The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
The G4 Genome
Open accessAbstract
Recent experiments provide fascinating examples of how G4 DNA and G4 RNA structures--aka quadruplexes--may contribute to normal biology and to genomic pathologies. Quadruplexes are transient and therefore difficult to identify directly in living cells, which initially caused skepticism regarding not only their biological relevance but even their existence. There is now compelling evidence for functions of some G4 motifs and the corresponding quadruplexes in essential processes, including initiation of DNA replication, telomere maintenance, regulated recombination in immune evasion and the immune response, control of gene expression, and genetic and epigenetic instability. Recognition and resolution of quadruplex structures is therefore an essential component of genome biology. We propose that G4 motifs and structures that participate in key processes compose the G4 genome, analogous to the transcriptome, proteome, or metabolome. This is a new view of the genome, which sees DNA as not only a simple alphabet but also a more complex geography. The challenge for the future is to systematically identify the G4 motifs that form quadruplexes in living cells and the features that confer on specific G4 motifs the ability to function as structural elements.
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A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD
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Shelterin: the protein complex that shapes and safeguards human telomeres
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Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication
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Expandable DNA repeats and human disease
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Small-molecule–induced DNA damage identifies alternative DNA structures in human genes
Rodriguez, R., Miller, K. M., Forment, J. V., Bradshaw, C. R., Nikan, M., Britton, S., Oelschlaegel, T., Xhemalce, B., Balasubramanian, S., & Jackson, S. P. (2012) · Nature Chemical Biology · doi:10.1038/nchembio.780 · Cited by 741
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Regulation of Murine Telomere Length by Rtel
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Mutagenic Capacity of Endogenous G4 DNA Underlies Genome Instability in FANCJ-Defective C. elegans
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Rudimentary G-quadruplex-based telomere capping in Saccharomyces cerevisiae
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Cited by
Biffi, G., Di Antonio, M., Tannahill, D., & Balasubramanian, S. (2014) · Nature Chemistry · doi:10.1038/nchem.1805 · Cited by 606
Heterochromatin protein 1α interacts with parallel RNA and DNA G-quadruplexes
Roach, R. J., Garavís, M., González, C., Jameson, G. B., Filichev, V. V., & Hale, T. K. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkz1138 · Cited by 518
Maizels, N. (2015) · EMBO reports · doi:10.15252/embr.201540607 · Cited by 305
Self-citationFunctions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1
Nguyen, H. D., Yadav, T., Giri, S., Saez, B., Graubert, T. A., & Zou, L. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.01.029 · Cited by 267
Bloom's Syndrome: Clinical Spectrum, Molecular Pathogenesis, and Cancer Predisposition
Cunniff, C., Bassetti, J. A., & Ellis, N. A. (2017) · Molecular Syndromology · doi:10.1159/000452082 · Cited by 265
Metadata
- Authors
- Maizels, N., & Gray, L. T.
- Venue
- PLoS Genetics
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-04-18
- Volume
- 9
- Issue
- 4
- Pages
- e1003468
- ISSN
- 1553-7390 (ISSN-L)
- 1553-7404
- OpenAlex
- W2007634776
- Cited by
- 491
- References
- 10
- FWCI
- 20.98
- Type
- journal article
- Language
- en
- Open access
- gold
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