Genetic compensation: A phenomenon in search of mechanisms

Network biology: understanding the cell's functional organization

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Untitled work

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Functional profiling of the Saccharomyces cerevisiae genome

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Gene Action in the X-chromosome of the Mouse (Mus musculus L.)

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The Transcriptional Landscape of the Mammalian Genome

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Nature, Nurture, or Chance: Stochastic Gene Expression and Its Consequences

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Antisense Transcription in the Mammalian Transcriptome

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MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship

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Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke

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RNA‐binding proteins and post‐transcriptional gene regulation

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The long noncoding RNA Malat1 regulates CD8+ T cell differentiation by mediating epigenetic repression

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Combined shRNA over CRISPR/cas9 as a methodology to detect off-target effects and a potential compensatory mechanism

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Genetic paradox explained by nonsense

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A SlCLV3-SlWUS module regulates auxin and ethylene homeostasis in low light-induced tomato flower abscission

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A Regeneration Toolkit

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An Improved CRISPR/dCas9 Interference Tool for Neuronal Gene Suppression

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C1GALT1 high expression is associated with poor survival of patients with pancreatic ductal adenocarcinoma and promotes cell invasiveness through integrin αv

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Renal Ciliopathies: Sorting Out Therapeutic Approaches for Nephronophthisis

Stokman, M. F., Saunier, S., & Benmerah, A. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.653138 · Cited by 43

Endothelial pannexin 1–TRPV4 channel signaling lowers pulmonary arterial pressure in mice

Daneva, Z., Ottolini, M., Chen, Y., Klimentova, E., Kuppusamy, M., Shah, S. A., Minshall, R. D., Seye, C. I., Laubach, V. E., Isakson, B. E., et al. (2021) · eLife · doi:10.7554/elife.67777 · Cited by 40

GPR37L1 identifies spinal cord astrocytes and protects neuropathic pain after nerve injury

Xu, J., Yan, Z., Bang, S., Velmeshev, D., & Ji, R. (2025) · Neuron · doi:10.1016/j.neuron.2025.01.012 · Cited by 46

Melanin-concentrating hormone and food intake control: Sites of action, peptide interactions, and appetition

Lord, M. N., Subramanian, K. S., Kanoski, S. E., & Noble, E. E. (2020) · Peptides · doi:10.1016/j.peptides.2020.170476 · Cited by 43

PSCs Reveal PUFA-Provoked Mitochondrial Stress as a Central Node Potentiating RPE Degeneration in Bietti’s Crystalline Dystrophy

Zhang, Z., Yan, B., Gao, F., Li, Q., Meng, X., Chen, P., Zhou, L., Deng, W., Li, C., Xu, W., et al. (2020) · Molecular Therapy · doi:10.1016/j.ymthe.2020.07.024 · Cited by 42

Acute HSF1 depletion induces cellular senescence through the MDM2-p53-p21 pathway in human diploid fibroblasts

Oda, T., Sekimoto, T., Kurashima, K., Fujimoto, M., Nakai, A., & Yamashita, T. (2018) · Journal of Cell Science · doi:10.1242/jcs.210724 · Cited by 42

Telomerase Deficiency Predisposes to Heart Failure and Ischemia-Reperfusion Injury

Ait‐Aissa, K., Heisner, J. S., Toro, L. N., Bruemmer, D., Doyon, G., Harmann, L. M., Geurts, A. M., Camara, A. K. S., & Beyer, A. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00031 · Cited by 41

Dopamine regulation of contextual fear and associated neural circuit function

Stubbendorff, C., & Stevenson, C. W. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14772 · Cited by 42

Epicardial Contribution to the Developing and Injured Heart: Exploring the Cellular Composition of the Epicardium

Streef, T. J., & Smits, A. M. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.750243 · Cited by 41

Transcriptional adaptation upregulates utrophin in Duchenne muscular dystrophy

Falcucci, L., Dooley, C. M., Adamóski, D., Juan, T., Martinez, J., Georgieva, A. M., Mamchaoui, K., Cirzi, C., & Stainier, D. Y. R. (2025) · Nature · doi:10.1038/s41586-024-08539-x · Cited by 40

Cyclic nucleotide‐dependent inhibitory signaling interweaves with activating pathways to determine platelet responses

