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Observational Research, Randomised Trials, and Two Views of Medical Science
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Two views exist of medical science, says the author, one emphasizing discovery and explanation, the other emphasizing evaluation of interventions.
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“Because the strengths and limitations of methods used to conduct research with routinely collected data may be contentious, a clear description of a study’s objectives is essential [23,24].”
From The Reporting of Studies Conducted Using Observational Routinely-Collected Health Data (RECORD) statement. (2015) · cites this paper as [23]
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Metadata
- Authors
- Vandenbroucke, J. P.
- Affiliations
- Royal Netherlands Academy of Arts and Sciences (NL)
- Corresponding author
- Vandenbroucke, Jan P
- ORCID
- Vandenbroucke, Jan P
- Venue
- PLoS Medicine
- Publisher
- Public Library of Science (PLoS)
- Published
- 2008-03-11
- Volume
- 5
- Issue
- 3
- Pages
- e67
- ISSN
- 1549-1277 (ISSN-L)
- 1549-1676
- PMC
- PMC2265762
- OpenAlex
- W2090226269
- Cited by
- 416
- References
- 66
- Citations by year
- 2026: 15 · 2025: 5 · 2024: 15 · 2023: 32 · 2022: 22 · 2021: 23 · 2020: 23 · 2019: 25 · 2018: 14 · 2017: 14 · 2016: 17 · 2015: 26 · 2014: 20 · 2013: 36 · 2012: 31
- FWCI
- 30.62
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- London School of Hygiene and Tropical Medicine
- Topics
- Physical Sciences › Mathematics › Statistics and Probability › Advanced Causal Inference Techniques
- Social Sciences › Arts and Humanities › History and Philosophy of Science › Philosophy of Biology and Scientific Explanation
- Health Sciences › Nursing › Research and Theory › Methodologies in Health Research and Practice
- Keywords
- observational studies, randomised trials, medical sciences, intervention evaluation, philosophy of medicine
- MeSH terms
- Contraceptives, Oral, Evaluation Studies as Topic, Factor V, Female, Follow-Up Studies, Humans, Prospective Studies, Retrospective Studies, Case-Control Studies, Randomized Controlled Trials as Topic, Biomedical Research, Venous Thromboembolism
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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