S. M., Koerse, D., Wendel, T. J., Callen, E., Boom, J., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.24.529205 · Cited by 4 · see citing works
Physiological concentrations of glucocorticoids induce pathological DNA double‐strand breaks
Akter, S., Shimba, A., Ikuta, K., Mahmud, M. R. A., Yamada, S., Sasanuma, H., Tsuda, M., Sone, M., Ago, Y., Murai, K., et al. (2022) · Genes to Cells · doi:10.1111/gtc.12993 · Cited by 2 · see citing works
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- Authors
- Hoa, N. N., Kobayashi, J., Omura, M., Hirakawa, M., Yang, S.-H., Komatsu, K., Paull, T. T., Takeda, S., & Sasanuma, H.
- Affiliations
- Kyoto University (JP)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Takeda, Shunichi
- Sasanuma, Hiroyuki
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2015-04-24
- Volume
- 10
- Issue
- 4
- Pages
- e0124495
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4409214
- OpenAlex
- W2043876753
- Cited by
- 38
- References
- 39
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- 2024: 4 · 2023: 1 · 2022: 4 · 2021: 6 · 2020: 6 · 2019: 1 · 2018: 6 · 2017: 4 · 2016: 5 · 2015: 1
- FWCI
- 2.32
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
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- Europe PMC (PubMed Central) (publishedVersion, cc-by)
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- Figshare (submittedVersion, cc-by)
- Kyoto University Research Information Repository (Kyoto University) (submittedVersion, cc-by)
- Kyoto University Research Information Repository (Kyoto University) (submittedVersion)
- Funders
- Japan Society for the Promotion of Science (26550025, 26241013)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
- Keywords
- BRCA1, CtIP, DNA2, homologous recombination, DNA double-strand break repair, DNA end resection, ionizing radiation, protein recruitment, Saccharomyces cerevisiae, DT40 cells, G2 phase
- MeSH terms
- Animals, Binding Sites, Carrier Proteins, Cell Line, Chickens, Chromosome Aberrations, DNA Helicases, Endodeoxyribonucleases, Enzyme Activation, Epistasis, Genetic, Humans, Mutation, Nuclear Proteins, Protein Binding, BRCA1 Protein, Protein Transport, Rad51 Recombinase, DNA Breaks, Double-Stranded, Gene Knock-In Techniques, Cell Cycle Checkpoints, Homologous Recombination
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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