Nagy, Z., & Smolenski, A. (2018) · Research and Practice in Thrombosis and Haemostasis · doi:10.1002/rth2.12122 · Cited by 40

The conditional nature of gene essentiality

Larrimore, K. E., & Rancati, G. I. (2019) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2019.07.015 · Cited by 39

Genetic dissection of the auxin response network

Israeli, A., Reed, J. W., & Ori, N. (2020) · Nature Plants · doi:10.1038/s41477-020-0739-7 · Cited by 42

Specific Hippocampal Interneurons Shape Consolidation of Recognition Memory

da Cruz, J. F. O., Busquets-García, A., Zhao, Z., Varilh, M., Lavanco, G., Bellocchio, L., Robin, L. M., Cannich, A., Julio‐Kalajzić, F., Lesté-Lasserre, T., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2020.108046 · Cited by 42

Genetics in Light of Transcriptional Adaptation

Kontarakis, Z., & Stainier, D. Y. R. (2020) · Trends in Genetics · doi:10.1016/j.tig.2020.08.008 · Cited by 41

Human carboxylesterases and fluorescent probes to image their activity in live cells

Singh, A., Gao, M., & Beck, M. W. (2021) · RSC Medicinal Chemistry · doi:10.1039/d1md00073j · Cited by 40

NEIL1 and NEIL2 DNA glycosylases protect neural crest development against mitochondrial oxidative stress

Han, D., Schomacher, L., Schüle, K. M., Mallick, M., Musheev, M. U., Karaulanov, E., Krebs, L., von Seggern, A., & Niehrs, C. (2019) · eLife · doi:10.7554/elife.49044 · Cited by 38

Applying Antibodies Inside Cells: Principles and Recent Advances in Neurobiology, Virology and Oncology

Zhang, C., Ötjengerdes, R., Roewe, J., Mejı́as, R., & Marschall, A. L. J. (2020) · BioDrugs · doi:10.1007/s40259-020-00419-w · Cited by 44

Novel Fanconi renotubular syndromes provide insights in proximal tubule pathophysiology

Lemaire, M. J. (2020) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00214.2020 · Cited by 39

Craniofacial genetics: Where have we been and where are we going?

Weinberg, S. M., Cornell, R. A., & Leslie, E. J. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007438 · Cited by 40

Mir-126 is a conserved modulator of lymphatic development

Kontarakis, Z., Rossi, A., Ramas, S., Dellinger, M. T., & Stainier, D. Y. R. (2018) · Developmental Biology · doi:10.1016/j.ydbio.2018.03.006 · Cited by 38

Isoflurane affects brain functional connectivity in rats 1 month after exposure

Stenroos, P., Pirttimäki, T., Paasonen, J., Paasonen, E., Salo, R. A., Koivisto, H., Natunen, T., Mäkinen, P. M., Kuulasmaa, T., Hiltunen, M. O., et al. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.117987 · Cited by 37

Rare mutations in the complement regulatory gene CSMD1 are associated with male and female infertility

Lee, A. S., Rusch, J., Lima, A. C., Usmani, A., Huang, N., Lepamets, M., Vigh‐Conrad, K. A., Worthington, R. E., Mägi, R., Wu, X., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12522-w · Cited by 42

SCO-spondin, a giant matricellular protein that regulates cerebrospinal fluid activity

Sepúlveda, V., Maurelia, F., González, M., Aguayo, J., & Caprile, T. (2021) · Fluids and Barriers of the CNS · doi:10.1186/s12987-021-00277-w · Cited by 45

Fishing forward and reverse: Advances in zebrafish phenomics

Fuentes, R., Letelier, J., Tajer, B. J., Valdivia, L. E., & Mullins, M. C. (2018) · Mechanisms of Development · doi:10.1016/j.mod.2018.08.007 · Cited by 38

LAMP3 deficiency affects surfactant homeostasis in mice

Lunding, L. P., Krause, D., Stichtenoth, G., Stamme, C., Lauterbach, N., Hegermann, J., Ochs, M., Schuster, B., Sedláček, R., Säftig, P., et al. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009619 · Cited by 36

NLRP6 contributes to inflammation and brain injury following intracerebral haemorrhage by activating autophagy

Xiao, H., Chen, H., Jiang, R., Zhang, L., Wang, L., Gan, H. K., Jiang, N., Zhao, J., Zhai, X., & Liang, P. (2020) · Journal of Molecular Medicine · doi:10.1007/s00109-020-01962-3 · Cited by 36

NADPH Oxidases Are Required for Full Platelet Activation In Vitro and Thrombosis In Vivo but Dispensable for Plasma Coagulation and Hemostasis

Vara, D. S., Mailer, R. K., Tarafdar, A., Wolska, N., Heestermans, M., Konrath, S., Spaeth, M., Renné, T., Schröder, K., & Pula, G. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.315565 · Cited by 38

A specific inhibitor of ALDH1A3 regulates retinoic acid biosynthesis in glioma stem cells

Li, J., Garavaglia, S., Ye, Z., Moretti, A., Belyaeva, O. V., Beiser, A., Ibrahim, M., Wilk, A. M., McClellan, S., Klyuyeva, A. V., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-02949-7 · Cited by 40

Pxr- and Nrf2- mediated induction of ABC transporters by heavy metal ions in zebrafish embryos

Hu, J., Tian, J., Zhang, F., Wang, H., & Yin, J. B. (2019) · Environmental Pollution · doi:10.1016/j.envpol.2019.113329 · Cited by 35

Dysregulation of STAT3 signaling is associated with endplate-oriented herniations of the intervertebral disc in Adgrg6 mutant mice

Liu, Z.-Y., Easson, G. W. D., Zhao, J.-J., Makki, N., Ahituv, N., Hilton, M. J., Tang, S. Y., & Gray, R. (2019) · PLoS Genetics · doi:10.1371/journal.pgen.1008096 · Cited by 31

Canalization and Robustness in Human Genetics and Disease

Gibson, G. C., & Lacek, K. A. (2020) · Annual Review of Genetics · doi:10.1146/annurev-genet-022020-022327 · Cited by 34

CB1 Receptors in the Anterior Piriform Cortex Control Odor Preference Memory

Terral, G., Busquets-García, A., Varilh, M., Achicallende, S., Cannich, A., Bellocchio, L., Río, I. B., Massa, F., Puente, N., Gómez, E. S., et al. (2019) · Current Biology · doi:10.1016/j.cub.2019.06.041 · Cited by 34

Effects of FGF14 and NaVβ4 deletion on transient and resurgent Na current in cerebellar Purkinje neurons

White, H. V., Brown, S. T., Bozza, T. C., & Raman, I. M. (2019) · The Journal of General Physiology · doi:10.1085/jgp.201912390 · Cited by 34

Defining the Neural Kinome: Strategies and Opportunities for Small Molecule Drug Discovery to Target Neurodegenerative Diseases

Krahn, A. I., Wells, C. I., Drewry, D. H., Beitel, L. K., Durcan, T. M., & Axtman, A. D. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00176 · Cited by 33

Machine learning-assisted discovery of growth decision elements by relating bacterial population dynamics to environmental diversity

Aida, H., Hashizume, T., Ashino, K., & Ying, B. (2022) · eLife · doi:10.7554/elife.76846 · Cited by 34

Phosphodiesterase inhibitors in psychiatric disorders

Sadeghi, M. A., Nassireslami, E., Zoshk, M. Y., Hosseini, Y., Abbasian, K., & Chamanara, M. (2023) · Psychopharmacology · doi:10.1007/s00213-023-06361-3 · Cited by 34

Functional genomic tools for emerging model species

Gudmunds, E., Wheat, C. W., Khila, A., & Husby, A. (2022) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2022.07.004 · Cited by 33

Rabs in Signaling and Embryonic Development

Nassari, S., Olmo, T. D., & Jean, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031064 · Cited by 37

Genetic compensation prevents myopathy and heart failure in an in vivo model of Bag3 deficiency

Diofano, F., Weinmann, K., Schneider, I., Thiessen, K. D., Rottbauer, W., & Just, S. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1009088 · Cited by 35

Design of efficacious somatic cell genome editing strategies for recessive and polygenic diseases

Carlson-Stevermer, J., Das, A., Abdeen, A. A., Fiflis, D., Grindel, B. I., Saxena, S., Akcan, T., Alam, T., Kletzien, H., Kohlenberg, L., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-20065-8 · Cited by 32

TNFα and IFNγ cooperate for efficient pro- to anti-inflammatory transition of macrophages during muscle regeneration

Babaeijandaghi, F., Paiero, A., Long, R., Tung, L. W., Smith, S. P., Cheng, R., Smandych, J., Kajabadi, N., Chang, C.-K., Ghassemi, A., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2209976119 · Cited by 35

Vascular Smooth Muscle TRPV4 (Transient Receptor Potential Vanilloid Family Member 4) Channels Regulate Vasoconstriction and Blood Pressure in Obesity

Zhu, Y., Chu, Y., Wang, S., Tang, J., Li, H., Feng, L., Yu, F., & Ma, X. (2023) · Hypertension · doi:10.1161/hypertensionaha.122.20109 · Cited by 32

Actuation of single downstream nodes in growth factor network steers immune cell migration

Pal, D. S., Banerjee, T., Lin, Y., de Trogoff, F., Borleis, J. A., Iglesias, P. A., & Devreotes, P. N. (2023) · Developmental Cell · doi:10.1016/j.devcel.2023.04.019 · Cited by 28

Reversible silencing of endogenous receptors in intact brain tissue using 2-photon pharmacology

Pittolo, S., Lee, H., Lladó, A., Tosi, S., Bosch, M., Bardia, L., Gómez‐Santacana, X., Llebaria, A., Soriano, E., Colombelli, J., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1900430116 · Cited by 34

Functional characterization of a novel PBX1 de novo missense variant identified in a patient with syndromic congenital heart disease

Alankarage, D., Szot, J. O., Pachter, N., Slavotinek, A. M., Selleri, L., Shieh, J. T. C., Winlaw, D. S., Giannoulatou, E., Chapman, G., & Dunwoodie, S. L. (2019) · Human Molecular Genetics · doi:10.1093/hmg/ddz231 · Cited by 32

Bi-allelic premature truncating variants in LTBP1 cause cutis laxa syndrome

Pottie, L., Adamo, C. S., Beyens, A., Lütke, S., Tapaneeyaphan, P., Clercq, A. D., Salmon, P., Rycke, R. M. D., Gezdirici, A., Güleç, E. Y., et al. (2021) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2021.04.016 · Cited by 34

Esrp1-Regulated Splicing of Arhgef11 Isoforms Is Required for Epithelial Tight Junction Integrity

Lee, S., Cieply, B. W., Yang, Y., Peart, N. J., Glaser, C., Chan, P., & Carstens, R. P. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.10.097 · Cited by 28

Gnrh2 maintains reproduction in fasting zebrafish through dynamic neuronal projection changes and regulation of gonadotropin synthesis, oogenesis, and reproductive behaviors

Marvel, M., Levavi‐Sivan, B., Wong, T., Zmora, N., & Zohar, Y. (2021) · Scientific Reports · doi:10.1038/s41598-021-86018-3 · Cited by 31

GABAAR α2-activated neuroimmune signal controls binge drinking and impulsivity through regulation of the CCL2/CX3CL1 balance

Aurelian, L., & Balan, I. S. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05220-4 · Cited by 31

CDNF and MANF regulate ER stress in a tissue-specific manner

Pakarinen, E., Lindholm, P., Saarma, M., & Lindahl, M. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04157-w · Cited by 30

Ultrastructural and biochemical features of cerebral microvessels of adult rat subjected to a low dose of silver nanoparticles.

Dąbrowska‐Bouta, B., Sułkowski, G., Frontczak‐Baniewicz, M., Skalska, J., Sałek, M., Orzelska‐Górka, J., & Strużyńska, L. (2018) · Toxicology · doi:10.1016/j.tox.2018.06.009 · Cited by 30

Understanding neurobehavioral genetics of zebrafish

Cheresiz, S. V., Volgin, A. D., Evsyukova, A. K., Bashirzade, A. A., Demin, K. A., de Abreu, M. S., Amstislavskaya, T. G., & Kalueff, A. V. (2020) · Journal of Neurogenetics · doi:10.1080/01677063.2019.1698565 · Cited by 32

Genotyping and Quantification of In Situ Hybridization Staining in Zebrafish

Dobrzycki, T., Krecsmarik, M., & Monteiro, R. M. (2020) · Journal of Visualized Experiments · doi:10.3791/59956 · Cited by 29

KIF14 controls ciliogenesis via regulation of Aurora A and is important for Hedgehog signaling

Pejšková, P., Reilly, M. L., Binó, L., Bernatík, O., Dolanská, L., Ganji, R. S., Zdráhal, Z., Benmerah, A., & Čajánek, L. (2020) · The Journal of Cell Biology · doi:10.1083/jcb.201904107 · Cited by 31

Nestin Is Required for Spindle Assembly and Cell-Cycle Progression in Glioblastoma Cells

Wang, Q., Wu, H., Hu, J., Fu, H., Qu, Y., Yang, Y., Cai, K. Q., Efimov, A., Wu, M., Yen, T. J., et al. (2021) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-20-0994 · Cited by 38

The GABAA Receptor α2 Subunit Activates a Neuronal TLR4 Signal in the Ventral Tegmental Area that Regulates Alcohol and Nicotine Abuse

Balan, I. S., Warnock, K. T., Puché, A. C., Gondré‐Lewis, M. C., June, H. L., & Aurelian, L. (2018) · Brain Sciences · doi:10.3390/brainsci8040072 · Cited by 28

The role of extracellular matrix stiffness in regulating cytoskeletal remodeling via vinculin in synthetic smooth muscle cells

Shen, K., Kenche, H., Zhao, H., Li, J., & Stone, J. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.11.142 · Cited by 28

Dual separable feedback systems govern firing rate homeostasis

Kulik, Y. D., Jones, R., Moughamian, A. J., Whippen, J., & Davis, G. W. (2019) · eLife · doi:10.7554/elife.45717 · Cited by 28

Marcksb plays a key role in the secretory pathway of zebrafish Bmp2b

Ding, Y., Wang, X., Wei, C., He, M., Wang, H., Wang, Y., Zhu, Z., & Sun, Y. (2019) · PLoS Genetics · doi:10.1371/journal.pgen.1008306 · Cited by 28

Large-scale generation and phenotypic characterization of zebrafish CRISPR mutants of DNA repair genes

Shin, U., Nakhro, K., Oh, C., Carrington, B., Song, H., Varshney, G. K., Kim, Y., Song, H., Jeon, S., Robbins, G. M., et al. (2021) · DNA repair · doi:10.1016/j.dnarep.2021.103173 · Cited by 30

A novel, ataxic mouse model of ataxia telangiectasia caused by a clinically relevant nonsense mutation

Perez, H. D., Abdallah, M. F., Chavira, J. I., Norris, A. S., Egeland, M. T., Vo, K. L., Buechsenschuetz, C. L., Sanghez, V., Kim, J. L., Pind, M., et al. (2021) · eLife · doi:10.7554/elife.64695 · Cited by 26

Lack of the myotendinous junction marker col22a1 results in posture and locomotion disabilities in zebrafish

Malbouyres, M., Guiraud, A., Lefrançois, C., Salamito, M., Nauroy, P., Bernard, L., Sohm, F., Allard, B., & Ruggiero, F. (2022) · Matrix Biology · doi:10.1016/j.matbio.2022.03.002 · Cited by 28

Analysis of a conditional gene trap reveals that tbx5a is required for heart regeneration in zebrafish

Grajevskaja, V., Camerota, D., Bellipanni, G., Balciuniene, J., & Balciunas, D. (2018) · PLoS ONE · doi:10.1371/journal.pone.0197293 · Cited by 29

Selective Depletion of CREB in Serotonergic Neurons Affects the Upregulation of Brain-Derived Neurotrophic Factor Evoked by Chronic Fluoxetine Treatment

Rafa–Zabłocka, K., Kreiner, G., Bagińska, M., & Nalepa, I. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00637 · Cited by 30

BACH family members regulate angiogenesis and lymphangiogenesis by modulating VEGFC expression

Cohen, B., Tempelhof, H., Raz, T., Oren, R., Nicenboim, J., Bochner, F., Even, R., Jelinski, A., Eilam, R., Ben‐Dor, S., et al. (2020) · Life Science Alliance · doi:10.26508/lsa.202000666 · Cited by 28

Patterns of Aneuploidy and Signaling Consequences in Cancer

Zhakula-Kostadinova, N., & Taylor, A. M. (2024) · Cancer Research · doi:10.1158/0008-5472.can-24-0169 · Cited by 31

Fishing for understanding: Unlocking the zebrafish gene editor’s toolbox

Simone, B. W., Martínez‐Gálvez, G., WareJoncas, Z., & Ekker, S. C. (2018) · Methods · doi:10.1016/j.ymeth.2018.07.012 · Cited by 28

Epistasis between Pax6Sey and genetic background reinforces the value of defined hybrid mouse models for therapeutic trials

Hickmott, J. W., Gunawardane, U., Jensen, K., Korecki, A. J., & Simpson, E. M. (2018) · Gene Therapy · doi:10.1038/s41434-018-0043-6 · Cited by 26

Compensatory growth renders Tcf7l1a dispensable for eye formation despite its requirement in eye field specification

Young, R., Hawkins, T. A., Cavodeassi, F., Stickney, H. L., Schwarz, Q., Lawrence, L. M., Wierzbicki, C., Cheng, B. Y.-L., Luo, J., Ambrosio, E. M., et al. (2019) · eLife · doi:10.7554/elife.40093 · Cited by 25

Gonadotropin-releasing hormone neuron development in vertebrates

Duan, C., & Allard, J. B. (2020) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2020.113465 · Cited by 29

Microfibril-associated glycoprotein 4 (Mfap4) regulates haematopoiesis in zebrafish

Ong, S. L. M., de Vos, I. J. H. M., Meroshini, M., Poobalan, Y., & Dunn, N. R. (2020) · Scientific Reports · doi:10.1038/s41598-020-68792-8 · Cited by 28

Transforming nanobodies into high-precision tools for protein function analysis

Gettemans, J., & Dobbelaer, B. D. (2020) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00435.2020 · Cited by 29

Genetic compensation of triacylglycerol biosynthesis in the green microalga Chlamydomonas reinhardtii

Lee, Y., Park, R., Miller, S. M., & Li, Y. (2022) · The Plant Journal · doi:10.1111/tpj.15874 · Cited by 28

Alternative splicing mediates the compensatory upregulation of MBNL2 upon MBNL1 loss-of-function

Nitschke, L., Hu, R.-C., Miller, A. N., Lucas, L., & Cooper, T. A. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkac1219 · Cited by 30

Mitochondrial CHCHD2 and CHCHD10: Roles in Neurological Diseases and Therapeutic Implications

Zhou, W., Ma, D., & Tan, E. (2019) · The Neuroscientist · doi:10.1177/1073858419871214 · Cited by 26

Pre-clinical Mouse Models of Neurodegenerative Lysosomal Storage Diseases

Favret, J., Weinstock, N. I., Feltri, M. L., & Shin, D. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.00057 · Cited by 28

Modeling Lysosomal Storage Diseases in the Zebrafish

Zhang, T., & Peterson, R. T. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.00082 · Cited by 27

Amyloid precursor protein-b facilitates cell adhesion during early development in zebrafish

Banote, R. K., Chebli, J., Şatır, T. M., Varshney, G. K., Camacho, R., Ledin, J., Burgess, S. M., Abramsson, A., & Zetterberg, H. (2020) · Scientific Reports · doi:10.1038/s41598-020-66584-8 · Cited by 26

Validating Small Molecule Chemical Probes for Biological Discovery

Vu, V., Szewczyk, M. M., Nie, D. Y., Arrowsmith, C. H., & Baršytė-Lovejoy, D. (2022) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-032620-105344 · Cited by 26

A critical appraisal of the tafazzin knockdown mouse model of Barth syndrome: what have we learned about pathogenesis and potential treatments?

Ren, M., Miller, P. C., Schlame, M., & Phoon, C. K. L. (2019) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00504.2019 · Cited by 26

History-dependent physiological adaptation to lethal genetic modification under antibiotic exposure

Koganezawa, Y., Umetani, M., Sato, M., & Wakamoto, Y. (2022) · eLife · doi:10.7554/elife.74486 · Cited by 22

Computational tools for inferring transcription factor activity

Hecker, D., Lauber, M., Ardakani, F. B., Ashrafiyan, S., Manz, Q., Kersting, J., Hoffmann, M., Schulz, M. H., & List, M. (2023) · PROTEOMICS · doi:10.1002/pmic.202200462 · Cited by 27

CRISPR activation: identifying and using novel genes for plant disease resistance breeding

McLaughlin, J. E., Foka, I. C. K., Lawton, M. A., & Di, R. (2025) · Frontiers in Genome Editing · doi:10.3389/fgeed.2025.1596600 · Cited by 28

Ca 2+ concentration–dependent premature death of igfbp5a −/− fish reveals a critical role of IGF signaling in adaptive epithelial growth

Liu, C., Xin, Y., Bai, Y., Lewin, G., He, G., Mai, K., & Duan, C. (2018) · Science Signaling · doi:10.1126/scisignal.aat2231 · Cited by 25

Engineering Inflammation‐Resistant Cartilage: Bridging Gene Therapy and Tissue Engineering

Bonato, A., Fisch, P., Ponta, S., Fercher, D., Manninen, M. J., Weber, D. M., Eklund, K. K., Barreto, G., & Zenobi‐Wong, M. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202202271 · Cited by 25

Toxicity of O-Phenylphenol on Craniofacial Cartilage Development Through Ros-Induced Oxidative Stress in Zebrafish Embryos

Chen, X., Guo, J. J., Huang, Y., Li, Z., Yuan, W., Zeng, S., Zhu, H., Zhong, Y., Lin, W., Lu, H., et al. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.164396 · Cited by 25

An optimized pipeline for parallel image-based quantification of gene expression and genotyping after in situ hybridization

Dobrzycki, T., Krecsmarik, M., Bonkhofer, F., Patient, R. K., & Monteiro, R. M. (2018) · Biology Open · doi:10.1242/bio.031096 · Cited by 24

Some ASOs that bind in the coding region of mRNAs and induce RNase H1 cleavage can cause increases in the pre-mRNAs that may blunt total activity

Liang, X., Nichols, J. G., Hoyos, C. L. D., & Crooke, S. T. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa715 · Cited by 24

Transient receptor potential melastatin 8 is required for nitroglycerin- and calcitonin gene-related peptide–induced migraine-like pain behaviors in mice

Wei, C., Kim, B., & McKemy, D. D. (2022) · Pain · doi:10.1097/j.pain.0000000000002635 · Cited by 24

Inhibition of Aryl Hydrocarbon Receptor (AhR) Expression Disrupts Cell Proliferation and Alters Energy Metabolism and Fatty Acid Synthesis in Colon Cancer Cells

Karasová, M., Procházková, J., Tylichová, Z., Fedr, R., Cigánek, M., Machala, M., Dvořák, Z., Vyhlídalová, B., Bartoňková, I., Ehrmann, J., et al. (2022) · Cancers · doi:10.3390/cancers14174245 · Cited by 25

Metabolic Rewiring toward Oxidative Phosphorylation Disrupts Intrinsic Resistance to Ferroptosis of the Colon Adenocarcinoma Cells

Gotorbe, C., Durivault, J., Meira, W., Cassim, S., Ždralević, M., Pouysségur, J., & Vučetić, M. (2022) · Antioxidants · doi:10.3390/antiox11122412 · Cited by 24

Complex peptide hormone signaling in plant stem cells

Selby, R., & Jones, D. S. (2023) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2023.102442 · Cited by 24

The recent advances and future perspectives of genetic compensation studies in the zebrafish model

Rouf, M. A., Wen, L., Mahendra, Y., Wang, J., Zhang, K., Liang, S., Wang, Y., Li, Z., Wang, Y., & Wang, G. (2022) · Genes & Diseases · doi:10.1016/j.gendis.2021.12.003 · Cited by 72

Genetic compensation induced by deleterious mutations but not gene knockdowns

Rossi, A., Kontarakis, Z., Gerri, C., Nolte, H., Hölper, S., Krüger, M., & Stainier, D. Y. R. (2015) · Nature · doi:10.1038/nature14580 · Cited by 1,226

Detouring the roadblocks in gene expression

Junker, J. P. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0107-5 · Cited by 4

How widespread is the phenomenon of dosage compensation?

Lucchesi, J. C. (1993) · Seminars in Developmental Biology · doi:10.1006/sedb.1993.1016 · Cited by 5

Genetics in Light of Transcriptional Adaptation

Kontarakis, Z., & Stainier, D. Y. R. (2020) · Trends in Genetics · doi:10.1016/j.tig.2020.08.008 · Cited by 41